Browse research from the Peninsula Medical School.

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Submissions from 2023

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Isolation of tumour-reactive lymphocytes from peripheral blood via microfluidic immunomagnetic cell sorting, Z Wang, Sharif Ahmed, Mahmoud Labib, H Wang, Licun Wu, Fatemeh Bavaghar-Zaeimi, Nastaran Shokri, Soraly Blanco, Saraf Karim, Kasia Czarnecka-Kujawa, Edward H. Sargent, A. J.Robert McGray, Perrot M de, and Shana O. Kelley

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Efficient Delivery of Biological Cargos into Primary Cells by Electrodeposited Nanoneedles via Cell-Cycle-Dependent Endocytosis, Z Wang, H Wang, Sichun Lin, Mahmoud Labib, Sharif Ahmed, Jagotamoy Das, Stephane Angers, Edward H. Sargent, and Shana O. Kelley

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A Qualitative Exploration of Patient and Staff Experiences of the Receipt and Delivery of Specialist Weight Management Services in the UK, Ross Watkins, Dawn Swancutt, Mia Alexander, Shokraneh Moghadam, Steve Perry, Sarah Dean, Rod Sheaff, Jonathan Pinkney, Mark Tarrant, and Jenny Lloyd

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Practitioners’ Ability to Remotely Develop Understanding for Personalised Care and Support Planning: a Thematic Analysis of Multiple Data Sources from the Feasibility Phase of the Dementia PersonAlised Care Team (D-PACT) Intervention., H Wheat

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Conversation Analysis of Clients’ Active Resistance to Veterinarians’ Proposals for Long-Term Dietary Change in Companion Animal Practice in Ontario, Canada, Hannah Wheat, Clare MacMartin, and Jason B. Coe

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Longitudinal realist evaluation of the dementia PersonAlised care team (D-PACT) intervention: protocol, Hannah Wheat, Lauren Weston, Tomasina M. Oh, Sarah Morgan-Trimmer, Wendy Ingram, Sarah Griffiths, Rod Sheaff, Paul Clarkson, Antonieta Medina-Lara, Crispin Musicha, Stuart Spicer, Obioha Ukoumunne, Victoria Allgar, Siobhan Creanor, Michael Clark, Cath Quinn, Alex Gude, Rose McCabe, Saqba Batool, Lorna Smith, Debra Richards, Hannah Shafi, Bethany Warwick, Reena Lasrado, Basharat Hussain, Hannah Jones, Sonia Dalkin, Angela Bate, Ian Sherriff, Louise Robinson, and Richard Byng

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More questions than answers to the diagnosis and management of cauda equina syndrome—Authors’ reply, Julie Woodfield, Ingrid Hoeritzauer, Aimun A.B. Jamjoom, Simon Lammy, Savva Pronin, Cathal J. Hannan, Anna Watts, Laura Hughes, Richard D.C. Moon, Holly Roy, Michael T.C. Poon, Paul Thorpe, Nisaharan Srikandarajah, Andreas K. Demetriades, Niall Eames, Philip J. Sell, and Patrick F.X. Statham

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Routinely used interventions to improve attachment in infants and young children: a national survey and two systematic reviews, Barry Wright, Pasco Fearon, Megan Garside, Eleni Tsappis, Elaine Amoah, Danya Glaser, Victoria Allgar, Helen Minnis, Matthew Woolgar, Rachel Churchill, Dean McMillan, Peter Fonagy, Alison O’Sullivan, and Michelle McHale

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Exploring basic science knowledge retention within a cohort of undergraduate medical students in the United Kingdom: A longitudinal study, Idrees Zafar, John Chilton, James Edwards, Helen Watson, and Daniel Zahra

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Investigating trial design variability in trials of disease-modifying therapies in Parkinson’s disease: a scoping review protocol, Marie Louise Zeissler, Timothy Boey, Danny Chapman, Gary Rafaloff, Thea Dominey, Karen G. Raphael, Susan Buff, Hari Venkatesh Pai, Emma King, Paul Sharpe, Fintan O’Brien, and Camille B. Carroll

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An International Multi-Stakeholder Delphi Survey Study on the Design of Disease Modifying Parkinson’s Disease Trials, Marie Louise Zeissler, Kevin McFarthing, Karen G. Raphael, Gary Rafaloff, Richard Windle, and Camille B. Carroll

