Show simple item record

dc.contributor.authorSneyd, J
dc.date.accessioned2017-08-21T10:42:24Z
dc.date.issued2017-12-01
dc.identifier.issn0007-0912
dc.identifier.issn1471-6771
dc.identifier.urihttp://hdl.handle.net/10026.1/9849
dc.description.abstract

Development targets in anaesthetic pharmacology have evolved from minimizing harm caused by unwanted effects through an era in which rapid onset and offset of drug effect were prioritised. Today's anaesthetists have access to a library of effective drugs whose characteristics offer controllable hypnosis, analgesia and paralysis with manageable off-target effects. The availability of these agents at generic prices inhibits commercial interest and this is reflected in the limited number of current anaesthetic drug development projects. Recently, questions around neonatal neurotoxicity, delirium and postoperative cognitive dysfunction have stimulated research to characterise these phenomena and explain them in mechanistic terms. Emergent basic science from these enquiries together with exploration of possible effects of anaesthetic drug choice on patient outcomes from cancer surgery may yield new targets for drug discovery.

dc.format.extenti44-i52
dc.format.mediumPrint
dc.languageen
dc.language.isoen
dc.publisherOxford University Press (OUP)
dc.subjectAnesthesiology
dc.subjectAnesthetics, Inhalation
dc.subjectAnesthetics, Intravenous
dc.subjectDesflurane
dc.subjectHumans
dc.subjectHypnotics and Sedatives
dc.subjectThiopental
dc.titleThiopental to desflurane - an anaesthetic journey. Where are we going next?
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/29161390
plymouth.issuesuppl_1
plymouth.volume119
plymouth.publisher-urlhttp://dx.doi.org/10.1093/bja/aex328
plymouth.publication-statusPublished online
plymouth.journalBritish Journal of Anaesthesia
dc.identifier.doi10.1093/bja/aex328
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Users by role
dc.publisher.placeEngland
dcterms.dateAccepted2017-08-21
dc.rights.embargodate2018-11-17
dc.identifier.eissn1471-6771
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1093/bja/aex328
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-12-01
rioxxterms.typeJournal Article/Review


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record


All items in PEARL are protected by copyright law.
Author manuscripts deposited to comply with open access mandates are made available in accordance with publisher policies. Please cite only the published version using the details provided on the item record or document. In the absence of an open licence (e.g. Creative Commons), permissions for further reuse of content should be sought from the publisher or author.
Theme by 
Atmire NV