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Submissions from 2022

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Antidepressants Trial in Parkinson's Disease (ADepT-PD): protocol for a randomised placebo-controlled trial on the effectiveness of escitalopram and nortriptyline on depressive symptoms in Parkinson’s disease, A. Schrag, C. Carroll, G. Duncan, S. Molloy, L. Grover, R. Hunter, R. Brown, N. Freemantle, J. Whipps, M. A. Serfaty, and G. Lewis

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Monogenic causes of Premature Ovarian Insufficiency are rare and mostly recessive, S Shekari, S Stankovic, EJ Gardner, G Hawkes, KA Kentistou, RN Beaumont, A Mörseburg, AR Wood, G Mishra, F Day, J Baptista, CF Wright, MN Weedon, E Hoffmann, KS Ruth, K Ong, JRB Perry, and A Murray

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Infection with the hepatitis C virus causes viral genotype-specific differences in cholesterol metabolism and hepatic steatosis, David A. Sheridan, Isaac Thom Shawa, E. Louise Thomas, Daniel J. Felmlee, Simon H. Bridge, Dermot Neely, Jeremy F. Cobbold, Elaine Holmes, Margaret F. Bassendine, and Simon D. Taylor-Robinson

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Outcome and mortality of hospital admission with COVID-19 for individuals with parkinsonian syndromes, L Sorrell, A King, J Inches, J Rideout, JR Sneyd, C Kobylecki, R Chaudhuri, R Walker, H Martin, and C Carroll

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Loot boxes and problem gambling: Investigating the “gateway hypothesis”, Stuart Gordon Spicer, Chris Fullwood, James Close, Laura Louise Nicklin, J Lloyd, and H Lloyd

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Influenza vaccination reduced myocardial infarctions in UK older adults: a prior event rate ratio study, AJ Streeter, LR Rodgers, F Hamilton, JAH Masoli, A Ble, WT Hamilton, and WE Henley

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Real-world effectiveness of pneumococcal vaccination in older adults: Cohort study using the UK Clinical Practice Research Datalink, AJ Streeter, LR Rodgers, J Masoli, NX Lin, A Blé, W Hamilton, and WE Henley

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A group-based behavioural intervention for weight management (PROGROUP) versus usual care in adults with severe obesity: a feasibility randomised controlled trial protocol, Dawn Swancutt, Mark Tarrant, Wendy Ingram, Sarah Baldrey, Lorna Burns, Richard Byng, Raff Calitri, Siobhan Creanor, Sarah Dean, Lucy Evans, Laura Gill, Elizabeth Goodwin, Lily Hawkins, Chris Hayward, Sarah Hind, Laura Hollands, Joanne Hosking, Jenny Lloyd, Shokraneh Moghadam, Helen Neilens, Mary O’Kane, Steve Perry, Rod Sheaff, Anne Spencer, Adrian Taylor, Thomas Ward, Ross Watkins, John Wilding, and Jonathan Pinkney

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Taking the biscuit: defining excessive quantities of free refreshments in a healthcare library, Andrew Tabner, Stuart G. Spicer, Kerryn Husk, Holly Blake, Caroline White, Suzanne Toft, and Graham Johnson

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Tailoring cultural offers to meet the needs of older people during uncertain times: a rapid realist review, Stephanie Tierney, Sebastien Libert, Jordan Gorenberg, Geoff Wong, Amadea Turk, Kerryn Husk, Helen J. Chatterjee, Kathryn Eccles, Caroline Potter, Emma Webster, Beth McDougall, Harriet Warburton, Lucy Shaw, Nia Roberts, and Kamal R. Mahtani

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Social prescribing for older people and the role of the cultural sector during the COVID-19 pandemic: What are link workers' views and experiences?, Stephanie Tierney, Caroline Potter, Kathryn Eccles, Oluwafunmi Akinyemi, Jordan Gorenberg, Sebastien Libert, Geoff Wong, Amadea Turk, Kerryn Husk, Helen J. Chatterjee, Emma Webster, Beth McDougall, Harriet Warburton, Lucy Shaw, and Kamal R. Mahtani

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The economic case for hospital discharge services for people experiencing homelessness in England: An in‐depth analysis with different service configurations providing specialist care, Michela Tinelli, Raphael Wittenberg, Michelle Cornes, Robert W. Aldridge, Michael Clark, Richard Byng, Graham Foster, James Fuller, Andrew Hayward, Nigel Hewett, Alan Kilmister, Jill Manthorpe, Joanne Neale, Elizabeth Biswell, and Martin Whiteford

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Comprehensive short and long read sequencing analysis for the Gaucher and Parkinson's disease-associated GBA gene., Marco Toffoli, Xiao Chen, Fritz J. Sedlazeck, Chiao Yin Lee, Stephen Mullin, Abigail Higgins, Sofia Koletsi, Monica Emili Garcia-Segura, Esther Sammler, Sonja W. Scholz, Anthony H.V. Schapira, Michael A. Eberle, and Christos Proukakis