Submissions from 2022

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Intraductal fully covered self-expanding metal stents in the management of post-liver transplant anastomotic strictures: a UK wide experience, Wafaa Ahmed, Dave Kyle, Amardeep Khanna, John Devlin, David Reffitt, Zeino Zeino, George Webster, Simon Phillpotts, Robert Gordon, Gareth Corbett, William Gelson, Manu Nayar, Haider Khan, Matthew Cramp, Jonathan Potts, Waleed Fateen, Hamish Miller, Bharat Paranandi, Matthew Huggett, Simon M. Everett, Vinod S. Hegade, Rebecca O’Kane, Ryan Scott, Neil McDougall, Phillip Harrison, and Deepak Joshi

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Money matters: time for prevention and early intervention to address family economic circumstances, Nick Axford and Vashti Berry

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How can we optimise learning from trials in child and adolescent mental health?, Nick Axford, Vashti Berry, Jenny Lloyd, and Katrina Wyatt

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Engaging youth at risk of violence in services: messages from research, Nick Axford, John Tredinnick-Rowe, S Rybczynska-Bunt, Lorna Burns, Finlay Green, and Tom Thompson

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Comment on: Disease gene identification strategies for exome sequencing by Gilissen et al. 2012, Julia Baptista

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NFAT Factors Are Dispensable for the Development but Are Critical for the Maintenance of Foxp3+ Regulatory T Cells, de Brito C Barahona and Amiya Kumar Patra

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Direct isolation of single cells from living brains of Drosophila melanogaster without dissociation for transcriptome analysis, Claudia S. Barros and Torsten Bossing

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Antihypertensives in dementia: Good or bad for the brain?, Lucy Beishon, Victoria J. Haunton, and Ronney B. Panerai

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Does social and economic disadvantage predict lower engagement with parenting interventions? An integrative analysis using individual participant data, Vashti Berry, G. J. Melendez-Torres, Nick Axford, Ulf Axberg, de Castro B Orobio, Frances Gardner, Maria Filomena Gaspar, BH Handegard, Judy Hutchings, A Meeting, Sinéad McGilloway, Stephen Scott, and Patty Leijten

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Social prescribing for children and young people, Marcello Bertotti, Dan Hayes, Vashti Berry, Paul Jarvis-Beesley, and Kerryn Husk

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Patient-reported outcome measures in MS: Do development processes and patient involvement support valid quantification of clinically important variables?, Trishna Bharadia, Jo Vandercappellen, Tanuja Chitnis, Piet Eelen, Birgit Bauer, Giampaolo Brichetto, Andrew Lloyd, Hollie Schmidt, Miriam King, Jennifer Fitzgerald, Thomas Hach, and Jeremy Hobart

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A phase II, randomized, open-label, 52-week study of seladelpar in patients with primary biliary cholangitis, Christopher L. Bowlus, Michael R. Galambos, Richard J. Aspinall, Gideon M. Hirschfield, David E.J. Jones, Yvonne Dörffel, Stuart C. Gordon, Stephen A. Harrison, Andreas E. Kremer, Marlyn J. Mayo, Paul J. Thuluvath, Cynthia Levy, Mark G. Swain, Guy W. Neff, David A. Sheridan, Carmen M. Stanca, Christoph P. Berg, Aparna Goel, Mitchell L. Shiffman, John M. Vierling, Pol Boudes, Alexandra Steinberg, Yun Jung Choi, and Charles A. McWherter

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Drivers and barriers of international migration of doctors to and from the United Kingdom: a scoping review, N. Brennan, N. Langdon, M. Bryce, L. Burns, N. Humphries, A. Knapton, and T. Gale

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Progress and challenges in the harmonisation of European undergraduate dental education: a systematic literature review with narrative synthesis., Marie Bryce, Daniel Zahra, Lorna Burns, Sally Hanks, and Thomas Gale

Personalising knowledge assessments to remove compensation and thereby improve preparation for safe practice - developing content adaptive progress testing, S Burr, J Kisielewska, D Zahra, I Hodgins, I Robinson, P Millin, T Gale, N Santos, and J Pêgo

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Evaluation of a complex intervention for prisoners with common mental health problems, near to and after release: the Engager randomised controlled trial, Richard Byng, Tim Kirkpatrick, Charlotte Lennox, Fiona C. Warren, Rob Anderson, Sarah Louise Brand, Lynne Callaghan, Lauren Carroll, Graham Durcan, Laura Gill, Sara Goodier, Jonathan Graham, Rebecca Greer, Mark Haddad, Tirril Harris, William Henley, Rachael Hunter, Sarah Leonard, Mike Maguire, Susan Michie, Christabel Owens, Mark Pearson, Cath Quinn, Sarah Rybczynska-Bunt, Caroline Stevenson, Amy Stewart, Alex Stirzaker, Roxanne Todd, Florian Walter, Lauren Weston, Nat Wright, Rod S. Taylor, and Jenny Shaw

