The Genetics of Parkinson’s Disease and Implications for Clinical Practice

Authors

Stephen Mullin, Peninsula Medical School
Jacob Oliver Day

ORCID

• Stephen Mullin: 0000-0002-1936-394X

Abstract

The genetic landscape of Parkinson’s disease (PD) is characterised by rare high penetrance pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a significant minority in PD cases and high frequency, low penetrance variants, which contribute a small increase of the risk of developing sporadic PD. This knowledge has the potential to have a major impact in the clinical care of people with PD. We summarise these genetic influences and discuss the implications for therapeutics and clinical trial design.

DOI

10.3390/genes12071006

Publication Date

2021-06-30

Publication Title

Genes

Volume

12

Issue

7

ISSN

2073-4425

Embargo Period

2021-07-06

First Page

1006

Last Page

1006

Recommended Citation

Mullin, S., & Day, J. (2021) 'The Genetics of Parkinson’s Disease and Implications for Clinical Practice', Genes, 12(7), pp. 1006-1006. Available at: 10.3390/genes12071006