Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease
dc.contributor.author | Jost, ST | |
dc.contributor.author | Visser-Vandewalle, V | |
dc.contributor.author | Rizos, A | |
dc.contributor.author | Loehrer, PA | |
dc.contributor.author | Silverdale, M | |
dc.contributor.author | Evans, J | |
dc.contributor.author | Samuel, M | |
dc.contributor.author | Petry-Schmelzer, JN | |
dc.contributor.author | Sauerbier, A | |
dc.contributor.author | Gronostay, A | |
dc.contributor.author | Barbe, MT | |
dc.contributor.author | Fink, GR | |
dc.contributor.author | Ashkan, K | |
dc.contributor.author | Antonini, A | |
dc.contributor.author | Martinez-Martin, P | |
dc.contributor.author | Chaudhuri, KR | |
dc.contributor.author | Timmermann, L | |
dc.contributor.author | Dafsari, HS | |
dc.contributor.author | Bhidayasiri, R | |
dc.contributor.author | Falup-Pecurariu, C | |
dc.contributor.author | Jeon, B | |
dc.contributor.author | Leta, V | |
dc.contributor.author | Borghammer, P | |
dc.contributor.author | Odin, P | |
dc.contributor.author | Schrag, A | |
dc.contributor.author | Storch, A | |
dc.contributor.author | Violante, MR | |
dc.contributor.author | Weintraub, D | |
dc.contributor.author | Adler, C | |
dc.contributor.author | Barone, P | |
dc.contributor.author | Brooks, DJ | |
dc.contributor.author | Brown, R | |
dc.contributor.author | Cantillon, M | |
dc.contributor.author | Carroll, Camille | |
dc.contributor.author | Coelho, M | |
dc.contributor.author | Henriksen, T | |
dc.contributor.author | Hu, M | |
dc.contributor.author | Jenner, P | |
dc.contributor.author | Kramberger, M | |
dc.contributor.author | Kumar, P | |
dc.contributor.author | Kurtis, M | |
dc.contributor.author | Lewis, S | |
dc.contributor.author | Litvan, I | |
dc.contributor.author | Lyons, K | |
dc.contributor.author | Martino, D | |
dc.contributor.author | Masellis, M | |
dc.contributor.author | Mochizuki, H | |
dc.contributor.author | Morley, JF | |
dc.contributor.author | Nirenberg, M | |
dc.contributor.author | Pagonabarraga, J | |
dc.contributor.author | Panicker, J | |
dc.contributor.author | Pavese, N | |
dc.contributor.author | Pekkonen, E | |
dc.contributor.author | Postuma, R | |
dc.contributor.author | Rosales, R | |
dc.contributor.author | Schapira, A | |
dc.contributor.author | Simuni, T | |
dc.contributor.author | Stocchi, F | |
dc.contributor.author | Subramanian, I | |
dc.contributor.author | Tagliati, M | |
dc.contributor.author | Tinazzi, M | |
dc.contributor.author | Toledo, J | |
dc.contributor.author | Tsuboi, Y | |
dc.contributor.author | Walker, R | |
dc.date.accessioned | 2021-08-09T12:34:52Z | |
dc.date.available | 2021-08-09T12:34:52Z | |
dc.date.issued | 2021-06-08 | |
dc.identifier.issn | 2090-8083 | |
dc.identifier.issn | 2373-8057 | |
dc.identifier.other | 48 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/17493 | |
dc.description.abstract |
<jats:title>Abstract</jats:title><jats:p>To identify predictors of 36-month follow-up quality of life (QoL) outcome after bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson’s disease (PD). In this ongoing, prospective, multicenter international study (Cologne, Manchester, London) including 73 patients undergoing STN-DBS, we assessed the following scales preoperatively and at 6-month and 36-month follow-up: PD Questionnaire-8 (PDQ-8), NMSScale (NMSS), Scales for Outcomes in PD (SCOPA)-motor examination, -activities of daily living, and -complications, and levodopa equivalent daily dose (LEDD). We analyzed factors associated with QoL improvement at 36-month follow-up based on (1) correlations between baseline test scores and QoL improvement, (2) step-wise linear regressions with baseline test scores as independent and QoL improvement as dependent variables, (3) logistic regressions and receiver operating characteristic curves using a dichotomized variable “QoL responders”/“non-responders”. At both follow-ups, NMSS total score, SCOPA-motor examination, and -complications improved and LEDD was reduced significantly. PDQ-8 improved at 6-month follow-up with subsequent decrements in gains at 36-month follow-up when 61.6% of patients were categorized as “QoL non-responders”. Correlations, linear, and logistic regression analyses found greater PDQ-8 improvements in patients with younger age, worse PDQ-8, and worse specific NMS at baseline, such as ‘difficulties experiencing pleasure’ and ‘problems sustaining concentration’. Baseline SCOPA scores were not associated with PDQ-8 changes. Our results provide evidence that 36-month QoL changes depend on baseline neuropsychological and neuropsychiatric non-motor symptoms burden. These findings highlight the need for an assessment of a wide range of non-motor and motor symptoms when advising and selecting individuals for DBS therapy.</jats:p> | |
dc.format.extent | 48- | |
dc.format.medium | Electronic | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Hindawi | |
dc.subject | EUROPAR and the International Parkinson and Movement Disorders Society Non-Motor Parkinson’s Disease Study Group | |
dc.title | Non-motor predictors of 36-month quality of life after subthalamic stimulation in Parkinson disease | |
dc.type | journal-article | |
dc.type | Journal Article | |
plymouth.author-url | https://www.ncbi.nlm.nih.gov/pubmed/34103534 | |
plymouth.issue | 1 | |
plymouth.volume | 7 | |
plymouth.publication-status | Published online | |
plymouth.journal | Parkinson's Disease | |
dc.identifier.doi | 10.1038/s41531-021-00174-x | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Medical School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/FoH - Applied Parkinson's Research | |
plymouth.organisational-group | /Plymouth/Research Groups/FoH - Community and Primary Care | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CCT&PS | |
plymouth.organisational-group | /Plymouth/Research Groups/Plymouth Institute of Health and Care Research (PIHR) | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dc.publisher.place | United States | |
dcterms.dateAccepted | 2021-02-19 | |
dc.rights.embargodate | 2021-8-11 | |
dc.identifier.eissn | 2373-8057 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1038/s41531-021-00174-x | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2021-06-08 | |
rioxxterms.type | Journal Article/Review |