Browse research from the Peninsula Medical School.

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Submissions from 2013

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The practice of commissioning healthcare from a private provider: learning from an in-depth case study, N Chambers, WR Sheaff, A Mahon, R Byng, R Mannion, N Charles, M Exworthy, and S Llewllyn

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Effectiveness of a motivational interviewing intervention on weight loss, physical activity and cardiovascular disease risk factors: a randomised controlled trial with a 12-month post-intervention follow-up., Sarah J. Hardcastle, Adrian H. Taylor, Martin P. Bailey, Robert A. Harley, and Martin S. Hagger

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Has incentive payment improved venous thrombo-embolism risk assessment and treatment of hospital in-patients?, Sue Child, Rod Sheaff, Olga Boiko, Alice Bateman, and Christian A. Gericke

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Critical appraisal of axitinib in the treatment of advanced renal cell carcinoma, J Ansari, SA Hussain, J Glaholm, and A Ansari

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A brisk walk, compared with being sedentary, reduces attentional bias and chocolate cravings among regular chocolate eaters with different body mass., Hwajung Oh and Adrian H. Taylor

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Acute effect of exercise on alcohol urges and attentional bias towards alcohol related images in high alcohol consumers, Adrian H. Taylor, Hwajung Oh, and Sarah Cullen

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An educational framework for managing and supporting medication adherence in Europe, S White, W Clyne, and C Mshelia

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A systematic review of educational interventions to change behaviour of prescribers in hospital settings, with a particular emphasis on new prescribers., Nicola Brennan and Karen Mattick

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Delivery and use of individualised feedback in large class medical teaching, SA Burr, E Brodier, and S Wilkinson

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Evidence-based programs in children's services: A critical appraisal, Nick Axford and Louise Morpeth

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Exercise referral for drug users aged 40 and over: results of a pilot study in the UK, Caryl M. Beynon, Amy Luxton, Rhiannon Whitaker, N. Tim Cable, Lucy Frith, Adrian H. Taylor, Lu Zou, Peter Angell, Scott Robinson, D Holland, S Holland, and Mark Gabbay

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Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells., Robin D.S. Doddrell, Xin Peng Dun, Aditya Shivane, M. Laura Feltri, Lawrence Wrabetz, Michael Wegner, Elisabeth Sock, C. Oliver Hanemann, and David B. Parkinson

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Molecular genetic studies of neurodegenerative disease., T Cooke, C Carroll, J Zajicek, S Ellard, and K Morrison

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PAin SoluTions In the Emergency Setting (PASTIES); a protocol for two open-label randomised trials of patient-controlled analgesia (PCA) versus routine care in the emergency department, JE Smith, M Rockett, R Squire, CJ Hayward, and et al

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Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage, P Wunderlich, K Glebov, N Kemmerling, NT Tien, H Neumann, and J Walter

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Simulation and assessment of dental extraction proficiency Type of project : Self Administered Postal Questionnaire, D. R. Moles, Nigel Honey, and Tom Gale

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Sudden unexpected death in epilepsy (SUDEP): Development of a safety checklist, Rohit Shankar, David Cox, Virupakshi Jalihal, Scott Brown, Jane Hanna, and Brendan McLean

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The effectiveness and cost-effectiveness of shared care: protocol for realist review, R Hardwick, M Pearson, R Anderson, and R Byng

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Trust in the health-care provider-patient relationship: a systematic mapping review of the evidence base., Nicola Brennan, Rebecca Barnes, Mike Calnan, Oonagh Corrigan, Paul Dieppe, and Vikki Entwistle

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Δ9-TETRAHYDROCANNABINOL IS PROTECTIVE THROUGH PPARγ DEPENDENT MITOCHONDRIAL BIOGENESIS IN A CELL CULTURE MODEL OF PARKINSON'S DISEASE., ML Zeissler, J Eastwood, Hanemann C Oliver, J Zajicek, and C Carroll

Submissions from 2012

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Neuropsychological outcomes in adults commencing highly active anti-retroviral treatment in South Africa: a prospective study, JA Joska, J Westgarth-Taylor, J Hoare, KGF Thomas, and et al

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Enamel Defects in Carriers of a Novel LAMA3 Mutation Underlying Epidermolysis Bullosa, WY Yuen, AM Pasmooij, C Stellingsma, and MF Jonkman

