Abstract

The RecQ family of DNA helicases has members in all organisms analysed. In humans, defects in three family members are associated with disease conditions: BLM is defective in Bloom's syndrome, WRN in Werner's syndrome and RTS in Rothmund-Thomson syndrome. In each case, cells from affected individuals show inherent genomic instability. The focus of our work is the Bloom's syndrome gene and its product, BLM. Here, we review the latest information concerning the roles of BLM in the maintenance of genome integrity.

DOI

10.1042/bst0290201

Publication Date

2001-05-01

Publication Title

Biochemical Society Transactions

Volume

29

Issue

2

Publisher

Portland Press Ltd.

ISSN

1470-8752

Embargo Period

2024-11-19

First Page

201

Last Page

204

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