Browse research from the Peninsula Medical School.

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Submissions from 2020

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Favourable outcomes for high-risk diffuse large B-cell lymphoma (IPI 3–5) treated with front-line R-CODOX-M/R-IVAC chemotherapy: results of a phase 2 UK NCRI trial, AK McMillan, EH Phillips, AA Kirkwood, S Barrans, and et al

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GATA-4, a potential novel therapeutic target for high-grade meningioma, regulates miR-497, a potential novel circulating biomarker for high-grade meningioma, Caterina Negroni, David A. Hilton, Emanuela Ercolano, Claire L. Adams, Kathreena M. Kurian, Daniele Baiz, and C. Oliver Hanemann

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Home Based Care: A care pathway innovation for Parkinson's disease, E Edwards, R Partridge, U Ankeny, J Langley, S Whipps, J Whipps, J Rideout, A Evans, S Bentley, M Swabey, H Matthews, N Stevens, R Chivers, T Dominey, K Triscott, and C Carroll

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Not so simple: the challenge of developing a non-motor symptoms app (NMS Assist) for people with Parkinson's (PwP), T Gorst, T Dominey, J Whipps, S Whipps, J Cooke, S Mullin, I Maramba, E Edwards, and C Carroll

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Oxygenation of the critically ill in selected intensive care units in the UK: are we usual?, Benjamin Post, Edward Palmer, Steve Harris, Mervyn Singer, and Daniel Martin

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Oxygen targets in the intensive care unit during mechanical ventilation for acute respiratory distress syndrome: a rapid review, Andrew F. Cumpstey, Alex H. Oldman, Andrew F. Smith, Daniel Martin, and Michael P.W. Grocott

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UK psychiatrists’ experience of withdrawal of antipsychotics prescribed for challenging behaviours in adults with intellectual disabilities and/or autism, S Deb, T Nancarrow, B Limbu, R Sheehan, and et al

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Using a Delphi process to inform the design of disease modifying trials in Parkinson's disease, M Zeissler, R Windle, K McFarthing, K Raphael, G Rafaloff, and C Carroll

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β-Cell Glucose Sensitivity determines hyperglycaemia in Polycystic Ovary Syndrome, J Tomlinson, A Mari, A Tura, K Bond, E Stenhouse, T Dew, RP Vincent, and J Pinkney

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Contributions of Fat and Carbohydrate Metabolism to Glucose Homeostasis in Childhood Change With Age and Puberty: A 12-Years Cohort Study (EARLYBIRD 77), Ornella Cominetti, Joanne Hosking, Alison Jeffery, Jonathan Pinkney, and Francois Pierre Martin

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ACCEPT - combining acalabrutinib with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP) for Diffuse Large B-cell Lymphoma (DLBCL): study protocol for a Phase Ib/II open-label non-randomised clinical trial, A Davies, S Barrans, C Burton, K Mercer, and et al

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Adult liver transplantation: A UK clinical guideline - part 1: pre-operation, Charles Millson, Aisling Considine, Matthew E. Cramp, Andrew Holt, Stefan Hubscher, John Hutchinson, Kate Jones, Joanna Leithead, Steven Masson, Krish Menon, Darius Mirza, James Neuberger, Raj Prasad, Anthony Pratt, Wendy Prentice, Liz Shepherd, Ken Simpson, Doug Thorburn, Rachel Westbrook, and Dhiraj Tripathi

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A Systematic Approach to Review of in vitro Methods in Brain Tumour Research (SAToRI-BTR): Development of a Preliminary Checklist for Evaluating Quality and Human Relevance, Mike Bracher, GJ Pilkington, C. Oliver Hanemann, and K Pilkington

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Final 5-year findings from the phase 3 HELIOS study of ibrutinib plus bendamustine and rituximab in patients with relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma, GAM Fraser, S Rule, and et al

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Awareness of bone health risks in people with epilepsy and intellectual disability, Rohit Shankar, Indermeet Sawhney, Asif Zia, and Bahar Yazdi

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FGF5 Regulates Schwann Cell Migration and Adhesion, Bing Chen, Rong Hu, Qing Min, Yankun Li, David B. Parkinson, and Xin Peng Dun

