Browse research from the Peninsula Medical School.

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Submissions from 2011

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Factors associated with variability in the assessment of UK doctors' professionalism: analysis of survey results, JL Campbell, M Roberts, C Wright, J Hill, and et al

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A tool to measure the attributes of receiving IV therapy in a home versus hospital setting: the Multiple Sclerosis Relapse Management Scale (MSRMS)., Afsane Riazi, Bernadette Porter, Jeremy Chataway, Alan J. Thompson, and Jeremy C. Hobart

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Protocol for a double-blind randomised placebo-controlled trial of lithium carbonate in patients with amyotrophic Lateral Sclerosis (LiCALS) [Eudract number: 2008-006891-31], Ammar Al-Chalabi, Pamela J. Shaw, Carolyn A. Young, Karen E. Morrison, Caroline Murphy, Marie Thornhill, Joanna Kelly, I. Nicholas Steen, P. Nigel Leigh, and Oliver Hanemann

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Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis, Peter Donnelly, Stephen Sawcer, Garrett Hellenthal, Matti Pirinen, Chris C.A. Spencer, Nikolaos A. Patsopoulos, Loukas Moutsianas, Alexander Dilthey, Zhan Su, Colin Freeman, Sarah E. Hunt, Sarah Edkins, Emma Gray, David R. Booth, Simon C. Potter, An Goris, Gavin Band, Annette Bang Oturai, Amy Strange, Janna Saarela, Céline Bellenguez, Bertrand Fontaine, Matthew Gillman, Bernhard Hemmer, Rhian Gwilliam, Frauke Zipp, Alagurevathi Jayakumar, Roland Martin, Stephen Leslie, and Stanley Hawkins

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Changes in iron-regulatory gene expression occur in human cell culture models of Parkinson's disease., C. B. Carroll, M. L. Zeissler, N. Chadborn, K. Gibson, G. Williams, J. P. Zajicek, K. E. Morrison, and C. O. Hanemann

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The Map of Medicine: a review of evidence for its impact on healthcare., Nicola Brennan, Karen Mattick, and Tricia Ellis

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NFATc1 affects mouse splenic B cell function by controlling the calcineurin–NFAT signaling network, Sankar Bhattacharyya, Jolly Deb, Amiya K. Patra, Pham DA Thuy, Wen Chen, Martin Vaeth, Friederike Berberich-Siebelt, Stefan Klein-Hessling, Edward D. Lamperti, Kurt Reifenberg, Julia Jellusova, Astrid Schweizer, Lars Nitschke, Ellen Leich, Andreas Rosenwald, Cornelia Brunner, Swen Engelmann, Ursula Bommhardt, Andris Avots, Martin R. Müller, Eisaku Kondo, and Edgar Serfling

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Designing clinical trials in older people., C. B. Carroll and J. P. Zajicek

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Patients' views of physical activity as treatment for depression: a qualitative study, Aidan Searle, Michael Calnan, Glyn Lewis, John Campbell, Adrian Taylor, and Katrina Turner

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Propofol and children--what we know and what we do not know., AE Rigby-Jones and JR Sneyd

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Exploring the Map of Medicine's potential in undergraduate medical education., Nicola Brennan and Karen Mattick

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Management of patient adherence to medications: protocol for an online survey of doctors, pharmacists and nurses in Europe, W Clyne, C Mshelia, S Hall, S McLachlan, and et al

Radiological findings in patients undergoing revision endoscopic sinus surgery: a retrospective case series study, HS Khalil, AZ Eweiss, and N Clifton

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The problem with health measurement., Stefan J. Cano and Jeremy C. Hobart

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Women's experience of colposcopy: a qualitative investigation, Dawn R. Swancutt, Sheila M. Greenfield, David M. Luesley, and Sue Wilson

Submissions from 2010

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Integrating the promotion of physical activity within a smoking cessation programme: findings from collaborative action research in UK Stop Smoking Services., Adrian H. Taylor, Emma S. Everson-Hock, and Michael Ussher

Study protocol for a randomized controlled trial comparing mindfulness-based cognitive therapy with maintenance anti-depressant treatment in the prevention of depressive relapse/recurrence: the PREVENT trial., Willem Kuyken, Sarah Byford, Richard Byng, Tim Dalgleish, Glyn Lewis, Rod Taylor, Edward R. Watkins, Rachel Hayes, Paul Lanham, David Kessler, Nicola Morant, and Alison Evans

