Browse research from the Peninsula Medical School.

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Submissions from 2017

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Hepatitis C virus and atherosclerosis: A legacy after virologic cure?, M. F. Bassendine, S. U. Nielsen, S. H. Bridge, D. J. Felmlee, D. A. Sheridan, C. J. Packard, and R. D. Neely

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Sudden unexpected death in epilepsy: Measures to reduce risk, Brendan McLean, Rohit Shankar, Jane Hanna, Caryn Jory, and Craig Newman

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Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity, Thomas Mindos, Xin peng Dun, Katherine North, Robin D.S. Doddrell, Alexander Schulz, Philip Edwards, James Russell, Bethany Gray, Sheridan L. Roberts, Aditya Shivane, Georgina Mortimer, Melissa Pirie, Nailing Zhang, Duojia Pan, Helen Morrison, and David B. Parkinson

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The Merlin tumour suppressor controls the repair capacity of Schwann cells following injury by regulating Hippo pathway signalling, Thomas Mindos, Xin peng Dun, Katherine North, Alexander Schulz, Bethany Gray, Duojia Pan, Philip Edwards, Aditya Shivane, Helen Morrison, and David B. Parkinson

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The role of p38alpha in Schwann cells in regulating peripheral nerve myelination and repair, Sheridan L. Roberts, Xin Peng Dun, Gemma Dee, Bethany Gray, Thomas Mindos, and David B. Parkinson

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Adapting to survive: addressing the global problem of Antimicrobial Resistance, Laura Bowater and Jonathan Pyatt

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A NOVEL FUNCTIONAL BIOASSAY PREDICTS 90-DAY SURVIVAL IN PATIENTS WITH SEVERE ALCOHOLIC HEPATITIS, E Yates, M Cramp, and A Dhanda

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Assessment of fidelity in individual level behaviour change interventions promoting physical activity among adults: a systematic review, Jeffrey D. Lambert, Colin J. Greaves, Paul Farrand, Rosina Cross, Anne M. Haase, and Adrian H. Taylor

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Can implementation of technology transform the management of Parkinson's? Lessons learnt from the Parkinson's KinetiGraph™ (PKG™) service evaluation project, C Thomas, B Mohammed, E Abdelgadir, MA Silverdale, C Kobylecki, L Osborne, M Smith, A Hulejczuk, AR Saha, PG Bain, and C Carroll

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Computerised cognitive–behavioural therapy for depression in adolescents: feasibility results and 4-month outcomes of a UK randomised controlled trial, Barry Wright, Lucy Tindall, Elizabeth Littlewood, Victoria Allgar, Paul Abeles, Dominic Trépel, and Shehzad Ali

GLOBAL PROTEOME AND PHOSPHOPROTEOME ANALYSIS OF MENINGIOMAS., J Dunn, S Ferluga, E Lasonder, and O Hanemann

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Implementing medical revalidation in the United Kingdom: Findings about organisational changes and impacts from a survey of Responsible Officers, Kieran Walshe, Alan Boyd, Marie Bryce, Kayleigh Luscombe, Abigail Tazzyman, John Tredinnick-Rowe, and Julian Archer

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Measuring treatment satisfaction in MS: Is the treatment satisfaction questionnaire for medication fit for purpose?, Patrick Vermersch, Jeremy Hobart, Catherine Dive-Pouletty, Sylvie Bozzi, Steven Hass, and Patricia K. Coyle

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MEDLINE TRANSPOSE: CONVERSION TOOL FOR PUBMED AND OVID MEDLINE INTERFACES, A Wanner and N Baumann

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Pneumococcal Vaccine Effectiveness and Its Interaction With Age: A UK Population Based Study in Older Adults, AJ Streeter, JAH Masoli, A Ble, D Melzer, and WE Henley

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Risk factors and functional abnormalities associated with adult onset secondary nocturnal enuresis in women, C Madhu, H Hashim, DG Enki, M Yaasin, and M Drake

SNOT-22 in a control population, SE Erskine, C Hopkins, A Clark, S Anari, N Kumar, A Robertson, S Sunkaraneni, JA Wilson, S Carrie, N Kara, J Ray, R Smith, CM Philpott, and Hisham Khalil

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The semiotics of minority language branding: A study of the Celtic languages, J Tredinnick-Rowe

TLL1 rs17047200 Increases the Risk of Fibrosis Progression in Caucasian Patients With Chronic Hepatitis C, Miya John, Mayada Metwally, Alessandra Mangia, Manuel Romero-Gomez, Thomas Berg, David Sheridan, Jacob George, and Mohammed Eslam

