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Submissions from 2022

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Examining Quality, Use and Impact of Psychotropic (Use) in older adults with intellectual disabilities (EQUIP): study protocol: Original, Ashleigh Gorman, Rohit Shankar, Marina Odalović, Philip McCallion, Éilish Burke, Malcolm Maclachlan, Mary McCarron, Martin Henman, Maeve Moran, Juliette O'Connell, Mike Walsh, and Marie O'Dwyer

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Oral microbes and the formation of cerebral abscesses: a single-centre retrospective study, Holly Roy, Raul Bescos, Ewen McColl, Umar Rehman, Elizabeth Cray, Louise A. Belfield, King David Nweze, Kevin Tsang, William Singleton, Peter Whitfield, and Zoe Brookes

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The role of mindfulness training in sustaining weight reduction: retrospective cohort analysis, P Hanson, M Lange, D Oduro-Donkor, E Shuttlewood, and et al

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Antihypertensives in dementia: Good or bad for the brain?, Lucy Beishon, Victoria J. Haunton, and Ronney B. Panerai

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Understanding how language revitalisation works: a realist synthesis, Brandon Wiltshire, Steven Bird, and Rebecca Hardwick

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Digital Peer-Supported Self-Management Intervention Codesigned by People With Long COVID: Mixed Methods Proof-of-Concept Study, H Wright, A Turner, S Ennis, C Percy, and et al

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Publisher Correction: Brain charts for the human lifespan, RAI Bethlehem, J Seidlitz, SR White, and et al

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Real-world effectiveness of pneumococcal vaccination in older adults: Cohort study using the UK Clinical Practice Research Datalink, AJ Streeter, LR Rodgers, J Masoli, NX Lin, A Blé, W Hamilton, and WE Henley

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The economic case for hospital discharge services for people experiencing homelessness in England: An in‐depth analysis with different service configurations providing specialist care, Michela Tinelli, Raphael Wittenberg, Michelle Cornes, Robert W. Aldridge, Michael Clark, Richard Byng, Graham Foster, James Fuller, Andrew Hayward, Nigel Hewett, Alan Kilmister, Jill Manthorpe, Joanne Neale, Elizabeth Biswell, and Martin Whiteford

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A paperless approach to clinical trial systems: from specification to validation and beyond., MP Bailey, H Abraham, D Maddock, R Ashford, and C Hayward

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Social prescribing for children and young people, Marcello Bertotti, Dan Hayes, Vashti Berry, Paul Jarvis-Beesley, and Kerryn Husk

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Could a Medication Help With Bleeding Between the Skull and the Brain?, A Chari, KS Lee, A Alamri, PJA Hutchinson, AG Kolias, and E Edlmann

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Comment on: Disease gene identification strategies for exome sequencing by Gilissen et al. 2012, Julia Baptista

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Cost-effectiveness of mirtazapine for agitated behaviors in dementia: findings from a randomized controlled trial, Catherine Henderson, Martin Knapp, Susan Stirling, Lee Shepstone, Juliet High, Clive Ballard, Peter Bentham, Alistair Burns, Nicolas Farina, Chris Fox, Julia Fountain, Paul Francis, Robert Howard, Iracema Leroi, Gill Livingston, Ramin Nilforooshan, Shirley Nurock, JT O’Brien, Annabel Price, Ann Marie Swart, Naji Tabet, Tanya Telling, Alan J. Thomas, and Sube Banerjee

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Development and evaluation of a collaborative care intervention for male prison leavers with mental health problems: the Engager research programme, Richard Byng, Charlotte Lennox, Tim Kirkpatrick, Cath Quinn, Rob Anderson, Sarah Louise Brand, Lynne Callaghan, Lauren Carroll, Graham Durcan, Laura Gill, Sara Goodier, Jonathan Graham, Rebecca Greer, Mark Haddad, Tirril Harris, William Henley, Rachael Hunter, Mike Maguire, Sarah Leonard, Susan Michie, Christabel Owens, Mark Pearson, Sarah Rybczynska-Bunt, Caroline Stevenson, Amy Stewart, Alex Stirzaker, Rod Taylor, Roxanne Todd, Florian Walter, Fiona C. Warren, Lauren Weston, Nat Wright, and Jenny Shaw

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Progress and challenges in the harmonisation of European undergraduate dental education: a systematic literature review with narrative synthesis., Marie Bryce, Daniel Zahra, Lorna Burns, Sally Hanks, and Thomas Gale