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Optimising a person-centred approach to stopping medicines in older people with multimorbidity and polypharmacy using the DExTruS framework: a realist review, Amadea Turk, Geoffrey Wong, Kamal R. Mahtani, Michelle Maden, Ruaraidh Hill, Ed Ranson, Emma Wallace, Janet Krska, Dee Mangin, Richard Byng, Daniel Lasserson, and Joanne Reeve

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Germline homozygous missense DEPDC5 variants cause severe refractory early-onset epilepsy, macrocephaly and bilateral polymicrogyria, Athina Ververi, Sara Zagaglia, Lara Menzies, Julia Baptista, Richard Caswell, Stephanie Baulac, Sian Ellard, Sally Lynch, Thomas S. Jacques, Maninder Singh Chawla, Martin Heier, Mari Ann Kulseth, Inger Lise Mero, Anne Katrine Våtevik, Ichraf Kraoua, Rhouma H Ben, Younes T Ben, Zouhour Miladi, Youssef Turki I Ben, Wendy D. Jones, Emma Clement, Christin Eltze, Kshitij Mankad, Ashirwad Merve, Jennifer Parker, Bethan Hoskins, Ronit Pressler, Sniya Sudhakar, Catherine Devile, Tessa Homfray, Marios Kaliakatsos, Robert Robinson, Sara Margrete Bøen Keim, Imen Habibi, Alexandre Reymond, Sanjay M. Sisodiya, and Jane A. Hurst

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Presentation cardiac troponin and early computed tomography coronary angiography in patients with suspected acute coronary syndrome: a pre-specified secondary analysis of the RAPID-CTCA trial, Kang Ling Wang, Carl Roobottom, Jason E. Smith, Steve Goodacre, Katherine Oatey, R O’Brien, Robert F. Storey, Nick Curzen, Liza Keating, Attila Kardos, Dirk Felmeden, Praveen Thokala, Nicholas L. Mills, David E. Newby, and Alasdair J. Gray

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‘Everyone is trying to outcompete each other’: A qualitative study of medical student attitudes to a novel peer‐assessed undergraduate teamwork module, Helen R. Watson, Mary Kate Dolley, Mohammad Perwaiz, Jocelyn Saxelby, Gianluca Bertone, Steven Burr, Tracey Collett, Robert Jeffery, and Daniel Zahra

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Equality pledges: A novel approach to embedding EDI and promoting positive culture change in a UK university, HR Watson, H Wisdom, C Michael, N Marshall, and H Neve

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Impact of COVID‐19 on social prescribing across an Integrated Care System: A Researcher in Residence study, Debra Westlake, Julian Elston, Alex Gude, Felix Gradinger, Kerryn Husk, and Sheena Asthana

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Interrogating intervention delivery and participants’ emotional states to improve engagement and implementation: A realist informed multiple case study evaluation of Engager, Lauren Weston, Sarah Rybczynska-Bunt, Cath Quinn, Charlotte Lennox, Mike Maguire, Mark Pearson, Alex Stirzaker, Graham Durcan, Caroline Stevenson, Jonathan Graham, Lauren Carroll, Rebecca Greer, Mark Haddad, Rachael Hunter, Rob Anderson, Roxanne Todd, Sara Goodier, Sarah Brand, Susan Michie, Tim Kirkpatrick, Sarah Leonard, Tirril Harris, William Henley, Jenny Shaw, Christabel Owens, and Richard Byng

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Brief opportunistic interventions by general practitioners to promote smoking cessation: a conversation analytic study, H. Wheat, R. K. Barnes, P. Aveyard, F. Stevenson, and R. Begh

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Understanding how language revitalisation works: a realist synthesis, Brandon Wiltshire, Steven Bird, and Rebecca Hardwick

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Duration of External Neck Stabilisation (DENS) following odontoid fracture in older or frail adults: protocol for a randomised controlled trial of collar versus no collar, Julie Woodfield, Ellie Edlmann, Polly L. Black, Julia Boyd, Phillip Correia Copley, Gina Cranswick, Helen Eborall, Catriona Keerie, Sadaquate Khan, Julia Lawton, David J. Lowe, John Norrie, Angela Niven, Matthew J. Reed, Susan Deborah Shenkin, Patrick Statham, Andrew Stoddart, James Tomlinson, and Paul M. Brennan

