Browse research from the School of Biomedical Sciences.
Submissions from 2017
The Dynamics of Plasma Membrane, Metabolism and Respiration (PM-M-R) in Penicillium ochrochloron CBS 123824 in Response to Different Nutrient Limitations—A Multi-level Approach to Study Organic Acid Excretion in Filamentous Fungi, P Vrabl, CW Schinagl, DJ Artmann, A Krüger, and et al
Erratum for Maler et al., “Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages”, Mareike D. Maler, Peter J. Nielsen, Nicole Stichling, Idan Cohen, Zsolt Ruzsics, Connor Wood, Peggy Engelhard, Maarit Suomalainen, Ildiko Gyory, Michael Huber, Joachim Müller-Quernheim, Wolfgang W. Schamel, Siamon Gordon, Thilo Jakob, Stefan F. Martin, Willi Jahnen-Dechent, Urs F. Greber, Marina A. Freudenberg, and György Fejer
Integrative review of cervical cancer screening in Western Asian and Middle Eastern Arab countries., S Ali, H Skirton, MT Clark, and C Donaldson
Probiotic Modulation of Innate Cell Pathogen Sensing and Signaling Events, Andrew Foey and Amy Llewellyn
Nutrient-extraction blender preparation reduces postprandial glucose responses from fruit juice consumption, K. M. Redfern, V. L. Cammack, N. Sweet, L. A. Preston, SoBHCS Student Team, M. A. Jarvis, and G. A. Rees
A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages, Angela Casini, Carian E. Boorsma, der Veen TA van, Kurnia S.S. Putri, Almeida A de, Christina Draijer, Thais Mauad, Gyorgy Fejer, Corry Anke Brandsma, den Berge M van, Yohan Bossé, Don Sin, Ke Hao, Anja Reithmeier, Göran Andersson, Peter Olinga, Wim Timens, and Barbro N. Melgert
Identification of the direct regulon of NtcA during early acclimation to nitrogen starvation in the cyanobacterium Synechocystis sp. PCC 6803, J Giner-Lamia, R Robles-Rengel, MA Hernandez-Prieto, and et al
Red cell genotyping precision medicine: a conference summary, GA Denomme, WQ Anani, ND Avent, G Bein, and et al
Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages, Marina A. Freudenberg, Mareike D. Maler, Peter J. Nielsen, Nicole Stichling, Idan Cohen, Zsolt Ruzsics, Connor Wood, Peggy Engelhard, Maarit Suomalainen, Ildiko Gyory, Michael Huber, Joachim Müller-Quernheim, Wolfgang W.A. Schamel, Siamon Gordon, Thilo Jakob, Stefan F. Martin, Willi Jahnen-Dechent, Urs F. Greber, and György Fejer
Bioleaching of Pyrite by Iron-Oxidizing Acidophiles under the Influence of Reactive Oxygen Species, D Huynh, S Bellenberg, M Vera Véliz, A Poetsch, and W Sand
The effect of dietary nitrate supplementation on the spatial heterogeneity of quadriceps deoxygenation during heavy-intensity cycling., BC Breese, DC Poole, D Okushima, SJ Bailey, AM Jones, N Kondo, T Amano, and S Koga
Purification and Characterization of 221, the Cationic Peptide that Inhibits Staphylococcus aureus, MA Mahrous, J Burnie, J Tagg, and M Upton
A comparison of nutritional intake and daily physical activity of girls aged 8-11 years old in Makkah, Saudi Arabia according to weight status, R Al-Kutbe, A Payne, Looy A de, and GA Rees
Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia, SH Witt, F Streit, Bipolar Disorders Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, and Schizophrenia Working Group of the Psychiatric Genomics Consortium
The effect of timing and composition of gestational weight gain in obese pregnant women on infant birth weight: A prospective cohort study., KM Redfern, GA Rees, and JH Pinkney