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Promoting learning from null or negative results in prevention science trials, Nick Axford, Vashti Berry, Jenny Lloyd, Tim Hobbs, and Katrina Wyatt

Topological features of integrin adhesion complexes revealed by multiplexed proximity biotinylation, Megan R. Chastney, Craig Lawless, JD Humphries, Stacey Warwood, Matthew C. Jones, David Knight, Claus Jorgensen, and MJ Humphries

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After the fire: Post-pandemic reflections, Daniel Martin

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An audit of emotional logic for mental health self-care improving social connection, Abigail Turton, Marian Langsford, Lorenzo D Di, Daniel Zahra, Julie Henshelwood, and Trevor Griffiths

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Barriers and facilitators to GP–patient communication about emotional concerns in UK primary care: a systematic review, Daisy Parker, Richard Byng, Chris Dickens, Debbie Kinsey, and Rose McCabe

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Dementia prevention, intervention, and care: 2020 report of the Lancet Commission, G Livingston, J Huntley, A Sommerlad, and et al

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Developing a roadmap to improve trial delivery for underserved groups: results from a UK multi-stakeholder process, Miles D. Witham, Eleanor Anderson, Camille Carroll, Paul M. Dark, Kim Down, Alistair S. Hall, Joanna Knee, Rebecca H. Maier, Gail A. Mountain, Gary Nestor, Laurie Oliva, Sarah R. Prowse, Amanda Tortice, James Wason, and Lynn Rochester

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Remimazolam; a role for anaesthesia/ sedation?, J Sneyd and A Rigby-Jones

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Smartphone-based optical assays in the food safety field, J. L.D. Nelis, A. S. Tsagkaris, M. J. Dillon, J. Hajslova, and C. T. Elliott

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The cardiac output optimisation following liver transplant (COLT) trial: a feasibility randomised controlled trial, D Martin, Rahul Koti, Kurinchi Gurusamy, Louise Longworth, Jeshika Singh, Farid Froghi, F Soggiu, Susan Mallett, Nick Schofield, Linda Selves, Douglas Thorburn, Christine Eastgate, Helder Filipe, Margaret McNeil, Zacharias Anastasiou, Brian Davidson, Lasitha Abeysundara, Zacharias Anastasiou, Janice Baker, Elaine Burrell, Judith C. Leen, James Cuell, Brian Davidson, Christine Eastgate, Helder Filipe, Kate Flavin, Farid Froghi, Kate Fryer, Vignesh Gopalan, Kurinchi Gurusamy, Vivienne Hannon, N/A Katherine, N/A Horner, Sarah James, Rupinda Kaur, Rahul Koti, Louise Longworth, D Martin, K Martin, Susan Mallet, and Margaret McNeil

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The changing face of neurosurgery for the older person, Ellie Edlmann and Peter C. Whitfield

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The Effectiveness of a Community-Based Mentoring Program for Children Aged 5–11 Years: Results from a Randomized Controlled Trial, Nick Axford, Gretchen Bjornstad, Justin Matthews, Laura Whybra, Vashti Berry, Obioha C. Ukoumunne, Tim Hobbs, Zoe Wrigley, Lucy Brook, Rod Taylor, Tim Eames, Angeliki Kallitsoglou, Sarah Blower, and Georgina Warner

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Effect of zinc treatment on clinical outcomes in patients with liver cirrhosis: A systematic review and meta-analysis, HK Tan, A Streeter, ME Cramp, and AD Dhanda

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Effect of zinc treatment on clinical outcomes in patients with liver cirrhosis: A systematic review and meta-analysis, Huey K. Tan, Adam Streeter, Matthew E. Cramp, and Ashwin D. Dhanda

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Oxidative stress in alcohol-related liver disease, Huey K. Tan, Euan Yates, Kristen Lilly, and Ashwin D. Dhanda

