ORCID
- Dhanda, Ashwin: 0000-0002-0523-0193
Abstract
Severe combined immunodeficiency (SCID) is a group of genetic disorders characterized by significant impairment of T cell differentiation, with or without abnormal B and NK cell differentiation. Without hematopoietic stem cell transplant (HSCT), the condition usually leads to an early death, typically due to infections. The most frequent genetic cause of SCID affects the common gamma chain, necessary for cytokine signaling. A similar phenotype is observed with mutations in the Janus-associated kinase 3 (JAK3) gene, the immediate downstream signaling molecule
DOI
10.1007/s10875-021-00999-4
Publication Date
2021-02-22
Publication Title
Journal of Clinical Immunology
Volume
41
Issue
5
ISSN
0271-9142
Embargo Period
2022-02-22
Organisational Unit
Peninsula Medical School
Creative Commons License
This work is licensed under a Creative Commons Attribution-Share Alike 4.0 International License.
First Page
1103
Last Page
1105
Recommended Citation
Moodley, P., Whyte, A., & Dhanda, A. (2021) 'Recurrent Chronic HEV in Severe Combined Immunodeficiency', Journal of Clinical Immunology, 41(5), pp. 1103-1105. Available at: https://doi.org/10.1007/s10875-021-00999-4