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Presentation, management, and outcomes of cauda equina syndrome up to one year after surgery, using clinician and participant reporting: a multi-centre prospective cohort study, Julie Woodfield, Ingrid Hoeritzauer, Aimun A.B. Jamjoom, Josephine Jung, Simon Lammy, Savva Pronin, Cathal J. Hannan, Anna Watts, Laura Hughes, Richard D.C. Moon, Stacey Darwish, Holly Roy, Phillip C. Copley, Michael T.C. Poon, Paul Thorpe, Nisaharan Srikandarajah, Gordan Grahovac, Andreas K. Demetriades, Niall Eames, Philip J. Sell, Patrick F.X. Statham, Mohamed Abdelsadg, Motaz MS Abulaila, Usman Ahmed, Qasim Ajmi, Rafid Al-Mahfoudh, Chadi Ali, Meriem Amarouche, Amin Andalib, M Arora, M Arora, Mariam Awan, Mirza A Baig, Antony Bateman, Iwan Bennett, Imran Bhatti, Peter Bodkin, Lalasa Bommireddy, George Bonanos, Anouk Borg, Alexandros Boukas, James Bourne, Rachael Brennan, J Brown, K Brown, Oliver Burton, Christopher Busby, Neil Chiverton, Simon Clark, Phillip C. Copley, S Cudlip, Y Cunningham, R Dardis, Stacey Darwish, B Davies, Andreas K. Demetriades, S Deore, C Derham, M Dherijha, G Dobson, J Duncan, A Durnford, AZE Durst, EW Dyson, Niall Eames, Ellie Edlmann, A Edwards-Bailey, A Elserius, B Elson, V Fadelalla, DM Fountain, A Gardner, A Ghosh, JR Gill, SA Glasmacher, R Gordon, Gordan Grahovac, R Grenfell, A Habeebullah, N Haliasos, T Hammett, Cathal J. Hannan, CS Hill, Ingrid Hoeritzauer, D Holmes, K Hossain-Ibrahim, Laura Hughes, M Hussain, S Hussain, and R Ibrahim

Submissions from 2021

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Subcutaneous cladribine to treat multiple sclerosis: experience in 208 patients, Kimberley Allen-Philbey, Trane S De, Zhifeng Mao, Cesar Álvarez-González, Joela Mathews, Amy MacDougall, Andrea Stennett, Xia Zhou, Ozlem Yildiz, Ashok Adams, Lucia Bianchi, Camilla Blain, Christine Chapman, Karen Chung, Cris S. Constantinescu, Catherine Dalton, Rachel A. Farrell, Leonora Fisniku, Helen Ford, Bruno Gran, Jeremy Hobart, Zhaleh Khaleeli, Miriam Mattoscio, Sue Pavitt, Owen Pearson, Luca Peruzzotti-Jametti, Antonio Scalfari, Basil Sharrack, Eli Silber, Emma C. Tallantyre, Stewart Webb, Benjamin P. Turner, Monica Marta, Sharmilee Gnanapavan, Gunnar Juliusson, Gavin Giovannoni, David Baker, and Klaus Schmierer

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Diagnosing Autism Spectrum Disorders in Deaf Children Using Two Standardised Assessment Instruments: The ADIR-Deaf Adaptation and the ADOS-2 Deaf Adaptation, Victoria Allgar, Barry Wright, Amelia Taylor, Ann Le Couter, and Helen Phillips

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Mapping of population disparities in the cholangiocarcinoma urinary metabolome, Munirah Alsaleh, Zoe Leftley, Thomas O’Connor, Thomas Hughes, Thomas A. Barbera, Larry K. Koomson, Abigail Zabron, Helen Reeves, Matthew Cramp, Stephen D. Ryder, Shaun Greer, Martin Prince, Paiboon Sithithaworn, Narong Khuntikeo, Watcharin Loilome, Puangrat Yongvanit, I. Jane Cox, Roger Williams, Christopher A. Wadsworth, Elaine Holmes, Kathryn Nash, Ross Andrews, and Simon D. Taylor-Robinson

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Real-World Outcomes of Direct-Acting Antiviral Treatment and Retreatment in United Kingdom–Based Patients Infected With Hepatitis C Virus Genotypes/Subtypes Endemic in Africa, Elihu Aranday-Cortes, C. Patrick McClure, Christopher Davis, William L. Irving, Kazeem Adeboyejo, Lily Tong, Silva Filipe A da, Vattipally Sreenu, Kosh Agarwal, David Mutimer, Benjamin Stone, Matthew E. Cramp, Emma C. Thomson, Jonathan K. Ball, and John McLauchlan

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Analysis of Coastal health outcomes., S Asthana and A Gibson

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Averting a public health crisis in England’s coastal communities: a call for public health research and policy, Sheena Asthana and Alex Gibson

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The coagulopathy of liver disease: a shift in thinking, Alexandra Ballantine, Daniel Martin, and Sonali V. Thakrar