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Efficacy and Safety of Alemtuzumab Through 9 Years of Follow-up in Patients with Highly Active Disease: Post Hoc Analysis of CARE-MS I and II Patients in the TOPAZ Extension Study, Tjalf Ziemssen, Ann D. Bass, Regina Berkovich, Giancarlo Comi, Sara Eichau, Jeremy Hobart, Samuel F. Hunter, Christopher LaGanke, Volker Limmroth, Daniel Pelletier, Carlo Pozzilli, Sven Schippling, Livia Sousa, Anthony Traboulsee, Bernard M.J. Uitdehaag, Wijmeersch B Van, Zia Choudhry, Nadia Daizadeh, and Barry A. Singer

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Epilepsy, anti-seizure medication, intellectual disability and challenging behaviour – Everyone's business, no one's priority, R. Shankar, M. O. Kinney, V. Chester, S. Tromans, R. T. Alexander, H. Angus-Leppan, M. Bagary, H. Cock, J. Devapriam, A. Hassiotis, M. Mula, M. Reuber, H. Ring, A. Roy, and M. Scheepers

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Migrating Schwann cells direct axon regeneration within the peripheral nerve bridge, Qing Min, David B. Parkinson, and Xin Peng Dun

Clinical guidance on pharmacotherapy for the treatment of attention-deficit hyperactivity disorder (ADHD) for people with intellectual disability, Rohit Shankar, Jonjo Miller, and Bhathika Perera

Creating Capable Communities for People with Intellectual Disabilities: Challenges and Opportunities, Rohit Shankar, Sarah Lennard, Richard Sharpe, Rebecca Goodey, and Sharon Hudson

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Integrating the voluntary sector in personalised care: mixed methods study of the outcomes from wellbeing co-ordination for adults with complex needs, Felix Gradinger, Julian Elston, Sheena Asthana, Chloe Myers, Sue Wroe, and Richard Byng

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State of the Art and Future Challenges in Multiple Sclerosis Research and Medical Management: An Insight into the 5th International Porto Congress of Multiple Sclerosis, María José Sá, dos Reis R Soares, Ayse Altintas, Elisabeth Gulowsen Celius, Claudia Chien, Giancarlo Comi, Francesc Graus, Jan Hillert, Jeremy Hobart, Gulfaraz Khan, Najib Kissani, Dawn Langdon, Maria Isabel Leite, Darin T. Okuda, Jacqueline Palace, Regina María Papais-Alvarenga, Inês Mendes-Pinto, and Fu Dong Shi

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EEG Markers in Emotionally Unstable Personality Disorder—A Possible Outcome Measure for Neurofeedback: A Narrative Review, Rohit Shankar, Cailín Boland, Virupakshi Jalihal, Catriona Organ, Katy Oak, Brendan McLean, Richard Laugharne, Wessel Woldman, and Randy Beck

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Creating Capable Communities for People with Intellectual Disabilities: Challenges and Opportunities, S Lennard, R Sharpe, R Goodey, S Hudson, and R Shankar

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Measuring quality of life in ALS/MND: validation of the WHOQOL-BREF, Carolyn A. Young, Roger Mills, Ammar Al-Chalabi, Georgina Burke, Siddharthan Chandran, David J. Dick, John Ealing, C. Oliver Hanemann, Timothy Harrower, Christopher J. Mcdermott, Tahir Majeed, Ashwin Pinto, Kevin Talbot, Jannette Walsh, Timothy L. Williams, and Alan Tennant

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General practitioners’ and psychiatrists’ attitudes towards antidepressant withdrawal, J McCabe, M Wilcock, K Atkinson, R Laugharne, and R Shankar

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Open letter from UK based academic scientists to the secretaries of state for digital, culture, media and sport and for health and social care regarding the need for independent funding for the prevention and treatment of gambling harms, Heather Wardle, James Banks, Paul Bebbington, Lindsey Blank, Jones OBE H Bowden, Stephanie Bramley, Christopher Bunn, Emma Casey, Rebecca Cassidy, Samuel R. Chamberlain, James Close, Nathan Critchlow, Fiona Dobbie, Carolyn Downs, Simon Dymond, Emanuele Fino, Elizabeth Goyder, Cindy Gray, Mark Griffiths, Peter Grindrod, Lee Hogan, Alice Hoon, Kate Hunt, Richard James, Bev John, Jill Manthorpe, Jim McCambridge, David McDaid, Martin McKee, Sally McManus, Antony Moss, Caroline Norrie, David J. Nutt, Jim Orford, Rob Pryce, Richard Purves, Gerda Reith, A Roberts, E Roberts, Gareth Roderique-Davies, J Rogers, RD Rogers, Stephen Sharman, John Strang, Richard Tunney, John Turner, Robert West, and David Zendle

