ORCID
- Mullin, Stephen: 0000-0002-1936-394X
Abstract
The genetic landscape of Parkinson’s disease (PD) is characterised by rare high penetrance pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a significant minority in PD cases and high frequency, low penetrance variants, which contribute a small increase of the risk of developing sporadic PD. This knowledge has the potential to have a major impact in the clinical care of people with PD. We summarise these genetic influences and discuss the implications for therapeutics and clinical trial design.
DOI
10.3390/genes12071006
Publication Date
2021-06-28
Publication Title
Genes
Volume
12
Issue
7
First Page
1006
Last Page
1006
ISSN
2073-4425
Embargo Period
2021-07-06
Organisational Unit
Peninsula Medical School
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Day, J. O., & Mullin, S. (2021) 'The Genetics of Parkinson’s Disease and Implications for Clinical Practice', Genes, 12(7), pp. 1006-1006. Available at: https://doi.org/10.3390/genes12071006
