ORCID
- Carroll, Camille: 0000-0001-7472-953X
Abstract
Background Parkinson’s disease has been identified as a risk factor for severe Coronavirus disease 2019 (COVID-19) outcomes. However, whether the significant high risk of death from COVID-19 in people with Parkinson’s disease is specific to the disease itself or driven by other concomitant and known risk factors such as comorbidities, age, and frailty remains unclear. Objective To investigate clinical profiles and outcomes of people with Parkinson’s disease and atypical parkinsonian syndromes who tested positive for COVID-19 in the hospital setting in a multicentre UK-based study. Methods A retrospective cohort study of Parkinson’s disease patients with a positive SARS-CoV-2 test admitted to hospital between February 2020 and July 2021. An online survey was used to collect data from clinical care records, recording patient, Parkinson’s disease and COVID-19 characteristics. Associations with time-to-mortality and severe outcomes were analysed using either the Cox proportional hazards model or logistic regression models, as appropriate. Results Data from 552 admissions were collected: 365 (66%) male; median (inter-quartile range) age 80 (74–85) years. The 34-day all-cause mortality rate was 38.4%; male sex, increased age and frailty, Parkinson’s dementia syndrome, requirement for respiratory support and no vaccination were associated with increased mortality risk. Community-acquired COVID-19 and co-morbid chronic neurological disorder were associated with increased odds of requiring respiratory support. Hospital-acquired COVID-19 and delirium were associated with requiring an increase in care level post-discharge. Conclusions This first, multicentre, UK-based study on people with Parkinson’s disease or atypical parkinsonian syndromes, hospitalised with COVID-19, adds and expands previous findings on clinical profiles and outcomes in this population.
DOI
10.1371/jourl.pone.0285349
Publication Date
2023-07-31
Publication Title
PLoS ONE
Volume
18
Issue
7
ISSN
1932-6203
Embargo Period
2023-08-05
Organisational Unit
Peninsula Medical School
Recommended Citation
Sorrell, L., Leta, V., Barnett, A., Stevens, K., King, A., Inches, J., Kobylecki, C., Walker, R., Chaudhuri, K., Martin, H., Rideout, J., Sneyd, J., Campbell, S., & Carroll, C. (2023) 'Clinical features and outcomes of hospitalised patients with COVID-19 and Parkinsonian disorders: A multicentre UK-based study', PLoS ONE, 18(7). Available at: https://doi.org/10.1371/jourl.pone.0285349
