Abstract
Limited clinical benefits derived from anti-VEGF therapy have driven the identification of new targets involved in tumor angiogenesis. Here, we report an integrative meta-analysis to define the transcriptional program underlying angiogenesis in human cancer. This approach identified ELTD1, an orphan G-protein-coupled receptor whose expression is induced by VEGF/bFGF and repressed by DLL4 signaling. Extensive analysis of multiple cancer types demonstrates significant upregulation of ELTD1 in tumor-associated endothelial cells, with a higher expression correlating with favorable prognosis. Importantly, ELTD1 silencing impairs endothelial sprouting and vessel formation in vitro and in vivo, drastically reducing tumor growth and greatly improving survival. Collectively, these results provide insight into the regulation of tumor angiogenesis and highlight ELTD1 as key player in blood vessel formation.
DOI
10.1016/j.ccr.2013.06.004
Publication Date
2013-08-01
Publication Title
Cancer Cell
Volume
24
Issue
2
Publisher
Elsevier BV
ISSN
1535-6108
Embargo Period
2024-11-19
First Page
229
Last Page
241
Recommended Citation
Masiero, M., Simões, F., Han, H., & et al. (2013) 'A Core Human Primary Tumor Angiogenesis Signature Identifies the Endothelial Orphan Receptor ELTD1 as a Key Regulator of Angiogenesis', Cancer Cell, 24(2), pp. 229-241. Elsevier BV: Available at: https://doi.org/10.1016/j.ccr.2013.06.004
