Browse research from the School of Biomedical Sciences.
Submissions from 2014
Insulin acutely improves mitochondrial function of rat and human skeletal muscle by increasing coupling efficiency of oxidative phosphorylation., Raid B. Nisr and Charles Affourtit
Application of Microarray and Functional-Based Screening Methods for the Detection of Antimicrobial Resistance Genes in the Microbiomes of Healthy Humans, Roderick M. Card, Philip J. Warburton, Nikki MacLaren, Peter Mullany, Elaine Allan, and Muna F. Anjum
A workflow for bacterial metabolic fingerprinting and lipid profiling: application to Ciprofloxacin challenged Escherichia coli, J. William Allwood, Haitham AlRabiah, Elon Correa, Andrew Vaughan, Yun Xu, Mathew Upton, and Royston Goodacre
Differentially Expressed MicroRNAs in Maternal Plasma for the Noninvasive Prenatal Diagnosis of Down Syndrome (Trisomy 21), J Kamhieh-Milz, Reham Fadl Hassan Moftah, Gürkan Bal, Matthias Futschik, Viktor Sterzer, Omid Khorramshahi, Martin Burow, Gundula Thiel, Annegret Stuke-Sontheimer, Rabih Chaoui, S Kamhieh-Milz, and Abdulgabar Salama
Evidence that duplications of 22q11.2 protect against schizophrenia, E Rees, G Kirov, MC O'Donovan, Wellcome Trust Case Control Consortium, and et al
Galleria mellonella infection model demonstrates high lethality of ST69 and ST127 uropathogenic E. coli., Majed F. Alghoribi, Tarek M. Gibreel, Andrew R. Dodgson, Scott A. Beatson, and Mathew Upton
Nuclear HER4 mediates acquired resistance to trastuzumab and is associated with poor outcome in HER2 positive breast cancer, SNM Nafi, D Generali, G Kramer-Marek, M Gijsen, and et al
The complete genome sequence of Escherichia coli EC958: a high quality reference sequence for the globally disseminated multidrug resistant E. coli O25b:H4-ST131 clone., Brian M. Forde, Zakour NL Ben, Mitchell Stanton-Cook, Minh Duy Phan, Makrina Totsika, Kate M. Peters, Kok Gan Chan, Mark A. Schembri, Mathew Upton, and Scott A. Beatson
UniHI 7: an enhanced database for retrieval and interactive analysis of human molecular interaction networks, Ravi Kiran Reddy Kalathur, José Pedro Pinto, Miguel A. Hernández-Prieto, Rui S.R. MacHado, Dulce Almeida, Gautam Chaurasia, and Matthias E. Futschik
Submissions from 2013
Novel insights into pancreatic β-cell glucolipotoxicity from real-time functional analysis of mitochondrial energy metabolism in INS-1E insulinoma cells., Jonathan Barlow and Charles Affourtit
International multicenter evaluation of the DiversiLab bacterial typing system for Escherichia coli and Klebsiella spp., Guido M. Voets, Hall MA Leverstein-van, Susanne Kolbe-Busch, der Zanden A van, Deirdre Church, Martin Kaase, Andrea Grisold, Mathew Upton, Elaine Cloutman-Green, Rafael Cantón, Alexander W. Friedrich, Ad C. Fluit, and DiversiLab Study Group
The Serum Resistome of a Globally Disseminated Multidrug Resistant Uropathogenic Escherichia coli Clone, Minh Duy Phan, Kate M. Peters, Sohinee Sarkar, Samuel W. Lukowski, Luke P. Allsopp, Danilo Gomes Moriel, Maud E.S. Achard, Makrina Totsika, Vikki M. Marshall, Mathew Upton, Scott A. Beatson, and Mark A. Schembri
A FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug-resistant uropathogenic Escherichia coli ST131., Makrina Totsika, Maria Kostakioti, Thomas J. Hannan, Mathew Upton, Scott A. Beatson, James W. Janetka, Scott J. Hultgren, and Mark A. Schembri
A Core Human Primary Tumor Angiogenesis Signature Identifies the Endothelial Orphan Receptor ELTD1 as a Key Regulator of Angiogenesis, M Masiero, FC Simões, HD Han, and et al
Towards Clinical Molecular Diagnosis of Inherited Cardiac Conditions: A Comparison of Bench-Top Genome DNA Sequencers, X Li, AJ Buckton, AL Wilkinson, S John, and et al
Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology., Holly Hardy, Jennifer Harris, Eleanor Lyon, Jane Beal, and Andrew D. Foey
