Browse research from the Peninsula Medical School.

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Submissions from 2016

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Emotional logic development profiles – validating the benefits and safety of emotional logic training, Trevor Griffiths, Daniel Zahra, and Marian Langsford

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Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth, A McIntyre, A Hulikova, I Ledaki, C Snell, and et al

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Making a difference: a qualitative study of an inter-professional social engagement project, R Ayres, R carter, and S stevens

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The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors, L. Zhou, J. Lyons-Rimmer, S. Ammoun, J. Müller, E. Lasonder, V. Sharma, E. Ercolano, D. Hilton, I. Taiwo, M. Barczyk, and C. O. Hanemann

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CD147 handles lipid: a new role for anti-cancer target, Thomas F. Baumert and Daniel J. Felmlee

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Delta-9-tetrahydrocannabinol protects against MPP+ toxicity in SH-SY5Y cells by restoring proteins involved in mitochondrial biogenesis, Camille B. Carroll, Marie Louise Zeissler, Jordan Eastwood, Kieran McCorry, Oliver O. Hanemann, and John P. Zajicek

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Diverse impacts of the rs58542926 E167K variant in TM6SF2 on viral and metabolic liver disease phenotypes, Jacob George, Mohammed Eslam, Alessandra Mangia, Thomas Berg, Henry Lik Yuen Chan, William L. Irving, Gregory J. Dore, Maria Lorena Abate, Elisabetta Bugianesi, Leon A. Adams, Mustafa A.M. Najim, Luca Miele, Martin Weltman, Lindsay Mollison, Wendy Cheng, Stephen Riordan, Janett Fischer, Manuel Romero-Gomez, Ulrich Spengler, Jacob Nattermann, Antony Rahme, David Sheridan, David R. Booth, Duncan McLeod, Elizabeth Powell, Christopher Liddle, Mark W. Douglas, and der Poorten D van

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Training to promote dementia support., J Kwakwa, H Ashforth, A Pritchard, and R Trout

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A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development., Amiya Kumar Patra

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Key points to facilitate the adoption of computer-based assessments., SA Burr, AC Chatterjee, S Gibson, L Coombes, and S Wilkinson

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Accounting for test reliability in student progression: the reliable change index, Daniel Zahra, Craig Hedge, Francesca Pesola, and Steven Burr

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The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer, LL da Motta, I Ledaki, K Purshouse, S Haider, and et al

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When I say.........capability, Hilary Neve and Sally Hanks

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CUMSUM cannot define competency, E. J. Drake and J. R. Sneyd

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'He left me a message on Facebook': comparing the risk profiles of self-harming patients who leave paper suicide notes with those who leave messages on new media, JR Barrett, H Shetty, M Broadbent, S Cross, and et al

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What approaches to social prescribing work, for whom, and in what circumstances? A protocol for a realist review, Kerryn Husk, Kelly Blockley, Rebecca Lovell, Alison Bethel, Dan Bloomfield, Sara Warber, Mark Pearson, Iain Lang, Richard Byng, and Ruth Garside

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The association between habitual physical activity and cigarette cravings, and influence of smokers’ characteristics in disadvantaged smokers not ready to quit, M. Haasova, F. C. Warren, T. Thompson, M. Ussher, and A. H. Taylor

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Activation of multiple growth factor signalling pathways is frequent in meningiomas, David A. Hilton, Aditya Shivane, Leanne Kirk, Kayleigh Bassiri, Doyo G. Enki, and C. Oliver Hanemann

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Measuring arm function early after stroke: is the DASH good enough?, Jeremy Hobart, Karen Baker, Louise Barrett, E. Diane Playford, Trefor Aspden, and Afsane Riazi

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‘Midwives Overboard!’ Inside their hearts are breaking, their makeup may be flaking but their smile still stays on, S Pezaro, W Clyne, A Turner, and et al

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The importance of nerve microenvironment for schwannoma development, Helen Morrison, Alexander Schulz, Robert Büttner, Christian Hagel, Stephan L. Baader, Lan Kluwe, Johannes Salamon, Victor Felix Mautner, Thomas Mindos, David B. Parkinson, Jeffrey R. Gehlhausen, and D. Wade Clapp

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NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells, Hani Alrefai, Khalid Muhammad, Ronald Rudolf, Duong Anh Thuy Pham, Stefan Klein-Hessling, Amiya K. Patra, Andris Avots, Valesca Bukur, Ugur Sahin, Stefan Tenzer, Matthias Goebeler, Andreas Kerstan, and Edgar Serfling