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Patient-orientated longitudinal study of multiple sclerosis in south west England (The South West Impact of Multiple Sclerosis Project, SWIMS) 1: protocol and baseline characteristics of cohort., John P. Zajicek, Wendy M. Ingram, Jane Vickery, Siobhan Creanor, Dave E. Wright, and Jeremy C. Hobart

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First‐trimester combined screening for trisomy 21 at 7–14 weeks' gestation, D Wright, K Spencer, KK Kagan, N Tørring, and et al

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Selecting GLP-1 agonists in the management of type 2 diabetes: differential pharmacology and therapeutic benefits of liraglutide and exenatide., J Pinkney, T Fox, and L Ranganath

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ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma, Sylwia Ammoun, Clare H. Cunliffe, Jeffrey C. Allen, Luis Chiriboga, Filippo G. Giancotti, David Zagzag, C. Oliver Hanemann, and Matthias A. Karajannis

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Cross-trimester repeated measures testing for Down's syndrome screening: an assessment., D. Wright, I. Bradbury, F. Malone, M. D'Alton, A. Summers, T. Huang, S. Ball, A. Baker, B. Nix, D. Aitken, J. Crossley, H. Cuckle, and K. Spencer

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CBD & D9-THC - the two faces of cannabis, N/A Zeissler, CB Carroll, and J Zajicek

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The transition from medical student to junior doctor: today's experiences of Tomorrow's Doctors., Nicola Brennan, Oonagh Corrigan, Jon Allard, Julian Archer, Rebecca Barnes, Alan Bleakley, Tracey Collett, and Bere SR de

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Bio-informatics analysis of a gene co-expression module in adipose tissue containing the diet-responsive gene Nnat., X Li.X, PA Thomason, DJ Withers, and J Scott

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Cannabinoids Are Neuroprotective in a Human Cell Culture Model of Parkinson's Disease, CB Carroll, ML Zeissler, V Stone, CO Hanemann, and JP Zajicek

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Changes in Iron-Regulatory Gene Expression Occur in Human Cell Culture Models of PD, CB Carroll, ML Zeissler, N Chadborn, K Gibson, GJ Williams, KE Morrison, JP Zajicek, and CO Hanemann

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Effects of HIF-1 and HIF2 on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts, S Biswas, H Troy, R Leek, Y-L Chung, and et al

Endoscopic Resection and Topical 5-Fluorouracil as an Alternative Treatment to Craniofacial Resection for the Management of Primary Intestinal-Type Sinonasal Adenocarcinoma, S Mackie, T Malik, and H Khalil

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Impact of workplace based assessment on doctors' education and performance: a systematic review., A Miller and J Archer

Persistent CSF Rhinorrhoea, Pneumocephalus, and Recurrent Meningitis Following Misdiagnosis of Olfactory Neuroblastoma, N Barua, DA Hilton, W Mukonoweshuro, H Khalil, and L Pobereskin

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Physical activity as a treatment for depression: the TREAD randomised trial protocol, Helen Baxter, Rachel Winder, Melanie Chalder, Christine Wright, Sofie Sherlock, Anne Haase, Nicola J. Wiles, Alan A. Montgomery, Adrian H. Taylor, Ken R. Fox, Debbie A. Lawlor, Tim J. Peters, Deborah J. Sharp, John Campbell, and Glyn Lewis

Submissions from 2009

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Role of Hypoxia‐Inducible Factors in Epigenetic Regulation via Histone Demethylases, J Yang, I Ledaki, H Turley, KC Gatter, and et al

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Acquired neuromyotonia following upper respiratory tract infection: a case report., I Imam, S Edwards, and CO Hanemann

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Aquired neuromyotonia following upper respiratory tract infection, I Imam, S Edwards, and CO Hanemann

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Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin, insulin, and glucose., Katrina Kos, Steve Wong, Bee Tan, Anders Gummesson, Margareta Jernas, Niclas Franck, David Kerrigan, Fredrik H. Nystrom, Lena M.S. Carlsson, Harpal S. Randeva, Jonathan H. Pinkney, and John P.H. Wilding

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Cauda equina syndrome following a lumbar puncture., Alexandra J. Sinclair, Camille Carroll, and Brendan Davies