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Neutralizing Antibodies and Pathogenesis of Hepatitis C Virus Infection, Samira Fafi-Kremer, Catherine Fauvelle, Daniel J. Felmlee, Mirjam B. Zeisel, Quentin Lepiller, Isabel Fofana, Laura Heydmann, Françoise Stoll-Keller, and Thomas F. Baumert

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A new taxonomy for describing and defining adherence to medications, B Vrijens, S De Geest, DA Hughes, K Przemyslaw, and et al

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Being young in Cornwall, JF Tredinnick-Rowe

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Effectiveness of a gentamicin impregnated collagen sponge on reducing sternal wound infections following cardiac surgery: a meta-analysis of randomised controlled trials, S Creanor, A Barton, and A Marchbank

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A longitudinal study of the effect of Antarctic residence on energy dynamics and aerobic fitness, A Simpson and V Maynard

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Age before stage: insulin resistance rises before the onset of puberty: a 9-year longitudinal study (EarlyBird 26)., AN Jeffery, BS Metcalf, J Hosking, AJ Streeter, LD Voss, and TJ Wilkin

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Analysis and validation of a Parkinson's disease register as a recruitment tool for clinical studies., Camille Carroll, Amy Palmer, Christine Cosby, and John Zajicek

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Control of interneuron dendritic growth through NRG1/erbB4-mediated kalirin-7 disinhibition., M. E. Cahill, K. A. Jones, I. Rafalovich, Z. Xie, C. S. Barros, U. Müller, and P. Penzes

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Facilitated physical activity as a treatment for depressed adults: randomised controlled trial, Melanie Chalder, Nicola J. Wiles, John Campbell, Sandra P. Hollinghurst, Anne M. Haase, Adrian H. Taylor, Kenneth R. Fox, Ceire Costelloe, Aidan Searle, Helen Baxter, Rachel Winder, Christine Wright, Katrina M. Turner, Michael Calnan, Deborah A. Lawlor, Tim J. Peters, Deborah J. Sharp, Alan A. Montgomery, and Glyn Lewis

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Guided self-help concreteness training as an intervention for major depression in primary care: a Phase II randomized controlled trial., E. R. Watkins, R. S. Taylor, R. Byng, C. Baeyens, R. Read, K. Pearson, and L. Watson

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Neurofibromatosis 2011: a report of the Children's Tumor Foundation annual meeting., Michel Kalamarides, Maria T. Acosta, Dusica Babovic-Vuksanovic, Olli Carpen, Karen Cichowski, DG Evans, Filippo Giancotti, CO Hanemann, David Ingram, Alison C. Lloyd, Debra A. Mayes, Ludwine Messiaen, Helen Morrison, Kathryn North, Roger Packer, Duojia Pan, Anat Stemmer-Rachamimov, Meena Upadhyaya, David Viskochil, Margret R. Wallace, Kim Hunter-Schaedle, and Nancy Ratner

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Physical activity as an aid to smoking cessation during pregnancy (LEAP) trial: study protocol for a randomized controlled trial, Michael Ussher, Paul Aveyard, Isaac Manyonda, S Lewis, Robert West, B Lewis, Bess Marcus, Adrian H. Taylor, Pelham Barton, and Tim Coleman

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Producing multimedia resources for teaching medical students about the social context of medicine: a partnership approach, Tracey Collett and Priska Schoenborn

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Statins in Unconventional Secretion of Insulin-Degrading Enzyme and Degradation of the Amyloid-β Peptide, K Glebov and J Walter

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The role of insulin-like growth factors signaling in merlin-deficient human schwannomas., Sylwia Ammoun, M. Caroline Schmid, Natalia Ristic, Lu Zhou, David Hilton, Emanuela Ercolano, Camille Carroll, and C. Oliver Hanemann

Submissions from 2011

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Effect of exercise referral schemes in primary care on physical activity and improving health outcomes: systematic review and meta-analysis., T. G. Pavey, AH Taylor, K. R. Fox, M. Hillsdon, N. Anokye, J. L. Campbell, C. Foster, C. Green, T. Moxham, N. Mutrie, J. Searle, P. Trueman, and RS Taylor

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Factors associated with variability in the assessment of UK doctors' professionalism: analysis of survey results, JL Campbell, M Roberts, C Wright, J Hill, and et al

