Browse research from the Peninsula Medical School.

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Submissions from 2016

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Accessible polyvocality and paired talk: how family therapists talk positive connotation into being, Lynsey Williams and Tim Auburn

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Anti-envelope antibody responses in individuals at high risk of hepatitis C virus who resist infection, R. E. Swann, P. Mandalou, M. W. Robinson, M. M. Ow, S. K.H. Foung, J. McLauchlan, A. H. Patel, and M. E. Cramp

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Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries, Danial Martin

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The social, relational and mental health characteristics of justice-involved men in the south-west England, Alexandros Georgiadis, Richard Byng, Ross Coomber, and Cath Quinn

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How do brochures encourage walking in natural environments in the UK? A content analysis, Lewis R. Elliott, Mathew P. White, Adrian H. Taylor, and Charles Abraham

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Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models, K. J. Brennand, J Xu, B. J. Hartley, P. Kurup, A. Phillips, A. Topol, M Xu, C. Ononenyi, E. Foscue, S. M. Ho, T. D. Baguley, N. Carty, C. S. Barros, U. Müller, S. Gupta, P. Gochman, J. Rapoport, J. A. Ellman, C. Pittenger, B. Aronow, A. C. Nairn, M. W. Nestor, and P. J. Lombroso

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The Semantics of Remediation - primed to fail? The impact of negative word association upon student performance in remediation, JF Tredinnick-Rowe and J Read

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The increased expression of fatty acid-binding protein 9 in prostate cancer and its prognostic significance, MS Al Fayi, X Gou, SS Forootan, W Al-Jameel, and et al

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Single neuron transcriptomics identify SRSF/ SR protein B52 as a regulator of axon growth and Choline acetyltransferase splicing., Torsten Bossing and Boyin Liu

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Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015, GBD 2015 Risk Factors Collaborators

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Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015, GBD 2015 Disease and Injury Incidence and Prevalence Collaborators

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Global, regional, and national levels of maternal mortality, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015, GBD 2015 Maternal Mortality Collaborators

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Evidence for energy conservation during pubertal growth. A 10-year longitudinal study (EarlyBird 71), M Mostazir, A Jeffery, J Hosking, B Metcalf, L Voss, and T Wilkin

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Head injury in the elderly - what are the outcomes of neurosurgical care?, KJ Whitehouse, DS Jeyaretna, DG Enki, and PC Whitfield

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Head Injury in the Elderly: What Are the Outcomes of Neurosurgical Care?, Kathrin Joanna Whitehouse, Deva Sanjeeva Jeyaretna, Doyo Gragn Enki, and Peter C. Whitfield

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Inequity in cardiovascular care in the English National Health Service (NHS): a scoping review of the literature, Sheena Asthana, Graham Moon, Alex Gibson, Trevor Bailey, Paul Hewson, and Chris Dibben

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What happens when 55% of acute psychiatric beds are closed in six days: an unexpected naturalistic observational study, Richard Laugharne, Matt Branch, Anji Mitchell, Lindsay Parkin, Phil Confue, Rohit Shankar, Diane Wilson-James, Mike Marshall, Maria Edgecombe, Bernie Keaney, Kiran Gill, and Juliet Harrison

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Rigour in moderation processes is more important than the choice of method, Daniel Zahra, Iain Robinson, Martin Roberts, Lee Coombes, Josephine Cockerill, and Steven Burr

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Getting real in the community: Evaluating the “making a difference” interdisciplinary social engagement project, R Ayres, S Stevens, and de Bere S Regan

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MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C., Khaled Thabet, Anastasia Asimakopoulos, Maryam Shojaei, Manuel Romero-Gomez, Alessandra Mangia, William L. Irving, Thomas Berg, Gregory J. Dore, Henning Grønbæk, David Sheridan, Maria Lorena Abate, Elisabetta Bugianesi, Martin Weltman, Lindsay Mollison, Wendy Cheng, Stephen Riordan, Janett Fischer, Ulrich Spengler, Jacob Nattermann, Ahmed Wahid, Angela Rojas, Rose White, Mark W. Douglas, Duncan McLeod, Elizabeth Powell, Christopher Liddle, David van der Poorten, Jacob George, and Mohammed Eslam

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How Can Physical Activity Referral Rates for Breast Cancer Patients be Increased?, M Queen, C Karatzaferi, SR Bloxham, U Panwar, and et al