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Variation in referral and access to new psychological therapy services by age: an empirical quantitative study, Richard Byng, Sophie Pettit, Adam Qureshi, William Lee, Alex Stirzaker, Alex Gibson, and William Henley

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Variation in the use of corticosteroids for the treatment of acute severe alcoholic hepatitis in the post-STOPAH era: results of a UK national survey, A Dhanda, S Atkinson, and M Thursz

Submissions from 2016

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Identifying applicants suitable to a career in nursing: a value-based approach to undergraduate selection, Marian Traynor, Despina Galanouli, Martin Roberts, Lawrence Leonard, and Thomas Gale

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It’s just common sense! Why do negative perceptions of sociology teaching in medical education persist and is there any change in sight?, L Brooks, T Collett, and S Forrest

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The history of sociology teaching in United Kingdom (UK) undergraduate medical education: an introduction and rallying call!, T Collett, L Brooks, and S Forrest

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Development and validation of a novel bioassay to determine glucocorticoid sensitivity, Emily L. Williams, Madeleine L. Stimpson, Peter L. Collins, Doyo G. Enki, Ashish Sinha, Richard W. Lee, and Ashwin D. Dhanda

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The RAPID-CTCA trial (Rapid Assessment of Potential Ischaemic Heart Disease with CTCA) — a multicentre parallel-group randomised trial to compare early computerised tomography coronary angiography versus standard care in patients presenting with suspected or confirmed acute coronary syndrome: study protocol for a randomised controlled trial, Alasdair J. Gray, Carl Roobottom, Jason E. Smith, Steve Goodacre, Katherine Oatey, R O’Brien, Robert F. Storey, Lumine Na, Steff C. Lewis, Praveen Thokala, and David E. Newby

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Detailed statistical analysis plan for a cluster randomised controlled trial of the Healthy Lifestyles Programme (HeLP), a novel school-based intervention to prevent obesity in school children, S Creanor, J Lloyd, M Hillsdon, S Dean, and et al

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Evaluating the educational environment of an international animal model-based wet lab course for undergraduate students, Michail Ch Sideris, Apostolos E. Papalois, Thanos Athanasiou, Ioannis Dimitropoulos, Korina Theodoraki, Francois Sousa Dos Santos, Georgios Paparoidamis, Nikolaos Staikoglou, Dimitrios Pissas, Peter C. Whitfield, Alexandros Rampotas, Savvas Papagrigoriadis, Vassilios Papalois, Georgios Zografos, and Georgios Tsoulfas

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Factors associated with study attrition in a pilot randomised controlled trial to explore the role of exercise-assisted reduction to stop (EARS) smoking in disadvantaged groups, T. P. Thompson, C. J. Greaves, R. Ayres, P. Aveyard, F. C. Warren, R. Byng, RS Taylor, J. L. Campbell, M. Ussher, S. Michie, R. West, and AH Taylor

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Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2), K Glebov, P Wunderlich, I Karaca, and J Walter

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Has the ‘Fast-Track’ referral system affected the route of presentation and/or clinical outcomes in patients with colorectal cancer?, Luke Thornton, Harriet Reader, Stevan Stojkovic, Victoria Allgar, and Nick Woodcock

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Modifying Hofstee standard setting for assessments that vary in difficulty, and to determine boundaries for different levels of achievement, SA Burr, J Whittle, LC Fairclough, L Coombes, and I Todd

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Posttraumatic Stress Disorder Among Older Patients with Chronic Obstructive Pulmonary Disease, MC Chung, RCM Jones, SA Harding, and J Campbell

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Promoting and maintaining physical activity in the transition to retirement: a systematic review of interventions for adults around retirement age, S. Baxter, M. Johnson, N. Payne, H. Buckley-Woods, L. Blank, E. Hock, A. Daley, A. Taylor, T. Pavey, G. Mountain, and E. Goyder

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Rare variants analysis of cutaneous malignant melanoma genes in Parkinson's disease, S. J. Lubbe, V. Escott-Price, A. Brice, T. Gasser, A. M. Pittman, J. Bras, J. Hardy, P. Heutink, N. M. Wood, A. B. Singleton, D. G. Grosset, C. B. Carroll, M. H. Law, F. Demenais, M. M. Iles, D. T. Bishop, J. Newton-Bishop, N. M. Williams, and H. R. Morris

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Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism, DN Mitroi, AU Deutschmann, M Raucamp, I Karunakaran, K Glebov, M Hans, J Walter, J Saba, M Gräler, D Ehninger, E Sopova, O Shupliakov, D Swandulla, and Echten-Deckert G van

