Submissions from 2021
The impact of smoking cessation on multiple sclerosis disease progression, Jeff Rodgers, Tim Friede, Frederick W. Vonberg, Cris S. Constantinescu, Alasdair Coles, Jeremy Chataway, Martin Duddy, Hedley Emsley, H Ford, Leonora Fisniku, Ian Galea, Timothy Harrower, Jeremy Hobart, Huseyin Huseyin, Christopher M. Kipps, Monica Marta, Gavin V. Mcdonnell, Brendan Mclean, Owen R. Pearson, David Rog, Klaus Schmierer, Basil Sharrack, Agne Straukiene, Heather C. Wilson, DV Ford, Rod M. Middleton, and Richard Nicholas
Estimating the correlation between semi-competing risk survival endpoints, Yinghui Wei, Lexy Sorrell, M Wojtys, and Peter Rowe
Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial, Nick Curzen, Zoe Nicholas, Beth Stuart, Sam Wilding, Kayleigh Hill, James Shambrook, Zina Eminton, Darran Ball, Camilla Barrett, Lucy Johnson, Jacqui Nuttall, Kim Fox, Derek Connolly, P O’Kane, Alex Hobson, Anoop Chauhan, Neal Uren, Gerry McCann, Colin Berry, Justin Carter, Carl Roobottom, Mamas Mamas, Ronak Rajani, Ian Ford, Pamela Douglas, and Mark Hlatky
Early computed tomography coronary angiography in patients with suspected acute coronary syndrome: randomised controlled trial, Alasdair J. Gray, Carl Roobottom, Jason E. Smith, Steve Goodacre, Katherine Oatey, R O’Brien, Robert F. Storey, Nick Curzen, Liza Keating, Attila Kardos, Dirk Felmeden, Robert J. Lee, Praveen Thokala, Steff C. Lewis, and David E. Newby
Diagnosing Autism Spectrum Disorders in Deaf Children Using Two Standardised Assessment Instruments: The ADIR-Deaf Adaptation and the ADOS-2 Deaf Adaptation, Victoria Allgar, Barry Wright, Amelia Taylor, Ann Le Couter, and Helen Phillips
Teaching, research or balanced? An exploration of the experiences of biomedical scientists working in UK medical schools, Tracey Collett, Steve Capey, James Edwards, Darrell J. Evans, John C. McLachlan, Helen Watson, and David Bristow
Pathogenesis of Chronic Subdural Hematoma: A Cohort Evidencing de Novo and Transformational Origins, Ellie Edlmann, Peter C. Whitfield, Angelos Kolias, and Peter J. Hutchinson
A Case of Clinically Diagnosed ANCA Negative Granulomatosis With Polyangiitis, A Walkden, M Salem, M Stavrakas, and H Khalil
Alcohol’s Impact on the Gut and Liver, Ashwin D. Dhanda, Keith Pohl, and Prebashan Moodley
An economic evaluation of vagus nerve stimulation as an adjunctive treatment to anti-seizure medications for the treatment of drug-resistant epilepsy in England, Vicki Pollit, Christopher Raspin, Rohit Shankar, Francesca Barion, Joanna Murphy, Laura Sawyer, and Vanessa Danielson
Redesigning walking brochures using behaviour change theory: implications for walking intentions in natural environments, Lewis R. Elliott, Mathew P. White, Lora E. Fleming, Charles Abraham, and Adrian H. Taylor
Long covid clinics should be run as research hubs, Margaret McCartney and Richard Byng
REiNS: Genotype-Phenotype Correlations in Neurofibromatosis and Their Potential Clinical use, Clemens O. Hanemann
Feasibility of Routine Quality of Life Measurement for People Living With Dementia in Long-Term Care, M Hoben, S Banerjee, AS Beeber, SA Chamberlain, and et al
Stopping the overmedication of people with intellectual disability, autism or both (STOMP) and supporting treatment and appropriate medication in paediatrics (STAMP): Report number: PS05/21, Asit Biswas, D Baldwin, Ken Courtenay, Avinash Hiremath, Sujeet Jaydeokar, Mark Lovell, Heather McAlister, and Rohit Shankar