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Development and evaluation of a collaborative care intervention for male prison leavers with mental health problems: the Engager research programme, Richard Byng, Charlotte Lennox, Tim Kirkpatrick, Cath Quinn, Rob Anderson, Sarah Louise Brand, Lynne Callaghan, Lauren Carroll, Graham Durcan, Laura Gill, Sara Goodier, Jonathan Graham, Rebecca Greer, Mark Haddad, Tirril Harris, William Henley, Rachael Hunter, Mike Maguire, Sarah Leonard, Susan Michie, Christabel Owens, Mark Pearson, Sarah Rybczynska-Bunt, Caroline Stevenson, Amy Stewart, Alex Stirzaker, Rod Taylor, Roxanne Todd, Florian Walter, Fiona C. Warren, Lauren Weston, Nat Wright, and Jenny Shaw

Implications of research that excludes under-served populations, Camille Carroll

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Could a Medication Help With Bleeding Between the Skull and the Brain?, A Chari, KS Lee, A Alamri, PJA Hutchinson, AG Kolias, and E Edlmann

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Loot box engagement: relationships with educational attainment, employment status and earnings in a cohort of 16,000 UK gamers, James Close, Stuart Gordon Spicer, Laura Louise Nicklin, J Lloyd, and H Lloyd

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Gambling and Gaming in the United Kingdom during the COVID-19 Lockdown, James Close, Stuart Gordon Spicer, Laura Louise Nicklin, J Lloyd, Ben Whalley, and H Lloyd

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The Development and Internal Evaluation of a Predictive Model to Identify for Whom Mindfulness-Based Cognitive Therapy Offers Superior Relapse Prevention for Recurrent Depression Versus Maintenance Antidepressant Medication, Zachary D. Cohen, Robert J. DeRubeis, Rachel Hayes, Edward R. Watkins, Glyn Lewis, Richard Byng, Sarah Byford, Catherine Crane, Willem Kuyken, Tim Dalgleish, and Susanne Schweizer

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Recessive PRDM13 mutations cause fatal perinatal brainstem dysfunction with cerebellar hypoplasia and disrupt Purkinje cells differentiation, Marion Coolen, Nami Altin, Karthyayani Rajamani, Eva Pereira, Karine Siquier-Pernet, Lombardi E Puig, Nadjeda Moreno, Giulia Barcia, Marianne Yvert, Annie Laquerrière, Aurore Pouliet, Patrick Nitschké, Nathalie Boddaert, Antonio Rausell, Féréchté Razavi, Alexandra Afenjar, de Villemeur T Billette, Almundher Al-Maawali, Khalid Al-Thihli, Julia Baptista, Ana Beleza-Meireles, Catherine Garel, Marine Legendre, Antoinette Gelot, Lydie Burglen, Sébastien Moutton, and Vincent Cantagrel

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A Tailored Approach: A model for literature searching in complex systematic reviews, Chris Cooper, Andrew Booth, Kerryn Husk, Rebecca Lovell, Julia Frost, Ute Schauberger, Nicky Britten, and Ruth Garside

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A systematic review identifying outcome measures used in evaluating adults sustaining cervical spine fractures, Phillip C. Copley, Daniel Tadross, Nadia Salloum, Julie Woodfield, Ellie Edlmann, Michael Poon, Sadaquate Khan, and Paul M. Brennan

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Insights into nervous system repair from the fruit fly, David Coupe and Torsten Bossing

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Oxygen Targets During Mechanical Ventilation in the ICU: A Systematic Review and Meta-Analysis, Andrew F. Cumpstey, Alex H. Oldman, Daniel S. Martin, Andrew Smith, and Michael P.W. Grocott

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What factors have influenced quality of life in people with dementia and their family carers during the COVID-19 pandemic: a qualitative study, Stephanie Daley, Nazire Akarsu, Elise Armsby, Nicolas Farina, Yvonne Feeney, Bethany Fine, Laura Hughes, Joanna Pooley, Naji Tabet, Georgia Towson, and Sube Banerjee

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Challenges of Incorporating Digital Health Technology Outcomes in a Clinical Trial: Experiences from PD STAT, Jacob O. Day, Stephen Smith, Alastair J. Noyce, Jane Alty, Alison Jeffery, Rebecca Chapman, and Camille Carroll