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The impact of large scale licensing examinations in highly developed countries: a systematic review, Julian Archer, Nick Lynn, Lee Coombes, Martin Roberts, Tom Gale, Tristan Price, and de Bere S Regan

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Western medical acupuncture in a group setting for knee osteoarthritis: results of a pilot randomised controlled trial, Adrian White, Liz Tough, Vicky Eyre, Jane Vickery, Anthea Asprey, Cath Quinn, Fiona Warren, Colin Pritchard, Nadine E. Foster, Rod S. Taylor, Martin Underwood, and Paul Dieppe

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Feminism in Cornwall, JF Tredinnick-Rowe

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Evaluating your professionalism, Steven Burr, Hilary Neve, and Yee Leung

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Accessible polyvocality and paired talk: how family therapists talk positive connotation into being, Lynsey Williams and Tim Auburn

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Anti-envelope antibody responses in individuals at high risk of hepatitis C virus who resist infection, R. E. Swann, P. Mandalou, M. W. Robinson, M. M. Ow, S. K.H. Foung, J. McLauchlan, A. H. Patel, and M. E. Cramp

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Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries, Danial Martin

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The social, relational and mental health characteristics of justice-involved men in the south-west England, Alexandros Georgiadis, Richard Byng, Ross Coomber, and Cath Quinn

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How do brochures encourage walking in natural environments in the UK? A content analysis, Lewis R. Elliott, Mathew P. White, Adrian H. Taylor, and Charles Abraham

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Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models, K. J. Brennand, J Xu, B. J. Hartley, P. Kurup, A. Phillips, A. Topol, M Xu, C. Ononenyi, E. Foscue, S. M. Ho, T. D. Baguley, N. Carty, C. S. Barros, U. Müller, S. Gupta, P. Gochman, J. Rapoport, J. A. Ellman, C. Pittenger, B. Aronow, A. C. Nairn, M. W. Nestor, and P. J. Lombroso

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The Semantics of Remediation - primed to fail? The impact of negative word association upon student performance in remediation, JF Tredinnick-Rowe and J Read

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The increased expression of fatty acid-binding protein 9 in prostate cancer and its prognostic significance, MS Al Fayi, X Gou, SS Forootan, W Al-Jameel, and et al

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Single neuron transcriptomics identify SRSF/ SR protein B52 as a regulator of axon growth and Choline acetyltransferase splicing., Torsten Bossing and Boyin Liu

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Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015, GBD 2015 Risk Factors Collaborators

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Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015, GBD 2015 Disease and Injury Incidence and Prevalence Collaborators

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Global, regional, and national levels of maternal mortality, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015, GBD 2015 Maternal Mortality Collaborators

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Evidence for energy conservation during pubertal growth. A 10-year longitudinal study (EarlyBird 71), M Mostazir, A Jeffery, J Hosking, B Metcalf, L Voss, and T Wilkin

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Head injury in the elderly - what are the outcomes of neurosurgical care?, KJ Whitehouse, DS Jeyaretna, DG Enki, and PC Whitfield

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Head Injury in the Elderly: What Are the Outcomes of Neurosurgical Care?, Kathrin Joanna Whitehouse, Deva Sanjeeva Jeyaretna, Doyo Gragn Enki, and Peter C. Whitfield

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Inequity in cardiovascular care in the English National Health Service (NHS): a scoping review of the literature, Sheena Asthana, Graham Moon, Alex Gibson, Trevor Bailey, Paul Hewson, and Chris Dibben

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What happens when 55% of acute psychiatric beds are closed in six days: an unexpected naturalistic observational study, Richard Laugharne, Matt Branch, Anji Mitchell, Lindsay Parkin, Phil Confue, Rohit Shankar, Diane Wilson-James, Mike Marshall, Maria Edgecombe, Bernie Keaney, Kiran Gill, and Juliet Harrison

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Rigour in moderation processes is more important than the choice of method, Daniel Zahra, Iain Robinson, Martin Roberts, Lee Coombes, Josephine Cockerill, and Steven Burr

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Getting real in the community: Evaluating the “making a difference” interdisciplinary social engagement project, R Ayres, S Stevens, and de Bere S Regan

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MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C., Khaled Thabet, Anastasia Asimakopoulos, Maryam Shojaei, Manuel Romero-Gomez, Alessandra Mangia, William L. Irving, Thomas Berg, Gregory J. Dore, Henning Grønbæk, David Sheridan, Maria Lorena Abate, Elisabetta Bugianesi, Martin Weltman, Lindsay Mollison, Wendy Cheng, Stephen Riordan, Janett Fischer, Ulrich Spengler, Jacob Nattermann, Ahmed Wahid, Angela Rojas, Rose White, Mark W. Douglas, Duncan McLeod, Elizabeth Powell, Christopher Liddle, David van der Poorten, Jacob George, and Mohammed Eslam

