Browse research from the Peninsula Medical School.

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Submissions from 2012

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Age before stage: insulin resistance rises before the onset of puberty: a 9-year longitudinal study (EarlyBird 26)., AN Jeffery, BS Metcalf, J Hosking, AJ Streeter, LD Voss, and TJ Wilkin

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Being young in Cornwall, JF Tredinnick-Rowe

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Physical activity as an aid to smoking cessation during pregnancy (LEAP) trial: study protocol for a randomized controlled trial, Michael Ussher, Paul Aveyard, Isaac Manyonda, S Lewis, Robert West, B Lewis, Bess Marcus, Adrian H. Taylor, Pelham Barton, and Tim Coleman

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Guided self-help concreteness training as an intervention for major depression in primary care: a Phase II randomized controlled trial., E. R. Watkins, R. S. Taylor, R. Byng, C. Baeyens, R. Read, K. Pearson, and L. Watson

Submissions from 2011

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NFATc1 affects mouse splenic B cell function by controlling the calcineurin–NFAT signaling network, Sankar Bhattacharyya, Jolly Deb, Amiya K. Patra, Pham DA Thuy, Wen Chen, Martin Vaeth, Friederike Berberich-Siebelt, Stefan Klein-Hessling, Edward D. Lamperti, Kurt Reifenberg, Julia Jellusova, Astrid Schweizer, Lars Nitschke, Ellen Leich, Andreas Rosenwald, Cornelia Brunner, Swen Engelmann, Ursula Bommhardt, Andris Avots, Martin R. Müller, Eisaku Kondo, and Edgar Serfling

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Exploring the Map of Medicine's potential in undergraduate medical education., Nicola Brennan and Karen Mattick

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The Map of Medicine: a review of evidence for its impact on healthcare., Nicola Brennan, Karen Mattick, and Tricia Ellis

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The problem with health measurement., Stefan J. Cano and Jeremy C. Hobart

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Designing clinical trials in older people., C. B. Carroll and J. P. Zajicek

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Changes in iron-regulatory gene expression occur in human cell culture models of Parkinson's disease., C. B. Carroll, M. L. Zeissler, N. Chadborn, K. Gibson, G. Williams, J. P. Zajicek, K. E. Morrison, and C. O. Hanemann

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Statins in Unconventional Secretion of Insulin-Degrading Enzyme and Degradation of the Amyloid-β Peptide, K Glebov and J Walter

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Neurofibromatosis 2011: a report of the Children's Tumor Foundation annual meeting., Michel Kalamarides, Maria T. Acosta, Dusica Babovic-Vuksanovic, Olli Carpen, Karen Cichowski, DG Evans, Filippo Giancotti, CO Hanemann, David Ingram, Alison C. Lloyd, Debra A. Mayes, Ludwine Messiaen, Helen Morrison, Kathryn North, Roger Packer, Duojia Pan, Anat Stemmer-Rachamimov, Meena Upadhyaya, David Viskochil, Margret R. Wallace, Kim Hunter-Schaedle, and Nancy Ratner

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Effect of exercise referral schemes in primary care on physical activity and improving health outcomes: systematic review and meta-analysis., T. G. Pavey, AH Taylor, K. R. Fox, M. Hillsdon, N. Anokye, J. L. Campbell, C. Foster, C. Green, T. Moxham, N. Mutrie, J. Searle, P. Trueman, and RS Taylor

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A tool to measure the attributes of receiving IV therapy in a home versus hospital setting: the Multiple Sclerosis Relapse Management Scale (MSRMS)., Afsane Riazi, Bernadette Porter, Jeremy Chataway, Alan J. Thompson, and Jeremy C. Hobart

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Propofol and children--what we know and what we do not know., AE Rigby-Jones and JR Sneyd

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Patients' views of physical activity as treatment for depression: a qualitative study, Aidan Searle, Michael Calnan, Glyn Lewis, John Campbell, Adrian Taylor, and Katrina Turner

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Women's experience of colposcopy: a qualitative investigation, Dawn R. Swancutt, Sheila M. Greenfield, David M. Luesley, and Sue Wilson