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The Liverpool alcohol‐related liver disease algorithm identifies twice as many emergency admissions compared to standard methods when applied to Hospital Episode Statistics for England, Ashwin Dhanda, Keith Bodger, Steve Hood, Clive Henn, Michael Allison, Chioma Amasiatu, Robyn Burton, Matthew Cramp, Ewan Forrest, Meetal Khetani, Alastair MacGilchrist, Steven Masson, Richard Parker, Nick Sheron, Ken Simpson, Nikhil Vergis, Martin White, Ahmed Saleh, Alex Boyd, Alison Brind, Alka Joshi, Angie Rund, Ankur Srivastava, Anne McCune, Anthony Gartland, Ben Hudson, Bill Stableforth, Christopher John, Ema Maxan, Esther Unitt, Frederica Beetteridge, Heather Lewis, Helen Fellows, Ihteshamul Haq, Janisha Patel, Jennifer Ryan, Jeremy Cobbold, Keith Pohl, Kevin Raeburn, Lynsey Corless, and Michael Johnston

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Mental Imagery to Reduce Alcohol- related harm in patients with alcohol dependence and alcohol-related liver damaGE: the MIRAGE pilot trial protocol, Ashwin D. Dhanda, Hannah Allende, Victoria Allgar, Jackie Andrade, Matthew Peter Bailey, Lynne Callaghan, Laura Cocking, Elizabeth Goodwin, Annie Hawton, Christopher Hayward, Ben Hudson, Alison Jeffery, Angela King, Victoria Lavers, Joe Lomax, C. Anne McCune, Richard Parker, Christopher Rollinson, Jonny Wilks, and S Creanor

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Patients with moderate to severe COVID-19 have an impaired cytokine response with an exhausted and senescent immune phenotype, Ashwin D. Dhanda, Dan Felmlee, Paula Boeira, Prebashan Moodley, Huey Tan, Leticia De Paula Scalioni, Kristen Lilly, David A. Sheridan, and Matthew E. Cramp

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Evaluating the feasibility of a real world pharmacovigilance study (OPTIMISE:MS), Ruth Dobson, Matthew Craner, Ed Waddingham, Aleisha Miller, Jayant Pindoria, Ana Cavey, Camilla Blain, Luca G De, Nikos Evangelou, Helen Ford, Paul Gallagher, Katila George, Ramos Dias R Geraldes, Paula Harman, Jeremy Hobart, Tanya King, Ruth Linighan, Niall MacDougall, Monica Marta, Stephanie Mitchell, Richard Nicholas, David Rog, Antonio Scalfari, Neil Scolding, Stewart Webb, Sarah White, Judith Wilton, Carolyn Young, and Paul M. Matthews

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UNC45A deficiency causes microvillus inclusion disease–like phenotype by impairing myosin VB–dependent apical trafficking, Rémi Duclaux-Loras, Corinne Lebreton, Jérémy Berthelet, Fabienne Charbit-Henrion, Ophelie Nicolle, de Courtils C Revenu, Stephanie Waich, Taras Valovka, Anis Khiat, Marion Rabant, Caroline Racine, Ida Chiara Guerrera, Júlia Baptista, Maxime M. Mahe, Michael W. Hess, Béatrice Durel, Nathalie Lefort, Céline Banal, Mélanie Parisot, Cecile Talbotec, Florence Lacaille, Emmanuelle Ecochard-Dugelay, Arzu Meltem Demir, Georg F. Vogel, Laurence Faivre, Astor Rodrigues, Darren Fowler, Andreas R. Janecke, Thomas Müller, Lukas A. Huber, Fernando Rodrigues-Lima, Frank M. Ruemmele, Holm H. Uhlig, Bene F Del, Grégoire Michaux, Nadine Cerf-Bensussan, and Marianna Parlato

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Brief intervention to reduce fatigue impact in patients with inflammatory arthritis: design and outcomes of a single-arm feasibility study, E Dures, S Bridgewater, B Abbott, J Adams, A Berry, LM McCracken, S Creanor, S Hewlett, J Lomax, M Ndosi, J Thorn, M Urban, and P Ewings

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CSF rhinorrhoea after endonasal intervention to the skull base (CRANIAL): A multicentre prospective observational study, E Edlmann