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Port dumping and participation in England: Developing an ecosystem approach through local ecological knowledge, Jeremy Anbleyth-Evans, Shaw Nozaki Lacy, Carolina Aguirre-Muñoz, and John Tredinnick-Rowe

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Randomised clinical trial: palliative long-term abdominal drains vs large-volume paracentesis in refractory ascites due to cirrhosis, Lucia Macken, Stephen Bremner, Heather Gage, Morro Touray, Peter Williams, David Crook, Louise Mason, Debbie Lambert, Catherine J. Evans, Max Cooper, Jean Timeyin, Shani Steer, Mark Austin, Nick Parnell, Sam J. Thomson, David Sheridan, Mark Wright, Peter Isaacs, Ahmed Hashim, and Sumita Verma

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Rationing bytes: managing demand for digital forensic examinations, Brian Rappert, Hannah Wheat, and Dana Wilson-Kovacs

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The Potential of MLN3651 in Combination with Selumetinib as a Treatment for Merlin-Deficient Meningioma, Rimmer J. Lyons, Emanuela Ercolano, Daniele Baiz, Mahindra Makhija, Allison Berger, Todd Sells, Steve Stroud, David Hilton, Claire L. Adams, and C. Oliver Hanemann

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Research with older people in a world with COVID-19: identification of current and future priorities, challenges and opportunities, Miles D. Witham, Sarah J. Richardson, Camille B. Carroll, Jacqueline Close, Adam L. Gordon, J O'Brien, Terence J. Quinn, Lynn Rochester, Avan A. Sayer, Susan D. Shenkin, der Velde N van, and Jean Woo

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Trace element deficiency is highly prevalent and associated with infection and mortality in patients with alcoholic hepatitis, Ashwin Dhanda, Stephen Atkinson, Nikhil Vergis, Doyo Enki, Andrew Fisher, Robert Clough, Matthew Cramp, and Mark Thursz

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In reply to: Helmich and Bloem (2020) “The Impact of the COVID-19 Pandemic on Parkinson’s Disease: Hidden Sorrows and Emerging Opportunities”, Emma Edwards and Camille Carroll

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Admission Decision-Making in Hospital Emergency Departments: The Role of the Accompanying Person, Susanna Rance, Debra Westlake, Heather Brant, Ingrid Holme, Ruth Endacott, Jonathan Pinkney, and Richard Byng

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General practitioners' and psychiatrists' attitudes towards antidepressant withdrawal, Rohit Shankar, Joanne McCabe, Mike Wilcock, Kate Atkinson, and Richard Laugharne

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Marked variability in bioactivity between commercially available bovine colostrum for human use; implications for clinical trials, RJ Playford, M Cattell, and T Marchbank

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HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis, Marta Palomo-Irigoyen, Encarni Pérez-Andrés, Marta Iruarrizaga-Lejarreta, Adrián Barreira-Manrique, Miguel Tamayo-Caro, Laura Vila-Vecilla, Leire Moreno-Cugnon, Nagore Beitia, Daniela Medrano, David Fernández-Ramos, Juan José Lozano, Satoshi Okawa, José L. Lavín, Natalia Martín-Martín, James D. Sutherland, Juan VG de, Monika Gonzalez-Lopez, Nuria Macías-Cámara, David Mosén-Ansorena, Liyam Laraba, CO Hanemann, Emanuela Ercolano, David B. Parkinson, Christopher W. Schultz, Marcos J. Araúzo-Bravo, Alex M. Ascensión, Daniela Gerovska, Haizea Iribar, Ander Izeta, Peter Pytel, Philipp Krastel, Alessandro Provenzani, Pierfausto Seneci, Ruben D. Carrasco, Sol A Del, María Luz Martinez-Chantar, Rosa Barrio, Eduard Serra, Conxi Lazaro, Adrienne M. Flanagan, Myriam Gorospe, Nancy Ratner, Ana M. Aransay, Arkaitz Carracedo, Marta Varela-Rey, and Ashwin Woodhoo