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Objectively measured physical activity and its association with adiponectin and other novel metabolic markers: a longitudinal study in children (EarlyBird 38)., BS Metcalf, AN Jeffery, J Hosking, LD Voss, N Sattar, and TJ Wilkin

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Chemotherapy related encephalopathy in a patient with Stage IV cervical carcinoma treated with cisplatin and 5-fluorouracil: a case report, AL Chue, IN Fernando, SA Hussain, and DA Yates

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The size of the treatment effect: do patients and proxies agree?, der Linden FAH van, Jolijn J. Kragt, Jeremy C. Hobart, Martin Klein, Alan J. Thompson, der Ploeg HM van, Chris H. Polman, and Bernard M.J. Uitdehaag

Submissions from 2008

Exposing the key functions of a complex intervention for shared care in mental health: case study of a process evaluation., Richard Byng, Ian Norman, Sally Redfern, and Roger Jones

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The cervical dystonia impact profile (CDIP-58): can a Rasch developed patient reported outcome measure satisfy traditional psychometric criteria?, Stefan J. Cano, Thomas T. Warner, Alan J. Thompson, Kailash P. Bhatia, Ray Fitzpatrick, and Jeremy C. Hobart

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A guide to medication review, W Clyne, A Blenkinsopp, and R Seal

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c-Jun is a negative regulator of myelination., David B. Parkinson, Ambily Bhaskaran, Peter Arthur-Farraj, Luke A. Noon, Ashwin Woodhoo, Alison C. Lloyd, M. Laura Feltri, Lawrence Wrabetz, Axel Behrens, Rhona Mirsky, and Kristján R. Jessen

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A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs), D Melzer, JRB Perry, D Hernandez, and et al

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Surveillance of cirrhosis for hepatocellular carcinoma: a cost-utility analysis., Coon J. Thompson, G. Rogers, P. Hewson, D. Wright, R. Anderson, S. Jackson, S. Ryder, M. Cramp, and K. Stein

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Beyond the limits of clinical governance? The case of mental health in English primary care, Linda Gask, Anne Rogers, Stephen Campbell, and Rod Sheaff

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Women's colposcopy experience and preferences: a mixed methods study., Dawn R. Swancutt, Sheila M. Greenfield, and Sue Wilson

Submissions from 2007

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The feminisation of British neurology: implications for workforce planning., C. B. Carroll, DSNAP Tengah, C. Lawthom, and G. Venables

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Hypoxia-regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer, SA Hussain, R Ganesan, G Reynolds, L Gross, and et al

Submissions from 2006

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Can learning organizations survive in the newer NHS?, Rod Sheaff and David Pilgrim

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Sowing date, transplanting, plant density and nitrogen fertilization affect indigo production from Isatis species in a Mediterranean region of Spain, E Sales, R Kanhonou, C Baixauli, A Giner, D Cooke, K Gilbert, I Arrillaga, J Segura, and R Ros

Submissions from 2005

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HCV-specific cellular immune responses in subjects exposed, but uninfected by HCV, MK Metzner, A Houldsworth, A Demaine, E Kaminski, and ME Cramp

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Muscle cramps and weakness secondary to graft versus host disease fasciitis., Camille B. Carroll, D. A. Hilton, M. Hamon, and J. P. Zajicek

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Construction and validation of a Bovine Innate Immune Microarray, L Donaldson, T Vuocolo, C Gray, Y Strandberg, and et al

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HCV-specific cellular immune responses in subjects exposed to but uninfected by HCV, M Metzner, A Houldsworth, AG Demaine, E Kaminski, and ME Cramp

Histopathological changes in the human larynx following expanded polytetrafluroethylene (Gore-Tex®) implantation, K Rajkumar, HS Khalil, M Elloy, E Sheffield, and DL Baldwin

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Laughing all the way to the item bank: how to improve your treatment effect by improving your outcome measurement, R Baron and J Hobart

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Quantifying drug-induced dyskinesias in the arms using digitised spiral-drawing tasks, Xuguang Liu, Camille B. Carroll, Shou Yan Wang, John Zajicek, and Peter G. Bain

Submissions from 2004

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Quantitative Analysis of Indigo and Indigo Precursors in Leaves of Isatis spp. and Polygonum tinctorium, KG Gilbert, HG Maule, B Rudolph, M Lewis, and et al