Planning and Evaluating Remote Consultation Services: A New Conceptual Framework Incorporating Complexity and Practical Ethics, Trisha Greenhalgh, Rebecca Rosen, Sara E. Shaw, Richard Byng, Stuart Faulkner, Teresa Finlay, Emily Grundy, Laiba Husain, Gemma Hughes, Claudia Leone, Lucy Moore, Chrysanthi Papoutsi, Catherine Pope, Sarah Rybczynska-Bunt, Alexander Rushforth, Joseph Wherton, Sietse Wieringa, and Gary W. Wood
Identifying Appropriate Delivery of and Referral to Pulmonary Rehabilitation in Uganda: A Survey Study of People Living with Chronic Respiratory Disease and Health Care Workers, W Katagira, AV Jones, MW Orme, ZK Yusuf, P Ndagire, J Nanyonga, R Kasiita, JN Kasolo, RB Miah, MC Steiner, R Jones, A Barton, B Kirenga, and SJ Singh
Study protocol for a randomised controlled trial assessing the impact of pulmonary rehabilitation on maximal exercise capacity for adults living with post-TB lung disease: Global RECHARGE Uganda, W Katagira, MW Orme, AV Jones, R Kasiita, and et al
Factors associated with interest in psychiatry in UK medical students: qualitative study, G Crowley, S Banerjee, L Page, and S Daley
The Use and Effectiveness of an Online Diagnostic Support System for Blood Film Interpretation: Comparative Observational Study, C Hutchinson, M Brereton, J Adams, La Salle B De, J Sims, K Hyde, R Chasty, R Brown, K Rees-Unwin, and J Burthem
Oro-mucosal midazolam maleate: Use and effectiveness in adults with epilepsy in the UK, Rohit Shankar, Melesina Goodwin, John Toland, Andrew Boyle, Amanda Grant, Josephine Pearson, Amanda Storer, Richard Higgins, Sharon Hudson, and Markus Reuber
Economic evaluation of a complex intervention (Engager) for prisoners with common mental health problems, near to and after release: a cost-utility and cost-consequences analysis, Rachael Maree Hunter, Rob Anderson, Tim Kirkpatrick, Charlotte Lennox, Fiona Warren, Rod S. Taylor, Jenny Shaw, Mark Haddad, Alex Stirzaker, Mike Maguire, and Richard Byng
The role of trust and hope in antipsychotic medication reviews between GPs and service users a realist review, L. M. Grünwald, C. Duddy, R. Byng, N. Crellin, and J. Moncrieff
Digital health technology for non-motor symptoms in people with Parkinson's disease: Futile or future?, Wamelen DJ van, Jirada Sringean, Dhaval Trivedi, Camille B. Carroll, Anette E. Schrag, Per Odin, Angelo Antonini, Bastiaan R. Bloem, Roongroj Bhidayasiri, and K. Ray Chaudhuri
Integrated care pathways in neurosurgery: A systematic review, Keng Siang Lee, Benjamin Davies, Stefan Yordanov, Daniel Stubbs, Ellie Edlmann, and Alexis Joannides
Exploring the Evidence for Broad-Spectrum Effectiveness of Perampanel: A Systematic Review of Clinical Data in Generalised Seizures, E Trinka, S Lattanzi, K Carpenter, T Corradetti, and et al
DLG5 variants are associated with multiple congenital anomalies including ciliopathy phenotypes, Mustafa K. Khokha, Jonathan Marquez, Nina Mann, Kathya Arana, Engin Deniz, Weizhen Ji, Monica Konstantino, Emily K. Mis, Charu Deshpande, Lauren Jeffries, Julie McGlynn, Hannah Hugo, Eugen Widmeier, Martin Konrad, Velibor Tasic, Raffaella Morotti, Julia Baptista, Sian Ellard, Saquib Ali Lakhani, and Friedhelm Hildebrandt
Oxygen for seizures, more questions than answers: A scoping review, Rohit Shankar, Alexander Nicholas Smith, and Julie Abraham
Analysis of Coastal health outcomes., C Whitty, B Loveless, S Asthana, and A Gibson
Cultural issues on accessing mental health services in Nepali and Iranian migrants communities in the UK, B Simkhada, M Vahdaninia, E van Teijlingen, H Blunt, and M Vahdani
