Mosaic tetracycline resistance genes encoding ribosomal protection proteins
Date
2016-08-03Author
Warburton, Philip
Amodeo, N
Roberts, AP
Subject
Animals Bacteria Bacterial Proteins Genes, Bacterial Humans Recombinant Proteins Tetracycline Resistance
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Show full item recordAbstract
First reported in 2003, mosaic tetracycline resistance genes are a subgroup of the genes encoding ribosomal protection proteins (RPPs). They are formed when two or more RPP-encoding genes recombine resulting in a functional chimera. To date, the majority of mosaic genes are derived from sections of three RPP genes, tet(O), tet(W) and tet(32), with others comprising tet(M) and tet(S). In this first review of mosaic genes, we report on their structure, diversity and prevalence, and suggest that these genes may be responsible for an under-reported contribution to tetracycline resistance in bacteria.
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Publisher
Oxford University Press (OUP)
Place of Publication
England
Journal
Journal of Antimicrobial Chemotherapy
Volume
71
Issue
12
Pagination
dkw304-dkw304
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