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Participation in environmental enhancement and conservation activities for health and well-being in adults: a review of quantitative and qualitative evidence, Ruth Garside, Kerryn Husk, Rebecca Lovell, Chris Cooper, and Will Stahl-Timmins

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Tspan5 is an independent favourable prognostic factor and suppresses tumour growth in gastric cancer, P He, S Wang, X Zhang, Y Gao, and et al

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A comparison of teaching three common ear, nose, and throat conditions to medical students through video podcasts and written handouts: a pilot study, M Edmond, F Neville, and HS Khalil

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Rising to the challenge: acute stress appraisals and selection centre performance in applicants to postgraduate specialty training in anaesthesia, Martin J. Roberts, Thomas C.E. Gale, John S. McGrath, and Mark R. Wilson

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The medical licensing examination debate, Julian Archer, Nick Lynn, Lee Coombes, Martin Roberts, Tom Gale, and de Bere S Regan

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Implementing a patient-initiated review system for people with rheumatoid arthritis: a prospective, comparative service evaluation, Victoria A. Goodwin, Priyamvada Paudyal, Mark G. Perry, Nikki Day, Annie Hawton, Christian Gericke, Obioha C. Ukoumunne, and Richard Byng

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Multi-component assessment of chronic obstructive pulmonary disease: an evaluation of the ADO and DOSE indices and the global obstructive lung disease categories in international primary care data sets, Rupert C. Jones, David Price, Niels H. Chavannes, Amanda J. Lee, Michael E. Hyland, Björn Ställberg, Karin Lisspers, Josefin Sundh, der Molen T van, and Ioanna Tsiligianni

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Health Worker Focused Distributed Simulation for Improving Capability of Health Systems in Liberia, Thomas C.E. Gale, Arunangsu Chatterjee, Nicholas E. Mellor, and Richard J. Allan

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Inter-Organizational Networks in Health Care: Program Networks, Care Networks, and Integrated Care, E Ferlie, K Montgomery, A Reff Pederson, R Sheaff, and J Schofield

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Interpreting multisource feedback: online study of consensus and variation among GP appraisers, John Campbell, Christine Wright, Luke McGowan, Martin J. Roberts, Di Jelley, and Arunangsu Chatterjee

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Low–Blood Glucose Avoidance Training Improves Glycemic Variability in Adults With Type 1 Diabetes Complicated by Impaired Awareness of Hypoglycemia: HypoCOMPaSS Trial, HK Tan, SA Little, L Leelarathna, E Walkinshaw, A Lubina-Solomon, J Hosking, J Speight, D Kerr, SR Heller, ML Evans, JAM Shaw, and D Flanagan

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Developing family interventions for adolescent HIV prevention in South Africa, C Kuo, M Atujuna, C Mathews, DJ Stein, and et al

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A study to assess the influence of interprofessional point of care simulation training on safety culture in the operating theatre environment of a university teaching hospital, Thomas Gale, Theresa Hinde, Ian Anderson, Martin Roberts, and Paul Sice

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Twelve tips for assessment psychometrics, Lee Coombes, Martin Roberts, Daniel Zahra, and Steven Burr

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Bladder Sparing Approaches for Muscle-Invasive Bladder Cancers, OMS El-Taji, S Alam, and SA Hussain

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WAP four-disulfide core domain protein 2 gene(WFDC2) is a target of estrogen in ovarian cancer cells, Y Chen, S Wang, T Liu, and et al

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Fatty acid activated PPARγ promotes tumorigenicity of prostate cancer cells by up regulating VEGF via PPAR responsive elements of the promoter, FS Forootan, SS Forootan, X Gou, J Yang, and et al

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hTERT mediates gastric cancer metastasis partially through the indirect targeting of ITGB1 by microRNA-29a, B He, Y-F Xiao, B Tang, Y-Y Wu, and et al

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Decision analytic model exploring the cost and cost-offset implications of street triage, Margaret Heslin, Lynne Callaghan, Martin Packwood, Vincent Badu, and Sarah Byford

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How can frontline expertise and new models of care best contribute to safely reducing avoidable acute admissions? A mixed-methods study of four acute hospitals, J Pinkney, S Rance, J Benger, H Brant, S Joel-Edgar, D Swancutt, D Westlake, M Pearson, D Thomas, I Holme, R Endacott, R Anderson, M Allen, S Purdy, J Campbell, WR Sheaff, and R Byng