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Traboulsi syndrome caused by mutations in ASPH: An autosomal recessive disorder with overlapping features of Marfan syndrome, Gabriela Jones, Katie Johnson, Jacqueline Eason, Mark Hamilton, Deborah Osio, Farah Kanani, Julia Baptista, and Mohnish Suri

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Direct isolation of single cells from living brains of Drosophila melanogaster without dissociation for transcriptome analysis, Claudia S. Barros and Torsten Bossing

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A process evaluation, with mediation analysis, of a web-based intervention to augment primary care exercise referral schemes: the e-coachER randomised controlled trial, Jeffrey Lambert, A Taylor, Adam Streeter, Colin Greaves, Wendy M. Ingram, Sarah Dean, Kate Jolly, Nanette Mutrie, RS Taylor, Lucy Yardley, Lisa Price, and John Campbell

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Tauroursodeoxycholic acid in patients with amyotrophic lateral sclerosis: The TUDCA-ALS trial protocol, Alberto Albanese, TUDCA-ALS Study Group, Albert Christian Ludolph, Christopher J. McDermott, Philippe Corcia, Philip Van Damme, Leonard H. Van den Berg, Orla Hardiman, Gilberto Rinaldi, Nicola Vanacore, Brian Dickie, Paolo Tornese, Antoniangela Cocco, Maria Lo Giudice, Michela Matteoli, Eliana Lauranzano, Maria Luisa Malosio, Chiara Adriana Elia, Flavia Lombardo, Flavia Mayer, Maria Puopolo, Stefania Spila Alegiani, Adriano Chiò, Umberto Manera, Cristina Moglia, Andrea Calvo, Paolina Salamone, Giuseppe Fuda, Carlo Colosimo, Cristina Spera, Giuseppe Stipa, Domenico Frondizi, Christian Lunetta, Valeria Sansone, Claudia Tarlarini, Francesca Gerardi, Vincenzo Silani, Alberto Doretti, Eleonora Colombo, Gianluca Demirtzidis, Gioacchino Tedeschi, Francesca Trojsi, Carla Passaniti, Stefania Ballestrero, Johannes Dorst, Ulrike Weiland, Andrea Fromm, Maximilian Wiesenfarth, Katharina Kandler, Simon Witzel, and Oliver Hanemann

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Inhibition of YAP/TAZ-driven TEAD activity prevents growth of NF2-null schwannoma and meningioma, David B. Parkinson

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A Tailored Approach: A model for literature searching in complex systematic reviews, Chris Cooper, Andrew Booth, Kerryn Husk, Rebecca Lovell, Julia Frost, Ute Schauberger, Nicky Britten, and Ruth Garside

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A group-based behavioural intervention for weight management (PROGROUP) versus usual care in adults with severe obesity: a feasibility randomised controlled trial protocol, Dawn Swancutt, Mark Tarrant, Wendy Ingram, Sarah Baldrey, Lorna Burns, Richard Byng, Raff Calitri, Siobhan Creanor, Sarah Dean, Lucy Evans, Laura Gill, Elizabeth Goodwin, Lily Hawkins, Chris Hayward, Sarah Hind, Laura Hollands, Joanne Hosking, Jenny Lloyd, Shokraneh Moghadam, Helen Neilens, Mary O’Kane, Steve Perry, Rod Sheaff, Anne Spencer, Adrian Taylor, Thomas Ward, Ross Watkins, John Wilding, and Jonathan Pinkney

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Dexamethasone reduces vascular endothelial growth factor in comparison to placebo in post-operative chronic subdural hematoma samples: A target for future drug therapy?, Ellie Edlmann, Susan Giorgi-Coll, Eric P. Thelin, Peter J. Hutchinson, and Keri L.H. Carpenter

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Germline homozygous missense DEPDC5 variants cause severe refractory early-onset epilepsy, macrocephaly and bilateral polymicrogyria, Athina Ververi, Sara Zagaglia, Lara Menzies, Julia Baptista, Richard Caswell, Stephanie Baulac, Sian Ellard, Sally Lynch, Thomas S. Jacques, Maninder Singh Chawla, Martin Heier, Mari Ann Kulseth, Inger Lise Mero, Anne Katrine Våtevik, Ichraf Kraoua, Rhouma H Ben, Younes T Ben, Zouhour Miladi, Youssef Turki I Ben, Wendy D. Jones, Emma Clement, Christin Eltze, Kshitij Mankad, Ashirwad Merve, Jennifer Parker, Bethan Hoskins, Ronit Pressler, Sniya Sudhakar, Catherine Devile, Tessa Homfray, Marios Kaliakatsos, Robert Robinson, Sara Margrete Bøen Keim, Imen Habibi, Alexandre Reymond, Sanjay M. Sisodiya, and Jane A. Hurst