Proteomics of FACS-sorted heterogeneous Corynebacterium glutamicum populations, A Harst, SP Albaum, T Bojarzyn, C Trötschel, and A Poetsch
Acclimation of Oxygenic Photosynthesis to Iron Starvation Is Controlled by the sRNA IsaR1, Wolfgang R. Hess, Jens Georg, Gergana Kostova, Linda Vuorijoki, Verena Schön, Taro Kadowaki, Tuomas Huokko, Desirée Baumgartner, Maximilian Müller, Stephan Klähn, Yagut Allahverdiyeva, Yukako Hihara, Matthias E. Futschik, and Eva Mari Aro
Plasmodium falciparum infection induces dynamic changes in the erythrocyte phospho-proteome., G Bouyer, L Reininger, G Ramdani, Phillips L D, V Sharma, S Egee, G Langsley, and E Lasonder
Membrane-enriched proteome changes and prion protein expression during neural differentiation and in neuroblastoma cells, E. P. Melo, J. A. Macedo, D. Schrama, I. Duarte, E. Tavares, J. Renaut, M. E. Futschik, and P. M. Rodrigues
Clinical Proteomics: From Biological Sample to Clinical Exploitation, E Lasonder
The low affinity glucose transporter HxtB is also involved in glucose signalling and metabolism in Aspergillus nidulans, Laure Nicolas Annick Ries, Reis TF dos, Benjamin M. Nitsche, Lima PBA de, Assis LJ de, Laura Mellado, Steven D. Harris, Vera Meyer, Santos RAC dos, Diego M. Riaño-Pachón, and Gustavo H. Goldman
Cardiac auscultation versus two-dimensional transthoracic echocardiography in the detection of native aortic and mitral valve disease in Erbil city, N King, AN Daham, and MH Al-Meshhadani
VICTOR: Vinflunine in advanced metastatic transitional cell carcinoma of the urothelium: A retrospective analysis of the use of vinflunine in multi-centre real life setting as second line chemotherapy through Free of Charge Programme for patients in the UK and Ireland, SA Hussain, J Ansari, R Huddart, DG Power, and et al
Direct Substrate Delivery into Mitochondrial-Fission Deficient Pancreatic Islets Rescues Insulin Secretion, Martin Jastroch, Uma D. Kabra, Katrin Pfuhlmann, Adriana Migliorini, Susanne Keipert, Daniel Lamp, Olle Korsgren, Moritz Gegg, Stephen C. Woods, Paul T. Pfluger, Heiko Lickert, Charles Affourtit, and Matthias H. Tschöp
Global Proteome and Phospho-proteome Analysis of Merlin-deficient Meningioma and Schwannoma Identifies PDLIM2 as a Novel Therapeutic Target, C. Oliver Hanemann, Kayleigh Bassiri, Sara Ferluga, Vikram Sharma, Nelofer Syed, Claire L. Adams, and Edwin Lasonder
Permanent draft genome of Thiobacillus thioparus DSM 505T, an obligately chemolithoautotrophic member of the Betaproteobacteria, Rich Boden, Lee P. Hutt, Marcel Huntemann, Alicia Clum, Manoj Pillay, Krishnaveni Palaniappan, Neha Varghese, Natalia Mikhailova, Dimitrios Stamatis, Tatiparthi Reddy, Chris Daum, Nicole Shapiro, Natalia Ivanova, Nikos Kyrpides, and Tanja Woyke
Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder, AW Charney, DM Ruderfer, EA Stahl, and et al
AB0115 Comparison of the bacterial stool microbiota in established psoriatic arthritis (PSA) and psoriasis (PSC) - exploratory analysis of pilot data, M Castelino, M Tutino, J Moat, UZ Ijaz, R Parslew, A Al-Sharqi, RB Warren, C Quince, P Ho, M Upton, S Eyre, and A Barton
Application of the rainbow trout derived intestinal cell line (RTgutGC) for ecotoxicological studies: molecular and cellular responses following exposure to copper, Awadhesh N. Jha, Laura M. Langan, Glenn M. Harper, Stewart F. Owen, Wendy M. Purcell, and Simon K. Jackson
