School of Biomedical Sciences
Recent Submissions
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Non-allergist healthcare workers views on delivering a penicillin allergy de-labelling inpatient pathway: identifying the barriers and enablers
(Oxford University Press (OUP), 2023-12-28)Background Non-allergist delivered PADL is supported by UK and World Health Organization guidelines but is not yet routine in UK hospitals. Understanding the views of healthcare workers (HCWs) on managing patients with ... -
Mitochondrial involvement in sarcopenia
Sarcopenia lowers the quality‐of‐life for millions of people across the world, as accelerated loss of skeletal muscle mass and function contributes to both age‐ and disease‐related frailty. Physical activity remains the ... -
Amplifying PCR productivity and environmental sustainability through shortened cycling protocols
(Elsevier BVFrance, 2024-01)Since its inception in the 1980s, advancements in PCR technology using improved thermal cyclers, engineered DNA polymerases and commercial master mixes, have led to increased PCR productivity. Despite these advancements, ... -
Midterm Clinical Outcomes of Reimplantation Versus Remodeling Valve-Sparing Aortic Root Replacement in Patients With Connective Tissue Disorders: A Meta-Analysis
(Elsevier BVUnited States, 2024-02)This meta-analysis aimed to compare the midterm clinical outcomes of reimplantation versus remodeling techniques for valve-sparing aortic root replacement (VSARR) in patients with connective tissue disorders (CTDs). Studies ... -
Runx2 regulates peripheral nerve regeneration to promote Schwann cell migration and re-myelination
(MedknowIndia, 2024-07)Runx2 is a major regulator of osteoblast differentiation and function; however, the role of Runx2 in peripheral nerve repair is unclear. Here, we analyzed Runx2 expression following injury and found that it was specifically ... -
Transcatheter aortic valve implantation versus surgical aortic valve replacement in dialysis-dependent patients: a meta-analysis
(Ovid Technologies (Wolters Kluwer Health)United States, 2023-09)<jats:sec> <jats:title>Objectives</jats:title> <jats:p>This meta-analysis aims to compare the clinical outcomes of transcatheter aortic valve implantation (TAVI) versus aortic valve replacement ... -
Hypertension alters the function and expression profile of the peptide cotransporters PEPT1 and PEPT2 in the rodent renal proximal tubule
(Springer Science and Business Media LLCAustria, 2022-07)Hypertension is a major risk factor for kidney and cardiovascular disease. The treatment of hypertensive individuals by selected ACE inhibitors and certain di-and tripeptides halts the progression of renal deterioration ... -
Effect of ageing and hypertension on the expression and activity of PEPT2 in normal and hypertrophic hearts
(Springer Science and Business Media LLCAustria, 2021-02)Some dipeptides have been implicated in myocardial protection, but little is known about their membrane transporter PEPT2. The aim of this study was to determine whether the expression and activity of the cardiac-type ... -
Effect of methionine feeding on oxidative stress, intracellular calcium and contractility in cardiomyocytes isolated from male and female rats
(Springer Science and Business Media LLCNetherlands, 2021-05)Homocysteine (Hcy) is a breakdown product of methionine metabolism. The risk of cardiovascular disease (CVD) correlates with an increase in plasma Hcy levels. The aim of this study was to investigate whether 1% methionine ...