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Germline homozygous missense DEPDC5 variants cause severe refractory early-onset epilepsy, macrocephaly and bilateral polymicrogyria, A Ververi, S Zagaglia, SM Sisodiya, JA Hurst, and et al

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Multiplex Lateral Flow Assay and the Sample Preparation Method for the Simultaneous Detection of Three Marine Toxins, Clare Mills, Michael J. Dillon, Prabir Kumar Kulabhusan, Diana Senovilla-Herrero, and Katrina Campbell

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A systematic review identifying outcome measures used in evaluating adults sustaining cervical spine fractures, Phillip C. Copley, Daniel Tadross, Nadia Salloum, Julie Woodfield, Ellie Edlmann, Michael Poon, Sadaquate Khan, and Paul M. Brennan

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‘Pushing back’: People newly diagnosed with dementia and their experiences of the Covid‐19 pandemic restrictions in England, J Dixon, B Hicks, K Gridley, R Perach, and et al

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Adaptation of the STRiDE dementia survey into the Indonesian context in North Sumatra, Fasihah Irfani Fitri, Ika Mariana Gultom, Eka Mahendrayana, Engki Irawan, Aldy S. Rambe, Tara Puspitarini Sani, Yuda Turana, Imelda Theresia, Nicolas Farina, and Sube Banerjee

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Bi-allelic LETM1 variants perturb mitochondrial ion homeostasis leading to a clinical spectrum with predominant nervous system involvement, JDC Pereira Baptista

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Cataract, abnormal electroretinogram and visual evoked potentials in a child with SMA-LED2 - extending the phenotype, Agata Oliwa, Shuko Joseph, Eoghan Millar, Iain Horrocks, Dawn Penman, Julia Baptista, Thomas Cullup, Panayiotis Constantinou, Anne Marie Heuchan, Ruth Hamilton, and Cheryl Longman

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Early computed tomography coronary angiography in adults presenting with suspected acute coronary syndrome: the RAPID-CTCA RCT, Alasdair J. Gray, Carl Roobottom, Jason E. Smith, Steve Goodacre, Katherine Oatey, Rachel O’Brien, Robert F. Storey, Nick Curzen, Liza Keating, Attila Kardos, Dirk Felmeden, Robert J. Lee, Praveen Thokala, Steff C. Lewis, and David E. Newby

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Pharmacogenomics: an opportunity for personalised psychotropic prescribing in adults with intellectual disabilities, B Perera, C Steward, K Courtenay, T Andrews, and R Shankar

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Rapid exome sequencing in critically ill children impacts acute and long-term management of patients and their families: a retrospective regional evaluation, JDC Pereira Baptista

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Optimising a person-centred approach to stopping medicines in older people with multimorbidity and polypharmacy using the DExTruS framework: a realist review, Amadea Turk, Geoffrey Wong, Kamal R. Mahtani, Michelle Maden, Ruaraidh Hill, Ed Ranson, Emma Wallace, Janet Krska, Dee Mangin, Richard Byng, Daniel Lasserson, and Joanne Reeve

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Virtual Care and the Inverse Care Law: Implications for Policy, Practice, Research, Public and Patients, H Alami, P Lehoux, SE Shaw, and et al

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Mixed-methods feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): Study findings, Ann Hutchinson, Victoria Allgar, Judith Cohen, David C. Currow, Susan Griffin, Simon Hart, Kelly Hird, Andrew Hodge, Suzanne Mason, Matthew Northgraves, Joanne Reeve, Flavia Swan, and Miriam J. Johnson

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Tailoring cultural offers to meet the needs of older people during uncertain times: a rapid realist review, Stephanie Tierney, Sebastien Libert, Jordan Gorenberg, Geoff Wong, Amadea Turk, Kerryn Husk, Helen J. Chatterjee, Kathryn Eccles, Caroline Potter, Emma Webster, Beth McDougall, Harriet Warburton, Lucy Shaw, Nia Roberts, and Kamal R. Mahtani