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A tool to measure the attributes of receiving IV therapy in a home versus hospital setting: the Multiple Sclerosis Relapse Management Scale (MSRMS)., Afsane Riazi, Bernadette Porter, Jeremy Chataway, Alan J. Thompson, and Jeremy C. Hobart

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Protocol for a double-blind randomised placebo-controlled trial of lithium carbonate in patients with amyotrophic Lateral Sclerosis (LiCALS) [Eudract number: 2008-006891-31], Ammar Al-Chalabi, Pamela J. Shaw, Carolyn A. Young, Karen E. Morrison, Caroline Murphy, Marie Thornhill, Joanna Kelly, I. Nicholas Steen, P. Nigel Leigh, and Oliver Hanemann

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Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis, Stephen Sawcer, Garrett Hellenthal, Matti Pirinen, Chris C.A. Spencer, Nikolaos A. Patsopoulos, Loukas Moutsianas, Alexander Dilthey, Zhan Su, Colin Freeman, Sarah E. Hunt, Sarah Edkins, Emma Gray, David R. Booth, Simon C. Potter, An Goris, Gavin Band, Annette Bang Oturai, Amy Strange, Janna Saarela, Céline Bellenguez, Bertrand Fontaine, Matthew Gillman, Bernhard Hemmer, Rhian Gwilliam, Frauke Zipp, Alagurevathi Jayakumar, Roland Martin, Stephen Leslie, Stanley Hawkins, and Stanley Hawkins

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NFATc1 affects mouse splenic B cell function by controlling the calcineurin–NFAT signaling network, Sankar Bhattacharyya, Jolly Deb, Amiya K. Patra, Pham DA Thuy, Wen Chen, Martin Vaeth, Friederike Berberich-Siebelt, Stefan Klein-Hessling, Edward D. Lamperti, Kurt Reifenberg, Julia Jellusova, Astrid Schweizer, Lars Nitschke, Ellen Leich, Andreas Rosenwald, Cornelia Brunner, Swen Engelmann, Ursula Bommhardt, Andris Avots, Martin R. Müller, Eisaku Kondo, and Edgar Serfling

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Patients' views of physical activity as treatment for depression: a qualitative study, Aidan Searle, Michael Calnan, Glyn Lewis, John Campbell, Adrian Taylor, and Katrina Turner

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Changes in iron-regulatory gene expression occur in human cell culture models of Parkinson's disease., C. B. Carroll, M. L. Zeissler, N. Chadborn, K. Gibson, G. Williams, J. P. Zajicek, K. E. Morrison, and C. O. Hanemann

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Designing clinical trials in older people., C. B. Carroll and J. P. Zajicek

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Exploring the Map of Medicine's potential in undergraduate medical education., Nicola Brennan and Karen Mattick

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Management of patient adherence to medications: protocol for an online survey of doctors, pharmacists and nurses in Europe, W Clyne, C Mshelia, S Hall, S McLachlan, and et al

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Propofol and children--what we know and what we do not know., AE Rigby-Jones and JR Sneyd

Radiological findings in patients undergoing revision endoscopic sinus surgery: a retrospective case series study, HS Khalil, AZ Eweiss, and N Clifton

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The Map of Medicine: a review of evidence for its impact on healthcare., Nicola Brennan, Karen Mattick, and Tricia Ellis

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The problem with health measurement., Stefan J. Cano and Jeremy C. Hobart

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Women's experience of colposcopy: a qualitative investigation, Dawn R. Swancutt, Sheila M. Greenfield, David M. Luesley, and Sue Wilson

Submissions from 2010

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Integrating the promotion of physical activity within a smoking cessation programme: findings from collaborative action research in UK Stop Smoking Services., Adrian H. Taylor, Emma S. Everson-Hock, and Michael Ussher

Study protocol for a randomized controlled trial comparing mindfulness-based cognitive therapy with maintenance anti-depressant treatment in the prevention of depressive relapse/recurrence: the PREVENT trial., Willem Kuyken, Sarah Byford, Richard Byng, Tim Dalgleish, Glyn Lewis, Rod Taylor, Edward R. Watkins, Rachel Hayes, Paul Lanham, David Kessler, Nicola Morant, and Alison Evans

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Patient-orientated longitudinal study of multiple sclerosis in south west England (The South West Impact of Multiple Sclerosis Project, SWIMS) 1: protocol and baseline characteristics of cohort., John P. Zajicek, Wendy M. Ingram, Jane Vickery, Siobhan Creanor, Dave E. Wright, and Jeremy C. Hobart