Computational Molecular Networks and Network Pharmacology, K Ning, X Zhao, A Poetsch, W-H Chen, and J Yang
Effect Of Inorganic Nitrate Supplementation On O2 Uptake Kinetics And Exercise Tolerance, BC Breese, SP Cocksedge, C Thompson, LJ Wylie, AV Vanhatalo, AM Jones, and SJ Bailey
Erratum. Direct Substrate Delivery Into Mitochondrial Fission–Deficient Pancreatic Islets Rescues Insulin Secretion. Diabetes 2017;66:1247–1257, UD Kabra, K Pfuhlmann, A Migliorini, S Keipert, D Lamp, O Korsgren, M Gegg, SC Woods, PT Pfluger, H Lickert, C Affourtit, MH Tschöp, and M Jastroch
HDNetDB: A Molecular Interaction Database for Network-Oriented Investigations into Huntington’s Disease, Ravi Kiran Reddy Kalathur, Pinto J Pedro, Biswanath Sahoo, Gautam Chaurasia, and Matthias E. Futschik
Identification of the direct regulon of NtcA during early acclimation to nitrogen starvation in the cyanobacterium Synechocystis sp. PCC 6803., Joaquín Giner-Lamia, Rocío Robles-Rengel, Miguel A. Hernández-Prieto, MI Muro-Pastor, Francisco J. Florencio, and Matthias E. Futschik
Is there a long-term survival benefit with on pump coronary artery bypass grafting?, Nicola King
Kinetic Measurements of Di- and Tripeptide and Peptidomimetic Drug Transport in Different Kidney Regions Using the Fluorescent Membrane Potential-Sensitive Dye, DiS-C3-(3)., Nicola King, Othman A. Alghamdi, Graham L. Jones, and Pierre D.J. Moens
META-ANALYSIS COMPARING BIORESORBABLE VS. DRUG-ELUTING STENTS, N King, C Wood, and NA Smart
On vs. off pump coronary artery bypass grafting: the next chapter, Nicola King
Optimisation of methods for bacterial skin microbiome investigation: primer selection and comparison of the 454 versus MiSeq platform, Anne Barton, Madhura Castelino, Stephen Eyre, John Moat, Graeme Fox, Paul Martin, Pauline Ho, and Mathew Upton
Porphyromonas gingivalis-stimulated macrophage subsets exhibit differential induction and responsiveness to interleukin-10, Andrew D. Foey, Neama Habil, Khalid Al-Shaghdali, and St John Crean
Rapid RHD Zygosity Determination Using Digital PCR., Tracey E. Madgett, Kelly A. Sillence, Amr J. Halawani, Wajnat A. Tounsi, Kirsty A. Clarke, Michele Kiernan, and Neil D. Avent
Validity of Treadmill-Derived Critical Speed on Predicting 5000-Meter Track-Running Performance, A Nimmerichter, N Novak, C Triska, B Prinz, and BC Breese
Submissions from 2016
A single dose of epidermicin NI01 is sufficient to eradicate MRSA from the nares of cotton rats, Mathew Upton, Samantha Halliwell, Peter Warn, Abdul Sattar, and Jeremy P. Derrick
Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes, F. J. Rawson, M. T. Cole, J. M. Hicks, J. W. Aylott, W. I. Milne, C. M. Collins, S. K. Jackson, N. J. Silman, and P. M. Mendes
A holistic approach to dissecting SPARC family protein complexity reveals FSTL-1 as an inhibitor of pancreatic cancer cell growth, Natasha J. Hill, Katrina Viloria, Amanda Munasinghe, Sharan Asher, Roberto Bogyere, and Lucy Jones
Minimally invasive cardiac surgery: A systematic review and meta-analysis, Nicola King, Gudrun Dieberg, and Neil A. Smart
On- vs. off-pump coronary artery bypass grafting: A systematic review and meta-analysis, Nicola King, Gudrun Dieberg, and Neil A. Smart
The TRPM7 interactome defines a cytoskeletal complex linked to neuroblastoma progression, J Middelbeek, K Vrenken, D Visser, E Lasonder, and et al