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Personalising knowledge assessments to remove compensation and thereby improve preparation for safe practice - developing content adaptive progress testing, S Burr, J Kisielewska, D Zahra, I Hodgins, I Robinson, P Millin, T Gale, N Santos, and J Pêgo

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Antidepressant prescribing for adult people with an intellectual disability living in England, Rohit Shankar and David Branford

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Evaluation of a complex intervention for prisoners with common mental health problems, near to and after release: the Engager randomised controlled trial, Richard Byng, Tim Kirkpatrick, Charlotte Lennox, Fiona C. Warren, Rob Anderson, Sarah Louise Brand, Lynne Callaghan, Lauren Carroll, Graham Durcan, Laura Gill, Sara Goodier, Jonathan Graham, Rebecca Greer, Mark Haddad, Tirril Harris, William Henley, Rachael Hunter, Sarah Leonard, Mike Maguire, Susan Michie, Christabel Owens, Mark Pearson, Cath Quinn, Sarah Rybczynska-Bunt, Caroline Stevenson, Amy Stewart, Alex Stirzaker, Roxanne Todd, Florian Walter, Lauren Weston, Nat Wright, Rod S. Taylor, and Jenny Shaw

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Pharmacogenomics: An opportunity for personalised psychotropic prescribing in adults with intellectual disabilities, Rohit Shankar, Bhathika Perera, Charles Steward, Ken Courtenay, and Timothy Andrews

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Effectiveness of a targeted telephone-based case management service on activity in an Emergency Department in the UK: a pragmatic difference-in-differences evaluation, Julian Elston, Felix P. Gradinger, Adam J. Streeter, Stephen Macey, and Susan Martin

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Outcome and mortality of hospital admission with COVID-19 for individuals with parkinsonian syndromes, L Sorrell, A King, J Inches, J Rideout, JR Sneyd, C Kobylecki, R Chaudhuri, R Walker, H Martin, and C Carroll

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Longitudinal expression profiling identifies a poor risk subset of patients with ABC-type Diffuse Large B Cell Lymphoma, F Bewicke-Copley, K Korfi, S Araf, and et al

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Protocol: Remote care as the ‘new normal’? Multi-site case study in UK general practice, T Greenhalgh, SE Shaw, Nishio A Alvarez, A Booth, R Byng, A Clarke, F Dakin, R Davies, S Faulkner, N Hemmings, L Husain, A Kalin, E Ladds, L Moore, R Rosen, S Rybczynska-Bunt, J Wherton, and S Wieringa

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Remote care in UK general practice: baseline data on 11 case studies, T Greenhalgh, SE Shaw, Nishio A Alvarez, R Byng, A Clarke, F Dakin, S Faulkner, N Hemmings, L Husain, A Kalin, E Ladds, L Moore, R Rosen, S Rybczynska-Bunt, J Wherton, and S Wieringa

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Developing undergraduate autism education for medical students: a qualitative study, Y Dhuga, Y Feeney, L Gallaher, A White, and et al

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Loot boxes and problem gambling: Investigating the “gateway hypothesis”, Stuart Gordon Spicer, Chris Fullwood, James Close, Laura Louise Nicklin, J Lloyd, and H Lloyd

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Parkinson’s disease – palliative care needs assessment tool: adaptation and psychometric testing, Edward William Richfield, Victoria Allgar, Afaf Girgis, and Miriam J. Johnson

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Does social and economic disadvantage predict lower engagement with parenting interventions? An integrative analysis using individual participant data, Vashti Berry, G. J. Melendez-Torres, Nick Axford, Ulf Axberg, de Castro B Orobio, Frances Gardner, Maria Filomena Gaspar, BH Handegard, Judy Hutchings, A Meeting, Sinéad McGilloway, Stephen Scott, and Patty Leijten

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Social prescribing for older people and the role of the cultural sector during the COVID-19 pandemic: What are link workers' views and experiences?, Stephanie Tierney, Caroline Potter, Kathryn Eccles, Oluwafunmi Akinyemi, Jordan Gorenberg, Sebastien Libert, Geoff Wong, Amadea Turk, Kerryn Husk, Helen J. Chatterjee, Emma Webster, Beth McDougall, Harriet Warburton, Lucy Shaw, and Kamal R. Mahtani

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Durvalumab as monotherapy and in combination therapy in patients with lymphoma or chronic lymphocytic leukemia: The FUSION NHL 001 trial, C Casulo, A Santoro, G Cartron, and et al

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Socioeconomic inequality of long-term care for older people with and without dementia in England, B Hu, S Read, R Wittenberg, N Brimblecombe, and et al