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Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in a Parkinson disease mouse model, Anja Drinkut, Karsten Tillack, Durga P. Meka, Jorg B. Schulz, Sebastian Kügler, and Edgar R. Kramer

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Brain health: time matters in multiple sclerosis, Gavin Giovannoni, Helmut Butzkueven, Suhayl Dhib-Jalbut, Jeremy Hobart, Gisela Kobelt, George Pepper, Maria Pia Sormani, Christoph Thalheim, Anthony Traboulsee, and Timothy Vollmer

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Core Outcomes and Common Data Elements in Chronic Subdural Hematoma: A Systematic Review of the Literature Focusing on Baseline and Peri-Operative Care Data Elements, Aswin Chari, Katie C. Hocking, Ellie Edlmann, Carole Turner, Thomas Santarius, Peter J. Hutchinson, and Angelos G. Kolias

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“My patients are better than yours”: optimistic bias about patients’ medication adherence by European health care professionals, W Clyne, S McLachlan, C Mshelia, P Jones, and et al

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Socio-economic factors, gender and smoking as determinants of COPD in a low-income country of sub-Saharan Africa: FRESH AIR Uganda, Gemert F. van, N Chavannes, B Kirenga, R Jones, S Williams, I Tsiligianni, J Vonk, J Kocks, Jong C de, and der Molen T van

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Steps to prevent SUDEP: the validity of risk factors in the SUDEP and seizure safety checklist: a case control study, Rohit Shankar, Matthew Walker, Brendan McLean, Richard Laugharne, Fucundo Ferrand, Jane Hanna, and Craig Newman

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AMEE 2016, KG Gilbert, H Neve, and H Lloyd

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Understanding students’ experiences of professionalism learning: a ‘threshold’ approach, Hilary Neve, Helen Lloyd, and Tracey Collett

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Contribution of murine IgG Fc regions to antibody binding to the capsule ofBurkholderia pseudomallei, Michael J. Dillon, Rachael A. Loban, Dana E. Reed, Peter Thorkildson, Kathryn J. Pflughoeft, Sujata G. Pandit, Paul J. Brett, Mary N. Burtnick, and David P. AuCoin

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Current status and recommendations for biomarkers and biobanking in neurofibromatosis, C. Oliver Hanemann, Jaishri O. Blakeley, Fabio P. Nunes, Kent Robertson, Anat Stemmer-Rachamimov, Victor Mautner, Andreas Kurtz, Michael Ferguson, Brigitte C. Widemann, D. Gareth Evans, Rosalie Ferner, Steven L. Carroll, Bruce Korf, Pierre Wolkenstein, Pamela Knight, and Scott R. Plotkin

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Current whole-body MRI applications in the neurofibromatoses, S Ahlawat, LM Fayad, MS Khan, MA Bredella, GJ Harris, DG Evans, S Farschtschi, MA Jacobs, A Chhabra, JM Salamon, R Wenzel, VF Mautner, E Dombi, W Cai, SR Plotkin, JO Blakeley, and CO Hanemann

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Neurocognitive outcomes in neurofibromatosis clinical trials, KS Walsh, J Janusz, PL Wolters, S Martin, BP Klein-Tasman, MA Toledo-Tamula, HL Thompson, JM Payne, KK Hardy, Blank P de, C Semerjian, LS Gray, SE Solomon, N Ullrich, and CO Hanemann

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Patient-reported outcomes of pain and physical functioning in neurofibromatosis clinical trials., CO Hanemann, PL Wolters, S Martin, VL Merker, JH Tonsgard, SE Soloman, A Baldwin, AL Bergner, K Walsh, HL Thompson, KL Gardner, CM HIngtgen, E Schorry, WN Dudley, and B Franklin

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Sleep and pulmonary outcomes for clinical trials of airway plexiform neurofibromas in NF1, SR Plotkin, SD Davis, KA Robertson, S Akshintala, J Allen, MJ Fisher, JO Blakeley, BC Widemann, RE Ferner, CL Marcus, and CO Hanemann

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Comparison of Statistical Algorithms for the Detection of Infectious Disease Outbreaks in Large Multiple Surveillance Systems, DG Enki, PH Garthwaite, CP Farrington, and et al

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Women's knowledge and utilization of prenatal screening tests: A Turkish study, M Seven, A Akyüz, K Eroglu, S Daack-Hirsch, and H Skirton