Synthetic epidermicin NI01 can protect Galleria mellonella larvae from infection with Staphylococcus aureus, Tarek M. Gibreel and Mathew Upton
Genome Sequence of Hydrothermal Arsenic-Respiring Bacterium Marinobacter santoriniensis NKSG1T., Kim M. Handley, Mathew Upton, Scott A. Beatson, Marina Héry, and Jonathan R. Lloyd
Dynamic Circadian Protein–Protein Interaction Networks Predict Temporal Organization of Cellular Functions, Thomas Wallach, Katja Schellenberg, Bert Maier, Ravi Kiran Reddy Kalathur, Pablo Porras, Erich E. Wanker, Matthias E. Futschik, and Achim Kramer
High-throughput phenotyping of uropathogenic E. coli isolates with Fourier transform infrared spectroscopy., Haitham Alrabiah, Elon Correa, Mathew Upton, and Royston Goodacre
Molecular Basis for Jagged-1/Serrate Ligand Recognition by the Notch Receptor, P Whiteman, BH de Madrid, P Taylor, D Li, and et al
Macrophage subset sensitivity to endotoxin tolerisation by Porphyromonas gingivalis., Andrew D. Foey and St John Crean
Novel Polyomaviruses of Nonhuman Primates: Genetic and Serological Predictors for the Existence of Multiple Unknown Polyomaviruses within the Human Population, Nelly Scuda, Nadege Freda Madinda, Chantal Akoua-Koffi, Edgard Valerie Adjogoua, Diana Wevers, Jörg Hofmann, Kenneth N. Cameron, SAJ Leendertz, Emmanuel Couacy-Hymann, Martha Robbins, Christophe Boesch, Michael A. Jarvis, Ugo Moens, Lawrence Mugisha, Sébastien Calvignac-Spencer, FH Leendertz, and Bernhard Ehlers
Suppression of T cell-induced osteoclast formation, S Karieb and SW Fox
Tailoring 3D Single-Walled Carbon Nanotubes Anchored to Indium Tin Oxide for Natural Cellular Uptake and Intracellular Sensing, F. J. Rawson, C. L. Yeung, S. K. Jackson, and P. M. Mendes
TetAB(46), a predicted heterodimeric ABC transporter conferring tetracycline resistance in Streptococcus australis isolated from the oral cavity, Philip J. Warburton, Lena Ciric, Avigdor Lerner, Lorna A. Seville, Adam P. Roberts, Peter Mullany, and Elaine Allan
WAP four-disulfide core domain protein 2 mediates the proliferation of human ovarian cancer cells through the regulation of growth- and apoptosis-associated genes, YAO CHEN, XIA MU, S WANG, L ZHAO, and et al
Submissions from 2012
Huntington's Disease and its therapeutic target genes: a global functional profile based on the HD Research Crossroads database, Ravi Kiran R. Kalathur, Miguel A. Hernández-Prieto, and Matthias E. Futschik
Iron Deprivation in Synechocystis : Inference of Pathways, Non-coding RNAs, and Regulatory Elements from Comprehensive Expression Profiling, MA Hernández-Prieto, V Schön, J Georg, L Barreira, and et al
Iron Deprivation in Synechocystis : Inference of Pathways, Non-coding RNAs, and Regulatory Elements from Comprehensive Expression Profiling, Miguel A. Hernández-Prieto, Verena Schön, Jens Georg, Luísa Barreira, João Varela, Wolfgang R. Hess, and Matthias E. Futschik
Lactobacillus casei strain Shirota selectively modulates macrophage subset cytokine production, N Habil, J Beal, and AD Foey
Non Invasive Prenatal Diagnosis of Aneuploidy: Next Generation Sequencing or Fetal DNA Enrichment?, N. D. Avent, A. Webb, T. E. Madgett, T. Miran, K. Sillence, N. Kaushik, and M. Kiernan
Zinc modifies the effect of phyto-oestrogens on osteoblast and osteoclast differentiation in vitro., S Karieb and SW Fox
Escherichia coli-mediated impairment of ureteric contractility is uropathogenic E. coli specific., Rachel V. Floyd, Mathew Upton, Scott J. Hultgren, Susan Wray, Theodor V. Burdyga, and Craig Winstanley
Underweight and overweight men have greater exercise-induced dyspnoea than normal weight men, MMF Subhan, SA Ali, SSI Bokhari, MN Khan, and HR Ahmad
Gene Expression Analysis in Human Breast Cancer Associated Blood Vessels, DT Jones, T Lechertier, R Mitter, JMJ Herbert, and et al