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Brief intervention to reduce fatigue impact in patients with inflammatory arthritis: design and outcomes of a single-arm feasibility study, E Dures, S Bridgewater, B Abbott, J Adams, A Berry, LM McCracken, S Creanor, S Hewlett, J Lomax, M Ndosi, J Thorn, M Urban, and P Ewings

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Duration of External Neck Stabilisation (DENS) following odontoid fracture in older or frail adults: protocol for a randomised controlled trial of collar versus no collar, Julie Woodfield, Ellie Edlmann, Polly L. Black, Julia Boyd, Phillip Correia Copley, Gina Cranswick, Helen Eborall, Catriona Keerie, Sadaquate Khan, Julia Lawton, David J. Lowe, John Norrie, Angela Niven, Matthew J. Reed, Susan Deborah Shenkin, Patrick Statham, Andrew Stoddart, James Tomlinson, and Paul M. Brennan

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Interrogating intervention delivery and participants’ emotional states to improve engagement and implementation: A realist informed multiple case study evaluation of Engager, Lauren Weston, Sarah Rybczynska-Bunt, Cath Quinn, Charlotte Lennox, Mike Maguire, Mark Pearson, Alex Stirzaker, Graham Durcan, Caroline Stevenson, Jonathan Graham, Lauren Carroll, Rebecca Greer, Mark Haddad, Rachael Hunter, Rob Anderson, Roxanne Todd, Sara Goodier, Sarah Brand, Susan Michie, Tim Kirkpatrick, Sarah Leonard, Tirril Harris, William Henley, Jenny Shaw, Christabel Owens, and Richard Byng

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How can we optimise learning from trials in child and adolescent mental health?, Nick Axford, Vashti Berry, Jenny Lloyd, and Katrina Wyatt

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Influenza vaccination reduced myocardial infarctions in UK older adults: a prior event rate ratio study, AJ Streeter, LR Rodgers, F Hamilton, JAH Masoli, A Ble, WT Hamilton, and WE Henley

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Comprehensive short and long read sequencing analysis for the Gaucher and Parkinson's disease-associated GBA gene., Marco Toffoli, Xiao Chen, Fritz J. Sedlazeck, Chiao Yin Lee, Stephen Mullin, Abigail Higgins, Sofia Koletsi, Monica Emili Garcia-Segura, Esther Sammler, Sonja W. Scholz, Anthony H.V. Schapira, Michael A. Eberle, and Christos Proukakis

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Bi-allelic variants in WNT7B disrupt the development of multiple organs in humans, JDC Pereira Baptista

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Using medical education as a tool to train doctors as social innovators, Nagina Khan, Anne Rogers, Colin Melville, Rohit Shankar, Wolfgang Gilliar, Peter Byrne, Alex Serafimov, Sridevi Sira Mahalingappa, Simran Sehdev, Anna Sri, and Subodh Dave

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Deprescribing medicines in older people living with multimorbidity and polypharmacy: the TAILOR evidence synthesis, Joanne Reeve, Michelle Maden, Ruaraidh Hill, Amadea Turk, Kamal Mahtani, Geoff Wong, Dan Lasserson, Janet Krska, Dee Mangin, Richard Byng, Emma Wallace, and Ed Ranson

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Dysmorphism and immunodeficiency - one of the differential diagnoses is PAX1 related Otofaciocervical Syndrome Type 2, JDC Pereira Baptista

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Evaluating the feasibility of a real world pharmacovigilance study (OPTIMISE:MS), Ruth Dobson, Matthew Craner, Ed Waddingham, Aleisha Miller, Jayant Pindoria, Ana Cavey, Camilla Blain, Luca G De, Nikos Evangelou, Helen Ford, Paul Gallagher, Katila George, Ramos Dias R Geraldes, Paula Harman, Jeremy Hobart, Tanya King, Ruth Linighan, Niall MacDougall, Monica Marta, Stephanie Mitchell, Richard Nicholas, David Rog, Antonio Scalfari, Neil Scolding, Stewart Webb, Sarah White, Judith Wilton, Carolyn Young, and Paul M. Matthews

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Invasive coronary angiography as a tool in cardiac evaluation for liver transplant candidates, JS Nayagam, BC Norton, S Belete, J Rosinhas, K Ramos, ME Cramp, R O'Kane, WJ Cash, Z Milan, C Nicholson, K Menon, A Prachalias, P Srinivasan, G Auzinger, J Byrne, PA MacCarthy, N Melikian, K Agarwal, VR Aluvihare, D Joshi, and MA Heneghan

