Abstract
The pharmacokinetics of propofol are relatively well described in the pediatric population. Recent work has confirmed the validity of allometric scaling for predicting propofol disposition across different species and for describing pediatric ontogenesis. In the first year of life, allometric models require adjustment to reflect ontogeny of maturation. Pharmacodynamic data for propofol in children are scarcer, because of practical difficulties in data collection and the limitations of currently available depth of anesthesia monitors for pediatric use. Hence, questions relating to the comparative sensitivity of children to propofol, and differences in time to peak effect relative to adults, remain unanswered. K(eo) half-lives have been determined for pediatric kinetic models using time to peak effect techniques but are not currently incorporated into commercially available target-controlled infusion pumps.
DOI
10.1111/j.1460-9592.2010.03454.x
Publication Date
2011-03-01
Publication Title
Paediatr Anaesth
Volume
21
Issue
3
Organisational Unit
Peninsula Medical School
Keywords
Algorithms, Anesthesia, Intravenous, Anesthetics, Body Weight, Child, Consciousness Monitors, Drug Delivery Systems, Humans, Infant, Newborn, Infusions, Propofol
First Page
247
Last Page
254
Recommended Citation
Rigby-Jones, A., & Sneyd, J. (2011) 'Propofol and children--what we know and what we do not know.', Paediatr Anaesth, 21(3), pp. 247-254. Available at: https://doi.org/10.1111/j.1460-9592.2010.03454.x