High metabolic potential may contribute to the success of ST131 uropathogenic Escherichia coli., Tarek M. Gibreel, Andrew R. Dodgson, John Cheesbrough, Frederick J. Bolton, Andrew J. Fox, and Mathew Upton
CyanoEXpress: A web database for exploration and visualisation of the integrated transcriptome of cyanobacterium Synechocystis sp. PCC6803, MA Hernandez-Prieto
Antimicrobial peptides as therapeutic agents., Mathew Upton, Paul Cotter, and John Tagg
Increased water current induces micro-architectural changes to the vertebral bone of juvenile rainbow trout (Oncorhynchus mykiss), MAG Owen, B Eynon, S Woodgate, SJ Davies, and S Fox
Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase, R Szklarczyk, BFJ Wanschers, TD Cuypers, JJ Esseling, and et al
Oral health and pathology: a macrophage account., Rebecca Merry, Louise Belfield, Paul McArdle, Andrew McLennan, Stjohn Crean, and Andrew Foey
Submissions from 2011
Butyrate regulation of distinct macrophage subsets: Opposing effects on M1 and M2 macrophages, AD Foey
Experimentally controlled downregulation of the histone chaperone FACT inPlasmodium bergheireveals that it is critical to male gamete fertility, EC Laurentino, S Taylor, GR Mair, E Lasonder, and et al
Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α, AS Coutts, IM Pires, L Weston, FM Buffa, and et al
Probiotic bacterial strains differentially modulate macrophage cytokine production in a strain-dependent and cell subset-specific manner., N. Habil, W. Al-Murrani, J. Beal, and A. D. Foey
Isolation of bacterial extrachromosomal DNA from human dental plaque associated with periodontal disease, using transposon-aided capture (TRACA), Philip J. Warburton, Elaine Allan, Stephanie Hunter, John Ward, Veronica Booth, William G. Wade, and Peter Mullany
2D DIGE analysis of maternal plasma for potential biomarkers of Down Syndrome., Wendy E. Heywood, Tracey E. Madgett, Darrell Wang, Amanda Wallington, Julie Hogg, Kevin Mills, and Neil D. Avent
DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo, J-L Li, RCA Sainson, CE Oon, H Turley, and et al
Genetic Organisation, Mobility and Predicted Functions of Genes on Integrated, Mobile Genetic Elements in Sequenced Strains of Clostridium difficile, Michael S.M. Brouwer, Philip J. Warburton, Adam P. Roberts, Peter Mullany, and Elaine Allan
RN181 suppresses hepatocellular carcinoma growth by inhibition of the ERK/MAPK pathway, S Wang, X Huang, Y Li, H Lao, and et al
Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine., Scott G. Hansen, Julia C. Ford, Matthew S. Lewis, Abigail B. Ventura, Colette M. Hughes, Lia Coyne-Johnson, Nathan Whizin, Kelli Oswald, Rebecca Shoemaker, Tonya Swanson, Alfred W. Legasse, Maria J. Chiuchiolo, Christopher L. Parks, Michael K. Axthelm, Jay A. Nelson, Michael A. Jarvis, Michael Piatak, Jeffrey D. Lifson, and Louis J. Picker
Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species., Charles Affourtit, Martin Jastroch, and Martin D. Brand
Phytoestrogens directly inhibit TNF-α-induced bone resorption in RAW264.7 cells by suppressing c-fos-induced NFATc1 expression., S Karieb and SW Fox
A Replicating Cytomegalovirus-Based Vaccine Encoding a Single Ebola Virus Nucleoprotein CTL Epitope Confers Protection against Ebola Virus, Yoshimi Tsuda, Patrizia Caposio, Christopher J. Parkins, Sara Botto, Ilhem Messaoudi, Luka Cicin-Sain, Heinz Feldmann, and Michael A. Jarvis
Insights into a Multidrug Resistant Escherichia coli Pathogen of the Globally Disseminated ST131 Lineage: Genome Analysis and Virulence Mechanisms, Makrina Totsika, Scott A. Beatson, Sohinee Sarkar, P Minh-Duy, Nicola K. Petty, Nathan Bachmann, Marek Szubert, Hanna E. Sidjabat, David L. Paterson, Mathew Upton, and Mark A. Schembri
Submissions from 2010
Expression profiling and cross-species RNA interference (RNAi) of desiccation-induced transcripts in the anhydrobiotic nematode Aphelenchus avenae, W Reardon, S Chakrabortee, TC Pereira, T Tyson, MC Banton, KM Dolan, BA Culleton, MJ Wise, AM Burnell, and A Tunnacliffe
Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC., Henning Lauterbach, Barbara Bathke, Stefanie Gilles, Claudia Traidl-Hoffmann, Christian A. Luber, György Fejer, Marina A. Freudenberg, Gayle M. Davey, David Vremec, Axel Kallies, Li Wu, Ken Shortman, Paul Chaplin, Mark Suter, Meredith O'Keeffe, and Hubertus Hochrein
Biparental mucus feeding: a unique example of parental care in an Amazonian cichlid., Jonathan Buckley, Richard J. Maunder, Andrew Foey, Janet Pearce, Adalberto L. Val, and Katherine A. Sloman
New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes, H Sheldon, E Heikamp, H Turley, R Dragovic, and et al
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls, The Wellcome Trust Case Control Consortium
A five‐gene signature as a potential predictor of metastasis and survival in colorectal cancer, J Hao, J Chen, H Sui, X Si‐Ma, and et al
Universal Features of Post-Transcriptional Gene Regulation Are Critical for Plasmodium Zygote Development, GR Mair, E Lasonder, LS Garver, BMD Franke-Fayard, and et al
Comparison and consolidation of microarray data sets of human tissue expression, Jenny Russ and Matthias E. Futschik
Inferring modules from human protein interactome classes, Enrico Capobianco, Elisabetta Marras, Antonella Travaglione, Gautam Chaurasia, and Matthias Futschik
Short RNA half-lives in the slow-growing marine cyanobacterium Prochlorococcus, Sallie W. Chisholm, Claudia Steglich, Debbie Lindell, Matthias Futschik, Trent Rector, and Robert Steen
Submissions from 2009
A Novel Cre Recombinase Imaging System for Tracking Lymphotropic Virus Infection In Vivo, Bernadette M. Dutia, Stuart J. Reid, Derek D. Drummond, Yvonne Ligertwood, Ian Bennet, Willard Rietberg, Ondine Silvia, Michael A. Jarvis, and Anthony A. Nash
Choreography of the Transcriptome, Photophysiology, and Cell Cycle of a Minimal Photoautotroph, Prochlorococcus, Erik R. Zinser, Debbie Lindell, Zackary I. Johnson, Matthias E. Futschik, Claudia Steglich, Maureen L. Coleman, Matthew A. Wright, Trent Rector, Robert Steen, Nathan McNulty, Luke R. Thompson, and Sallie W. Chisholm
Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge., Scott G. Hansen, Cassandra Vieville, Nathan Whizin, Lia Coyne-Johnson, Don C. Siess, Derek D. Drummond, Alfred W. Legasse, Michael K. Axthelm, Kelli Oswald, Charles M. Trubey, Michael Piatak, Jeffrey D. Lifson, Jay A. Nelson, Michael A. Jarvis, and Louis J. Picker
Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications, J-L Li and AL Harris
DNA replication in the human malaria parasite and potential for novel drug development, J Li
Endotoxin emissions from commercial composting activities, Lewis Deacon, Louise Pankhurst, Jian Liu, Gillian H. Drew, Enda T. Hayes, Simon Jackson, J Longhurst, P Longhurst, Simon Pollard, and Sean Tyrrel
UniHI 4: new tools for query, analysis and visualization of the human protein–protein interactome, Gautam Chaurasia, Soniya Malhotra, Jenny Russ, Sigrid Schnoegl, Christian Hänig, Erich E. Wanker, and Matthias E. Futschik
Submissions from 2008
Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo., György Fejer, Lisa Drechsel, Jan Liese, Ulrike Schleicher, Zsolt Ruzsics, Nicola Imelli, Urs F. Greber, Simone Keck, Bernd Hildenbrand, Anne Krug, Christian Bogdan, and Marina A. Freudenberg
Proteomic Profiling of Plasmodium Sporozoite Maturation Identifies New Proteins Essential for Parasite Development and Infectivity, E Lasonder, CJ Janse, G-J van Gemert, GR Mair, and et al
Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity., Stefan F. Martin, Jan C. Dudda, Eva Bachtanian, Annalisa Lembo, Stefanie Liller, Christoph Dürr, Markus M. Heimesaat, Stefan Bereswill, György Fejer, Ralitsa Vassileva, Thilo Jakob, N Freudenberg, Christian C. Termeer, Caroline Johner, Chris Galanos, and MA Freudenberg