Comparative proteomics and functional analysis reveal a role of plasmodium falciparum osmiophilic bodies in malaria parasite transmission, Pietro Alano, P Suárez-Cortes, Vikram Sharma, Lucia Bertuccini, Giulia Costa, Naa Lamiley Bannerman, Anna Rosa Sannella, Kim Williamson, Michael Klemba, Elena A. Levashina, and Edwin Lasonder
Mitochondrial involvement in skeletal muscle insulin resistance – a case of imbalanced bioenergetics, Charles Affourtit
Comment on: Resistance gene naming and numbering: is it a new gene or not?, Adam P. Roberts and Philip J. Warburton
Proteomics of Human Dendritic Cell Subsets Reveals Subset-Specific Surface Markers and Differential Inflammasome Function., K Worah, TS Mathan, TP Vu Manh, S Keerthikumar, and et al
Comprehensive analysis of type 1 fimbriae regulation in fimB -null strains from the multidrug resistant Escherichia coli ST131 clone, Scott A. Beatson, Sohinee Sarkar, Leah W. Roberts, Minh Duy Phan, Lendl Tan, Alvin W. Lo, Kate M. Peters, David L. Paterson, Mathew Upton, Glen C. Ulett, Makrina Totsika, and Mark A. Schembri
Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder, J Song, SE Bergen, and et al
Maternal Lifestyle Factors and Fetal Macrosomia Risk: A Review, KM Redfern, GA Rees, and JH Pinkney
Mosaic tetracycline resistance genes encoding ribosomal protection proteins, Philip J. Warburton, Nina Amodeo, and Adam P. Roberts
Correction: Direct Measurements of Oxygen Gradients in Spheroid Culture System Using Electron Parametric Resonance Oximetry, Laura M. Langan, Nicholas J.F. Dodd, Stewart F. Owen, Wendy M. Purcell, Simon K. Jackson, and Awadhesh N. Jha
Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression., E Lasonder, SR Rijpma, BC van Schaijk, WA Hoeijmakers, and et al
A scoping study investigating student perceptions towards inquiry based learning in the laboratory, N King, der Touw T Van, L Spowart, and C Lawlor
Effect of exercise training on liver function in adults who are overweight or exhibit fatty liver disease: a systematic review and meta-analysis, N. A. Smart, N. King, J. R. McFarlane, P. L. Graham, and G. Dieberg
Extracellular Proteins: Novel Key Components of Metal Resistance in Cyanobacteria?, Joaquín Giner-Lamia, Sara B. Pereira, Miquel Bovea-Marco, Matthias E. Futschik, Paula Tamagnini, and Paulo Oliveira
Domestic shower hose biofilms contain fungal species capable of causing opportunistic infection, Mathew Upton, John Moat, Athanasios Rizoulis, and Graeme Fox
Effect of dietary components on the gut microbiota of aquatic animals. A never-ending story?, E. Ringø, Z. Zhou, J. L.G. Vecino, S. Wadsworth, J. Romero, Krogdahl, R. E. Olsen, A. Dimitroglou, A. Foey, S. Davies, M. Owen, H. L. Lauzon, L. L. Martinsen, P. De Schryver, P. Bossier, S. Sperstad, and D. L. Merrifield
Supplementation of formulated diets for tilapia (Oreochromis niloticus) with selected exogenous enzymes: Overall performance and effects on intestinal histology and microbiota, A. A. Adeoye, A. Jaramillo-Torres, S. W. Fox, D. L. Merrifield, and S. J. Davies
The unfolded protein response and its potential role in Huntington's disease elucidated by a systems biology approach, RKR Kalathur, J Giner-Lamia, S Machado, T Barata, KRS Ayasolla, and ME Futschik
The Transcriptional Landscape of the Photosynthetic Model Cyanobacterium Synechocystis sp. PCC6803, Matthias E. Futschik, Miguel A. Hernández-Prieto, Trudi Ann Semeniuk, and Joaquín Giner-Lamia