Management evaluation of metastasis in the brain (MEMBRAIN)—a United Kingdom and Ireland prospective, multicenter observational study, J Jung, J Tailor, E Dalton, LJ Glancz, J Roach, R Zakaria, S Lammy, A Chari, KP Budohoski, LJ Livermore, K Yu, MD Jenkinson, PM Brennan, L Brazil, C Bunce, E Bourmpaki, K Ashkan, F Vergani, S Achawa, R Al-Mahfoudh, E Albanese, M Amoo, R Ashida, K Benton, H Bhatt, I Coulter, P D’Urso, A Dapaah, K Dawson, and G Dobson

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GDNF and Parkinson’s Disease: Where Next? A Summary from a Recent Workshop, Roger A. Barker, A Bjorklund, Don M. Gash, Alan Whone, Laar A Van, Jeffrey H. Kordower, Krystof Bankiewicz, Karl Kieburtz, Mart Saarma, Sigrid Booms, Henri J. Huttunen, Adrian P. Kells, Massimo S. Fiandaca, A. Jon Stoessl, David Eidelberg, Howard Federoff, Merja H. Voutilainen, David T. Dexter, Jamie Eberling, Patrik Brundin, Lyndsey Isaacs, Leah Mursaleen, Eros Bresolin, Camille Carroll, Alasdair Coles, Brian Fiske, Helen Matthews, Codrin Lungu, Richard K. Wyse, Simon Stott, and Anthony E. Lang

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Challenges to well-being for general practice trainee doctors: a qualitative study of their experiences and coping strategies, Sarah Ansell, James Read, and Marie Bryce

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Measuring upper limb function in MS: Which existing patient reported outcomes are fit for purpose?, James Close, Kathryn Baines, Laurie Burke, and Jeremy Hobart

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Defining the characteristics of intermediate care models including transitional care: an international Delphi study, Duygu Sezgin, Rónán O’Caoimh, Mark R. O’Donovan, Mohamed A. Salem, Siobhán Kennelly, Luz Lopez Samaniego, Cristina Arnal Carda, Rafael Rodriguez-Acuña, Marco Inzitari, Teija Hammar, Claire Holditch, Janet Prvu Bettger, Martin Vernon, Áine Carroll, Felix Gradinger, Gaston Perman, Martin Wilson, Antoine Vella, Antonio Cherubini, Helen Tucker, Maria Pia Fantini, Graziano Onder, Regina Roller-Wirnsberger, Luis Miguel Gutiérrez-Robledo, Matteo Cesari, Paula Bertoluci, Magdalena Kieliszek, der Vlegel-Brouwer W van, Michelle Nelson, Leocadio Rodríguez Mañas, Eleftheria Antoniadou, François Barriere, Sebastian Lindblom, Grace Park, Isidoro Pérez, Dolores Alguacil, Douglas Lowdon, Maria Eugenia Alkiza, Cristina Alonso Bouzon, John Young, Ana Carriazo, Aaron Liew, and Anne Hendry

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Help to Overcome Problems Effectively for Cancer Survivors: Development and Evaluation of a Digital Self-Management Program, F Martin, H Wright, L Moody, B Whiteman, and et al

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How healthcare systems shape a purchaser’s strategies and actions when managing chronic care, Bart A.C. Noort, Kees Ahaus, der Vaart T van, Naomi Chambers, and Rod Sheaff

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Clinical features and genetic risk of demyelination following anti-TNF treatment, Simeng Lin, Harry D. Green, Peter Hendy, Neel M. Heerasing, Neil Chanchlani, Benjamin Hamilton, Gareth J. Walker, Graham A. Heap, Jeremy Hobart, Roswell J. Martin, Alasdair J. Coles, Peter M. Irving, Guy Chung-Faye, J. R.Fraser Cummings, Ellina Lytvyak, Vibeke Andersen, Andrew R. Wood, Jessica Tyrrell, Robin N. Beaumont, Michael N. Weedon, Nicholas A. Kennedy, Alexander Spiers, Timothy Harrower, James R. Goodhand, and Tariq Ahmad

