ORCID
- Carroll, Camille: 0000-0001-7472-953X
Abstract
AbstractTo identify predictors of 36-month follow-up quality of life (QoL) outcome after bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s disease (PD). In this ongoing, prospective, multicenter international study (Cologne, Manchester, London) including 73 patients undergoing STN-DBS, we assessed the following scales preoperatively and at 6-month and 36-month follow-up: PD Questionnaire-8 (PDQ-8), NMSScale (NMSS), Scales for Outcomes in PD (SCOPA)-motor examination, -activities of daily living, and -complications, and levodopa equivalent daily dose (LEDD). We analyzed factors associated with QoL improvement at 36-month follow-up based on (1) correlations between baseline test scores and QoL improvement, (2) step-wise linear regressions with baseline test scores as independent and QoL improvement as dependent variables, (3) logistic regressions and receiver operating characteristic curves using a dichotomized variable “QoL responders”/“non-responders”. At both follow-ups, NMSS total score, SCOPA-motor examination, and -complications improved and LEDD was reduced significantly. PDQ-8 improved at 6-month follow-up with subsequent decrements in gains at 36-month follow-up when 61.6% of patients were categorized as “QoL non-responders”. Correlations, linear, and logistic regression analyses found greater PDQ-8 improvements in patients with younger age, worse PDQ-8, and worse specific NMS at baseline, such as ‘difficulties experiencing pleasure’ and ‘problems sustaining concentration’. Baseline SCOPA scores were not associated with PDQ-8 changes. Our results provide evidence that 36-month QoL changes depend on baseline neuropsychological and neuropsychiatric non-motor symptoms burden. These findings highlight the need for an assessment of a wide range of non-motor and motor symptoms when advising and selecting individuals for DBS therapy.
DOI
10.1038/s41531-021-00174-x
Publication Date
2021-06-08
Publication Title
Parkinson's Disease
Volume
7
Issue
1
ISSN
2090-8083
Embargo Period
2021-08-11
Organisational Unit
Peninsula Medical School
Recommended Citation
Jost, S. T., Visser-Vandewalle, V., Rizos, A., Loehrer, P., Silverdale, M., Evans, J., Samuel, M., Petry-Schmelzer, J., Sauerbier, A., Gronostay, A., Barbe, M., Fink, G., Ashkan, K., Antonini, A., Martinez-Martin, P., Chaudhuri, K., Timmermann, L., Dafsari, H., Bhidayasiri, R., Falup-Pecurariu, C., Jeon, B., Leta, V., Borghammer, P., Odin, P., Schrag, A., Storch, A., Violante, M., Weintraub, D., Adler, C., Barone, P., Brooks, D., Brown, R., Cantillon, M., Carroll, C., Coelho, M., Henriksen, T., Hu, M., Jenner, P., Kramberger, M., Kumar, P., Kurtis, M., Lewis, S., Litvan, I., Lyons, K., Martino, D., Masellis, M., Mochizuki, H., Morley, J., Nirenberg, M., Pagonabarraga, J., Panicker, J., Pavese, N., Pekkonen, E., Postuma, R., Rosales, R., Schapira, A., Simuni, T., Stocchi, F., Subramanian, I., Tagliati, M., Tinazzi, M., Toledo, J., Tsuboi, Y., & Walker, R. (2021) 'Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease', Parkinson's Disease, 7(1). Available at: https://doi.org/10.1038/s41531-021-00174-x