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Dual PI-3 kinase/mTOR inhibition impairs autophagy flux and induces cell death independent of apoptosis and necroptosis, Shouqing Luo, Robert W. Button, Joseph H. Vincent, and Conor J. Strang

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Accessible polyvocality and paired talk: how family therapists talk positive connotation into being, Lynsey Williams and Tim Auburn

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A Core Curriculum for Sociology in UK Undergraduate Medical Education, T Collett, L Brooks, S Forrest, J Harden, M Kelly, K Kendall, Stewart S MacBride, M Sbaiti, and F Stevenson

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A multinational cross-sectional survey of the management of patient medication adherence by European healthcare professionals, W Clyne, C Mshelia, S McLachlan, P Jones, and et al

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An Exploratory Analysis of the Smoking and Physical Activity Outcomes From a Pilot Randomized Controlled Trial of an Exercise Assisted Reduction to Stop Smoking Intervention in Disadvantaged Groups, Tom Paul Thompson, Colin J. Greaves, Richard Ayres, Paul Aveyard, Fiona C. Warren, Richard Byng, RS Taylor, John L. Campbell, Michael Ussher, Colin Green, Susan Michie, Robert West, and A Taylor

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Anti-envelope antibody responses in individuals at high risk of hepatitis C virus who resist infection, A. H. Patel, R. E. Swann, P. Mandalou, M. W. Robinson, M. M. Ow, S. K.H. Foung, J. McLauchlan, and M. E. Cramp

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A qualitative study of diverse providers' behaviour in response to commissioners, patients and innovators in England: Research protocol, Rod Sheaff, Joyce Halliday, Mark Exworthy, Pauline Allen, Russell Mannion, Sheena Asthana, Alex Gibson, and Jonathan Clark

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Brain health: time matters in multiple sclerosis, Gavin Giovannoni, Helmut Butzkueven, Suhayl Dhib-Jalbut, Jeremy Hobart, Gisela Kobelt, George Pepper, Maria Pia Sormani, Christoph Thalheim, Anthony Traboulsee, and Timothy Vollmer

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Can’t Count or Won’t Count? Embedding Quantitative Methods in Substantive Sociology Curricula: A Quasi-Experiment, Luke Sloan, Malcolm Williams, Sin Yi Cheung, Carole Sutton, Sebastian Stevens, and Libby Runham

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Chromosomal microarray testing in adults with intellectual disability presenting with comorbid psychiatric disorders, Kate Wolfe, André Strydom, Deborah Morrogh, Jennifer Carter, Peter Cutajar, Mo Eyeoyibo, Angela Hassiotis, Jane McCarthy, Raja Mukherjee, Dimitrios Paschos, Nagarajan Perumal, Stephen Read, Rohit Shankar, Saif Sharif, Suchithra Thirulokachandran, Johan H. Thygesen, Christine Patch, Caroline Ogilvie, Frances Flinter, Andrew McQuillin, and Nick Bass

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Core Outcomes and Common Data Elements in Chronic Subdural Hematoma: A Systematic Review of the Literature Focusing on Baseline and Peri-Operative Care Data Elements, Angelos G. Kolias, Aswin Chari, Katie C. Hocking, Ellie Edlmann, Carole Turner, Thomas Santarius, and Peter J. Hutchinson

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DeShazer, M.K.Mammographies: The Cultural Discourses of Breast Cancer Narratives. Michigan: University of Michigan Press. 2013. 239 pp £28.50 ISBN 978–0472118823 (hbk), J Tredinnick‐Rowe

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Determining the haemodynamic significance of arterial stenosis: the relationship between CT angiography, computational fluid dynamics, and non-invasive fractional flow reserve, C. L. Pang, R. Alcock, N. Pilkington, T. Reis, and C. Roobottom

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Experience of Using Simulation Technology and Analytics During the Ebola Crisis to Empower Frontline Health Workers and Improve the Integrity of Public Health Systems, Nicholas Mellor, Hetty Horton, David Luke, Jon Meadows, Arunangsu Chatterjee, and Thomas Gale

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Exploring the relationship between childhood obesity and proximity to the coast: A rural/urban perspective, Benedict W. Wheeler, Sophie L. Wood, Philippe R. Demougin, Sahran Higgins, Kerryn Husk, and Mathew White

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Factors associated with study attrition in a pilot randomised controlled trial to explore the role of exercise-assisted reduction to stop (EARS) smoking in disadvantaged groups, T. P. Thompson, C. J. Greaves, R. Ayres, P. Aveyard, F. C. Warren, R. Byng, RS Taylor, J. L. Campbell, M. Ussher, S. Michie, R. West, and AH Taylor