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COVID-19: An update from England’s high consequence infectious diseases intensive care unit leads, Daniel Martin, Sarah Platt, Peter Hampshire, and Chris Meadows

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Speech Therapy in the Treatment of Globus Pharyngeus: Development of a Mobile Application to Improve Patient Access, Hisham Khalil, D Grech-Marguerat, Marios Stavrakas, Abdulaziz Abushaala, Robert Hart, and Arunangsu Chatterjee

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Favourable outcomes for high‐risk Burkitt lymphoma patients (IPI 3‐5) treated with rituximab plus CODOX‐M/IVAC: Results of a phase 2 UK NCRI trial, EH Phillips, C Burton, AA Kirkwood, S Barrans, and et al

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Perioperative Quality Initiative (POQI) consensus statement on fundamental concepts in perioperative fluid management: fluid responsiveness and venous capacitance, GS Martin, DA Kaufman, PE Marik, NI Shapiro, DZH Levett, J Whittle, DB MacLeod, D Chappell, J Lacey, T Woodcock, K Mitchell, MLNG Malbrain, TM Woodcock, D Martin, CHE Imray, MW Manning, H Howe, MPW Grocott, MG Mythen, TJ Gan, and TE Miller

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Is It Possible to Conduct a Multi-Arm Multi-Stage Platform Trial in Parkinson’s Disease: Lessons Learned from Other Neurodegenerative Disorders and Cancer, Marie Louise Zeissler, Vivien Li, Mahesh K.B. Parmar, and Camille Buchholz Carroll

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The effectiveness of the KiVa bullying prevention program in Wales, UK: results from a pragmatic cluster randomised controlled trial, Nick Axford, Gretchen Bjornstad, Suzy Clarkson, Obioha C. Ukoumunne, Zoe Wrigley, Justin Matthews, and Vashti Berry

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Applicability, safety, and biological activity of regulatory T cell therapy in liver transplantation, A Sánchez‐Fueyo, Gavin Whitehouse, Nathali Grageda, Matthew E. Cramp, Tiong Y. Lim, Marco Romano, Sarah Thirkell, Katie Lowe, Laura Fry, Julie Heward, Alex Kerr, Jakia Ali, Chris Fisher, Gillian Lewis, Andrew Hope, Elisavet Kodela, Mike Lyne, Farzin Farzaneh, Shahram Kordasti, I Rebollo‐Mesa, Lozano J Jose, Niloufar Safinia, Nigel Heaton, Robert Lechler, M Martínez‐Llordella, and Giovanna Lombardi

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Ben Fine. Micro-economics. A Critical Companion. London 2016 (Pluto), W Sheaff

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Resource pack to support workplace compassion, W Clyne and K Deeny

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Preferences of nursing and medical students for working with older adults and people with dementia: a systematic review, M Hebditch, S Daley, J Wright, and et al

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Postoperative Remote Automated Monitoring and Virtual Hospital-to-Home Care System Following Cardiac and Major Vascular Surgery: User Testing Study, M McGillion, C Ouellette, A Good, and et al

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Valproate risk form—Surveying 215 clinicians involving 4775 encounters, Heather Angus-Leppan, Melika M. Moghim, Hannah Cock, Lucy Kinton, Marie Synnott Wells, and Rohit Shankar

A historical database cohort study addressing the clinical patterns prior to idiopathic pulmonary fibrosis (IPF) diagnosis in UK primary care, R Jones, D Thickett, J Voorham, and D Price

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A novel lung health programme addressing awareness and behaviour-change aiming to prevent chronic respiratory diseases in rural Uganda: a two-year train-the-trainer programme, R Jones, B Kirenga, S Buteme, S Williams, and Gemert F van

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Book Review: Microeconomics: A Critical Companion by Ben Fine, R Sheaff