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Dexamethasone reduces vascular endothelial growth factor in comparison to placebo in post-operative chronic subdural hematoma samples: A target for future drug therapy?, Ellie Edlmann, Susan Giorgi-Coll, Eric P. Thelin, Peter J. Hutchinson, and Keri L.H. Carpenter

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Impact of ‘Enhanced’ Intermediate Care Integrating Acute, Primary and Community Care and the Voluntary Sector in Torbay and South Devon, UK, Julian Elston, Felix Gradinger, Sheena Asthana, Matthew Fox, Louise Dawson, Dawn Butler, and Richard Byng

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Effectiveness of a targeted telephone-based case management service on activity in an Emergency Department in the UK: a pragmatic difference-in-differences evaluation, Julian Elston, Felix P. Gradinger, Adam J. Streeter, Stephen Macey, and Susan Martin

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Description of the cross‐cultural process adopted in the STRiDE (STrengthening Responses to dementia in DEveloping countries) program: A methodological overview, Nicolas Farina, Roxanne Jacobs, Tara Puspitarini Sani, Marguerite Schneider, Imelda Theresia, Yuda Turana, Fasihah Irfani Fitri, Emiliano Albanese, K Lorenz‐Dant, Sumaiyah Docrat, PD Toit, Cleusa P. Ferri, Ishtar Govia, A Comas‐Herrera, Aliaa Ibnidris, Martin Knapp, and Sube Banerjee

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Barriers to healthcare and their relationship to well-being and social support for autistic adults during COVID-19, Charlotte Featherstone, Richard A. Sharpe, Nick Axford, Sheena Asthana, Susan Ball, and Kerryn Husk

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Adaptation of the STRiDE dementia survey into the Indonesian context in North Sumatra, Fasihah Irfani Fitri, Ika Mariana Gultom, Eka Mahendrayana, Engki Irawan, Aldy S. Rambe, Tara Puspitarini Sani, Yuda Turana, Imelda Theresia, Nicolas Farina, and Sube Banerjee

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Real Talk: A Realist Dialogic Approach in a Realist Evaluation, Emilie Francis-Auton, Mitchell N. Sarkies, Chiara Pomare, Janet C. Long, Rebecca Hardwick, Hoa Mi Nguyen, and Jeffrey Braithwaite

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Young‐onset colorectal cancer: Insights from an English population‐based study, Joshua Franklyn, Joe Lomax, Peter L.Z. Labib, Amy Baker, Supriya Balasubramanya, Joe Natale, Muhammad Abdalkoddus, Joanne Hosking, Mark G. Coleman, and Sebastian Smolarek

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Effect of post-operative goal-directed fluid therapy (GDFT) on organ function after orthotopic liver transplantation: Secondary outcome analysis of the COLT randomised control trial, Farid Froghi, Vignesh Gopalan, Zachos Anastasiou, Rahul Koti, Kurinchi Gurusamy, Christine Eastgate, Margaret McNeil, Helder Filipe, Manuel Pinto, Jeshika Singh, Louise Longworth, Susan Mallett, Nick Schofield, Douglas Thorburn, Daniel Martin, and Brian R. Davidson

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Preparedness of recent medical graduates to meet anticipated healthcare needs, T Gale, N Brennan, N Langdon, J Read, N Keates, L Burns, H Khalil, and K Mattick

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Deletion of RBP-Jkappa gene in mesenchymal cells causes rickets like symptoms in the mouse, Y Gao, JV Walker, C Tredwin, and B Hu

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Early computed tomography coronary angiography in adults presenting with suspected acute coronary syndrome: the RAPID-CTCA RCT, Alasdair J. Gray, Carl Roobottom, Jason E. Smith, Steve Goodacre, Katherine Oatey, Rachel O’Brien, Robert F. Storey, Nick Curzen, Liza Keating, Attila Kardos, Dirk Felmeden, Robert J. Lee, Praveen Thokala, Steff C. Lewis, and David E. Newby

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Heat shock protein amplification improves cerebellar myelination in the Npc1nih mouse model, James Gray, María E. Fernández-Suárez, Maysa Falah, D Smith, C Smith, Ecem Kaya, Ashley M. Palmer, Cathrine K. Fog, Thomas Kirkegaard, and Frances M. Platt

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Protocol: Remote care as the ‘new normal’? Multi-site case study in UK general practice, T Greenhalgh, SE Shaw, Nishio A Alvarez, A Booth, R Byng, A Clarke, F Dakin, R Davies, S Faulkner, N Hemmings, L Husain, A Kalin, E Ladds, L Moore, R Rosen, S Rybczynska-Bunt, J Wherton, and S Wieringa