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How Can Physical Activity Referral Rates for Breast Cancer Patients be Increased?, M Queen, C Karatzaferi, SR Bloxham, U Panwar, and et al

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Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in a Parkinson disease mouse model, Anja Drinkut, Karsten Tillack, Durga P. Meka, Jorg B. Schulz, Sebastian Kügler, and Edgar R. Kramer

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Brain health: time matters in multiple sclerosis, Gavin Giovannoni, Helmut Butzkueven, Suhayl Dhib-Jalbut, Jeremy Hobart, Gisela Kobelt, George Pepper, Maria Pia Sormani, Christoph Thalheim, Anthony Traboulsee, and Timothy Vollmer

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Core Outcomes and Common Data Elements in Chronic Subdural Hematoma: A Systematic Review of the Literature Focusing on Baseline and Peri-Operative Care Data Elements, Aswin Chari, Katie C. Hocking, Ellie Edlmann, Carole Turner, Thomas Santarius, Peter J. Hutchinson, and Angelos G. Kolias

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“My patients are better than yours”: optimistic bias about patients’ medication adherence by European health care professionals, W Clyne, S McLachlan, C Mshelia, P Jones, and et al

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Socio-economic factors, gender and smoking as determinants of COPD in a low-income country of sub-Saharan Africa: FRESH AIR Uganda, Gemert F. van, N Chavannes, B Kirenga, R Jones, S Williams, I Tsiligianni, J Vonk, J Kocks, Jong C de, and der Molen T van

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Steps to prevent SUDEP: the validity of risk factors in the SUDEP and seizure safety checklist: a case control study, Rohit Shankar, Matthew Walker, Brendan McLean, Richard Laugharne, Fucundo Ferrand, Jane Hanna, and Craig Newman

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AMEE 2016, KG Gilbert, H Neve, and H Lloyd

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Understanding students’ experiences of professionalism learning: a ‘threshold’ approach, Hilary Neve, Helen Lloyd, and Tracey Collett

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Contribution of murine IgG Fc regions to antibody binding to the capsule ofBurkholderia pseudomallei, Michael J. Dillon, Rachael A. Loban, Dana E. Reed, Peter Thorkildson, Kathryn J. Pflughoeft, Sujata G. Pandit, Paul J. Brett, Mary N. Burtnick, and David P. AuCoin

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Current status and recommendations for biomarkers and biobanking in neurofibromatosis, C. Oliver Hanemann, Jaishri O. Blakeley, Fabio P. Nunes, Kent Robertson, Anat Stemmer-Rachamimov, Victor Mautner, Andreas Kurtz, Michael Ferguson, Brigitte C. Widemann, D. Gareth Evans, Rosalie Ferner, Steven L. Carroll, Bruce Korf, Pierre Wolkenstein, Pamela Knight, and Scott R. Plotkin

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Current whole-body MRI applications in the neurofibromatoses, S Ahlawat, LM Fayad, MS Khan, MA Bredella, GJ Harris, DG Evans, S Farschtschi, MA Jacobs, A Chhabra, JM Salamon, R Wenzel, VF Mautner, E Dombi, W Cai, SR Plotkin, JO Blakeley, and CO Hanemann

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Neurocognitive outcomes in neurofibromatosis clinical trials, KS Walsh, J Janusz, PL Wolters, S Martin, BP Klein-Tasman, MA Toledo-Tamula, HL Thompson, JM Payne, KK Hardy, Blank P de, C Semerjian, LS Gray, SE Solomon, N Ullrich, and CO Hanemann

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Patient-reported outcomes of pain and physical functioning in neurofibromatosis clinical trials., CO Hanemann, PL Wolters, S Martin, VL Merker, JH Tonsgard, SE Soloman, A Baldwin, AL Bergner, K Walsh, HL Thompson, KL Gardner, CM HIngtgen, E Schorry, WN Dudley, and B Franklin

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Sleep and pulmonary outcomes for clinical trials of airway plexiform neurofibromas in NF1, SR Plotkin, SD Davis, KA Robertson, S Akshintala, J Allen, MJ Fisher, JO Blakeley, BC Widemann, RE Ferner, CL Marcus, and CO Hanemann