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Correction to:: Do pain, anxiety and depression influence quality of life for people with amyotrophic lateral sclerosis/motor neuron disease? A national study reconciling previous conflicting literature (Journal of Neurology, (2020), 267, 3, (607-615), 10.1007/s00415-019-09615-3), Rhiannon Edge, the TONiC study group, Roger Mills, Alan Tennant, Peter J. Diggle, Carolyn A. Young, Ammar Al-Chalabi, Timothy L. Williams, David J. Dick, Kevin Talbot, Georgina Burke, Tahir Majeed, John Ealing, Christopher J. McDermott, Ashwin Pinto, Siddharthan Chandran, Jannette Walsh, C. Oliver Hanemann, and Timothy Harrower

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Do pain, anxiety and depression influence quality of life for people with amyotrophic lateral sclerosis/motor neuron disease? A national study reconciling previous conflicting literature, Rhiannon Edge, the TONiC study group, Roger Mills, Alan Tennant, Peter J. Diggle, Carolyn A. Young, Ammar Al-Chalabi, Timothy L. Williams, David J. Dick, Kevin Talbot, Georgina Burke, Tahir Majeed, John Ealing, Christopher J. McDermott, Ashwin Pinto, Siddharthan Chandran, Jannette Walsh, Oliver Hanemann, and Timothy Harrower

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Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial, Jeremy Chataway, Angelis F De, Peter Connick, RA Parker, Domenico Plantone, Anisha Doshi, Nevin John, Jonathan Stutters, David MacManus, Carrasco F Prados, Frederik Barkhof, Sebastien Ourselin, Marie Braisher, Moira Ross, Gina Cranswick, Sue H. Pavitt, Gavin Giovannoni, Wheeler-Kingshott CA Gandini, Clive Hawkins, Basil Sharrack, Roger Bastow, Christopher J. Weir, Nigel Stallard, Siddharthan Chandran, Jeremy Chataway, Wheeler-Kingshott CAM Gandini, Angelis F De, Domenico Plantone, Anisha Doshi, Nevin John, Thomas Williams, Marie Braisher, Tiggy Beyene, Vanessa Bassan, Alvin Zapata, Siddharthan Chandran, Peter Connick, Dawn Lyle, James Cameron, Daisy Mollison, Shuna Colville, Baljean Dhillon, Christopher J. Weir, RA Parker, Moira Ross, Gina Cranswick, Gavin Giovannoni, Sharmilee Gnanapavan, Richard Nicholas, Waqar Rashid, Julia Aram, Helen Ford, James Overell, Carolyn Young, Heinke Arndt, Martin Duddy, Joe Guadagno, Nikolaos Evangelou, Matthew Craner, Jacqueline Palace, Jeremy Hobart, Basil Sharrack, David Paling, Clive Hawkins, Seema Kalra, B McLean, Nigel Stallard, and Roger Bastow

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Mental health services for adults with mild intellectual disability, Rohit Shankar, Fabian Haut, and Ken Courtenay

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PROTOCOL: A comparison of the effectiveness of cognitive behavioural interventions based on delivery features for elevated symptoms of depression in adolescents, Gretchen J. Bjornstad, Shreya Sonthalia, Benjamin Rouse, Luke Timmons, Laura Whybra, and Nick Axford

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What approaches to social prescribing work, for whom, and in what circumstances? A realist review, Kerryn Husk, Kelly Blockley, Rebecca Lovell, Alison Bethel, Iain Lang, Richard Byng, and Ruth Garside

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Women’s Digital Care Record report, Health Education England

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Adult liver transplantation: UK clinical guideline - part 2: surgery and post-operation, Charles Millson, Aisling Considine, Matthew E. Cramp, Andrew Holt, Stefan Hubscher, John Hutchinson, Kate Jones, Joanna Leithead, Steven Masson, Krish Menon, Darius Mirza, James Neuberger, Raj Prasad, Anthony Pratt, Wendy Prentice, Liz Shepherd, Ken Simpson, Doug Thorburn, Rachel Westbrook, and Dhiraj Tripathi

