Browse research from the School of Biomedical Sciences.
Submissions from 2017
Rapid RHD Zygosity Determination Using Digital PCR., Kelly A. Sillence, Amr J. Halawani, Wajnat A. Tounsi, Kirsty A. Clarke, Michele Kiernan, Tracey E. Madgett, and Neil D. Avent
A comparison of nutritional intake and daily physical activity of girls aged 8-11 years old in Makkah, Saudi Arabia according to weight status, R Al-Kutbe, A Payne, Looy A de, and GA Rees
Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia, SH Witt, F Streit, Bipolar Disorders Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, and Schizophrenia Working Group of the Psychiatric Genomics Consortium
AB0115 Comparison of the bacterial stool microbiota in established psoriatic arthritis (PSA) and psoriasis (PSC) - exploratory analysis of pilot data, M Castelino, M Tutino, J Moat, UZ Ijaz, R Parslew, A Al-Sharqi, RB Warren, C Quince, P Ho, M Upton, S Eyre, and A Barton
The effect of timing and composition of gestational weight gain in obese pregnant women on infant birth weight: A prospective cohort study., KM Redfern, GA Rees, and JH Pinkney
Proteomics of FACS-sorted heterogeneous Corynebacterium glutamicum populations, A Harst, SP Albaum, T Bojarzyn, C Trötschel, and A Poetsch
Acclimation of Oxygenic Photosynthesis to Iron Starvation Is Controlled by the sRNA IsaR1, Jens Georg, Gergana Kostova, Linda Vuorijoki, Verena Schön, Taro Kadowaki, Tuomas Huokko, Desirée Baumgartner, Maximilian Müller, Stephan Klähn, Yagut Allahverdiyeva, Yukako Hihara, Matthias E. Futschik, Eva Mari Aro, and Wolfgang R. Hess
Effect Of Inorganic Nitrate Supplementation On O2 Uptake Kinetics And Exercise Tolerance, BC Breese, SP Cocksedge, C Thompson, LJ Wylie, AV Vanhatalo, AM Jones, and SJ Bailey
Plasmodium falciparum infection induces dynamic changes in the erythrocyte phospho-proteome., G Bouyer, L Reininger, G Ramdani, Phillips L D, V Sharma, S Egee, G Langsley, and E Lasonder
Membrane-enriched proteome changes and prion protein expression during neural differentiation and in neuroblastoma cells, J. A. Macedo, D. Schrama, I. Duarte, E. Tavares, J. Renaut, M. E. Futschik, P. M. Rodrigues, and E. P. Melo
Clinical Proteomics: From Biological Sample to Clinical Exploitation, E Lasonder
The low affinity glucose transporter HxtB is also involved in glucose signalling and metabolism in Aspergillus nidulans, Laure Nicolas Annick Ries, Reis TF dos, Benjamin M. Nitsche, Lima PBA de, Assis LJ de, Laura Mellado, Steven D. Harris, Vera Meyer, Santos RAC dos, Diego M. Riaño-Pachón, and Gustavo H. Goldman
Cardiac auscultation versus two-dimensional transthoracic echocardiography in the detection of native aortic and mitral valve disease in Erbil city, N King, AN Daham, and MH Al-Meshhadani
On vs. off pump coronary artery bypass grafting: the next chapter, Nicola King
Validity of Treadmill-Derived Critical Speed on Predicting 5000-Meter Track-Running Performance, A Nimmerichter, N Novak, C Triska, B Prinz, and BC Breese
VICTOR: Vinflunine in advanced metastatic transitional cell carcinoma of the urothelium: A retrospective analysis of the use of vinflunine in multi-centre real life setting as second line chemotherapy through Free of Charge Programme for patients in the UK and Ireland, SA Hussain, J Ansari, R Huddart, DG Power, and et al