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Correction: Corrigendum: NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells, H Alrefai, K Muhammad, R Rudolf, DAT Pham, S Klein-Hessling, AK Patra, A Avots, V Bukur, U Sahin, S Tenzer, M Goebeler, A Kerstan, and E Serfling

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A comparison of energy consumption between the use of a walking frame, crutches and a Stride-on rehabilitation scooter, N Patel, T Batten, A Roberton, and et al

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Detection of infectious disease outbreaks from laboratory data with reporting delays, A Noufaily, P Farrington, P Garthwaite, and et al

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Determining the haemodynamic significance of arterial stenosis: the relationship between CT angiography, computational fluid dynamics, and non-invasive fractional flow reserve, C. L. Pang, R. Alcock, N. Pilkington, T. Reis, and C. Roobottom

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Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2015: the Global Burden of Disease Study 2015, GBD 2015 HIV Collaborators

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Identification of blood biomarkers for use in point of care diagnosis tool for Alzheimer's disease, E. Jammeh, P. Zhao, C. Carroll, S. Pearson, and E. Ifeachor

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Making a difference: a qualitative study of an inter-professional social engagement project, R Ayres, S stevens, and de bere S regan

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Molecular mechanisms autonomic dysfunction and impaired cardiac contractility in critical illness, GL Ackland, J Whittle, A Toner, A Machhada, and et al

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Simultaneous targeting of Eph receptors in glioblastoma, S Ferluga, CML Tomé, DM Herpai, R D’Agostino, and W Debinski

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Social Stories in mainstream schools for children with autism spectrum disorder: a feasibility randomised controlled trial, David Marshall, Barry Wright, Victoria Allgar, Joy Adamson, Christine Williams, Hannah Ainsworth, Liz Cook, Danielle Varley, Lisa Hackney, Paul Dempster, Shehzad Ali, Dominic Trepel, Moore D Collingridge, Elizabeth Littlewood, and Dean McMillan

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Technology-Enabled Remote Monitoring and Self-Management — Vision for Patient Empowerment Following Cardiac and Vascular Surgery: User Testing and Randomized Controlled Trial Protocol, M McGillion, J Yost, A Turner, and et al

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The intact Kunitz domain protects the amyloid precursor protein from being processed by matriptase-2, A-M Beckmann, K Glebov, J Walter, O Merkel, M Mangold, F Schmidt, C Becker-Pauly, M Gütschow, and M Stirnberg

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Householders’ Mental Models of Domestic Energy Consumption: Using a Sort-And-Cluster Method to Identify Shared Concepts of Appliance Similarity, E Gabe-Thomas, I Walker, B Verplanken, and G Shaddick

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Provider plurality and supply-side reform, WR Sheaff and P Allen

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Achieving Consensus for the Design and Delivery of an Online Intervention to Support Midwives in Work-Related Psychological Distress: Results From a Delphi Study, S Pezaro and W Clyne

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Police Funding Arrangements in Engand and Wales: Report to the NRCN, AJS Gibson and S Asthana

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Progress testing in undergraduate dental education: the Peninsula experience and future opportunities, K Ali, L Coombes, E Kay, C Tredwin, and et al

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The Global Diffusion and Application of Medical Semiotics - From Medical Semiotics to Medical Semiology, JF Tredinnick-Rowe

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The (re)-introduction of semiotics into medical education: on the works of Thure von Uexküll, John Tredinnick-Rowe

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Maximum levels of hepatitis C virus lipoviral particles are associated with early and persistent infection, David A. Sheridan, Behzad Hajarizadeh, Fiona I. Fenwick, Gail V. Matthews, Tanya Applegate, Mark Douglas, Dermot Neely, Bev Askew, Gregory J. Dore, Andrew R. Lloyd, Jacob George, Margaret F. Bassendine, and Jason Grebely

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Emotional logic development profiles – validating the benefits and safety of emotional logic training, Daniel Zahra, Marian Langsford, and Trevor Griffiths

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Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth, A McIntyre, A Hulikova, I Ledaki, C Snell, and et al

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Exploring the relationship between childhood obesity and proximity to the coast: A rural/urban perspective, Sophie L. Wood, Philippe R. Demougin, Sahran Higgins, Kerryn Husk, Benedict W. Wheeler, and Mathew White

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Proteome and phosphoproteome analysis of stratified meningiomas, S Ferluga, J Dunn, E Lasonder, V Sharma, DA Hilton, C Adams, and CO Hanemann