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First‐trimester combined screening for trisomy 21 at 7–14 weeks' gestation, D Wright, K Spencer, KK Kagan, N Tørring, and et al

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Selecting GLP-1 agonists in the management of type 2 diabetes: differential pharmacology and therapeutic benefits of liraglutide and exenatide., J Pinkney, T Fox, and L Ranganath

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CBD & D9-THC - the two faces of cannabis, Zeissler, CB Carroll, and J Zajicek

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Bio-informatics analysis of a gene co-expression module in adipose tissue containing the diet-responsive gene Nnat., X Li.X, PA Thomason, DJ Withers, and J Scott

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Cannabinoids Are Neuroprotective in a Human Cell Culture Model of Parkinson's Disease, CB Carroll, ML Zeissler, V Stone, CO Hanemann, and JP Zajicek

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Changes in Iron-Regulatory Gene Expression Occur in Human Cell Culture Models of PD, CB Carroll, ML Zeissler, N Chadborn, K Gibson, GJ Williams, KE Morrison, JP Zajicek, and CO Hanemann

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Cross-trimester repeated measures testing for Down's syndrome screening: an assessment., D. Wright, I. Bradbury, F. Malone, M. D'Alton, A. Summers, T. Huang, S. Ball, A. Baker, B. Nix, D. Aitken, J. Crossley, H. Cuckle, and K. Spencer

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Effects of HIF-1 and HIF2 on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts, S Biswas, H Troy, R Leek, Y-L Chung, and et al

Endoscopic Resection and Topical 5-Fluorouracil as an Alternative Treatment to Craniofacial Resection for the Management of Primary Intestinal-Type Sinonasal Adenocarcinoma, S Mackie, T Malik, and H Khalil

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ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma, Sylwia Ammoun, Clare H. Cunliffe, Jeffrey C. Allen, Luis Chiriboga, Filippo G. Giancotti, David Zagzag, C. Oliver Hanemann, and Matthias A. Karajannis

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Impact of workplace based assessment on doctors' education and performance: a systematic review., A Miller and J Archer

Persistent CSF Rhinorrhoea, Pneumocephalus, and Recurrent Meningitis Following Misdiagnosis of Olfactory Neuroblastoma, N Barua, DA Hilton, W Mukonoweshuro, H Khalil, and L Pobereskin

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Physical activity as a treatment for depression: the TREAD randomised trial protocol, Helen Baxter, Rachel Winder, Melanie Chalder, Christine Wright, Sofie Sherlock, Anne Haase, Nicola J. Wiles, Alan A. Montgomery, Adrian H. Taylor, Ken R. Fox, Debbie A. Lawlor, Tim J. Peters, Deborah J. Sharp, John Campbell, and Glyn Lewis

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The transition from medical student to junior doctor: today's experiences of Tomorrow's Doctors., Nicola Brennan, Oonagh Corrigan, Jon Allard, Julian Archer, Rebecca Barnes, Alan Bleakley, Tracey Collett, and Bere SR de

Submissions from 2009

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Role of Hypoxia‐Inducible Factors in Epigenetic Regulation via Histone Demethylases, J Yang, I Ledaki, H Turley, KC Gatter, and et al

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Acquired neuromyotonia following upper respiratory tract infection: a case report., Ibrahim Imam, Simon Edwards, and C. Oliver Hanemann

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Aquired neuromyotonia following upper respiratory tract infection, I Imam, S Edwards, and CO Hanemann

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Cauda equina syndrome following a lumbar puncture., Alexandra J. Sinclair, Camille Carroll, and Brendan Davies

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Chemotherapy related encephalopathy in a patient with Stage IV cervical carcinoma treated with cisplatin and 5-fluorouracil: a case report, AL Chue, IN Fernando, SA Hussain, and DA Yates

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Objectively measured physical activity and its association with adiponectin and other novel metabolic markers: a longitudinal study in children (EarlyBird 38)., BS Metcalf, AN Jeffery, J Hosking, LD Voss, N Sattar, and TJ Wilkin

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Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin, insulin, and glucose., Katrina Kos, Steve Wong, Bee Tan, Anders Gummesson, Margareta Jernas, Niclas Franck, David Kerrigan, Fredrik H. Nystrom, Lena M.S. Carlsson, Harpal S. Randeva, Jonathan H. Pinkney, and John P.H. Wilding