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A phase I/II study of gemcitabine and fractionated cisplatin in an outpatient setting using a 21-day schedule in patients with advanced and metastatic bladder cancer, SA Hussain, DD Stocken, P Riley, DH Palmer, and et al

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Long-term results of a phase II study of synchronous chemoradiotherapy in advanced muscle invasive bladder cancer, SA Hussain, DD Stocken, DR Peake, JG Glaholm, and et al

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Stroke in Devon: knowledge was good, but action was poor., C. Carroll, J. Hobart, C. Fox, L. Teare, and J. Gibson

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Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death, David B. Parkinson, Ambily Bhaskaran, Sarah Dickinson, and Anna Droggiti

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Provision of 24 hour acute neurology care by neurologists: manpower requirements in the UK., C. Carroll and J. Zajicek

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A randomised controlled trial and cost effectiveness study of systematic screening (targeted and total population screening) versus routine practice for the detection of atrial fibrillation in the over 65s: (SAFE) [ISRCTN19633732], Dawn Swancutt, Richard Hobbs, David Fitzmaurice, Jonathan Mant, Ellen Murray, Sue Jowett, James Raftery, Stirling Bryan, Michael Davies, and Gregory Lip

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Do on-off variations cause discrepancies in the historical items of the UPDRS?, Camille B. Carroll and Peter G. Bain

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Quantitative analysis of indigo and indigo precursors in leaves of Isatis spp. and Polygonum tinctorium., KG Gilbert, HG Maule, B Rudolph, M Lewis, H Vandenburg, E Sales, S Tozzi, and DT Cooke

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Raised intracranial pressure presenting with spontaneous periorbital bruising: two case reports, S Hadjikoutis, CB Carroll, and GTP Plant

Submissions from 2003

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Complete analysis of the B‐cell response to a protein antigen, from in vivo germinal centre formation to 3‐D modelling of affinity maturation, CL Adams, MKL Macleod, Milner‐White E James, R Aitken, P Garside, and DI Stott

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Proapoptotic genes BAX and CD40L are predictors of survival in transitional cell carcinoma of the bladder, SA Hussain, R Ganesan, L Hiller, PG Murray, and et al

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A new HPLC-ELSD method to quantify indican in Polygonum tinctorium L. and to evaluate beta-glucosidase hydrolysis of indican for indigo production., LG Angelini, E Campeol, S Tozzi, KG Gilbert, DT Cooke, and P John

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A New HPLC‐ELSD Method To Quantify Indican in Polygonum tinctorium L. and To Evaluate β‐Glucosidase Hydrolysis of Indican for Indigo Production, LG Angelini, E Campeol, S Tozzi, and et al

Canal wall down mastoidectomy: A long term commitment to the outpatients?, HS Khalil and PC Windle-Taylor

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Constitutively active protein kinase B enhances Lck and Erk activities and influences thymocyte selection and activation., AK Patra

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Non-legitimate illness, embodied experience and the moral career: the case of ME/CFS, T Collett

Submissions from 2001

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Role of the Bloom's syndrome helicase in maintenance of genome stability, ID Hickson, SL Davies, J-L Li, NC Levitt, and et al

Submissions from 2000

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Qualitative analysis of indigo precursors from woad by HPLC and HPLC-MS, KG Gilbert, DJ Hill, C Crespo, A Mas, M Lewis, B Rudolph, and DT Cooke

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Qualitative analysis of indigo precursors from woad by HPLC and HPLC‐MS, KG Gilbert (nee Stoker), DJ Hill, C Crespo, A Mas, and et al

Submissions from 1998

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An Improved Method for the Large-Scale Processing of Woad (Isatis tinctoria) for Possible Commercial Production of Woad Indigo, KG Stoker, DT Cooke, and DJ Hill

Submissions from 1997

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Protein Phosphatase β, a Putative Type‐2A Protein Phosphatase from the Human Malaria Parasite Plasmodium Falciparum, J Li and DA Baker

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Reversal of parkinsonian symptoms in primates by antagonism of excitatory amino acid transmission: potential mechanisms of action., I. J. Mitchell and C. B. Carroll

Submissions from 1991

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Fludarabine phosphate for the treatment of low grade lymphoid malignancy, JS Whelan, CL Davis, S Rule, M Ranson, and et al