Direct Substrate Delivery into Mitochondrial-Fission Deficient Pancreatic Islets Rescues Insulin Secretion, Uma D. Kabra, Katrin Pfuhlmann, Adriana Migliorini, Susanne Keipert, Daniel Lamp, Olle Korsgren, Moritz Gegg, Stephen C. Woods, Paul T. Pfluger, Heiko Lickert, Charles Affourtit, Matthias H. Tschöp, and Martin Jastroch
Global Proteome and Phospho-proteome Analysis of Merlin-deficient Meningioma and Schwannoma Identifies PDLIM2 as a Novel Therapeutic Target, Kayleigh Bassiri, Sara Ferluga, Vikram Sharma, Nelofer Syed, Claire L. Adams, Edwin Lasonder, and C. Oliver Hanemann
Permanent draft genome of Thiobacillus thioparus DSM 505T, an obligately chemolithoautotrophic member of the Betaproteobacteria, Lee P. Hutt, Marcel Huntemann, Alicia Clum, Manoj Pillay, Krishnaveni Palaniappan, Neha Varghese, Natalia Mikhailova, Dimitrios Stamatis, Tatiparthi Reddy, Chris Daum, Nicole Shapiro, Natalia Ivanova, Nikos Kyrpides, Tanja Woyke, and Rich Boden
Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder, AW Charney, DM Ruderfer, EA Stahl, and et al
Computational Molecular Networks and Network Pharmacology, K Ning, X Zhao, A Poetsch, W-H Chen, and J Yang
META-ANALYSIS COMPARING BIORESORBABLE VS. DRUG-ELUTING STENTS, N King, C Wood, and NA Smart
Porphyromonas gingivalis-stimulated macrophage subsets exhibit differential induction and responsiveness to interleukin-10, Andrew D. Foey, Neama Habil, Khalid Al-Shaghdali, and St John Crean
Submissions from 2016
A single dose of epidermicin NI01 is sufficient to eradicate MRSA from the nares of cotton rats, Samantha Halliwell, Peter Warn, Abdul Sattar, Jeremy P. Derrick, and Mathew Upton
Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes, F. J. Rawson, M. T. Cole, J. M. Hicks, J. W. Aylott, W. I. Milne, C. M. Collins, S. K. Jackson, N. J. Silman, and P. M. Mendes
A holistic approach to dissecting SPARC family protein complexity reveals FSTL-1 as an inhibitor of pancreatic cancer cell growth, Katrina Viloria, Amanda Munasinghe, Sharan Asher, Roberto Bogyere, Lucy Jones, and Natasha J. Hill
Minimally invasive cardiac surgery: A systematic review and meta-analysis, Gudrun Dieberg, Neil A. Smart, and Nicola King
On- vs. off-pump coronary artery bypass grafting: A systematic review and meta-analysis, Nicola King, Gudrun Dieberg, and Neil A. Smart
The TRPM7 interactome defines a cytoskeletal complex linked to neuroblastoma progression, J Middelbeek, K Vrenken, D Visser, E Lasonder, and et al
Comparative proteomics and functional analysis reveal a role of plasmodium falciparum osmiophilic bodies in malaria parasite transmission, P Suárez-Cortes, Vikram Sharma, Lucia Bertuccini, Giulia Costa, Naa Lamiley Bannerman, Anna Rosa Sannella, Kim Williamson, Michael Klemba, Elena A. Levashina, Edwin Lasonder, and Pietro Alano
Mitochondrial involvement in skeletal muscle insulin resistance – a case of imbalanced bioenergetics, Charles Affourtit
Comment on: Resistance gene naming and numbering: is it a new gene or not?, Philip J. Warburton and Adam P. Roberts
Proteomics of Human Dendritic Cell Subsets Reveals Subset-Specific Surface Markers and Differential Inflammasome Function., K Worah, TS Mathan, TP Vu Manh, S Keerthikumar, and et al
Comprehensive analysis of type 1 fimbriae regulation in fimB -null strains from the multidrug resistant Escherichia coli ST131 clone, Sohinee Sarkar, Leah W. Roberts, Minh Duy Phan, Lendl Tan, Alvin W. Lo, Kate M. Peters, David L. Paterson, Mathew Upton, Glen C. Ulett, Scott A. Beatson, Makrina Totsika, and Mark A. Schembri