Direct Measurements of Oxygen Gradients in Spheroid Culture System Using Electron Parametric Resonance Oximetry, Laura M. Langan, Nicholas J.F. Dodd, Stewart F. Owen, Wendy M. Purcell, Simon K. Jackson, and Awadhesh N. Jha
Dual transcriptional-translational cascade permits cellular level tuneable expression control, Neil Dixon, Rosa Morra, Jayendra Shankar, Christopher J. Robinson, Samantha Halliwell, Lisa Butler, Mathew Upton, Sam Hay, and Jason Micklefield
Proteome Based Construction of the Lymphocyte Function-Associated Antigen 1 (LFA-1) Interactome in Human Dendritic Cells, C Eich, E Lasonder, LJ Cruz, I Reinieren-Beeren, and et al
Cytomegalovirus-based vaccine expressing Ebola virus glycoprotein protects nonhuman primates from Ebola virus infection, Michael A. Jarvis, Andrea Marzi, Aisling A. Murphy, F Feldmann, Christopher J. Parkins, Elaine Haddock, Patrick W. Hanley, Matthew J. Emery, Flora Engelmann, Ilhem Messaoudi, and H Feldmann
Palmitate-induced impairment of glucose-stimulated insulin secretion precedes mitochondrial dysfunction in mouse pancreatic islets, Charles Affourtit, Jonathan Barlow, Verena Hirschberg Jensen, and Martin Jastroch
Intracellular NAD+ levels are associated with LPS-induced TNF-α release in pro-inflammatory macrophages, Richard Andrew Billington, Abbas Jawad Al-Shabany, Alan John Moody, and Andrew David Foey
Self-disseminating vaccines for emerging infectious diseases, Michael A. Jarvis, Aisling A. Murphy, and Alec J. Redwood
Copy number variation in bipolar disorder, EK Green, E Rees, JTR Walters, K-G Smith, and et al
Effects of pre-procedural remote ischaemic pre-conditioning on the outcomes of elective percutaneous coronary intervention. A systematic review and meta-analysis, Nicola King, Gudrun Dieberg, and Neil A. Smart
Identification of an antibacterial protein by functional screening of a human oral metagenomic library, Peter Mullany, Preeti Arivaradarajan, Philip J. Warburton, Gunasekaran Paramasamy, Sean P. Nair, and Elaine Allan
P190BCR-ABL1 Signaling Modulates the Function of Tumour Suppressor Protein IKZF1, R Marke, M Demkes, E Lasonder, and et al
Palmitate-induced changes in energy demand cause reallocation of ATP supply in rat and human skeletal muscle cells., Charles Affourtit and Raid B. Nisr
Remote ischaemic pre-conditioning does not affect clinical outcomes following coronary Artery bypass grafting. A systematic review and meta-analysis, Nicola King, Gudrun Dieberg, and Neil A. Smart
Submissions from 2015
Lineage-Specific Methyltransferases Define the Methylome of the Globally Disseminated Escherichia coli ST131 Clone, Mark A. Schembri, Brian M. Forde, Minh Duy Phan, Jayde A. Gawthorne, Melinda M. Ashcroft, Mitchell Stanton-Cook, Sohinee Sarkar, Kate M. Peters, Kok Gan Chan, Teik Min Chong, Wai Fong Yin, Mathew Upton, and Scott A. Beatson
Genetic identification of cytomegaloviruses in a rural population of Côte d’Ivoire, Augustin Etile Anoh, Chantal Akoua-Koffi, Emmanuel Couacy-Hymann, Maude Pauly, Grit Schubert, Arsène Mossoun, Sabrina Weiss, SAJ Leendertz, Michael A. Jarvis, FH Leendertz, and Bernhard Ehlers
Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer's disease, X Li, J Long, T He, R Belshaw, and J Scott
IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide, R Ramcharan, T Aleksic, WP Kamdoum, S Gao, and et al