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Remote care in UK general practice: baseline data on 11 case studies, T Greenhalgh, SE Shaw, Nishio A Alvarez, R Byng, A Clarke, F Dakin, S Faulkner, N Hemmings, L Husain, A Kalin, E Ladds, L Moore, R Rosen, S Rybczynska-Bunt, J Wherton, and S Wieringa

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Remote care in UK general practice: baseline data on 11 case studies, T Greenhalgh, SE Shaw, Nishio A Alvarez, R Byng, A Clarke, F Dakin, S Faulkner, N Hemmings, L Husain, A Kalin, E Ladds, L Moore, R Rosen, S Rybczynska-Bunt, J Wherton, and S Wieringa

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Engaging Stakeholders in Realist Programme Theory Building: Insights from the Prospective Phase of a Primary Care Dementia Support Study, Sarah Griffiths, Lauren Weston, Sarah Morgan-Trimmer, Hannah Wheat, Alex Gude, Lorna Manger, Tomasina M. Oh, Paul Clarkson, Cath Quinn, Rod Sheaff, Mike Clark, Ian Sherriff, and Richard Byng

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Human Endogenous Retrovirus Type K promotes proliferation of Merlin-negative schwannoma and meningioma which can be inhibited by anti-retroviral and anti-TEAD drugs, CO Hanemann, E Maze, B Agit, S Reeves, D Hilton, DB Parkinson, L Laraba, E Ercolano, K Kurian, R Belshaw, and S Ammoun

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Dietary Nitrate Supplementation Does Not Alter Exercise Efficiency at High Altitude – Further Results From the Xtreme Alps Study, Philip J. Hennis, Andrew F. Cumpstey, Alasdair F. O’Doherty, Bernadette O. Fernandez, Edward T. Gilbert-Kawai, Kay Mitchell, Helen Moyses, Alexandra Cobb, Paula Meale, Helmut Pöhnl, Monty G. Mythen, Michael P.W. Grocott, Denny Z.H. Levett, Daniel S. Martin, and Martin Feelisch

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Timely intervention, monitoring and education MATTERS in MS (TIME MATTERS in MS): Development of a globally applicable quality improvement tool, Jeremy Hobart, Helmut Butzkueven, Jodi Haartsen, Tjalf Ziemssen, Thirusha Lane, and Gavin Giovannoni

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Double-blinded randomised placebo controlled trial of enterosgel (polymethylsiloxane polyhydrate) for the treatment of IBS with diarrhoea (IBS-D), Carol Angela Howell, Anu Kemppinen, Victoria Allgar, Matthew Dodd, Charles H. Knowles, John Mclaughlin, Preeti Pandya, Peter Whorwell, Elena Markaryan, and Yan Yiannakou

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Efficacy of prolonged-release fampridine versus placebo on walking ability, dynamic and static balance, physical impact of multiple sclerosis, and quality of life: an integrated analysis of MOBILE and ENHANCE, Raymond Hupperts, Claudio Gasperini, Jan Lycke, Tjalf Ziemssen, Peter Feys, Shan Xiao, Carlos Acosta, Thijs Koster, and Jeremy Hobart

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Mixed-methods feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE): Study findings, Ann Hutchinson, Victoria Allgar, Judith Cohen, David C. Currow, Susan Griffin, Simon Hart, Kelly Hird, Andrew Hodge, Suzanne Mason, Matthew Northgraves, Joanne Reeve, Flavia Swan, and Miriam J. Johnson

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Traboulsi syndrome caused by mutations in ASPH: An autosomal recessive disorder with overlapping features of Marfan syndrome, Gabriela Jones, Katie Johnson, Jacqueline Eason, Mark Hamilton, Deborah Osio, Farah Kanani, Julia Baptista, and Mohnish Suri

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Analysis of oxidative stress, inflammation and endothelial function following intravenous iron in chronic kidney disease in the Iron and Heart Trial, Xenophon Kassianides, Victoria Allgar, Iain C. Macdougall, Philip A. Kalra, and Sunil Bhandari

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Enhancing Trial Delivery in Parkinson’s Disease: Qualitative Insights from PD STAT, Angie A. Kehagia, Tracie K. North, Jane Grose, Alison N. Jeffery, Laura Cocking, Rebecca Chapman, and Camille Carroll