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Study of mirtazapine for agitated behaviours in dementia (SYMBAD): a randomised, double-blind, placebo-controlled trial, Sube Banerjee, Juliet High, Susan Stirling, Lee Shepstone, Ann Marie Swart, Tanya Telling, Catherine Henderson, Clive Ballard, Peter Bentham, Alistair Burns, Nicolas Farina, Chris Fox, Paul Francis, Robert Howard, Martin Knapp, Iracema Leroi, Gill Livingston, Ramin Nilforooshan, Shirley Nurock, John O'Brien, Annabel Price, Alan J. Thomas, and Naji Tabet

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A comparative study of the effect of the Time for Dementia programme on medical students, Sube Banerjee, Christopher Jones, Juliet Wright, Wendy Grosvenor, Molly Hebditch, Leila Hughes, Yvonne Feeney, Nicolas Farina, Sophie Mackrell, Ramin Nilforooshan, Chris Fox, Stephen Bremner, and Stephanie Daley

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Hematopoietic Stem and Progenitor Cell Maintenance and Multiple Lineage Differentiation Is an Integral Function of NFATc1, de Brito C Barahona, S Klein-Hessling, Edgar Serfling, and Amiya Kumar Patra

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Microtubule disruption upon CNS damage triggers mitotic entry via TNF signaling activation, Claudia S. Barros and Torsten Bossing

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Genotype-Phenotype Correlations in Neurofibromatosis and Their Potential Clinical use, Chetan Bettegowda, Meena Upadhayaya, D. Gareth Evans, Ae Rang Kim, Dimitrios Mathios, and Clemens O. Hanemann

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A multicentre prospective double blinded randomised controlled trial of intravenous iron (ferric Derisomaltose (FDI)) in Iron deficient but not anaemic patients with chronic kidney disease on functional status, S. Bhandari, V. Allgar, A. Lamplugh, I. Macdougall, and P. A. Kalra

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Emotions, psychological safety and recommendations for designing remediation programmes, Nicola Brennan

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Drivers of international migration of doctors to and from the United Kingdom, N Brennan, N Langdon, M Bryce, T Gale, A Knapton, L Burns, and N Humphries

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2020 Medical Graduates: The work and wellbeing of interim Foundation Year 1 doctors during COVID-19, B Burford, K Mattick, T Gale, G Vance, D Carrieri, N Brennan, and A Goulding

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Standard setting anchor statements: a double cross-over trial of two different methods., S Burr, T Martin, J Edwards, C Ferguson, K Gilbert, C Gray, A Hill, J Hosking, K Johnstone, J Kisielewska, C Milsom, S Moyes, A Rigby-Jones, I Robinson, N Toms, H Watson, and D Zahra

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Delivering Large-Scale Neurosurgical Studies in the UK: The Impact of Trainees, Aswin Chari, Rory J. Piper, Ellie Edlmann, Julie Woodfield, Paul M. Brennan, Carole Turner, Michael D. Jenkinson, Peter J. Hutchinson, Angelos G. Kolias, Daniel M. Fountain, Ruichong Ma, Ian Coulter, Aminul Ahmed, Aimun A.B. Jamjoom, Fahid T. Rasul, Claudia Craven, Michael T.C. Poon, Josephine Jung, Jignesh Tailor, Abdurrahman I. Islim, Mueez Waqar, Sara Venturini, Soham Bandyopadhyay, Robin Borchert, and Conor S. Gillespie

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The use of video for patient information and education: a scoping review of the variability and effectiveness of interventions, Arunangsu Chatterjee, Gary Strong, Madison Milne-Ives, Edward Meinert, Matthew Halkes, and Emma Wyatt-Haines

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Developmental Impact of Glutamate Transporter Overexpression on Dopaminergic Neuron Activity and Stereotypic Behavior, M Chohan, J Kopelman, H Yueh, Z Fazlali, N Greene, A Harris, P Balsam, ED Leonardo, E Kramer, J Veenstra-Vanderweele, and S Ahmari

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Secondary analysis of loot box data: Are high-spending “whales” wealthy gamers or problem gamblers?, James Close, Stuart Gordon Spicer, Laura Louise Nicklin, Maria Uther, J Lloyd, and H Lloyd