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Timely intervention, monitoring and education MATTERS in MS (TIME MATTERS in MS): Development of a globally applicable quality improvement tool, Jeremy Hobart, Helmut Butzkueven, Jodi Haartsen, Tjalf Ziemssen, Thirusha Lane, and Gavin Giovannoni

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Constipation in autistic people and people with learning disabilities, Rohit Shankar, Christina Maslen, Rebecca Hodge, Kim Tie, Richard Laugharne, and Kirsten Lamb

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Implications of research that excludes under-served populations, Camille Carroll

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Double-blinded randomised placebo controlled trial of enterosgel (polymethylsiloxane polyhydrate) for the treatment of IBS with diarrhoea (IBS-D), Carol Angela Howell, Anu Kemppinen, Victoria Allgar, Matthew Dodd, Charles H. Knowles, John Mclaughlin, Preeti Pandya, Peter Whorwell, Elena Markaryan, and Yan Yiannakou

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Making implementation science more real, Mitchell N. Sarkies, Emilie Francis-Auton, Janet C. Long, Chiara Pomare, Rebecca Hardwick, and Jeffrey Braithwaite

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Hematopoietic Stem and Progenitor Cell Maintenance and Multiple Lineage Differentiation Is an Integral Function of NFATc1, de Brito C Barahona, S Klein-Hessling, Edgar Serfling, and Amiya Kumar Patra

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Patient-reported outcome measures in MS: Do development processes and patient involvement support valid quantification of clinically important variables?, Trishna Bharadia, Jo Vandercappellen, Tanuja Chitnis, Piet Eelen, Birgit Bauer, Giampaolo Brichetto, Andrew Lloyd, Hollie Schmidt, Miriam King, Jennifer Fitzgerald, Thomas Hach, and Jeremy Hobart

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The development and implementation of a computer adaptive progress test across European countries, Neil Rice, José Miguel Pêgo, Carlos Fernando Collares, Jolanta Kisielewska, and Thomas Gale

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Updated diagnostic criteria and nomenclature for neurofibromatosis type 2 and schwannomatosis: An international consensus recommendation, Scott R. Plotkin, Ludwine Messiaen, Eric Legius, Patrice Pancza, Robert A. Avery, Jaishri O. Blakeley, Dusica Babovic-Vuksanovic, Rosalie Ferner, Michael J. Fisher, Jan M. Friedman, Marco Giovannini, David H. Gutmann, Clemens Oliver Hanemann, Michel Kalamarides, Hildegard Kehrer-Sawatzki, Bruce R. Korf, Victor Felix Mautner, Mia MacCollin, Laura Papi, Katherine A. Rauen, Vincent Riccardi, Elizabeth Schorry, Miriam J. Smith, Anat Stemmer-Rachamimov, David A. Stevenson, Nicole J. Ullrich, David Viskochil, Katharina Wimmer, Kaleb Yohay, SM Huson, P Wolkenstein, DG Evans, Monique Anten, Arthur Aylsworth, Diana Baralle, Sebastien Barbarot, Fred Barker, Shay Ben-Shachar, Amanda Bergner, Didier Bessis, Ignacio Blanco, Catherine Cassiman, Patricia Ciavarelli, Maurizio Clementi, Thierry Frébourg, Alicia Gomes, Dorothy Halliday, Hanson Arvid Heiberg CH Helen, Pascal Joly, Justin T. Jordan, Matthias Karajannis, Daniela Kroshinsky, Margarita Larralde, C Lázaro, L Le, M Link, R Listernick, C Mallucci, VL Merker, C Moertel, A Mueller, J Ngeow, R Oostenbrink, R Packer, A Parry, J Peltonen, D Pichard, B Poppe, N Rezende, LO Rodrigues, T Rosser, M Ruggieri, E Serra, V Steinke-Lange, SM Stivaros, A Taylor, J Toelen, J Tonsgard, E Trevisson, M Upadhyaya, A Varan, M Wilson, H Wu, and G Zadeh

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Predictors of loneliness during the Covid-19 pandemic in people with dementia and their carers in England: findings from the DETERMIND-C19 study, R Perach, S Read, B Hicks, PR Harris, and et al

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Bone health, intellectual disability and epilepsy: An observational community‐based study, R Winterhalder, J McCabe, C Young, K Lamb, and et al