Effects of pre-procedural remote ischaemic pre-conditioning on the outcomes of elective percutaneous coronary intervention. A systematic review and meta-analysis, Nicola King, Gudrun Dieberg, and Neil A. Smart
Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder, J Song, SE Bergen, and et al
Palmitate-induced changes in energy demand cause reallocation of ATP supply in rat and human skeletal muscle cells., Raid B. Nisr and Charles Affourtit
Maternal Lifestyle Factors and Fetal Macrosomia Risk: A Review, KM Redfern, GA Rees, and JH Pinkney
Mosaic tetracycline resistance genes encoding ribosomal protection proteins, Philip J. Warburton, Nina Amodeo, and Adam P. Roberts
Correction: Direct Measurements of Oxygen Gradients in Spheroid Culture System Using Electron Parametric Resonance Oximetry, Laura M. Langan, Nicholas J.F. Dodd, Stewart F. Owen, Wendy M. Purcell, Simon K. Jackson, and Awadhesh N. Jha
Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression., E Lasonder, SR Rijpma, BC van Schaijk, WA Hoeijmakers, and et al
A scoping study investigating student perceptions towards inquiry based learning in the laboratory, N King, der Touw T Van, L Spowart, and C Lawlor
Effect of exercise training on liver function in adults who are overweight or exhibit fatty liver disease: a systematic review and meta-analysis, N. A. Smart, N. King, J. R. McFarlane, P. L. Graham, and G. Dieberg
Extracellular Proteins: Novel Key Components of Metal Resistance in Cyanobacteria?, Joaquín Giner-Lamia, Sara B. Pereira, Miquel Bovea-Marco, Matthias E. Futschik, Paula Tamagnini, and Paulo Oliveira
Remote ischaemic pre-conditioning does not affect clinical outcomes following coronary Artery bypass grafting. A systematic review and meta-analysis, Nicola King, Gudrun Dieberg, and Neil A. Smart
Domestic shower hose biofilms contain fungal species capable of causing opportunistic infection, John Moat, Athanasios Rizoulis, Graeme Fox, and Mathew Upton
Effect of dietary components on the gut microbiota of aquatic animals. A never-ending story?, E. Ringø, Z. Zhou, J. L.G. Vecino, S. Wadsworth, J. Romero, Krogdahl, R. E. Olsen, A. Dimitroglou, A. Foey, S. Davies, M. Owen, H. L. Lauzon, L. L. Martinsen, P. De Schryver, P. Bossier, S. Sperstad, and D. L. Merrifield
Supplementation of formulated diets for tilapia (Oreochromis niloticus) with selected exogenous enzymes: Overall performance and effects on intestinal histology and microbiota, A. A. Adeoye, A. Jaramillo-Torres, S. W. Fox, D. L. Merrifield, and S. J. Davies
The unfolded protein response and its potential role in Huntington's disease elucidated by a systems biology approach, RKR Kalathur, J Giner-Lamia, S Machado, T Barata, KRS Ayasolla, and ME Futschik
The Transcriptional Landscape of the Photosynthetic Model Cyanobacterium Synechocystis sp. PCC6803, Miguel A. Hernández-Prieto, Trudi Ann Semeniuk, Joaquín Giner-Lamia, and Matthias E. Futschik
Direct Measurements of Oxygen Gradients in Spheroid Culture System Using Electron Parametric Resonance Oximetry, Laura M. Langan, Nicholas J.F. Dodd, Stewart F. Owen, Wendy M. Purcell, Simon K. Jackson, and Awadhesh N. Jha
Dual transcriptional-translational cascade permits cellular level tuneable expression control, Rosa Morra, Jayendra Shankar, Christopher J. Robinson, Samantha Halliwell, Lisa Butler, Mathew Upton, Sam Hay, Jason Micklefield, and Neil Dixon