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Physiological responses during ascent to high altitude and the incidence of acute mountain sickness, Alexandra B. Cobb, Denny Z.H. Levett, K Mitchell, Wynne Aveling, D Hurlbut, E Gilbert‐Kawai, Philip J. Hennis, MG Mythen, Michael P.W. Grocott, DS Martin, V. Ahuja, G Aref‐Adib, R. Burnham, A. Chisholm, K. Clarke, D Coates, M Coates, D. Cook, M. Cox, S. Dhillon, C. Dougall, P. Doyle, P. Duncan, M. Edsell, L. Edwards, L. Evans, P. Gardiner, Michael P.W. Grocott, P. Gunning, N. Hart, J. Harrington, J. Harvey, C. Holloway, D. Howard, D Hurlbut, C. Imray, C. Ince, der Kaaij J van, M. Khosravi, N. Kolfschoten, Denny Z.H. Levett, H Luery, A. Luks, D Martin, R. McMorrow, P. Meale, K Mitchell, H. Montgomery, G Morgan, J Morgan, A. Murray, M Mythen, S Newman, V O’Dwyer, J Pate, T Plant, V Pun, P Richards, A Richardson, G Rodway, J Simpson, C Stroud, M Stroud, J Stygal, B Symons, P Szawarski, Tulleken A Van, Tulleken C Van, A Vercueil, L Wandrag, M Wilson, J Windsor, B Basnyat, K. Clarke, T Hornbein, J Milledge, J West, S Abraham, T Adams, W Anseeuw, R Astin, B Basnyat, O Burdall, J Carroll, Alexandra B. Cobb, J Coppel, O Couppis, J Court, A Cumpstey, T Davies, S. Dhillon, N Diamond, C. Dougall, T Geliot, E Gilbert‐Kawai, G Gilbert‐Kawai, E Gnaiger, M Grocott, C Haldane, P Hennis, J Horscroft, D Howard, S Jack, B Jarvis, W Jenner, G Jones, J van der Kaaij, J Kenth, A Kotwica, R Kumar BC, J Lacey, V Laner, D Levett, D Martin, P Meale, K Mitchell, Z Mahomed, J Moonie, A Murray, M Mythen, P Mythen, K O’Brien, I Ruggles‐Brice, K Salmon, A Sheperdigian, T Smedley, B Symons, C Tomlinson, A Vercueil, L Wandrag, S Ward, A Wight, C Wilkinson, S Wythe, M Feelisch, E Gilbert‐Kawai, M Grocott, M Hanson, D Levett, D Martin, K Mitchell, H Montgomery, R Moon, A Murray, M Mythen, and M Peters

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Developmental impact of glutamate transporter overexpression on dopaminergic neuron activity and stereotypic behavior, M Cohan, Jared M. Kopelman, Hannah Yueh, Hannah Yueh, Natasha Greene, Alexander Z. Harris, Peter D. Balsam, E. David Leonardo, Edgar R. Kramer, Jeremy Veenstra-VanderWeele, and Susanne E. Ahmari

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Teaching, research or balanced? An exploration of the experiences of biomedical scientists working in UK medical schools, Tracey Collett, Steve Capey, James Edwards, Darrell J. Evans, John C. McLachlan, Helen Watson, and David Bristow

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Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial, Nick Curzen, Zoe Nicholas, Beth Stuart, Sam Wilding, Kayleigh Hill, James Shambrook, Zina Eminton, Darran Ball, Camilla Barrett, Lucy Johnson, Jacqui Nuttall, Kim Fox, Derek Connolly, P O’Kane, Alex Hobson, Anoop Chauhan, Neal Uren, Gerry McCann, Colin Berry, Justin Carter, Carl Roobottom, Mamas Mamas, Ronak Rajani, Ian Ford, Pamela Douglas, and Mark Hlatky

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Covid-19 and the quality of life of people with dementia and their carers—The TFD-C19 study, Stephanie Daley, Nicolas Farina, Laura Hughes, Elise Armsby, Nazire Akarsu, Joanna Pooley, Georgia Towson, Yvonne Feeney, Naji Tabet, Bethany Fine, and Sube Banerjee

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Combining Realist approaches and Normalization Process Theory to understand implementation: a systematic review, Sonia Michelle Dalkin, Rebecca J.L. Hardwick, Catherine A. Haighton, and Tracy L. Finch

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TAM receptors as potential therapeutic targets in NF2-related schwannomas and meningiomas, F Dave, S Ammoun, and CO Hanemann

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The Genetics of Parkinson’s Disease and Implications for Clinical Practice, Jacob Oliver Day and Stephen Mullin

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Current Trends and Challenges for Rapid SMART Diagnostics at Point-of-Site Testing for Marine Toxins, Michael Dillon, Maja A. Zaczek-Moczydlowska, Christine Edwards, Andrew D. Turner, Peter I. Miller, Heather Moore, April McKinney, Linda Lawton, and Katrina Campbell

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OPTIMISE: MS study protocol: a pragmatic, prospective observational study to address the need for, and challenges with, real world pharmacovigilance in multiple sclerosis, Ruth Dobson, Matthew Craner, Ed Waddingham, Aleisha Miller, Ana Cavey, Stewart Webb, Cheryl Hemingway, Jeremy Hobart, Nikos Evangelou, Neil Scolding, David Rog, Richard Nicholas, Monica Marta, Camilla Blain, Carolyn Anne Young, Helen L. Ford, and Paul M. Matthews

