Bio-informatics analysis of a gene co-expression module in adipose tissue containing the diet-responsive gene Nnat.

Authors

X Li.X
PA Thomason
DJ Withers
J Scott

Abstract

Obesity causes insulin resistance in target tissues - skeletal muscle, adipose tissue, liver and the brain. Insulin resistance predisposes to type-2 diabetes (T2D) and cardiovascular disease (CVD). Adipose tissue inflammation is an essential characteristic of obesity and insulin resistance. Neuronatin (Nnat) expression has been found to be altered in a number of conditions related to inflammatory or metabolic disturbance, but its physiological roles and regulatory mechanisms in adipose tissue, brain, pancreatic islets and other tissues are not understood.

DOI

10.1186/1752-0509-4-175

Publication Date

2010-01-01

Publication Title

BMC Syst Biol

Volume

4

Publisher

Springer Science and Business Media LLC

ISSN

1752-0509

Embargo Period

2024-11-19

Comments

PMCID: PMC3022651

Additional Links

http://www.ncbi.nlm.nih.gov/pubmed/21187013

Keywords

Adipose Tissue, Animals, Cattle, Computational Biology, Diet, Dogs, Gene Expression Profiling, Gene Expression Regulation, Gene Regulatory Networks, Genomics, Humans, Membrane Proteins, Mice, Nerve Tissue Proteins, Promoter Regions, Genetic, Protein Interaction Mapping, Transcription, Genetic

First Page

175

Recommended Citation

Li.X, X., Thomason, P., Withers, D., & Scott, J. (2010) 'Bio-informatics analysis of a gene co-expression module in adipose tissue containing the diet-responsive gene Nnat.', BMC Syst Biol, 4, pp. 175. Springer Science and Business Media LLC: Available at: https://doi.org/10.1186/1752-0509-4-175