Submissions from 2010

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ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma, Sylwia Ammoun, Clare H. Cunliffe, Jeffrey C. Allen, Luis Chiriboga, Filippo G. Giancotti, David Zagzag, C. Oliver Hanemann, and Matthias A. Karajannis

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Physical activity as a treatment for depression: the TREAD randomised trial protocol, Helen Baxter, Rachel Winder, Melanie Chalder, Christine Wright, Sofie Sherlock, Anne Haase, Nicola J. Wiles, Alan A. Montgomery, Adrian H. Taylor, Ken R. Fox, Debbie A. Lawlor, Tim J. Peters, Deborah J. Sharp, John Campbell, and Glyn Lewis

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The transition from medical student to junior doctor: today's experiences of Tomorrow's Doctors., Nicola Brennan, Oonagh Corrigan, Jon Allard, Julian Archer, Rebecca Barnes, Alan Bleakley, Tracey Collett, and Bere SR de

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Changes in Iron-Regulatory Gene Expression Occur in Human Cell Culture Models of PD, CB Carroll, ML Zeissler, N Chadborn, K Gibson, GJ Williams, KE Morrison, JP Zajicek, and CO Hanemann

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Cannabinoids Are Neuroprotective in a Human Cell Culture Model of Parkinson's Disease, CB Carroll, ML Zeissler, V Stone, CO Hanemann, and JP Zajicek

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Selecting GLP-1 agonists in the management of type 2 diabetes: differential pharmacology and therapeutic benefits of liraglutide and exenatide., J Pinkney, T Fox, and L Ranganath

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Integrating the promotion of physical activity within a smoking cessation programme: findings from collaborative action research in UK Stop Smoking Services., Adrian H. Taylor, Emma S. Everson-Hock, and Michael Ussher

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Cross-trimester repeated measures testing for Down's syndrome screening: an assessment., D. Wright, I. Bradbury, F. Malone, M. D'Alton, A. Summers, T. Huang, S. Ball, A. Baker, B. Nix, D. Aitken, J. Crossley, H. Cuckle, and K. Spencer

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Patient-orientated longitudinal study of multiple sclerosis in south west England (The South West Impact of Multiple Sclerosis Project, SWIMS) 1: protocol and baseline characteristics of cohort., John P. Zajicek, Wendy M. Ingram, Jane Vickery, Siobhan Creanor, Dave E. Wright, and Jeremy C. Hobart

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CBD & D9-THC - the two faces of cannabis, N/A Zeissler, CB Carroll, and J Zajicek

Submissions from 2009

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Aquired neuromyotonia following upper respiratory tract infection, I Imam, S Edwards, and CO Hanemann

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Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin, insulin, and glucose., Katrina Kos, Steve Wong, Bee Tan, Anders Gummesson, Margareta Jernas, Niclas Franck, David Kerrigan, Fredrik H. Nystrom, Lena M.S. Carlsson, Harpal S. Randeva, Jonathan H. Pinkney, and John P.H. Wilding

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Objectively measured physical activity and its association with adiponectin and other novel metabolic markers: a longitudinal study in children (EarlyBird 38)., BS Metcalf, AN Jeffery, J Hosking, LD Voss, N Sattar, and TJ Wilkin

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The size of the treatment effect: do patients and proxies agree?, der Linden FAH van, Jolijn J. Kragt, Jeremy C. Hobart, Martin Klein, Alan J. Thompson, der Ploeg HM van, Chris H. Polman, and Bernard M.J. Uitdehaag

Submissions from 2008

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The cervical dystonia impact profile (CDIP-58): can a Rasch developed patient reported outcome measure satisfy traditional psychometric criteria?, Stefan J. Cano, Thomas T. Warner, Alan J. Thompson, Kailash P. Bhatia, Ray Fitzpatrick, and Jeremy C. Hobart

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Beyond the limits of clinical governance? The case of mental health in English primary care, Linda Gask, Anne Rogers, Stephen Campbell, and Rod Sheaff

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c-Jun is a negative regulator of myelination., David B. Parkinson, Ambily Bhaskaran, Peter Arthur-Farraj, Luke A. Noon, Ashwin Woodhoo, Alison C. Lloyd, M. Laura Feltri, Lawrence Wrabetz, Axel Behrens, Rhona Mirsky, and Kristján R. Jessen