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Factors associated with change over time in quality of life of people with dementia: longitudinal analyses from the MODEM cohort study, Derek King, Nicolas Farina, Clare Burgon, Yvonne Feeney, Sharne Berwald, Elizabeth Bustard, Laura Gallaher, Ruth Habibi, Raphael Wittenberg, Adelina Comas-Herrera, Martin Knapp, and Sube Banerjee

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A process evaluation, with mediation analysis, of a web-based intervention to augment primary care exercise referral schemes: the e-coachER randomised controlled trial, Jeffrey Lambert, A Taylor, Adam Streeter, Colin Greaves, Wendy M. Ingram, Sarah Dean, Kate Jolly, Nanette Mutrie, RS Taylor, Lucy Yardley, Lisa Price, and John Campbell

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Conducting Randomized Controlled Trials of Complex Interventions in Prisons: A Sisyphean Task?, Charlotte Lennox, Sarah Leonard, Jane Senior, Caroline Hendricks, Sarah Rybczynska-Bunt, Cath Quinn, Richard Byng, and Jenny Shaw

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Past, present and future of conservative oxygen therapy in critical care, Daniel Martin, David Harrison, Paul Mouncey, B. Ronan O'Driscoll, Mike Grocott, Lorna Miller, Doug Gould, Alvin Richards-Belle, and Kathryn Rowan

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Editorial: Nutrition and Metabolism in School-Age Children, F-P Martin, J Pinkney, and JM Saavedra

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A special issue of Essays in Biochemistry on current educational developments in molecular bioscience, LV Mello and HR Watson

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Multiplex Lateral Flow Assay and the Sample Preparation Method for the Simultaneous Detection of Three Marine Toxins, Clare Mills, Michael J. Dillon, Prabir Kumar Kulabhusan, Diana Senovilla-Herrero, and Katrina Campbell

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Global developments in social prescribing, DF Morse, S Sandhu, K Mulligan, S Tierney, M Polley, Giurca B Chiva, S Slade, S Dias, KR Mahtani, L Wells, H Wang, B ‍Zhao, Figueiredo CEM De, JJ Meijs, HK Nam, KH Lee, C Wallace, M Elliott, JM Mendive, D Robinson, M Palo, W Herrmann, Nielsen R Østergaard, and K Husk

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Exploring right ventricular function applicability in a prediction model to identify preterm infants with early bronchopulmonary dysplasia (REPORT-BPD study): a mixed-methods observational cohort feasibility study protocol, Wisam S. Muhsen, Eirik Nestaas, Joanne Hosking, and Jos Latour

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Invasive coronary angiography as a tool in cardiac evaluation for liver transplant candidates, JS Nayagam, BC Norton, S Belete, J Rosinhas, K Ramos, ME Cramp, R O'Kane, WJ Cash, Z Milan, C Nicholson, K Menon, A Prachalias, P Srinivasan, G Auzinger, J Byrne, PA MacCarthy, N Melikian, K Agarwal, VR Aluvihare, D Joshi, and MA Heneghan

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Tangrams: a simple visual tool for communicating the complexities of professionalism, H Neve and S Hanks

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What matters most to adults with a tracheostomy in ICU and the implications for clinical practice: a qualitative systematic review and metasynthesis, Helen Newman, Gemma Clunie, Sarah Wallace, Christina Smith, Daniel Martin, and Natalie Pattison

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Cataract, abnormal electroretinogram and visual evoked potentials in a child with SMA-LED2 - extending the phenotype, Agata Oliwa, Shuko Joseph, Eoghan Millar, Iain Horrocks, Dawn Penman, Julia Baptista, Thomas Cullup, Panayiotis Constantinou, Anne Marie Heuchan, Ruth Hamilton, and Cheryl Longman

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Inhibition of YAP/TAZ-driven TEAD activity prevents growth of NF2-null schwannoma and meningioma, David B. Parkinson

