Presentation, management, and outcomes of cauda equina syndrome up to one year after surgery, using clinician and participant reporting: a multi-centre prospective cohort study
dc.contributor.author | Woodfield, J | |
dc.contributor.author | Hoeritzauer, I | |
dc.contributor.author | Jamjoom, AAB | |
dc.contributor.author | Jung, J | |
dc.contributor.author | Lammy, S | |
dc.contributor.author | Pronin, S | |
dc.contributor.author | Hannan, CJ | |
dc.contributor.author | Watts, A | |
dc.contributor.author | Hughes, L | |
dc.contributor.author | Moon, RDC | |
dc.contributor.author | Darwish, S | |
dc.contributor.author | Roy, H | |
dc.contributor.author | Copley, PC | |
dc.contributor.author | Poon, MTC | |
dc.contributor.author | Thorpe, P | |
dc.contributor.author | Srikandarajah, N | |
dc.contributor.author | Grahovac, G | |
dc.contributor.author | Demetriades, AK | |
dc.contributor.author | Eames, N | |
dc.contributor.author | Sell, PJ | |
dc.contributor.author | Statham, PFX | |
dc.contributor.author | Abdelsadg, M | |
dc.contributor.author | Abulaila, MMS | |
dc.contributor.author | Ahmed, U | |
dc.contributor.author | Ajmi, Q | |
dc.contributor.author | Al-Mahfoudh, R | |
dc.contributor.author | Ali, C | |
dc.contributor.author | Amarouche, M | |
dc.contributor.author | Andalib, A | |
dc.contributor.author | Arora, M | |
dc.contributor.author | Arora, M | |
dc.contributor.author | Awan, M | |
dc.contributor.author | Baig Mirza, A | |
dc.contributor.author | Bateman, A | |
dc.contributor.author | Bennett, I | |
dc.contributor.author | Bhatti, I | |
dc.contributor.author | Bodkin, P | |
dc.contributor.author | Bommireddy, L | |
dc.contributor.author | Bonanos, G | |
dc.contributor.author | Borg, A | |
dc.contributor.author | Boukas, A | |
dc.contributor.author | Bourne, J | |
dc.contributor.author | Brennan, R | |
dc.contributor.author | Brown, J | |
dc.contributor.author | Brown, K | |
dc.contributor.author | Burton, O | |
dc.contributor.author | Busby, C | |
dc.contributor.author | Chiverton, N | |
dc.contributor.author | Clark, S | |
dc.contributor.author | Copley, PC | |
dc.contributor.author | Cudlip, S | |
dc.contributor.author | Cunningham, Y | |
dc.contributor.author | Dardis, R | |
dc.contributor.author | Darwish, S | |
dc.contributor.author | Davies, B | |
dc.contributor.author | Demetriades, AK | |
dc.contributor.author | Deore, S | |
dc.contributor.author | Derham, C | |
dc.contributor.author | Dherijha, M | |
dc.contributor.author | Dobson, G | |
dc.contributor.author | Duncan, J | |
dc.contributor.author | Durnford, A | |
dc.contributor.author | Durst, AZE | |
dc.contributor.author | Dyson, EW | |
dc.contributor.author | Eames, N | |
dc.contributor.author | Edlmann, Ellie | |
dc.contributor.author | Edwards-Bailey, A | |
dc.contributor.author | Elserius, A | |
dc.contributor.author | Elson, B | |
dc.contributor.author | Fadelalla, M | |
dc.contributor.author | Fountain, DM | |
dc.contributor.author | Gardner, A | |
dc.contributor.author | Ghosh, A | |
dc.contributor.author | Gill, JR | |
dc.contributor.author | Glasmacher, SA | |
dc.contributor.author | Gordon, R | |
dc.contributor.author | Grahovac, G | |
dc.contributor.author | Grenfell, R | |
dc.contributor.author | Habeebullah, A | |
dc.contributor.author | Haliasos, N | |
dc.contributor.author | Hammett, T | |
dc.contributor.author | Hannan, CJ | |
dc.contributor.author | Hill, CS | |
dc.contributor.author | Hoeritzauer, I | |
dc.contributor.author | Holmes, D | |
dc.contributor.author | Hossain-Ibrahim, K | |
dc.contributor.author | Hughes, L | |
dc.contributor.author | Hussain, M | |
dc.contributor.author | Hussain, S | |
dc.contributor.author | Ibrahim, R | |
dc.contributor.author | Jamjoom, AAB | |
dc.contributor.author | John, B | |
dc.contributor.author | Joshi, S | |
dc.contributor.author | Jung, J | |
dc.contributor.author | Kennion, O | |
dc.contributor.author | Khan, M | |
dc.contributor.author | Klejnotowska, A | |
dc.contributor.author | Kumaria, A | |
dc.contributor.author | LaCava, R | |
dc.contributor.author | Lammy, S | |
dc.contributor.author | Lawrence, A | |
dc.contributor.author | Lea, M | |
dc.contributor.author | Leung, AHC | |
dc.contributor.author | Liew, I | |
dc.contributor.author | Luo, W | |
dc.contributor.author | MacCormac, O | |
dc.contributor.author | Manfield, J | |
dc.contributor.author | Mannion, R | |
dc.contributor.author | Merola, J | |
dc.contributor.author | Mishra, P | |
dc.contributor.author | Mohmoud, KA | |
dc.contributor.author | Moon, R | |
dc.contributor.author | Morrison, R | |
dc.contributor.author | Murray, O | |
dc.contributor.author | Nader-Sepahi, A | |
dc.contributor.author | Nnandi, C | |
dc.contributor.author | Pandit, A | |
dc.contributor.author | Patel, N | |
dc.contributor.author | Philip, A | |
dc.contributor.author | Poon, MTC | |
dc.contributor.author | Prasad, KSM | |
dc.contributor.author | Pronin, S | |