The Challenge of Regulation in a Minimal Photoautotroph: Non-Coding RNAs in Prochlorococcus, Claudia Steglich, Matthias E. Futschik, Debbie Lindell, Bjoern Voss, Sallie W. Chisholm, and Wolfgang R. Hess
Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria., Nadeene Parker, Charles Affourtit, Antonio Vidal-Puig, and Martin D. Brand
Massive Autophosphorylation of the Ser/Thr-Rich Domain Controls Protein Kinase Activity of TRPM6 and TRPM7, K Clark, J Middelbeek, NA Morrice, and et al
The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility, R Pandithage, R Lilischkis, K Harting, A Wolf, and et al
Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells, LS Harrington, RCA Sainson, CK Williams, JM Taylor, and et al
Transforming growth factor-beta enables NFATc1 expression during osteoclastogenesis., SW Fox, KE Evans, and AC Lovibond
Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function., Fionula M. Brennan, Nicola M.G. Smith, Sally Owen, Ching Li, Parisa Amjadi, Patricia Green, Anna Andersson, Andrew C. Palfreeman, Philippa Hillyer, Andrew Foey, Jonathan T. Beech, and Marc Feldmann
Systems biology meets stress ecology: linking molecular and organismal stress responses in Daphnia magna, L-H Heckmann, RM Sibly, R Connon, HL Hooper, and et al
The two homologous chaperonin 60 proteins of Mycobacterium tuberculosis have distinct effects on monocyte differentiation into osteoclasts, VR Winrow, J Mesher, S Meghji, CJ Morris, M Maguire, S Fox, ARM Coates, P Tormay, DR Blake, and B Henderson
Submissions from 2007
Delta-like 4 Notch Ligand Regulates Tumor Angiogenesis, Improves Tumor Vascular Function, and Promotes Tumor Growth In vivo, J-L Li, RCA Sainson, W Shi, R Leek, and et al
The Potential of New Tumor Endothelium-Specific Markers for the Development of Antivascular Therapy, J-L Li and AL Harris
Interleukin-10 inhibits osteoclastogenesis by reducing NFATc1 expression and preventing its translocation to the nucleus., KE Evans and SW Fox
UniHI: an entry gate to the human protein interactome, Gautam Chaurasia, Yasir Iqbal, Christian Hänig, Hanspeter Herzel, Erich E. Wanker, and Matthias E. Futschik
Submissions from 2006
Up-Regulation of Endothelial Delta-like 4 Expression Correlates with Vessel Maturation in Bladder Cancer, NS Patel, MS Dobbie, M Rochester, G Steers, and et al
Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function, CK Williams, J-L Li, M Murga, AL Harris, and G Tosato
Lung Nodule Detection in Screening Computed Tomography, I Gori, R Bellotti, P Cerello, SC Cheran, and et al
Submissions from 2005
Endogenous human cytomegalovirus gB is presented efficiently by MHC class II molecules to CD4+ CTL, David C. Johnson, Nagendra R. Hegde, Claire Dunn, David M. Lewinsohn, Michael A. Jarvis, and Jay A. Nelson
Notch signaling from tumor cells: A new mechanism of angiogenesis, J-L Li and AL Harris
Current insights into the role of transforming growth factor-beta in bone resorption, SW Fox and AC Lovibond
Submissions from 2004
Model selection and efficiency testing for normalization of cDNA microarray, Matthias Futschik and Toni Crompton
Submissions from 2003
Functional Interaction between the Bloom's Syndrome Helicase and the RAD51 Paralog, RAD51L3 (RAD51D), JP Braybrooke, J-L Li, L Wu, and et al
Characterisation of a sexual stage-specific gene encoding ORC1 homologue in the human malaria parasite Plasmodium falciparum, J-L Li and LS Cox
Complete analysis of the B‐cell response to a protein antigen, from in vivo germinal centre formation to 3‐D modelling of affinity maturation, CL Adams, MKL Macleod, EJ Milner-White, and et al
A longitudinal study of the effect of subcutaneous estrogen replacement on bone in young women with Turner's syndrome, G Khastgir, JWW Studd, SW Fox, J Jones, J aghband-Zadeh, and JWM Chow