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Making a difference: a qualitative study of an inter-professional social engagement project, R Ayres, R carter, and S stevens

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The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors, L. Zhou, J. Lyons-Rimmer, S. Ammoun, J. Müller, E. Lasonder, V. Sharma, E. Ercolano, D. Hilton, I. Taiwo, M. Barczyk, and C. O. Hanemann

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CD147 handles lipid: a new role for anti-cancer target, Daniel J. Felmlee and Thomas F. Baumert

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Delta-9-tetrahydrocannabinol protects against MPP+ toxicity in SH-SY5Y cells by restoring proteins involved in mitochondrial biogenesis, Marie Louise Zeissler, Jordan Eastwood, Kieran McCorry, Oliver O. Hanemann, John P. Zajicek, and Camille B. Carroll

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Diverse impacts of the rs58542926 E167K variant in TM6SF2 on viral and metabolic liver disease phenotypes, Mohammed Eslam, Alessandra Mangia, Thomas Berg, Henry Lik Yuen Chan, William L. Irving, Gregory J. Dore, Maria Lorena Abate, Elisabetta Bugianesi, Leon A. Adams, Mustafa A.M. Najim, Luca Miele, Martin Weltman, Lindsay Mollison, Wendy Cheng, Stephen Riordan, Janett Fischer, Manuel Romero-Gomez, Ulrich Spengler, Jacob Nattermann, Antony Rahme, David Sheridan, David R. Booth, Duncan McLeod, Elizabeth Powell, Christopher Liddle, Mark W. Douglas, der Poorten D van, and Jacob George

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Training to promote dementia support., J Kwakwa, H Ashforth, A Pritchard, and R Trout

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A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development., Amiya Kumar Patra

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Key points to facilitate the adoption of computer-based assessments., SA Burr, AC Chatterjee, S Gibson, L Coombes, and S Wilkinson

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Accounting for test reliability in student progression: the reliable change index, Daniel Zahra, Craig Hedge, Francesca Pesola, and Steven Burr

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The BET inhibitor JQ1 selectively impairs tumour response to hypoxia and downregulates CA9 and angiogenesis in triple negative breast cancer, LL da Motta, I Ledaki, K Purshouse, S Haider, and et al

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When I say.........capability, Hilary Neve and Sally Hanks

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CUMSUM cannot define competency, E. J. Drake and J. R. Sneyd

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'He left me a message on Facebook': comparing the risk profiles of self-harming patients who leave paper suicide notes with those who leave messages on new media, JR Barrett, H Shetty, M Broadbent, S Cross, and et al

What approaches to social prescribing work, for whom, and in what circumstances? A protocol for a realist review, Kerryn Husk, Kelly Blockley, Rebecca Lovell, Alison Bethel, Dan Bloomfield, Sara Warber, Mark Pearson, Iain Lang, Richard Byng, and Ruth Garside

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The association between habitual physical activity and cigarette cravings, and influence of smokers’ characteristics in disadvantaged smokers not ready to quit, M. Haasova, F. C. Warren, T. Thompson, M. Ussher, and A. H. Taylor

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Activation of multiple growth factor signalling pathways is frequent in meningiomas, David A. Hilton, Aditya Shivane, Leanne Kirk, Kayleigh Bassiri, Doyo G. Enki, and C. Oliver Hanemann

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Measuring arm function early after stroke: is the DASH good enough?, Karen Baker, Louise Barrett, E. Diane Playford, Trefor Aspden, Afsane Riazi, and Jeremy Hobart

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‘Midwives Overboard!’ Inside their hearts are breaking, their makeup may be flaking but their smile still stays on, S Pezaro, W Clyne, A Turner, and et al

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New perspectives for preventing hepatitis C virus liver graft infection, Daniel J. Felmlee, Audrey Coilly, Raymond T. Chung, Didier Samuel, and Thomas F. Baumert

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The Effectiveness and Micro-costing Analysis of a Universal, School-Based, Social–Emotional Learning Programme in the UK: A Cluster-Randomised Controlled Trial, Vashti Berry, Nick Axford, Sarah Blower, Rod S. Taylor, Rhiannon Tudor Edwards, Kate Tobin, Carys Jones, and Tracey Bywater