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Cauda equina syndrome following a lumbar puncture., Alexandra J. Sinclair, Camille Carroll, and Brendan Davies

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Women's colposcopy experience and preferences: a mixed methods study., Dawn R. Swancutt, Sheila M. Greenfield, and Sue Wilson

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Surveillance of cirrhosis for hepatocellular carcinoma: a cost-utility analysis., Coon J. Thompson, G. Rogers, P. Hewson, D. Wright, R. Anderson, S. Jackson, S. Ryder, M. Cramp, and K. Stein

Submissions from 2007

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The feminisation of British neurology: implications for workforce planning., C. B. Carroll, DSNAP Tengah, C. Lawthom, and G. Venables

Submissions from 2006

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Sowing date, transplanting, plant density and nitrogen fertilization affect indigo production from Isatis species in a Mediterranean region of Spain, E Sales, R Kanhonou, C Baixauli, A Giner, D Cooke, K Gilbert, I Arrillaga, J Segura, and R Ros

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Can learning organizations survive in the newer NHS?, Rod Sheaff and David Pilgrim

Submissions from 2005

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Muscle cramps and weakness secondary to graft versus host disease fasciitis., Camille B. Carroll, D. A. Hilton, M. Hamon, and J. P. Zajicek

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Quantifying drug-induced dyskinesias in the arms using digitised spiral-drawing tasks, Xuguang Liu, Camille B. Carroll, Shou Yan Wang, John Zajicek, and Peter G. Bain

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HCV-specific cellular immune responses in subjects exposed to but uninfected by HCV, M Metzner, A Houldsworth, AG Demaine, E Kaminski, and ME Cramp

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HCV-specific cellular immune responses in subjects exposed, but uninfected by HCV, MK Metzner, A Houldsworth, A Demaine, E Kaminski, and ME Cramp

Submissions from 2004

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Do on-off variations cause discrepancies in the historical items of the UPDRS?, Camille B. Carroll and Peter G. Bain

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Stroke in Devon: knowledge was good, but action was poor., C. Carroll, J. Hobart, C. Fox, L. Teare, and J. Gibson

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Provision of 24 hour acute neurology care by neurologists: manpower requirements in the UK., C. Carroll and J. Zajicek

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Quantitative analysis of indigo and indigo precursors in leaves of Isatis spp. and Polygonum tinctorium., KG Gilbert, HG Maule, B Rudolph, M Lewis, H Vandenburg, E Sales, S Tozzi, and DT Cooke

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Raised intracranial pressure presenting with spontaneous periorbital bruising: two case reports, S Hadjikoutis, CB Carroll, and GTP Plant

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Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death, David B. Parkinson, Ambily Bhaskaran, Sarah Dickinson, and Anna Droggiti

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A randomised controlled trial and cost effectiveness study of systematic screening (targeted and total population screening) versus routine practice for the detection of atrial fibrillation in the over 65s: (SAFE) [ISRCTN19633732], Dawn Swancutt, Richard Hobbs, David Fitzmaurice, Jonathan Mant, Ellen Murray, Sue Jowett, James Raftery, Stirling Bryan, Michael Davies, and Gregory Lip

Submissions from 2003

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Complete analysis of the B‐cell response to a protein antigen, from in vivo germinal centre formation to 3‐D modelling of affinity maturation, CL Adams, MKL Macleod, Milner‐White E James, R Aitken, P Garside, and DI Stott

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A new HPLC-ELSD method to quantify indican in Polygonum tinctorium L. and to evaluate beta-glucosidase hydrolysis of indican for indigo production., LG Angelini, E Campeol, S Tozzi, KG Gilbert, DT Cooke, and P John

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Non-legitimate illness, embodied experience and the moral career: the case of ME/CFS, T Collett

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Constitutively active protein kinase B enhances Lck and Erk activities and influences thymocyte selection and activation., AK Patra

Submissions from 2000

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Qualitative analysis of indigo precursors from woad by HPLC and HPLC-MS, KG Gilbert, DJ Hill, C Crespo, A Mas, M Lewis, B Rudolph, and DT Cooke

Submissions from 1997

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Reversal of parkinsonian symptoms in primates by antagonism of excitatory amino acid transmission: potential mechanisms of action., I. J. Mitchell and C. B. Carroll