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Presentation cardiac troponin and early computed tomography coronary angiography in patients with suspected acute coronary syndrome: a pre-specified secondary analysis of the RAPID-CTCA trial, Kang Ling Wang, Carl Roobottom, Jason E. Smith, Steve Goodacre, Katherine Oatey, R O’Brien, Robert F. Storey, Nick Curzen, Liza Keating, Attila Kardos, Dirk Felmeden, Praveen Thokala, Nicholas L. Mills, David E. Newby, and Alasdair J. Gray

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Factors associated with change over time in quality of life of people with dementia: longitudinal analyses from the MODEM cohort study, Derek King, Nicolas Farina, Clare Burgon, Yvonne Feeney, Sharne Berwald, Elizabeth Bustard, Laura Gallaher, Ruth Habibi, Raphael Wittenberg, Adelina Comas-Herrera, Martin Knapp, and Sube Banerjee

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Provision of mental health care to healthcare workers during COVID-19: A call for the practice of vulnerability, J Hoare

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The effect of increasing intestinal short‐chain fatty acid concentration on gut permeability and liver injury in the context of liver disease: A systematic review, Keith Pohl, Prebashan Moodley, and Ashwin Dhanda

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Deletion of RBP-Jkappa gene in mesenchymal cells causes rickets like symptoms in the mouse, Y Gao, JV Walker, C Tredwin, and B Hu

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Tangrams: a simple visual tool for communicating the complexities of professionalism, H Neve and S Hanks

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Mental Imagery to Reduce Alcohol- related harm in patients with alcohol dependence and alcohol-related liver damaGE: the MIRAGE pilot trial protocol, Ashwin D. Dhanda, Hannah Allende, Victoria Allgar, Jackie Andrade, Matthew Peter Bailey, Lynne Callaghan, Laura Cocking, Elizabeth Goodwin, Annie Hawton, Christopher Hayward, Ben Hudson, Alison Jeffery, Angela King, Victoria Lavers, Joe Lomax, C. Anne McCune, Richard Parker, Christopher Rollinson, Jonny Wilks, and S Creanor

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“A fog that impacts everything”: a qualitative study of health-related quality of life in people living with HIV who have cognitive impairment, K Alford, S Daley, S Banerjee, and et al

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Global developments in social prescribing, DF Morse, S Sandhu, K Mulligan, S Tierney, M Polley, Giurca B Chiva, S Slade, S Dias, KR Mahtani, L Wells, H Wang, B ‍Zhao, Figueiredo CEM De, JJ Meijs, HK Nam, KH Lee, C Wallace, M Elliott, JM Mendive, D Robinson, M Palo, W Herrmann, Nielsen R Østergaard, and K Husk

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UNC45A deficiency causes microvillus inclusion disease–like phenotype by impairing myosin VB–dependent apical trafficking, Rémi Duclaux-Loras, Corinne Lebreton, Jérémy Berthelet, Fabienne Charbit-Henrion, Ophelie Nicolle, de Courtils C Revenu, Stephanie Waich, Taras Valovka, Anis Khiat, Marion Rabant, Caroline Racine, Ida Chiara Guerrera, Júlia Baptista, Maxime M. Mahe, Michael W. Hess, Béatrice Durel, Nathalie Lefort, Céline Banal, Mélanie Parisot, Cecile Talbotec, Florence Lacaille, Emmanuelle Ecochard-Dugelay, Arzu Meltem Demir, Georg F. Vogel, Laurence Faivre, Astor Rodrigues, Darren Fowler, Andreas R. Janecke, Thomas Müller, Lukas A. Huber, Fernando Rodrigues-Lima, Frank M. Ruemmele, Holm H. Uhlig, Bene F Del, Grégoire Michaux, Nadine Cerf-Bensussan, and Marianna Parlato

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Development of 'Core Outcome Sets' for Meningioma in Clinical Studies (The COSMIC Project): protocol for two systematic literature reviews, eDelphi surveys and online consensus meetings, EORTC BTG, ICOM, EANO, SNO, RANO-PRO, BNOS, SBNS, BIMS, TBTC, International Brain Tumour Alliance, Brainstrust, and Brain Tumour Foundation of Canada; Christopher P. Millward; Terri S. Armstrong; Heather Barrington; Sabrina Bell; Andrew R. Brodbelt; Helen Bulbeck; Anna Crofton; Linda Dirven; Theo Georgious; Paul L. Grundy; Abdurrahman I. Islim; Mohsen Javadpour; Sumirat M. Keshwara; Shelli D. Koszdin; Anthony G. Marson; Michael W. McDermott; Torstein R. Meling; Kathy Oliver; Puneet Plaha; Matthias Preusser; Thomas Santarius; Nisaharan Srikandarajah; Martin J.B. Taphoorn; Carole Turner; Colin Watts; Michael Weller; Paula R. Williamson; Gelareh Zadeh; Amir H. Zamanipoor Najafabadi; and Oliver Hanemann

