Abstract
The RecQ family of DNA helicases has members in all organisms analysed. In humans, defects in three family members are associated with disease conditions: BLM is defective in Bloom's syndrome, WRN in Werner's syndrome and RTS in Rothmund-Thomson syndrome. In each case, cells from affected individuals show inherent genomic instability. The focus of our work is the Bloom's syndrome gene and its product, BLM. Here, we review the latest information concerning the roles of BLM in the maintenance of genome integrity.
DOI
10.1042/bst0290201
Publication Date
2001-05-01
Publication Title
Biochemical Society Transactions
Volume
29
Issue
2
Publisher
Portland Press Ltd.
ISSN
1470-8752
Embargo Period
2024-11-19
First Page
201
Last Page
204
Recommended Citation
Hickson, I., Davies, S., Li, J., Levitt, N., & et al. (2001) 'Role of the Bloom's syndrome helicase in maintenance of genome stability', Biochemical Society Transactions, 29(2), pp. 201-204. Portland Press Ltd.: Available at: https://doi.org/10.1042/bst0290201