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Comparison of Statistical Algorithms for the Detection of Infectious Disease Outbreaks in Large Multiple Surveillance Systems, DG Enki, PH Garthwaite, CP Farrington, and et al

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Women's knowledge and utilization of prenatal screening tests: A Turkish study, M Seven, A Akyüz, K Eroglu, S Daack-Hirsch, and H Skirton

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Correction: Corrigendum: NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells, H Alrefai, K Muhammad, R Rudolf, DAT Pham, S Klein-Hessling, AK Patra, A Avots, V Bukur, U Sahin, S Tenzer, M Goebeler, A Kerstan, and E Serfling

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A comparison of energy consumption between the use of a walking frame, crutches and a Stride-on rehabilitation scooter, N Patel, T Batten, A Roberton, and et al

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Detection of infectious disease outbreaks from laboratory data with reporting delays, A Noufaily, P Farrington, P Garthwaite, and et al

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Determining the haemodynamic significance of arterial stenosis: the relationship between CT angiography, computational fluid dynamics, and non-invasive fractional flow reserve, C. L. Pang, R. Alcock, N. Pilkington, T. Reis, and C. Roobottom

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Estimates of global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2015: the Global Burden of Disease Study 2015, GBD 2015 HIV Collaborators

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Identification of blood biomarkers for use in point of care diagnosis tool for Alzheimer's disease, E. Jammeh, P. Zhao, C. Carroll, S. Pearson, and E. Ifeachor

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Making a difference: a qualitative study of an inter-professional social engagement project, R Ayres, S stevens, and de bere S regan

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Molecular mechanisms autonomic dysfunction and impaired cardiac contractility in critical illness, GL Ackland, J Whittle, A Toner, A Machhada, and et al

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Simultaneous targeting of Eph receptors in glioblastoma, S Ferluga, CML Tomé, DM Herpai, R D’Agostino, and W Debinski

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Social Stories in mainstream schools for children with autism spectrum disorder: a feasibility randomised controlled trial, David Marshall, Barry Wright, Victoria Allgar, Joy Adamson, Christine Williams, Hannah Ainsworth, Liz Cook, Danielle Varley, Lisa Hackney, Paul Dempster, Shehzad Ali, Dominic Trepel, Moore D Collingridge, Elizabeth Littlewood, and Dean McMillan

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Technology-Enabled Remote Monitoring and Self-Management — Vision for Patient Empowerment Following Cardiac and Vascular Surgery: User Testing and Randomized Controlled Trial Protocol, M McGillion, J Yost, A Turner, and et al

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The intact Kunitz domain protects the amyloid precursor protein from being processed by matriptase-2, A-M Beckmann, K Glebov, J Walter, O Merkel, M Mangold, F Schmidt, C Becker-Pauly, M Gütschow, and M Stirnberg

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Householders’ Mental Models of Domestic Energy Consumption: Using a Sort-And-Cluster Method to Identify Shared Concepts of Appliance Similarity, E Gabe-Thomas, I Walker, B Verplanken, and G Shaddick

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Provider plurality and supply-side reform, WR Sheaff and P Allen

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Achieving Consensus for the Design and Delivery of an Online Intervention to Support Midwives in Work-Related Psychological Distress: Results From a Delphi Study, S Pezaro and W Clyne

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Police Funding Arrangements in Engand and Wales: Report to the NRCN, AJS Gibson and S Asthana

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Progress testing in undergraduate dental education: the Peninsula experience and future opportunities, K Ali, L Coombes, E Kay, C Tredwin, and et al

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The Global Diffusion and Application of Medical Semiotics - From Medical Semiotics to Medical Semiology, JF Tredinnick-Rowe

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The (re)-introduction of semiotics into medical education: on the works of Thure von Uexküll, John Tredinnick-Rowe

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Maximum levels of hepatitis C virus lipoviral particles are associated with early and persistent infection, David A. Sheridan, Behzad Hajarizadeh, Fiona I. Fenwick, Gail V. Matthews, Tanya Applegate, Mark Douglas, Dermot Neely, Bev Askew, Gregory J. Dore, Andrew R. Lloyd, Jacob George, Margaret F. Bassendine, and Jason Grebely

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Emotional logic development profiles – validating the benefits and safety of emotional logic training, Daniel Zahra, Marian Langsford, and Trevor Griffiths

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Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth, A McIntyre, A Hulikova, I Ledaki, C Snell, and et al

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Exploring the relationship between childhood obesity and proximity to the coast: A rural/urban perspective, Sophie L. Wood, Philippe R. Demougin, Sahran Higgins, Kerryn Husk, Benedict W. Wheeler, and Mathew White