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Present status and advances in bladder pain syndrome: central sensitisation and the urinary microbiome, I Offiah, R Campbell, A Dua, L Bombieri, and R Freeman

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Recessive PRDM13 mutations cause fatal perinatal brainstem dysfunction with cerebellar hypoplasia and disrupt Purkinje cells differentiation, Marion Coolen, Nami Altin, Karthyayani Rajamani, Eva Pereira, Karine Siquier-Pernet, Lombardi E Puig, Nadjeda Moreno, Giulia Barcia, Marianne Yvert, Annie Laquerrière, Aurore Pouliet, Patrick Nitschké, Nathalie Boddaert, Antonio Rausell, Féréchté Razavi, Alexandra Afenjar, de Villemeur T Billette, Almundher Al-Maawali, Khalid Al-Thihli, Julia Baptista, Ana Beleza-Meireles, Catherine Garel, Marine Legendre, Antoinette Gelot, Lydie Burglen, Sébastien Moutton, and Vincent Cantagrel

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Young‐onset colorectal cancer: Insights from an English population‐based study, Joshua Franklyn, Joe Lomax, Peter L.Z. Labib, Amy Baker, Supriya Balasubramanya, Joe Natale, Muhammad Abdalkoddus, Joanne Hosking, Mark G. Coleman, and Sebastian Smolarek

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Conducting Randomized Controlled Trials of Complex Interventions in Prisons: A Sisyphean Task?, Charlotte Lennox, Sarah Leonard, Jane Senior, Caroline Hendricks, Sarah Rybczynska-Bunt, Cath Quinn, Richard Byng, and Jenny Shaw

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A cohort study of the impact of COVID‐19 on the quality of life of people newly diagnosed with dementia and their family carers, B Hicks, S Read, B Hu, S Banerjee, and et al

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Delivering Large-Scale Neurosurgical Studies in the UK: The Impact of Trainees, Aswin Chari, Rory J. Piper, Ellie Edlmann, Julie Woodfield, Paul M. Brennan, Carole Turner, Michael D. Jenkinson, Peter J. Hutchinson, Angelos G. Kolias, Daniel M. Fountain, Ruichong Ma, Ian Coulter, Aminul Ahmed, Aimun A.B. Jamjoom, Fahid T. Rasul, Claudia Craven, Michael T.C. Poon, Josephine Jung, Jignesh Tailor, Abdurrahman I. Islim, Mueez Waqar, Sara Venturini, Soham Bandyopadhyay, Robin Borchert, and Conor S. Gillespie

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Past, present and future of conservative oxygen therapy in critical care, Daniel Martin, David Harrison, Paul Mouncey, B. Ronan O'Driscoll, Mike Grocott, Lorna Miller, Doug Gould, Alvin Richards-Belle, and Kathryn Rowan

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Why do GPs rarely do video consultations? qualitative study in UK general practice, T Greenhalgh, E Ladds, G Hughes, L Moore, and et al

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A special issue of Essays in Biochemistry on current educational developments in molecular bioscience, LV Mello and HR Watson

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Clinical risk in remote consultations in general practice: findings from in-Covid-19 pandemic qualitative research, Rebecca Rosen, Sietse Wieringa, Trisha Greenhalgh, Claudia Leone, Sarah Rybczynska-Bunt, Gemma Hughes, Lucy Moore, Sara E. Shaw, Joseph Wherton, and Richard Byng

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The Development and Internal Evaluation of a Predictive Model to Identify for Whom Mindfulness-Based Cognitive Therapy Offers Superior Relapse Prevention for Recurrent Depression Versus Maintenance Antidepressant Medication, Zachary D. Cohen, Robert J. DeRubeis, Rachel Hayes, Edward R. Watkins, Glyn Lewis, Richard Byng, Sarah Byford, Catherine Crane, Willem Kuyken, Tim Dalgleish, and Susanne Schweizer