Proteome Based Construction of the Lymphocyte Function-Associated Antigen 1 (LFA-1) Interactome in Human Dendritic Cells, C Eich, E Lasonder, LJ Cruz, I Reinieren-Beeren, and et al
Cytomegalovirus-based vaccine expressing Ebola virus glycoprotein protects nonhuman primates from Ebola virus infection, Andrea Marzi, Aisling A. Murphy, F Feldmann, Christopher J. Parkins, Elaine Haddock, Patrick W. Hanley, Matthew J. Emery, Flora Engelmann, Ilhem Messaoudi, H Feldmann, and Michael A. Jarvis
Palmitate-induced impairment of glucose-stimulated insulin secretion precedes mitochondrial dysfunction in mouse pancreatic islets, Jonathan Barlow, Verena Hirschberg Jensen, Martin Jastroch, and Charles Affourtit
Intracellular NAD+ levels are associated with LPS-induced TNF-α release in pro-inflammatory macrophages, Richard Andrew Billington, Abbas Jawad Al-Shabany, Alan John Moody, and Andrew David Foey
Self-disseminating vaccines for emerging infectious diseases, Aisling A. Murphy, Alec J. Redwood, and Michael A. Jarvis
Copy number variation in bipolar disorder, EK Green, E Rees, JTR Walters, K-G Smith, and et al
Identification of an antibacterial protein by functional screening of a human oral metagenomic library, Preeti Arivaradarajan, Philip J. Warburton, Gunasekaran Paramasamy, Sean P. Nair, Elaine Allan, and Peter Mullany
P190BCR-ABL1 Signaling Modulates the Function of Tumour Suppressor Protein IKZF1, R Marke, M Demkes, E Lasonder, and et al
Submissions from 2015
Lineage-Specific Methyltransferases Define the Methylome of the Globally Disseminated Escherichia coli ST131 Clone, Brian M. Forde, Minh Duy Phan, Jayde A. Gawthorne, Melinda M. Ashcroft, Mitchell Stanton-Cook, Sohinee Sarkar, Kate M. Peters, Kok Gan Chan, Teik Min Chong, Wai Fong Yin, Mathew Upton, Mark A. Schembri, and Scott A. Beatson
Genetic identification of cytomegaloviruses in a rural population of Côte d’Ivoire, Augustin Etile Anoh, Chantal Akoua-Koffi, Emmanuel Couacy-Hymann, Maude Pauly, Grit Schubert, Arsène Mossoun, Sabrina Weiss, SAJ Leendertz, Michael A. Jarvis, FH Leendertz, and Bernhard Ehlers
Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer's disease, X Li, J Long, T He, R Belshaw, and J Scott
The expression of Toll-like receptor 4, 7 and co-receptors in neurochemical sub-populations of rat trigeminal ganglion sensory neurons, M. P. Helley, W. Abate, S. K. Jackson, J. H. Bennett, and S. W.N. Thompson
IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide, R Ramcharan, T Aleksic, WP Kamdoum, S Gao, and et al
Fetal Sex and RHD Genotyping with Digital PCR Demonstrates Greater Sensitivity than Real-time PCR, Kelly A. Sillence, Llinos A. Roberts, Heidi J. Hollands, Hannah P. Thompson, Michele Kiernan, Tracey E. Madgett, Welch C Ross, and Neil D. Avent
Fast, Ultrasensitive Detection of Reactive Oxygen Species Using a Carbon Nanotube Based-Electrocatalytic Intracellular Sensor, Frankie J. Rawson, Jacqueline Hicks, Nicholas Dodd, Wondwossen Abate, David J. Garrett, Nga Yip, Gyorgy Fejer, Alison J. Downard, Kim H.R. Baronian, Simon K. Jackson, and Paula M. Mendes
IGF-1R inhibition induces schedule-dependent sensitization of melanoma to temozolomide, R Ramcharan, T Aleksic, S Gao, WP Kamdoum, and et al
Antibiotic-resistant ST38, ST131 and ST405 strains are the leading uropathogenic Escherichia coli clones in Riyadh, Saudi Arabia., Majed F. Alghoribi, Tarek M. Gibreel, Garry Farnham, Johani SM Al, Hanan H. Balkhy, and Mathew Upton
Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis, DC Singleton, P Rouhi, CE Zois, S Haider, and et al
Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition, I Ledaki, A McIntyre, S Wigfield, F Buffa, and et al
On the mechanism by which dietary nitrate improves human skeletal muscle function, Charles Affourtit, Stephen J. Bailey, Andrew M. Jones, Miranda J. Smallwood, and Paul G. Winyard
Novel Human Embryonic Stem Cell Regulators Identified by Conserved and Distinct CpG Island Methylation State, Steve Pells, Eirini Koutsouraki, Sofia Morfopoulou, Sara Valencia-Cadavid, Simon R. Tomlinson, Ravi Kalathur, Matthias E. Futschik, and Sousa PA De
StemChecker: a web-based tool to discover and explore stemness signatures in gene sets, José P. Pinto, Ravi K. Kalathur, Daniel V. Oliveira, Tânia Barata, RSR Machado, S Machado, Ivette Pacheco-Leyva, Isabel Duarte, and Matthias E. Futschik
Third-generation cephalosporin resistance conferred by a chromosomally encoded blaCMY-23 gene in the Escherichia coli ST131 reference strain EC958., Minh Duy Phan, Kate M. Peters, Sohinee Sarkar, Brian M. Forde, Alvin W. Lo, Mitchell Stanton-Cook, Leah W. Roberts, Mathew Upton, Scott A. Beatson, and Mark A. Schembri
Discovery of a polyomavirus in European badgers (Meles meles) and the evolution of host range in the family Polyomaviridae, Sarah C. Hill, Aisling A. Murphy, Matthew Cotten, Anne L. Palser, Phillip Benson, Sandrine Lesellier, Eamonn Gormley, Céline Richomme, Sylvia Grierson, Deirdre Ni Bhuachalla, Mark Chambers, Paul Kellam, María Laura Boschiroli, Bernhard Ehlers, Michael A. Jarvis, and Oliver G. Pybus
Mitochondrialuncouplingprotein-2isnotinvolvedin palmitate-induced impairmentofglucose-stimulatedinsulinsecretion in INS-1Einsulinomacellsandisnotneededfortheamplification of insulin release, jensen V. hirschberg and Charles Affourtit
Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signalling in HER2-amplified breast cancer, W-Y Leung, I Roxanis, H Sheldon, FM Buffa, and et al
Hyperbaric oxygen therapy accelerates osteoblast differentiation and promotes bone formation, H Al-Hadi, G Smerdon, and SW Fox
Aspergillus nidulans protein kinase A plays an important role in cellulase production, Gustavo Henrique Goldman, Assis LJ de, Laure Nicolas Annick Ries, Marcela Savoldi, Reis TF dos, and Neil Andrew Brown
Molecular characterization of a multidrug resistance IncF plasmid from the globally disseminated Escherichia coli ST131 clone., Minh Duy Phan, Brian M. Forde, Kate M. Peters, Sohinee Sarkar, Steven Hancock, Mitchell Stanton-Cook, Zakour NL Ben, Mathew Upton, Scott A. Beatson, and Mark A. Schembri
Palmitate-induced impairment of glucose-stimulated insulin secretion by pancreatic beta cells is disconnected from concomitant mitochondrial respiratory defects, C Affourtit, J Barlow, VH Jensen, and M Jastroch
Uncoupling protein-2 attenuates palmitoleate protection against the cytotoxic production of mitochondrial reactive oxygen species in INS-1E insulinoma cells., Jonathan Barlow, Jensen V Hirschberg, and Charles Affourtit
Submissions from 2014
A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes, Richard Hill, Ravi Kiran Reddy Kalathur, Sergio Callejas, Laura Colaço, Ricardo Brandão, Beatriz Serelde, Antonio Cebriá, Carmen Blanco-Aparicio, Joaquín Pastor, Matthias Futschik, Ana Dopazo, and Wolfgang Link