Realist evaluation of Schwartz rounds® for enhancing the delivery of compassionate healthcare: understanding how they work, for whom, and in what contexts, J Maben, C Taylor, E Reynolds, I McCarthy, and M Leamy
Loot boxes, problem gambling and problem video gaming: A systematic review and meta-synthesis, Stuart Gordon Spicer, N Laura, L Joanne, U Maria, H Lloyd, and James Close
UK framework for basic epilepsy training and oromucosal midazolam administration, Rohit Shankar, Phil Tittensor, Sarah Tittensor, Erica Chisanga, Manny Bagary, and Caryn Jory
Acalabrutinib for treatment of diffuse large B-cell lymphoma: results from a phase Ib study, P Strati, S De Vos, J Ruan, KJ Maddocks, and et al
Degradation of lipid droplets by chimeric autophagy-tethering compounds, Yu Ding, Boxun Lu, Yuhua Fu, Ningxie Chen, Ziying Wang, and Shouqing Luo
Exploring the Evidence for Broad-Spectrum Effectiveness of Perampanel: A Systematic Review of Clinical Data in Generalised Seizures, Eugen Trinka, Simona Lattanzi, Kate Carpenter, Tommaso Corradetti, Bruna Nucera, Fabrizio Rinaldi, Rohit Shankar, and Francesco Brigo
Genotype-Phenotype Correlations in Neurofibromatosis and Their Potential Clinical use, Clemens O. Hanemann, Chetan Bettegowda, Meena Upadhayaya, D. Gareth Evans, Ae Rang Kim, and Dimitrios Mathios
Microtubule disruption upon CNS damage triggers mitotic entry via TNF signaling activation, Torsten Bossing and Claudia S. Barros
Treatment threshold for intra‐operative hypotension in clinical practice—a prospective cohort study in older patients in the UK, A. J. Wickham, D. T. Highton, S. Clark, D. Fallaha, D. J.N. Wong, and D. S. Martin
Eye Movement Desensitisation and Reprocessing Therapy for People with Intellectual Disability in the Treatment of Emotional Trauma and Post Traumatic Stress Disorder: A Scoping Review, AN Smith, R Laugharne, K Oak, and R Shankar
Assessing the impact of a new central venous access device training program for nurses: A Quasi-Experimental Evaluation study, Wendy Burt and Lucy Spowart
How to tie dangerous surgical knots: easily. Can we avoid this?, E Drabble, S Spanopoulou, E Sioka, E Politaki, and et al
Phase 1b study of tirabrutinib in combination with idelalisib or entospletinib in previously treated B-cell lymphoma., F Morschhauser, MJS Dyer, HS Walter, and et al
A clinical study to optimise a sand fly biting protocol for use in a controlled human infection model of cutaneous leishmaniasis (the FLYBITE study), Charles J.N. Lacey, Vivak Parkash, Helen Ashwin, Jovana Sadlova, Barbora Vojtkova, Georgina Jones, Nina Martin, Elizabeth Greensted, Victoria Allgar, Shaden Kamhawi, Jesus G. Valenzuela, Alison M. Layton, Charles L. Jaffe, Petr Volf, and Paul M. Kaye
A Report From The NIHR UK Working Group On Remote Trial Delivery For The COVID-19 Pandemic and Beyond, J Masoli, S Hudson, JT O’Brien, JD Williamson, CA Young, and CB Carroll
The effectiveness and usability of online, group-based interventions for people with severe obesity: Protocol for a systematic review: JMIR Research Protocols, M. Milne-Ives, D. Swancutt, L. Burns, J. Pinkney, M. Tarrant, R. Calitri, A. Chatterjee, and E. Meinert
The Genetics of Parkinson’s Disease and Implications for Clinical Practice, Stephen Mullin and Jacob Oliver Day
Combining Realist approaches and Normalization Process Theory to understand implementation: a systematic review, Catherine A. Haighton, Sonia Michelle Dalkin, Rebecca J.L. Hardwick, and Tracy L. Finch