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The size of the treatment effect: do patients and proxies agree?, der Linden FAH van, Jolijn J. Kragt, Jeremy C. Hobart, Martin Klein, Alan J. Thompson, der Ploeg HM van, Chris H. Polman, and Bernard M.J. Uitdehaag

Submissions from 2008

Exposing the key functions of a complex intervention for shared care in mental health: case study of a process evaluation., Richard Byng, Ian Norman, Sally Redfern, and Roger Jones

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The cervical dystonia impact profile (CDIP-58): can a Rasch developed patient reported outcome measure satisfy traditional psychometric criteria?, Stefan J. Cano, Thomas T. Warner, Alan J. Thompson, Kailash P. Bhatia, Ray Fitzpatrick, and Jeremy C. Hobart

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A guide to medication review, W Clyne, A Blenkinsopp, and R Seal

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c-Jun is a negative regulator of myelination., David B. Parkinson, Ambily Bhaskaran, Peter Arthur-Farraj, Luke A. Noon, Ashwin Woodhoo, Alison C. Lloyd, M. Laura Feltri, Lawrence Wrabetz, Axel Behrens, Rhona Mirsky, and Kristján R. Jessen

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A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs), D Melzer, JRB Perry, D Hernandez, and et al

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Surveillance of cirrhosis for hepatocellular carcinoma: a cost-utility analysis., Coon J Thompson, G. Rogers, P. Hewson, D. Wright, R. Anderson, S. Jackson, S. Ryder, M. Cramp, and K. Stein

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Beyond the limits of clinical governance? The case of mental health in English primary care, Linda Gask, Anne Rogers, Stephen Campbell, and Rod Sheaff

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Women's colposcopy experience and preferences: a mixed methods study., Dawn R. Swancutt, Sheila M. Greenfield, and Sue Wilson

Submissions from 2007

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Hypoxia-regulated carbonic anhydrase IX expression is associated with poor survival in patients with invasive breast cancer, SA Hussain, R Ganesan, G Reynolds, L Gross, and et al

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The feminisation of British neurology: implications for workforce planning., C. B. Carroll, DSNAP Tengah, C. Lawthom, and G. Venables

Submissions from 2006

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Can learning organizations survive in the newer NHS?, Rod Sheaff and David Pilgrim

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Sowing date, transplanting, plant density and nitrogen fertilization affect indigo production from Isatis species in a Mediterranean region of Spain, E Sales, R Kanhonou, C Baixauli, A Giner, D Cooke, K Gilbert, I Arrillaga, J Segura, and R Ros

Submissions from 2005

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Construction and validation of a Bovine Innate Immune Microarray, L Donaldson, T Vuocolo, C Gray, Y Strandberg, and et al

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HCV-specific cellular immune responses in subjects exposed, but uninfected by HCV, MK Metzner, A Houldsworth, A Demaine, E Kaminski, and ME Cramp

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HCV-specific cellular immune responses in subjects exposed to but uninfected by HCV, M Metzner, A Houldsworth, AG Demaine, E Kaminski, and ME Cramp

Histopathological changes in the human larynx following expanded polytetrafluroethylene (Gore-Tex®) implantation, K Rajkumar, HS Khalil, M Elloy, E Sheffield, and DL Baldwin

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Laughing all the way to the item bank: how to improve your treatment effect by improving your outcome measurement, R Baron and J Hobart

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Muscle cramps and weakness secondary to graft versus host disease fasciitis., Camille B. Carroll, D. A. Hilton, M. Hamon, and J. P. Zajicek

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Quantifying drug-induced dyskinesias in the arms using digitised spiral-drawing tasks, Xuguang Liu, Camille B. Carroll, Shou Yan Wang, John Zajicek, and Peter G. Bain

Submissions from 2004

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Quantitative Analysis of Indigo and Indigo Precursors in Leaves of Isatis spp. and Polygonum tinctorium, KG Gilbert, HG Maule, B Rudolph, M Lewis, and et al

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A phase I/II study of gemcitabine and fractionated cisplatin in an outpatient setting using a 21-day schedule in patients with advanced and metastatic bladder cancer, SA Hussain, DD Stocken, P Riley, DH Palmer, and et al

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Long-term results of a phase II study of synchronous chemoradiotherapy in advanced muscle invasive bladder cancer, SA Hussain, DD Stocken, DR Peake, JG Glaholm, and et al