Fetal Sex and RHD Genotyping with Digital PCR Demonstrates Greater Sensitivity than Real-time PCR, Neil D. Avent, Kelly A. Sillence, Llinos A. Roberts, Heidi J. Hollands, Hannah P. Thompson, Michele Kiernan, Tracey E. Madgett, and Welch C Ross
Fast, Ultrasensitive Detection of Reactive Oxygen Species Using a Carbon Nanotube Based-Electrocatalytic Intracellular Sensor, Frankie J. Rawson, Jacqueline Hicks, Nicholas Dodd, Wondwossen Abate, David J. Garrett, Nga Yip, Gyorgy Fejer, Alison J. Downard, Kim H.R. Baronian, Simon K. Jackson, and Paula M. Mendes
IGF-1R inhibition induces schedule-dependent sensitization of melanoma to temozolomide, R Ramcharan, T Aleksic, S Gao, WP Kamdoum, and et al
Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis, DC Singleton, P Rouhi, CE Zois, S Haider, and et al
Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition, I Ledaki, A McIntyre, S Wigfield, F Buffa, and et al
On the mechanism by which dietary nitrate improves human skeletal muscle function, Charles Affourtit, Stephen J. Bailey, Andrew M. Jones, Miranda J. Smallwood, and Paul G. Winyard
Novel Human Embryonic Stem Cell Regulators Identified by Conserved and Distinct CpG Island Methylation State, Steve Pells, Eirini Koutsouraki, Sofia Morfopoulou, Sara Valencia-Cadavid, Simon R. Tomlinson, Ravi Kalathur, Matthias E. Futschik, and Sousa PA De
Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo, K. Christopher Garcia, Katja Spiess, Mads G. Jeppesen, Mikkel Malmgaard-Clausen, Karen Krzywkowski, Kalpana Dulal, Tong Cheng, Gertrud M. Hjortø, Olav Larsen, John S. Burg, Michael A. Jarvis, Hua Zhu, Thomas N. Kledal, and Mette M. Rosenkilde
StemChecker: a web-based tool to discover and explore stemness signatures in gene sets, José P. Pinto, Ravi K. Kalathur, Daniel V. Oliveira, Tânia Barata, RSR Machado, S Machado, Ivette Pacheco-Leyva, Isabel Duarte, and Matthias E. Futschik
Discovery of a polyomavirus in European badgers (Meles meles) and the evolution of host range in the family Polyomaviridae, Bernhard Ehlers, Sarah C. Hill, Aisling A. Murphy, Matthew Cotten, Anne L. Palser, Phillip Benson, Sandrine Lesellier, Eamonn Gormley, Céline Richomme, Sylvia Grierson, Deirdre Ni Bhuachalla, Mark Chambers, Paul Kellam, María Laura Boschiroli, Michael A. Jarvis, and Oliver G. Pybus
Mitochondrialuncouplingprotein-2isnotinvolvedin palmitate-induced impairmentofglucose-stimulatedinsulinsecretion in INS-1Einsulinomacellsandisnotneededfortheamplification of insulin release, Charles Affourtit and jensen V hirschberg
Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signalling in HER2-amplified breast cancer, W-Y Leung, I Roxanis, H Sheldon, FM Buffa, and et al
Osteoclastic resorptive capacity is suppressed in patients receiving hyperbaric oxygen therapy, HA Hadi, G Smerdon, and Simon Fox
Hyperbaric oxygen therapy accelerates osteoblast differentiation and promotes bone formation, H Al-Hadi, G Smerdon, and SW Fox
Antibiotic-resistant ST38, ST131 and ST405 strains are the leading uropathogenic Escherichia coli clones in Riyadh, Saudi Arabia., Majed F. Alghoribi, Tarek M. Gibreel, Garry Farnham, Johani SM Al, Hanan H. Balkhy, and Mathew Upton
Aspergillus nidulans protein kinase A plays an important role in cellulase production, Gustavo Henrique Goldman, Assis LJ de, Laure Nicolas Annick Ries, Marcela Savoldi, Reis TF dos, and Neil Andrew Brown