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The Effect of Pre-operative Exercise Intervention on Patient Outcomes Following Bariatric Surgery: a Systematic Review and Meta-analysis, Belinda J. Durey, Dominic Fritche, Daniel S. Martin, and Lawrence M.J. Best

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Letter to the Editor. A UK perspective on gender diversity in American neurosurgery training programs, Ellie Edlmann, Phillip Copley, Mark Hughes, and Julie Woodfield

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Balancing risks and benefits when recommencing oral anticoagulants after major bleeding, Ellie Edlmann and Catherine McMahon

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Pathogenesis of Chronic Subdural Hematoma: A Cohort Evidencing De Novo and Transformational Origins, Ellie Edlmann, Peter C. Whitfield, Angelos Kolias, and Peter J. Hutchinson

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Practical and clinical approaches using pacing to improve self-regulation in special populations such as children and people with mental health or learning disabilities, A Edwards, U Abonie, F Hettinga, D Pyne, T Oh, and R Polman

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Early Detection of Alzheimer's Disease with Blood Plasma Proteins Using Support Vector Machines, Chima S. Eke, Emmanuel Jammeh, Xinzhong Li, Camille Carroll, Stephen Pearson, and Emmanuel Ifeachor

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Protocol for a prospective double-blind, randomised, placebo-controlled feasibility trial of octreotide infusion during liver transplantation, Jeremy Fabes, Gareth Ambler, Bina Shah, Norman R. Williams, Daniel Martin, Brian R. Davidson, and Michael Spiro

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Health and wellbeing outcomes and social prescribing pathways in community‐based support for autistic adults: A systematic mapping review of reviews, Charlotte Featherstone, Richard A. Sharpe, Nick Axford, Sheena Asthana, and Kerryn Husk

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Health and wellbeing outcomes and social prescribing pathways in community‐based support for autistic adults: A systematic mapping review of reviews, C Featherstone, RA Sharpe, N Axford, S Asthana, and K Husk

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P-P06 Ward based goal directed fluid therapy (GDFT) in acute pancreatitis (GAP) trial: a feasibility randomised controlled trial [ISRCTN 36077283], F Froghi, F Soggiu, F Ricciardi, C Vindrola-Padros, L Floros, D Martin, H Filipe, M Varcada, K Gurusamy, S Bhattacharya, A Fanshawe, B Dolcea, P Mathur, and B Davidson

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Ward based goal directed fluid therapy (GDFT) in acute pancreatitis (GAP) trial: a feasibility randomised controlled trial [ISRCTN 36077283], F Froghi, F Soggiu, F Ricciardi, C Vindrola-Padros, L Floros, D Martin, H Filipe, M Varcada, K Gurusamy, S Bhattacharya, A Fanshawe, B Dolcea, P Mathur, and B Davidson

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Degradation of lipid droplets by chimeric autophagy-tethering compounds, Yuhua Fu, Ningxie Chen, Ziying Wang, Shouqing Luo, Yu Ding, and Boxun Lu

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Mental Health Provision in UK Secondary Schools, Megan Garside, Barry Wright, Roshanak Nekooi, and Victoria Allgar

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Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1, Rosemarie E. Gough, Matthew C. Jones, Thomas Zacharchenko, Shimin Le, Miao Yu, Guillaume Jacquemet, Ste P. Muench, Jie Yan, JD Humphries, Claus Jørgensen, MJ Humphries, and Benjamin T. Goult

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Early computed tomography coronary angiography in patients with suspected acute coronary syndrome: randomised controlled trial, Alasdair J. Gray, Carl Roobottom, Jason E. Smith, Steve Goodacre, Katherine Oatey, R O’Brien, Robert F. Storey, Nick Curzen, Liza Keating, Attila Kardos, Dirk Felmeden, Robert J. Lee, Praveen Thokala, Steff C. Lewis, and David E. Newby

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Planning and Evaluating Remote Consultation Services: A New Conceptual Framework Incorporating Complexity and Practical Ethics, Trisha Greenhalgh, Rebecca Rosen, Sara E. Shaw, Richard Byng, Stuart Faulkner, Teresa Finlay, Emily Grundy, Laiba Husain, Gemma Hughes, Claudia Leone, Lucy Moore, Chrysanthi Papoutsi, Catherine Pope, Sarah Rybczynska-Bunt, Alexander Rushforth, Joseph Wherton, Sietse Wieringa, and Gary W. Wood

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‘Do I have the capacity to make capacity judgements?’ Researcher reflections from a person-centred dementia support study, Sarah Griffiths, Alex Gude, Leanne Greene, Lauren Weston, Caroline L. Sutcliffe, Hannah Wheat, Tomasina M. Oh, and Richard Byng

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The role of trust and hope in antipsychotic medication reviews between GPs and service users a realist review, L. M. Grünwald, C. Duddy, R. Byng, N. Crellin, and J. Moncrieff

