ORCID
- Jones, Matt: 0000-0003-4723-3277
Abstract
An understanding of the mechanisms whereby cell adhesion complexes (ACs) relay signals bidirectionally across the plasma membrane is necessary to interpret the role of adhesion in regulating migration, differentiation, and growth. A range of AC types has been defined, but to date all have similar compositions and are dependent on a connection to the actin cytoskeleton. Recently, a new class of AC has been reported that normally lacks association with both the cytoskeleton and integrin-associated adhesome components, but is rich in components of the clathrin-mediated endocytosis machinery. The characterization of this new type of adhesion structure, which is emphasized by mitotic cells and cells in long-term culture, identifies a hitherto underappreciated link between the adhesion machinery and clathrin structures at the plasma membrane. While this discovery has implications for how ACs are assembled and disassembled, it raises many other issues. Consequently, to increase awareness within the field, and stimulate research, we explore a number of the most significant questions below.
DOI
10.1083/jcb.201811160
Publication Date
2019-07-01
Publication Title
Journal of Cell Biology
Volume
218
Issue
7
ISSN
0021-9525
Embargo Period
2023-08-12
Organisational Unit
Peninsula Medical School
First Page
2086
Last Page
2095
Recommended Citation
Lock, J. G., Baschieri, F., Jones, M., Humphries, J., Montagnac, G., Strömblad, S., & Humphries, M. (2019) 'Clathrin-containing adhesion complexes', Journal of Cell Biology, 218(7), pp. 2086-2095. Available at: https://doi.org/10.1083/jcb.201811160