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The importance of nerve microenvironment for schwannoma development, Alexander Schulz, Robert Büttner, Christian Hagel, Stephan L. Baader, Lan Kluwe, Johannes Salamon, Victor Felix Mautner, Thomas Mindos, David B. Parkinson, Jeffrey R. Gehlhausen, D. Wade Clapp, and Helen Morrison

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NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells, Hani Alrefai, Khalid Muhammad, Ronald Rudolf, Duong Anh Thuy Pham, Stefan Klein-Hessling, Amiya K. Patra, Andris Avots, Valesca Bukur, Ugur Sahin, Stefan Tenzer, Matthias Goebeler, Andreas Kerstan, and Edgar Serfling

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Participation in environmental enhancement and conservation activities for health and well-being in adults: a review of quantitative and qualitative evidence, Kerryn Husk, Rebecca Lovell, Chris Cooper, Will Stahl-Timmins, and Ruth Garside

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Tspan5 is an independent favourable prognostic factor and suppresses tumour growth in gastric cancer, P He, S Wang, X Zhang, Y Gao, and et al

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A comparison of teaching three common ear, nose, and throat conditions to medical students through video podcasts and written handouts: a pilot study, M Edmond, F Neville, and HS Khalil

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Rising to the challenge: acute stress appraisals and selection centre performance in applicants to postgraduate specialty training in anaesthesia, Martin J. Roberts, Thomas C.E. Gale, John S. McGrath, and Mark R. Wilson

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The medical licensing examination debate, Julian Archer, Nick Lynn, Lee Coombes, Martin Roberts, Tom Gale, and de Bere S Regan

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Implementing a patient-initiated review system for people with rheumatoid arthritis: a prospective, comparative service evaluation, Victoria A. Goodwin, Priyamvada Paudyal, Mark G. Perry, Nikki Day, Annie Hawton, Christian Gericke, Obioha C. Ukoumunne, and Richard Byng

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Multi-component assessment of chronic obstructive pulmonary disease: an evaluation of the ADO and DOSE indices and the global obstructive lung disease categories in international primary care data sets, Rupert C. Jones, David Price, Niels H. Chavannes, Amanda J. Lee, Michael E. Hyland, Björn Ställberg, Karin Lisspers, Josefin Sundh, der Molen T van, and Ioanna Tsiligianni

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Health Worker Focused Distributed Simulation for Improving Capability of Health Systems in Liberia, Thomas C.E. Gale, Arunangsu Chatterjee, Nicholas E. Mellor, and Richard J. Allan

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Inter-Organizational Networks in Health Care: Program Networks, Care Networks, and Integrated Care, R Sheaff and J Schofield

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Interpreting multisource feedback: online study of consensus and variation among GP appraisers, Christine Wright, John Campbell, Luke McGowan, Martin J. Roberts, Di Jelley, and Arunangsu Chatterjee

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Low–Blood Glucose Avoidance Training Improves Glycemic Variability in Adults With Type 1 Diabetes Complicated by Impaired Awareness of Hypoglycemia: HypoCOMPaSS Trial, HK Tan, SA Little, L Leelarathna, E Walkinshaw, A Lubina-Solomon, J Hosking, J Speight, D Kerr, SR Heller, ML Evans, JAM Shaw, and D Flanagan

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Measuring spinal surgical success: the proportion achieving acceptable symptoms, Jeremy Hobart

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The Hippo signalling pathway maintains quiescence in Drosophila neural stem cells, Rouven Ding, Kevin Weynans, Torsten Bossing, Claudia S. Barros, and Christian Berger

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Developing family interventions for adolescent HIV prevention in South Africa, C Kuo, M Atujuna, C Mathews, DJ Stein, and et al

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A study to assess the influence of interprofessional point of care simulation training on safety culture in the operating theatre environment of a university teaching hospital, Theresa Hinde, Thomas Gale, Ian Anderson, Martin Roberts, and Paul Sice

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Twelve tips for assessment psychometrics, Lee Coombes, Martin Roberts, Daniel Zahra, and Steven Burr

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An Exploratory Analysis of the Smoking and Physical Activity Outcomes From a Pilot Randomized Controlled Trial of an Exercise Assisted Reduction to Stop Smoking Intervention in Disadvantaged Groups, Tom Paul Thompson, Colin J. Greaves, Richard Ayres, Paul Aveyard, Fiona C. Warren, Richard Byng, RS Taylor, John L. Campbell, Michael Ussher, Colin Green, Susan Michie, Robert West, and A Taylor