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Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2), K Glebov, P Wunderlich, I Karaca, and J Walter

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Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries, Danial Martin

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Has the ‘Fast-Track’ referral system affected the route of presentation and/or clinical outcomes in patients with colorectal cancer?, Luke Thornton, Harriet Reader, Stevan Stojkovic, Victoria Allgar, and Nick Woodcock

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Identification of blood biomarkers for use in point of care diagnosis tool for Alzheimer's disease, E. Jammeh, P. Zhao, C. Carroll, S. Pearson, and E. Ifeachor

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Inequity in cardiovascular care in the English National Health Service (NHS): a scoping review of the literature, Sheena Asthana, Graham Moon, Alex Gibson, Trevor Bailey, Paul Hewson, and Chris Dibben

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Learning organizations: Panacea or irrelevance?, Rod Sheaff

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Lone parents’ experiences of Higher Education, Lucy Spowart

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Making a difference: a qualitative study of an inter-professional social engagement project, R Ayres, S stevens, and de bere S regan

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Measuring spinal surgical success: the proportion achieving acceptable symptoms, Jeremy Hobart

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Modifying Hofstee standard setting for assessments that vary in difficulty, and to determine boundaries for different levels of achievement, SA Burr, J Whittle, LC Fairclough, L Coombes, and I Todd

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New perspectives for preventing hepatitis C virus liver graft infection, Thomas F. Baumert, Daniel J. Felmlee, Audrey Coilly, Raymond T. Chung, and Didier Samuel

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Patient- and carer-held health records: Can they improve annual health checks for patients with learning disability?, Rohit Shankar, Guy Bradley-Smith, Philip Brigham, John Devapriam, Amy Osborne, and Sharon Axby

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Postpartum Regression of a Presumed Cavernous Meningioma, See Yung Phang and Peter Whitfield

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Posttraumatic Stress Disorder Among Older Patients with Chronic Obstructive Pulmonary Disease, MC Chung, RCM Jones, SA Harding, and J Campbell

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Promoting and maintaining physical activity in the transition to retirement: a systematic review of interventions for adults around retirement age, S. Baxter, M. Johnson, N. Payne, H. Buckley-Woods, L. Blank, E. Hock, A. Daley, A. Taylor, T. Pavey, G. Mountain, and E. Goyder

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Proteome and phosphoproteome analysis of stratified meningiomas, S Ferluga, J Dunn, E Lasonder, V Sharma, DA Hilton, C Adams, and CO Hanemann

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¿Que es la Semiótica Médica?, JF Tredinnick-Rowe

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Rare variants analysis of cutaneous malignant melanoma genes in Parkinson's disease, H. R. Morris, S. J. Lubbe, V. Escott-Price, A. Brice, T. Gasser, A. M. Pittman, J. Bras, J. Hardy, P. Heutink, N. M. Wood, A. B. Singleton, D. G. Grosset, C. B. Carroll, M. H. Law, F. Demenais, M. M. Iles, D. T. Bishop, J. Newton-Bishop, and N. M. Williams

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Social Stories in mainstream schools for children with autism spectrum disorder: a feasibility randomised controlled trial, David Marshall, Barry Wright, Victoria Allgar, Joy Adamson, Christine Williams, Hannah Ainsworth, Liz Cook, Danielle Varley, Lisa Hackney, Paul Dempster, Shehzad Ali, Dominic Trepel, Moore D Collingridge, Elizabeth Littlewood, and Dean McMillan

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Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism, DN Mitroi, AU Deutschmann, M Raucamp, I Karunakaran, K Glebov, M Hans, J Walter, J Saba, M Gräler, D Ehninger, E Sopova, O Shupliakov, D Swandulla, and Echten-Deckert G van

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The Effectiveness and Micro-costing Analysis of a Universal, School-Based, Social–Emotional Learning Programme in the UK: A Cluster-Randomised Controlled Trial, Vashti Berry, Nick Axford, Sarah Blower, Rod S. Taylor, Rhiannon Tudor Edwards, Kate Tobin, Carys Jones, and Tracey Bywater

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The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells, Christian Berger, Rouven Ding, Kevin Weynans, Torsten Bossing, and Claudia S. Barros

