Abstract
Studies have suggested that Research Diagnostic Criteria for Schizoaffective Disorder Bipolar type (RDC-SABP) might identify a more genetically homogenous subgroup of bipolar disorder. Aiming to identify loci associated with RDC-SABP, we have performed a replication study using independent RDC-SABP cases (n = 144) and controls (n = 6,559), focusing on the 10 loci that reached a p-value <10−5 for RDC-SABP in the Wellcome Trust Case Control Consortium (WTCCC) bipolar disorder sample. Combining the WTCCC and replication datasets by meta-analysis (combined RDC-SABP, n = 423, controls, n = 9,494), we observed genome-wide significant association at one SNP, rs2352974, located within the intron of the gene TRAIP on chromosome 3p21.31 (p-value, 4.37 × 10−8). This locus did not reach genome-wide significance in bipolar disorder or schizophrenia large Psychiatric Genomic Consortium datasets, suggesting that it may represent a relatively specific genetic risk for the bipolar subtype of schizoaffective disorder.
DOI
10.1002/ajmg.b.32572
Publication Date
2017-08-29
Publication Title
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Publisher
Wiley
Embargo Period
2024-11-19
Recommended Citation
Green, E. (2017) 'Genome wide significant locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar Type.', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, . Wiley: Available at: https://doi.org/10.1002/ajmg.b.32572