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REiNS: Genotype-Phenotype Correlations in Neurofibromatosis and Their Potential Clinical use, Clemens O. Hanemann

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Developing a UK widening participation forum, Enam Haque, Andy Spencer, and Louise Alldridge

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Assessing sociology and psychology in UK undergraduate medical education: Square peg in a round hole?, J Harden, T Collett, S Forrest, and K Kendall

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FC 096THE EFFECT OF INCREMENTAL START OF HAEMODIALYSIS ON BLOOD PRESSURE AND INTERDIALYTIC WEIGHT GAIN: PRELIMINARY FINDINGS FROM THE ENDURE STUDY, A Hazara, V Allgar, M Twiddy, and S Bhandari

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A mixed-method feasibility study of a novel transitional regime of incremental haemodialysis: study design and protocol, Adil M. Hazara, Victoria Allgar, Maureen Twiddy, and Sunil Bhandari

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Link worker perspectives of early implementation of social prescribing: a ‘Researcher-in-Residence’ study, Emma Hazeldine, Gemma Gowan, Rachel Wigglesworth, Julie Pollard, Sheena Asthana, and Kerryn Husk

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Combinatorial mathematical modelling approaches to interrogate rear retraction dynamics in 3D cell migration, Joseph H.R. Hetmanski, Matthew C. Jones, Fatima Chunara, Jean Marc Schwartz, and Patrick T. Caswell

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The remote assessment of parkinsonism supporting the ongoing development of interventions in Gaucher disease, Abigail Louise Higgins, Marco Toffoli, Stephen Mullin, Chiao Yin Lee, Sofia Koletsi, Micol Avenali, Fabio Blandini, and Anthony H.V. Schapira

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Study Protocol on Defining Core Outcomes and Data Elements in Chronic Subdural Haematoma, Dana C. Holl, Aswin Chari, Christian Iorio-Morin, Ruben Dammers, der Gaag NA van, Angelos G. Kolias, Peter J. Hutchinson, and Ellie Edlmann

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Economic evaluation of a complex intervention (Engager) for prisoners with common mental health problems, near to and after release: a cost-utility and cost-consequences analysis, Rachael Maree Hunter, Rob Anderson, Tim Kirkpatrick, Charlotte Lennox, Fiona Warren, Rod S. Taylor, Jenny Shaw, Mark Haddad, Alex Stirzaker, Mike Maguire, and Richard Byng

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The Use and Effectiveness of an Online Diagnostic Support System for Blood Film Interpretation: Comparative Observational Study, C Hutchinson, M Brereton, J Adams, La Salle B De, J Sims, K Hyde, R Chasty, R Brown, K Rees-Unwin, and J Burthem

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Evaluation of the MP Rapid 2019-NCOV IgM/IgG combo POCT test vs. an established platform-based method, N. Jassam, J. H. Barth, V. Allgar, S. Glover, F. Stevenson, N. Lauber, V. Houghton, Z. Hanif, J. Child, and B. Clark

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Using realist approaches in nutrition and dietetics research, Gemma Jenkins, Isabella Maugeri, Claire Palermo, and Rebecca Hardwick

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Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease, Stefanie T. Jost, Veerle Visser-Vandewalle, Alexandra Rizos, Philipp A. Loehrer, Monty Silverdale, Julian Evans, Michael Samuel, Jan Niklas Petry-Schmelzer, Anna Sauerbier, Alexandra Gronostay, Michael T. Barbe, Gereon R. Fink, Keyoumars Ashkan, Angelo Antonini, Pablo Martinez-Martin, K. Ray Chaudhuri, Lars Timmermann, Haidar S. Dafsari, Roongroj Bhidayasiri, Cristian Falup-Pecurariu, Beomseok Jeon, Valentina Leta, Per Borghammer, Per Odin, Anette Schrag, Alexander Storch, Mayela Rodriguez Violante, Daniel Weintraub, Charles Adler, Paolo Barone, David J. Brooks, Richard Brown, Marc Cantillon, Camille Carroll, Miguel Coelho, Tove Henriksen, Michele Hu, Peter Jenner, Milica Kramberger, Padma Kumar, Mónica Kurtis, Simon Lewis, Irene Litvan, Kelly Lyons, Davide Martino, Mario Masellis, Hideki Mochizuki, James F. Morley, Melissa Nirenberg, Javier Pagonabarraga, J Panicker, N Pavese, E Pekkonen, R Postuma, R Rosales, A Schapira, T Simuni, F Stocchi, I Subramanian, M Tagliati, M Tinazzi, J Toledo, Y Tsuboi, and R Walker