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Genome-wide association study of pain in Parkinson's disease implicates TRPM8 as a risk factor, Nigel M. Williams, Leon Hubbard, Cynthia Sandor, Caleb Webber, Hannah Hendry, Camille Carroll, Michael Lawton, K. Ray Chaudhuri, Huw Morris, Michele T. Hu, Donald G. Grosset, Christopher Kobylecki, and Monty Silverdale

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Lacosamide in the general population and in people with intellectual disability: Similar responses?: Similar responses?, Rohit Shankar, Jon Allard, William Henley, Brendan Mclean, Adrian Sellers, Sharon Hudson, Sanjeev Rajakulendran, Adrian Pace, Sarah Pashley, Melissa Maguire, Monica Mohan, Shan Ellawela, Phil Tittensor, Sunil Ram, and Manny Bagary

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Recovery from recurrent depression with mindfulness-based cognitive therapy and antidepressants: a qualitative study with illustrative case studies, Alice Tickell, Richard Byng, Catherine Crane, Felix Gradinger, Rachel Hayes, James Robson, Jessica Cardy, Alice Weaver, Nicola Morant, and Willem Kuyken

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Reply to Tasker and to Lellouche and L’Her, Edward Palmer, Daniel Martin, Mervyn Singer, and Steve Harris

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Managerial workarounds in three European DRG systems, Rod Sheaff, Verdiana Morando, Naomi Chambers, Mark Exworthy, Ann Mahon, Richard Byng, and Russell Mannion

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Patients’ experiences of seeking help for emotional concerns in primary care: doctor as drug, detective and collaborator, Daisy Parker, Richard Byng, Chris Dickens, and Rose McCabe

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A Rapid Robust Method for Subgrouping Non-NF2 Meningiomas According to Genotype and Detection of Lower Levels of M2 Macrophages in AKT1 E17K Mutated Tumours, Claire L. Adams, Emanuela Ercolano, Sara Ferluga, Agbolahan Sofela, Foram Dave, Caterina Negroni, Kathreena M. Kurian, David A. Hilton, and C. Oliver Hanemann

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Capturing the role of context in complex system change: an application of the Canadian Context and Capabilities for Integrating Care (CCIC) Framework to the English Context, Sheena Asthana, Felix Gradinger, Julian Elston, Susan Martin, and Richard Byng

Expanding Clinical Presentations Due to Variations in THOC2 mRNA Nuclear Export Factor, Jozef Gecz, Raman Kumar, Elizabeth Palmer, Alison E. Gardner, Renee Carroll, Siddharth Banka, Ola Abdelhadi, Dian Donnai, Ype Elgersma, Cynthia J. Curry, Alice Gardham, Mohnish Suri, Rishikesh Malla, Lauren Ilana Brady, Mark Tarnopolsky, Dimitar N. Azmanov, Vanessa Atkinson, Michael Black, Gareth Baynam, Lauren Dreyer, Robin Z. Hayeems, Christian R. Marshall, Gregory Costain, Marja W. Wessels, Julia Baptista, James Drummond, Melanie Leffler, and Michael Field

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Improving epilepsy management with EpSMon: A Templar to highlight the multifaceted challenges of incorporating digital technologies into routine clinical practice, C Newman, S Ashby, B McLean, and R Shankar

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On brain atlas choice and automatic segmentation methods: a comparison of MAPER & FreeSurfer using three atlas databases, SN Yaakub, RA Heckemann, SS Keller, and et al

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Recurrent TTN metatranscript‐only c.39974–11T>G splice variant associated with autosomal recessive arthrogryposis multiplex congenita and myopathy, SJ Bryen, LJ Ewans, J Pinner, and et al

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Epilepsy in People with Intellectual Disabilities, R Shankar and M Walker

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Epilepsy in people with intellectual disability, Regi Alexander, Sabyasachi Bhaumik, Rohit Shankar, and Matthew C. Walker

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Reviving clinical governance? A qualitative study of the impact of professional regulatory reform on clinical governance in healthcare organisations in England, Tristan Price, John Tredinnick-Rowe, Kieran Walshe, Abigail Tazzyman, Jane Ferguson, Alan Boyd, Julian Archer, and Marie Bryce