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The impact of large scale licensing examinations in highly developed countries: a systematic review, Julian Archer, Nick Lynn, Lee Coombes, Martin Roberts, Tom Gale, Tristan Price, and de Bere S Regan

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The social, relational and mental health characteristics of justice-involved men in the south-west England, Alexandros Georgiadis, Richard Byng, Ross Coomber, and Cath Quinn

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Western medical acupuncture in a group setting for knee osteoarthritis: results of a pilot randomised controlled trial, Adrian White, Liz Tough, Vicky Eyre, Jane Vickery, Anthea Asprey, Cath Quinn, Fiona Warren, Colin Pritchard, Nadine E. Foster, Rod S. Taylor, Martin Underwood, and Paul Dieppe

Submissions from 2015

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Evidence-based health policymaking in Iraqi Kurdistan: Facilitators and barriers from the perspectives of policymakers and advisors, S Shabu, N Al-Tawil, M Fuller, and R Sheaff

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Mechanisms of Hepatitis C Viral Resistance to Direct Acting Antivirals, Daniel J. Felmlee and Asma Ahmed

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Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer, J Yang, A AlTahan, DT Jones, FM Buffa, and et al

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Pilot randomised controlled trial of protective socks against usual care to reduce skin tears in high risk people “STOPCUTS”: study protocol, RJ Powell, CJ Hayward, CL Snelgrove, K Polverino, and et al

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Burkholderia pseudomallei Capsular Polysaccharide Recognition by a Monoclonal Antibody Reveals Key Details toward a Biodefense Vaccine and Diagnostics against Melioidosis, Alba Silipo, Roberta Marchetti, Michael J. Dillon, Mary N. Burtnick, Mark A. Hubbard, Marielle Tamigney Kenfack, Yves Blériot, Charles Gauthier, Paul J. Brett, David P. Aucoin, Rosa Lanzetta, and Antonio Molinaro

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King's Parkinson's disease pain scale, the first scale for pain in PD: An international validation, Alexandra Rizos, K. Ray Chaudhuri, C. Trenkwalder, O. Rascol, S. Pal, D. Martino, C. Carroll, D. Paviour, C. Falup-Pecurariu, B. Kessel, M. Silverdale, A. Todorova, A. Sauerbier, P. Odin, A. Antonini, and P. Martinez-Martin

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Interaction between non-executive and executive directors in English National Health Service trust boards: an observational study, Ray Jones, Rod Sheaff, Ruth Endacott, and Val Woodward

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PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer, S-J Fan, C Snell, H Turley, J-L Li, and et al

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A mixed-methods study of the implementation of medication adherence policy solutions: how do European countries compare?, W Clyne and S McLachlan

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The Paradox of Giving – insights into the gift economy, JF Tredinnick-Rowe

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International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways, Heather J. Cordell, Younghun Han, George F. Mells, Y Li, Gideon M. Hirschfield, Casey S. Greene, Gang Xie, Brian D. Juran, Dakai Zhu, David C. Qian, James A.B. Floyd, Katherine I. Morley, Daniele Prati, Ana Lleo, Daniele Cusi, Erik M. Schlicht, Craig Lammert, Elizabeth J. Atkinson, LL Chan, Andrade M de, Tobias Balschun, Andrew L. Mason, Robert P. Myers, Jinyi Zhang, Piotr Milkiewicz, Jia Qu, Joseph A. Odin, Velimir A. Luketic, Bruce R. Bacon, and Henry C. Bodenheimer

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Involving parents in school-based programmes to prevent and reduce bullying: what effect does it have?, Nick Axford, David P. Farrington, Suzy Clarkson, Gretchen J. Bjornstad, Zoe Wrigley, and Judy Hutchings

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Cornish Self-determination: a semiotic analysis of political cartooning, G Bona i Fonoll, E Gruffydd, JF Tredinnick-Rowe, and S Khanwalkar

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Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease, Daniels CM LaPash, E Paffenroth, EV Austin, K Glebov, D Lewis, J Walter, and A Messing

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‘But I’ve been teaching for 20 years…’: encouraging teaching accreditation for experienced staff working in higher education, Lucy Spowart, Rebecca Turner, Deborah Shenton, and Pauline Kneale

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Achieving Consensus in the Development of an Online Intervention Designed to Effectively Support Midwives in Work-Related Psychological Distress: Protocol for a Delphi Study, S Pezaro and W Clyne

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Features of Blastocystis spp. in xenic culture revealed by deconvolutional microscopy, R Nagel, C Gray, H Bielefeldt-Ohmann, and RJ Traub