Zanubrutinib for the treatment of relapsed or refractory mantle cell lymphoma, CS Tam, S Opat, D Simpson, G Cull, and et al
Biomarkers for differentiating grade II meningiomas from grade I: a systematic review, Agbolahan A. Sofela, Lucy McGavin, Peter C. Whitfield, and C. Oliver Hanemann
Efficacy and safety assessment of prolonged maintenance with subcutaneous rituximab in patients with relapsed or refractory indolent non-Hodgkin lymphoma: results of the phase III MabCute study, S Rule, WG Barreto, J Briones, AM Carella, and et al
Loc680254 regulates Schwann cell proliferation through Psrc1 and Ska1 as a microRNA sponge following sciatic nerve injury, C Yao, Q Wang, Y Wang, J Wu, and et al
Clival Mucocele: A Rare Yet not Forgotten Pathology, M Stavrakas, HS Khalil, N Tsetsos, and S Muquit
A mixed-method feasibility study of a novel transitional regime of incremental haemodialysis: study design and protocol, Adil M. Hazara, Victoria Allgar, Maureen Twiddy, and Sunil Bhandari
Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease, Stefanie T. Jost, Haidar S. Dafsari, Veerle Visser-Vandewalle, Alexandra Rizos, Philipp A. Loehrer, Monty Silverdale, Julian Evans, Michael Samuel, Jan Niklas Petry-Schmelzer, Anna Sauerbier, Alexandra Gronostay, Michael T. Barbe, Gereon R. Fink, Keyoumars Ashkan, Angelo Antonini, Pablo Martinez-Martin, K. Ray Chaudhuri, Lars Timmermann, Roongroj Bhidayasiri, Cristian Falup-Pecurariu, Beomseok Jeon, Valentina Leta, Per Borghammer, Per Odin, Anette Schrag, Alexander Storch, Mayela Rodriguez Violante, Daniel Weintraub, Charles Adler, Paolo Barone, David J. Brooks, Richard Brown, Marc Cantillon, Camille Carroll, Miguel Coelho, Tove Henriksen, Michele Hu, Peter Jenner, Milica Kramberger, Padma Kumar, Mónica Kurtis, Simon Lewis, Irene Litvan, Kelly Lyons, Davide Martino, Mario Masellis, Hideki Mochizuki, James F. Morley, Melissa Nirenberg, Javier Pagonabarraga, J Panicker, N Pavese, E Pekkonen, R Postuma, R Rosales, A Schapira, T Simuni, F Stocchi, I Subramanian, M Tagliati, M Tinazzi, J Toledo, Y Tsuboi, and R Walker
Eye Movement Desensitisation and Reprocessing Therapy for People with Intellectual Disability in the Treatment of Emotional Trauma and Post Traumatic Stress Disorder: A Scoping Review, Rohit Shankar, Alexander Nicholas Smith, Richard Laugharne, and Katy Oak
Mental Health and Wellbeing in Dentistry: A Rapid Evidence Assessment, Anastasios Plessas, Martha Paisi, Marie Bryce, Lorna Burns, Timothy O'Brien, Robert Witton, and Yaniv Hanoch
Sex-based inequalities in contemporary UK hospital management of stable chest pain, Gareth Morgan-Hughes, Michelle Claire Williams, Margaret Loudon, Carl A. Roobottom, Stelios Iacovides, Franchesca Wotton, Alice Veitch, M Schmitt, and Russel Bull
The coagulopathy of liver disease: a shift in thinking, Alexandra Ballantine, Daniel Martin, and Sonali V. Thakrar
Patient‐centred measurement of recovery from day‐case surgery using wrist worn accelerometers: a pilot and feasibility study, AM Ratcliffe, B Zhai, Y Guan, DG Jackson, and et al
Balancing risks and benefits when recommencing oral anticoagulants after major bleeding, Ellie Edlmann and Catherine McMahon
Quality of life in people living with HIV-associated neurocognitive disorder: A scoping review study, K Alford, S Daley, S Banerjee, and JH Vera
Current practice and adaptations being made for people with autism admitted to in-patient psychiatric services across the UK, Rohit Shankar, Keir Jones, Satheesh Gangadharan, Philip Brigham, and Edward Smith
