ORCID
- Haunton, Victoria: 0000-0001-6078-5469
Abstract
Hypertension is associated with both ageing and dementia. Despite this, optimal blood pressure targets in dementia remain unclear. Both high and low blood pressure are associated with poorer cognition. Changes in vascular physiology in dementia may increase the vulnerability of the brain to hypoperfusion associated with antihypertensives. We discuss the potential risks of antihypertensives in the context of altered cerebral haemodynamics, and evidence from antihypertensive trials in dementia. We suggest that individualised blood pressure targets should be the focus for antihypertensive therapy in dementia, rather than strict control to uniform targets extrapolated from trials in cognitively healthy individuals.
DOI
10.1177/0271678x221133473
Publication Date
2022-10-25
Publication Title
Journal of Cerebral Blood Flow & Metabolism
ISSN
0271-678X
Embargo Period
2023-10-17
Organisational Unit
Peninsula Medical School
Recommended Citation
Beishon, L., Haunton, V., & Panerai, R. (2022) 'Antihypertensives in dementia: Good or bad for the brain?', Journal of Cerebral Blood Flow & Metabolism, . Available at: https://doi.org/10.1177/0271678x221133473