Heat-killed probiotic bacteria differentially regulate colonic epithelial cell production of human β-defensin-2: dependence on inflammatory cytokines., N. Habil, W. Abate, J. Beal, and A. D. Foey
TGFβR2 is a major target of miR-93 in nasopharyngeal carcinoma aggressiveness, X Lyu, W Fang, L Cai, H Zheng, and et al
Fabrication and evaluation of a micro(bio)sensor array chip for multiple parallel measurements of important cell biomarkers, Roy M. Pemberton, Timothy Cox, Rachel Tuffin, Guido A. Drago, John Griffiths, Robin Pittson, Graham Johnson, Jinsheng Xu, Ian C. Sage, Rhodri Davies, Simon K. Jackson, Gerry Kenna, Richard Luxton, and John P. Hart
Human cytomegalovirus-encoded pUL7 is a novel CEACAM1-like molecule responsible for promotion of angiogenesis., Jason D. Macmaniman, Andrew Meuser, Sara Botto, Patricia P. Smith, Fenyong Liu, Michael A. Jarvis, Jay A. Nelson, and Patrizia Caposio
On the Dynamics of the Adenylate Energy System: Homeorhesis vs Homeostasis, la De, IM Fuente, JM Cortés, E Valero, and et al
Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation, K Bensaad, E Favaro, CA Lewis, B Peck, and et al
Multiple metabolomics of uropathogenic E. coli reveal different information content in terms of metabolic potential compared to virulence factors., Haitham AlRabiah, Yun Xu, Nicholas J.W. Rattray, Andrew A. Vaughan, Tarek Gibreel, Ali Sayqal, Mathew Upton, J. William Allwood, and Royston Goodacre
ADAM10 mediates trastuzumab resistance and is correlated with survival in HER2 positive breast cancer, K Feldinger, D Generali, G Kramer-Marek, M Gijsen, and et al
Nuclear HER4 mediates acquired resistance to trastuzumab and is associated with poor outcome in HER2 positive breast cancer, SN Mohd Nafi, D Generali, G Kramer-Marek, M Gijsen, and et al
Toward a systems-level understanding of gene regulatory, protein interaction, and metabolic networks in cyanobacteria, MA Hernández-Prieto, Trudi A. Semeniuk, and Matthias E. Futschik
StemCellNet: an interactive platform for network-oriented investigations in stem cell biology, José P. Pinto, Kalathur RK Reddy, Rui S.R. Machado, Joana M. Xavier, José Bragança, and Matthias E. Futschik
Targeting molecular networks for drug research, José P. Pinto, Rui S.R. Machado, Joana M. Xavier, and Matthias E. Futschik
Implementation of Fourier transform infrared spectroscopy for the rapid typing of uropathogenic Escherichia coli., S. E. Dawson, T. Gibreel, N. Nicolaou, H. AlRabiah, Y. Xu, R. Goodacre, and M. Upton
The bacterial skin microbiome in psoriatic arthritis, an unexplored link in pathogenesis: challenges and opportunities offered by recent technological advances., Madhura Castelino, Stephen Eyre, Mathew Upton, Pauline Ho, and Anne Barton
Global dissemination of a multidrug resistant Escherichia coli clone., Nicola K. Petty, Zakour NL Ben, Mitchell Stanton-Cook, Elizabeth Skippington, Makrina Totsika, Brian M. Forde, Minh Duy Phan, Moriel D Gomes, Kate M. Peters, Mark Davies, Benjamin A. Rogers, Gordon Dougan, Jesüs Rodriguez-Baño, Alvaro Pascual, Johann D.D. Pitout, Mathew Upton, David L. Paterson, Timothy R. Walsh, Mark A. Schembri, and Scott A. Beatson
Rab8 Binding to Immune Cell-Specific Adaptor LAX Facilitates Formation of trans-Golgi Network-Proximal CTLA-4 Vesicles for Surface Expression, MC Banton, KL Inder, E Valk, CE Rudd, and H Schneider