dc.contributor.author | Pujara, S | |
dc.contributor.author | Purushothaman, B | |
dc.contributor.author | Rajwani, K | |
dc.contributor.author | Rasul, FT | |
dc.contributor.author | Roy, Holly | |
dc.contributor.author | Sadek, A-R | |
dc.contributor.author | Schramm, M | |
dc.contributor.author | Scicluna, G | |
dc.contributor.author | Sell, PJ | |
dc.contributor.author | Shafafy, R | |
dc.contributor.author | Sharma, H | |
dc.contributor.author | Sheikh, A | |
dc.contributor.author | Sivasubramaniam, V | |
dc.contributor.author | Sofela, A | |
dc.contributor.author | Spink, G | |
dc.contributor.author | Srikandarajah, N | |
dc.contributor.author | Statham, PFX | |
dc.contributor.author | Stokes, S | |
dc.contributor.author | Strachan, E | |
dc.contributor.author | Thakar, C | |
dc.contributor.author | Thanabalasundaram, G | |
dc.contributor.author | Thorpe, P | |
dc.contributor.author | Ulbricht, C | |
dc.contributor.author | Watts, A | |
dc.contributor.author | Whitcher, A | |
dc.contributor.author | White, D | |
dc.contributor.author | Whitehouse, K | |
dc.contributor.author | Wilby, M | |
dc.contributor.author | Woodfield, J | |
dc.contributor.author | Zolnourian, A | |
dc.date.accessioned | 2023-02-14T12:37:09Z | |
dc.date.issued | 2023-01 | |
dc.identifier.issn | 2666-7762 | |
dc.identifier.issn | 2666-7762 | |
dc.identifier.other | 100545 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/20355 | |
dc.description.abstract |
BACKGROUND: Cauda equina syndrome (CES) results from nerve root compression in the lumbosacral spine, usually due to a prolapsed intervertebral disc. Evidence for management of CES is limited by its infrequent occurrence and lack of standardised clinical definitions and outcome measures. METHODS: This is a prospective multi-centre observational cohort study of adults with CES in the UK. We assessed presentation, investigation, management, and all Core Outcome Set domains up to one year post-operatively using clinician and participant reporting. Univariable and multivariable associations with the Oswestry Disability Index (ODI) and urinary outcomes were investigated. FINDINGS: In 621 participants with CES, catheterisation for urinary retention was required pre-operatively in 31% (191/615). At discharge, only 13% (78/616) required a catheter. Median time to surgery from symptom onset was 3 days (IQR:1-8) with 32% (175/545) undergoing surgery within 48 h. Earlier surgery was associated with catheterisation (OR:2.2, 95%CI:1.5-3.3) but not with admission ODI or radiological compression. In multivariable analyses catheter requirement at discharge was associated with pre-operative catheterisation (OR:10.6, 95%CI:5.8-20.4) and one-year ODI was associated with presentation ODI (r = 0.3, 95%CI:0.2-0.4), but neither outcome was associated with time to surgery or radiological compression. Additional healthcare services were required by 65% (320/490) during one year follow up. INTERPRETATION: Post-operative functional improvement occurred even in those presenting with urinary retention. There was no association between outcomes and time to surgery in this observational study. Significant healthcare needs remained post-operatively. FUNDING: DCN Endowment Fund funded study administration. Castor EDC provided database use. No other study funding was received. | |
dc.format.extent | 100545-100545 | |
dc.format.medium | Electronic-eCollection | |
dc.language | en | |
dc.language.iso | eng | |
dc.publisher | Elsevier BV | |
dc.subject | Back pain | |
dc.subject | Cauda equina syndrome | |
dc.subject | Cohort study | |
dc.subject | Spinal surgery | |
dc.subject | Urinary retention | |
dc.title | Presentation, management, and outcomes of cauda equina syndrome up to one year after surgery, using clinician and participant reporting: a multi-centre prospective cohort study | |
dc.type | journal-article | |
dc.type | Journal Article | |
plymouth.author-url | https://www.ncbi.nlm.nih.gov/pubmed/36426378 | |
plymouth.volume | 24 | |
plymouth.publication-status | Published | |
plymouth.journal | The Lancet Regional Health - Europe | |
dc.identifier.doi | 10.1016/j.lanepe.2022.100545 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Medical School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/FoH - Applied Parkinson's Research | |
plymouth.organisational-group | /Plymouth/Research Groups/Plymouth Institute of Health and Care Research (PIHR) | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
plymouth.organisational-group | /Plymouth/Users by role/Researchers in ResearchFish submission | |
dc.publisher.place | England | |
dcterms.dateAccepted | 2022-10-27 | |
dc.rights.embargodate | 2023-2-15 | |
dc.identifier.eissn | 2666-7762 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1016/j.lanepe.2022.100545 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2023-01 | |
rioxxterms.type | Journal Article/Review |