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Updated diagnostic criteria and nomenclature for neurofibromatosis type 2 and schwannomatosis: An international consensus recommendation, Scott R. Plotkin, Ludwine Messiaen, Eric Legius, Patrice Pancza, Robert A. Avery, Jaishri O. Blakeley, Dusica Babovic-Vuksanovic, Rosalie Ferner, Michael J. Fisher, Jan M. Friedman, Marco Giovannini, David H. Gutmann, Clemens Oliver Hanemann, Michel Kalamarides, Hildegard Kehrer-Sawatzki, Bruce R. Korf, Victor Felix Mautner, Mia MacCollin, Laura Papi, Katherine A. Rauen, Vincent Riccardi, Elizabeth Schorry, Miriam J. Smith, Anat Stemmer-Rachamimov, David A. Stevenson, Nicole J. Ullrich, David Viskochil, Katharina Wimmer, Kaleb Yohay, SM Huson, P Wolkenstein, DG Evans, Monique Anten, Arthur Aylsworth, Diana Baralle, Sebastien Barbarot, Fred Barker, Shay Ben-Shachar, Amanda Bergner, Didier Bessis, Ignacio Blanco, Catherine Cassiman, Patricia Ciavarelli, Maurizio Clementi, Thierry Frébourg, Alicia Gomes, Dorothy Halliday, Hanson Arvid Heiberg CH Helen, Pascal Joly, Justin T. Jordan, Matthias Karajannis, Daniela Kroshinsky, Margarita Larralde, C Lázaro, L Le, M Link, R Listernick, C Mallucci, VL Merker, C Moertel, A Mueller, J Ngeow, R Oostenbrink, R Packer, A Parry, J Peltonen, D Pichard, B Poppe, N Rezende, LO Rodrigues, T Rosser, M Ruggieri, E Serra, V Steinke-Lange, SM Stivaros, A Taylor, J Toelen, J Tonsgard, E Trevisson, M Upadhyaya, A Varan, M Wilson, H Wu, and G Zadeh

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The effect of increasing intestinal short‐chain fatty acid concentration on gut permeability and liver injury in the context of liver disease: A systematic review, Keith Pohl, Prebashan Moodley, and Ashwin Dhanda

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The effectiveness of interventions that support penicillin allergy assessment and de-labelling of adult and paediatric patients by non-allergy specialists: A systematic review and meta-analysis, Neil Powell, Jennie Stephens, Declan Kohl, Rhys Owens, Shadia Ahmed, Crispin Musicha, Mathew Upton, Bridie Kent, Sarah Tonkin-Crine, and Jonathan Sandoe

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Deprescribing medicines in older people living with multimorbidity and polypharmacy: the TAILOR evidence synthesis, Joanne Reeve, Michelle Maden, Ruaraidh Hill, Amadea Turk, Kamal Mahtani, Geoff Wong, Dan Lasserson, Janet Krska, Dee Mangin, Richard Byng, Emma Wallace, and Ed Ranson

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Review of the validity of DOPS as an assessment tool for the procedural skills of surgical trainees, M. Rela and T. Price

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The development and implementation of a computer adaptive progress test across European countries, Neil Rice, José Miguel Pêgo, Carlos Fernando Collares, Jolanta Kisielewska, and Thomas Gale

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Parkinson’s disease – palliative care needs assessment tool: adaptation and psychometric testing, Edward William Richfield, Victoria Allgar, Afaf Girgis, and Miriam J. Johnson

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Assessing the experience of person‐centred coordinated care of people with chronic conditions in the Netherlands: Validation of the Dutch P3CEQ, Mieke Rijken, James Close, Juliane Menting, Manon Lette, Annerieke Stoop, Nick Zonneveld, Bruin S de, Helen Lloyd, and M Heymans

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Clinical risk in remote consultations in general practice: findings from in-Covid-19 pandemic qualitative research, Rebecca Rosen, Sietse Wieringa, Trisha Greenhalgh, Claudia Leone, Sarah Rybczynska-Bunt, Gemma Hughes, Lucy Moore, Sara E. Shaw, Joseph Wherton, and Richard Byng

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Hypothesis: Disrupted Regulation of the Intracranial Vascular and Cerebrospinal Fluid Circulations Causes Nocturia, Holly A. Roy, Matthew D. Smith, Hollie Blaber, Christopher H. Fry, Erlick A. Pereira, and Marcus J. Drake

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Oral microbes and the formation of cerebral abscesses: a single-centre retrospective study, Holly Roy, Raul Bescos, Ewen McColl, Umar Rehman, Elizabeth Cray, Louise A. Belfield, King David Nweze, Kevin Tsang, William Singleton, Peter Whitfield, and Zoe Brookes

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Making implementation science more real, Mitchell N. Sarkies, Emilie Francis-Auton, Janet C. Long, Chiara Pomare, Rebecca Hardwick, and Jeffrey Braithwaite

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Opicapone in UK clinical practice: effectiveness, safety and cost analysis in patients with Parkinson's disease, Christine Schofield, K. Ray Chaudhuri, Camille Carroll, Jagdish C. Sharma, Nicola Pavese, Jonathan Evans, Thomas Foltynie, Heinz Reichmann, Laura Zurowska, Patrício Soares-Da-Silva, and Andrew Lees