ORCID
- Foey, Andrew: 0000-0003-0419-2268
Abstract
Macrophages are present in healthy oral mucosa and their numbers increase dramatically during disease. They can exhibit a diverse range of phenotypes characterised as a functional spectrum from pro-inflammatory to anti-inflammatory (regulatory) subsets. This review illustrates the role of these subsets in the oral inflammatory disease lichen planus, and the immunosuppressive disease oral squamous cell carcinoma (SCC). We conclude that the role of macrophages in driving progression in oral disease identifies them as potential therapeutic targets for a range of oral pathologies.
DOI
10.1016/j.bjoms.2010.10.020
Publication Date
2012-01-01
Publication Title
Br J Oral Maxillofac Surg
Volume
50
Issue
1
Organisational Unit
School of Biomedical Sciences
Keywords
Carcinoma, Squamous Cell, Cell Count, Cell Transformation, Neoplastic, Humans, Lichen Planus, Oral, Macrophages, Mouth Diseases, Mouth Mucosa, Mouth Neoplasms, Phenotype
First Page
2
Last Page
7
Recommended Citation
Merry, R., Belfield, L., McArdle, P., McLennan, A., Crean, S., & Foey, A. (2012) 'Oral health and pathology: a macrophage account.', Br J Oral Maxillofac Surg, 50(1), pp. 2-7. Available at: https://doi.org/10.1016/j.bjoms.2010.10.020