Averting a public health crisis in England’s coastal communities: a call for public health research and policy, Sheena Asthana and Alex Gibson
It’s the attraction of winning that draws you in” – A qualitative investigation of reasons and facilitators for videogame loot box engagement in UK gamers, Laura Louise Nicklin, Stuart Gordon Spicer, James Close, Jonathan Parke, Oliver Smith, T Rayman, H Lloyd, and J Lloyd
Terms of Engagement for Working with Patients in a Person-Centred Partnership: A Secondary Analysis of Qualitative Data., Debra Westlake and Helen Lloyd
The current status of perioperative hypnotics, the role of benzodiazepines and the case for remimazolam: a narrative review, J. Robert Sneyd, Pedro L. Gambus, and Ann E. Rigby-Jones
Practical and clinical approaches using pacing to improve self-regulation in special populations such as children and people with mental health or learning disabilities, A Edwards, U Abonie, F Hettinga, D Pyne, T Oh, and R Polman
A Review of Network and Computer Analysis of Epileptiform Discharge Free EEG to Characterize and Detect Epilepsy, Rohit Shankar, Caitlin West, Wessel Woldman, Katy Oak, and Brendan McLean
TARS Health Trainer Manual, T Thompson, A Taylor, L Callaghan, and C Greaves
Community Monitoring of Health Parameters in People with Intellectual Disabilities Prescribed Lithium, Rohit Shankar, Joshua Howkins, and Mike Wilcock
Barriers and facilitators to implementing a longitudinal dementia education programme into undergraduate healthcare curricula: a qualitative study, Y Feeney, S Daley, B Flaherty, and S Banerjee
Current Trends and Challenges for Rapid SMART Diagnostics at Point-of-Site Testing for Marine Toxins, Katrina Campbell, Michael Dillon, Maja A. Zaczek-Moczydlowska, Christine Edwards, Andrew D. Turner, Peter I. Miller, Heather Moore, April McKinney, and Linda Lawton
Categories of context in realist evaluation, Rod Sheaff, Natasha Doran, Michael Harris, Iain Lang, Antionieta Medina-Lara, Mauro Fornasiero, Susan Ball, Judith McGregor-Harper, and Rob Bethune
Ibrutinib for mantle cell lymphoma at first relapse: a United Kingdom real‐world analysis of outcomes in 211 patients, R McCulloch, D Lewis, N Crosbie, and et al
Bayesian statistics in the design and analysis of cluster randomised controlled trials and their reporting quality: a methodological systematic review, Adam J. Streeter, Amy Baker, Rana Moyeed, and Siobhan Creanor
Optimising the delivery of remediation programmes for doctors: A realist review, Tristan Price, Geoff Wong, Lyndsey Withers, Amanda Wanner, Jennifer Cleland, Tom Gale, L Prescott‐Clements, Julian Archer, Marie Bryce, and Nicola Brennan
Representing uncertainty in the Rescorla-Wagner model: Blocking, the redundancy effect, and outcome base rate, SG Spicer, AJ Wills, PM Jones, CJ Mitchell, and L Dome
Snowboarding, motherhood and mobility, Lucy Spowart
Combinatorial mathematical modelling approaches to interrogate rear retraction dynamics in 3D cell migration, Joseph H.R. Hetmanski, Patrick T. Caswell, Matthew C. Jones, Fatima Chunara, and Jean Marc Schwartz
Patients’ experiences of pharmacists in general practice: an exploratory qualitative study, GD Karampatakis, N Patel, G Stretch, and K Ryan
GP trainee responses to using SHERPA for multimorbidity consultations, Dawn R. Swancutt, Edmund Jack, Hilary A. Neve, John Tredinnick-Rowe, Nick Axford, and Richard Byng
2020 Medical Graduates: The work and wellbeing of interim Foundation Year 1 doctors during COVID-19, B Burford, K Mattick, T Gale, G Vance, D Carrieri, N Brennan, and A Goulding
