Mitogen-Activated Protein Kinase Cross-Talk Interaction Modulates the Production of Melanins in Aspergillus fumigatus

Authors

AO Manfiolli
FS Siqueira
Reis TF dos
Dijck P Van
S Schrevens
S Hoefgen
M Föge
M Straßburger
Leandro Jose De Assis, Peninsula Medical School
T Heinekamp
MC Rocha
S Janevska
AA Brakhage
I Malavazi
GH Goldman
V Valiante

ORCID

• Leandro Jose De Assis: 0000-0001-9782-437X

Abstract

Aspergillus fumigatus is the most important airborne human pathogenic fungus, causing thousands of deaths per year. Its lethality is due to late and often inaccurate diagnosis and the lack of efficient therapeutics. The failure of efficient prophylaxis and therapy is based on the ability of this pathogen to activate numerous salvage pathways that are capable of overcoming the different drug-derived stresses. A major role in the protection of A. fumigatus is played by melanins. Melanins are cell wall-associated macromolecules classified as virulence determinants. The understanding of the various signaling pathways acting in this organism can be used to elucidate the mechanism beyond melanin production and help to identify ideal drug targets.

DOI

10.1128/mbio.00215-19

Publication Date

2019-04-30

Publication Title

mBio

Volume

10

Issue

2

ISSN

2161-2129

Embargo Period

9999-12-31

Recommended Citation

Manfiolli, A., Siqueira, F., dos, R., Van, D., Schrevens, S., Hoefgen, S., Föge, M., Straßburger, M., De Assis, L., Heinekamp, T., Rocha, M., Janevska, S., Brakhage, A., Malavazi, I., Goldman, G., & Valiante, V. (2019) 'Mitogen-Activated Protein Kinase Cross-Talk Interaction Modulates the Production of Melanins in Aspergillus fumigatus', mBio, 10(2). Available at: 10.1128/mbio.00215-19" >https://doi.org/10.1128/mbio.00215-19