ORCID
- Carroll, Camille: 0000-0001-7472-953X
Abstract
Cannabinoids such as Δ9-tetrahydrocannabinol (Δ9-THC) are neuroprotective in animal and cell culture models of Parkinson's disease (PD). In a PD cell culture model we recently demonstrated that Δ9-THC is neuroprotective through activation of the nuclear receptor peroxisomal proliferator-activated receptor γ (PPARγ). Furthermore, activation by specific agonists rosiglitazone and pioglitazone, has also been found neuroprotective. PPARγ is a nuclear receptor whose activation can lead to the expression of proteins involved in the de novo synthesis of mitochondria. One such protein is the PPARγ co-activator 1 α (PGC1α) as it co-activates NRF-1 mediated gene expression which is essential for the production of nuclear encoded, mitochondrial proteins. Here we investigate the effect of Δ9-THC and pioglitazone on mitochondrial biogenesis.
DOI
10.1136/jnnp-2013-306573.150
Publication Date
2013-11-01
Publication Title
J Neurol Neurosurg Psychiatry
Volume
84
Issue
11
Organisational Unit
Peninsula Medical School
Keywords
["PARKINSON'S DISEASE", STROKE
Recommended Citation
Zeissler, M., Eastwood, J., Oliver, H., Zajicek, J., & Carroll, C. (2013) 'Δ9-TETRAHYDROCANNABINOL IS PROTECTIVE THROUGH PPARγ DEPENDENT MITOCHONDRIAL BIOGENESIS IN A CELL CULTURE MODEL OF PARKINSON'S DISEASE.', J Neurol Neurosurg Psychiatry, 84(11). Available at: https://doi.org/10.1136/jnnp-2013-306573.150