Real-World Outcomes of Direct-Acting Antiviral Treatment and Retreatment in United Kingdom–Based Patients Infected With Hepatitis C Virus Genotypes/Subtypes Endemic in Africa, Elihu Aranday-Cortes, C. Patrick McClure, Christopher Davis, William L. Irving, Kazeem Adeboyejo, Lily Tong, Silva Filipe A da, Vattipally Sreenu, Kosh Agarwal, David Mutimer, Benjamin Stone, Matthew E. Cramp, Emma C. Thomson, Jonathan K. Ball, and John McLauchlan
The neurology–psychiatry interface in epilepsy, V Murphy, B Hallahan, H O’Connell, B Wright, and et al
The use of video for patient information and education: a scoping review of the variability and effectiveness of interventions, Arunangsu Chatterjee, Gary Strong, Madison Milne-Ives, Edward Meinert, Matthew Halkes, and Emma Wyatt-Haines
Carbon Catabolite Repression in Filamentous Fungi Is Regulated by Phosphorylation of the Transcription Factor CreA, Assis LJ de, LP Silva, O Bayram, P Dowling, O Kniemeyer, T Krüger, AA Brakhage, Yingying Chen, L Dong, K Tan, KH Wong, LNA Ries, and GH Goldman
Downstream testing after CT coronary angiography: time for a rethink?, Gareth Morgan-Hughes, Michelle Claire Williams, Margaret Loudon, Carl A. Roobottom, Alice Veitch, Lingen R Van, Ben Holloway, Nicholas Bellenger, Matthias Schmitt, and Russel Bull
Evaluation of the MP Rapid 2019-NCOV IgM/IgG combo POCT test vs. an established platform-based method, N. Jassam, J. H. Barth, V. Allgar, S. Glover, F. Stevenson, N. Lauber, V. Houghton, Z. Hanif, J. Child, and B. Clark
Recurrent Chronic HEV in Severe Combined Immunodeficiency, Prebashan Moodley, Andrew F. Whyte, and Ashwin Dhanda
Using multiple case studies of health and justice services to inform the development of a new complex intervention for prison-leavers with common mental health problems (Engager), Charlotte Lennox, R Stevenson, Christabel Owens, Richard Byng, Sarah L. Brand, Mike Maguire, Graham Durcan, C Stevenson, Jenny Shaw, and Cath Quinn
Aesthetically Designing Video-Call Technology With Care Home Residents: A Focus Group Study, Sonam Zamir, Felicity Allman, Catherine Hagan Hennessy, Adrian Haffner Taylor, and Ray Brian Jones
Characteristics and mortality rates among patients requiring intermediate care: a national cohort study using linked databases, CJ Evans, L Potts, U Dalrymple, A Pring, and et al
Understanding Resource Allocation in social care for frail older people: lessons from a national survey, David Challis, Sheena Asthana, Karen Stewart, Jane Hughes, A Wordon, Sue Davies, Chengqiu Xie, and Alex Gibson
Psychometric properties and use of the DEMQOL suite of instruments in research: a systematic review protocol, M Hoben, SA Chamberlain, HM O'Rourke, B Elliott, and et al
Standard setting anchor statements: a double cross-over trial of two different methods., S Burr, T Martin, J Edwards, C Ferguson, K Gilbert, C Gray, A Hill, J Hosking, K Johnstone, J Kisielewska, C Milsom, S Moyes, A Rigby-Jones, I Robinson, N Toms, H Watson, and D Zahra
Link worker perspectives of early implementation of social prescribing: a ‘Researcher-in-Residence’ study, Emma Hazeldine, Gemma Gowan, Rachel Wigglesworth, Julie Pollard, Sheena Asthana, and Kerryn Husk
Attention deficit hyperactivity disorder (ADHD) in adults with intellectual disability, Rohit Shankar, Bhathika Perera, Laura Korb, and Ken Courtenay
Impact of influenza vaccination on amoxicillin prescriptions in older adults: A retrospective cohort study using primary care data, LR Rodgers, AJ Streeter, N Lin, W Hamilton, and WE Henley