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Identifying Appropriate Delivery of and Referral to Pulmonary Rehabilitation in Uganda: A Survey Study of People Living with Chronic Respiratory Disease and Health Care Workers, W Katagira, AV Jones, MW Orme, ZK Yusuf, P Ndagire, J Nanyonga, R Kasiita, JN Kasolo, RB Miah, MC Steiner, R Jones, A Barton, B Kirenga, and SJ Singh

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Clinical trials in pediatric ALS: a TRICALS feasibility study, Tessa Kliest, Eijk RPA Van, Ammar Al-Chalabi, Alberto Albanese, Peter M. Andersen, Maria Del Mar Amador, Geir BrÅthen, Veronique Brunaud-Danel, Lev Brylev, William Camu, Carvalho M De, Cristina Cereda, Hakan Cetin, Delia Chaverri, Adriano Chiò, Philippe Corcia, Philippe Couratier, Marchi F De, Claude Desnuelle, Es MA Van, JesÚs Esteban, Massimiliano Filosto, Redondo A GarcÍa, Julian Grosskreutz, Clemens O. Hanemann, Trygve HolmØy, Helle HØyer, Caroline Ingre, Blaz Koritnik, Magdalena Kuzma-Kozakiewicz, Thomas Lambert, Peter N. Leigh, Christian Lunetta, Jessica Mandrioli, Christopher J. Mcdermott, Thomas Meyer, Jesus S. Mora, Susanne Petri, MÓnica Povedano, Evy Reviers, and Nilo Riva

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University teacher development courses in the UK neoliberal higher education context., I Kushnir and L Spowart

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Integrated care pathways in neurosurgery: A systematic review, Keng Siang Lee, Stefan Yordanov, Daniel Stubbs, Ellie Edlmann, Alexis Joannides, and Benjamin Davies

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Revised diagnostic criteria for neurofibromatosis type 1 and Legius syndrome: an international consensus recommendation, Eric Legius, Ludwine Messiaen, Pierre Wolkenstein, Patrice Pancza, Robert A. Avery, Yemima Berman, Jaishri Blakeley, Dusica Babovic-Vuksanovic, Karin Soares Cunha, Rosalie Ferner, Michael J. Fisher, Jan M. Friedman, David H. Gutmann, Hildegard Kehrer-Sawatzki, Bruce R. Korf, V-F Mautner, Sirkku Peltonen, Katherine A. Rauen, Vincent Riccardi, Elizabeth Schorry, Anat Stemmer-Rachamimov, David A. Stevenson, Gianluca Tadini, Nicole J. Ullrich, David Viskochil, Katharina Wimmer, Kaleb Yohay, Alicia Gomes, Justin T. Jordan, V Mautner, Vanessa L. Merker, Miriam J. Smith, David A. Stevenson, Monique Anten, Arthur Aylsworth, Diana Baralle, Sebastien Barbarot, Fred Barker, Shay Ben-Shachar, Amanda Bergner, and Didier Bessis

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Using multiple case studies of health and justice services to inform the development of a new complex intervention for prison-leavers with common mental health problems (Engager), Charlotte Lennox, R Stevenson, Christabel Owens, Richard Byng, Sarah L. Brand, Mike Maguire, Graham Durcan, C Stevenson, Jenny Shaw, and Cath Quinn

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Realist evaluation of Schwartz rounds® for enhancing the delivery of compassionate healthcare: understanding how they work, for whom, and in what contexts, J Maben, C Taylor, E Reynolds, I McCarthy, and M Leamy

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Lifting the lid on perioperative goal-directed therapy, Daniel S. Martin

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A feasibility randomised controlled trial of targeted oxygen therapy in mechanically ventilated critically ill patients, Daniel S. Martin, Margaret McNeil, Chris Brew-Graves, Helder Filipe, Ronan O’Driscoll, Jia Liu Stevens, Rachel Burnish, Andrew F. Cumpstey, Norman R. Williams, Michael G. Mythen, and Michael P.W. Grocott

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A report from the NIHR UK working group on remote trial delivery for the COVID-19 pandemic and beyond, Jane A.H. Masoli, Kim Down, Gary Nestor, Sharon Hudson, John T. O’Brien, James D. Williamson, Carolyn A. Young, and Camille Carroll

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A Report From The NIHR UK Working Group On Remote Trial Delivery For The COVID-19 Pandemic and Beyond, J Masoli, S Hudson, JT O’Brien, JD Williamson, CA Young, and CB Carroll

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Human endogenous retrovirus type K promotes proliferation and confers sensitivity to anti-retroviral drugs in Merlin-negative schwannoma and meningioma., Emmanuel A. Maze, Bora Agit, Shona Reeves, David A. Hilton, David B. Parkinson, Liyam Laraba, Emanuela Ercolano, Kathreena M. Kurian, C. Oliver Hanemann, Robert D. Belshaw, and Sylwia Ammoun

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Long covid clinics should be run as research hubs, Margaret McCartney and Richard Byng