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dc.contributor.authorEdlmann, Een
dc.contributor.authorGiorgi-Coll, Sen
dc.contributor.authorWhitfield, PCen
dc.contributor.authorCarpenter, KLHen
dc.contributor.authorHutchinson, PJen
dc.date.accessioned2019-11-25T21:44:41Z
dc.date.available2019-11-25T21:44:41Z
dc.date.issued2017-05-30en
dc.identifier.urihttp://hdl.handle.net/10026.1/15180
dc.description.abstract

Chronic subdural haematoma (CSDH) is an encapsulated collection of blood and fluid on the surface of the brain. Historically considered a result of head trauma, recent evidence suggests there are more complex processes involved. Trauma may be absent or very minor and does not explain the progressive, chronic course of the condition. This review focuses on several key processes involved in CSDH development: angiogenesis, fibrinolysis and inflammation. The characteristic membrane surrounding the CSDH has been identified as a source of fluid exudation and haemorrhage. Angiogenic stimuli lead to the creation of fragile blood vessels within membrane walls, whilst fibrinolytic processes prevent clot formation resulting in continued haemorrhage. An abundance of inflammatory cells and markers have been identified within the membranes and subdural fluid and are likely to contribute to propagating an inflammatory response which stimulates ongoing membrane growth and fluid accumulation. Currently, the mainstay of treatment for CSDH is surgical drainage, which has associated risks of recurrence requiring repeat surgery. Understanding of the underlying pathophysiological processes has been applied to developing potential drug treatments. Ongoing research is needed to identify if these therapies are successful in controlling the inflammatory and angiogenic disease processes leading to control and resolution of CSDH.

en
dc.format.extent108 - ?en
dc.languageengen
dc.language.isoengen
dc.subjectAngiogenesisen
dc.subjectChronic subdural haematomaen
dc.subjectDrug therapyen
dc.subjectHead injuryen
dc.subjectInflammationen
dc.subjectAnimalsen
dc.subjectHematoma, Subdural, Chronicen
dc.subjectHumansen
dc.subjectInflammationen
dc.subjectNeovascularization, Pathologicen
dc.titlePathophysiology of chronic subdural haematoma: inflammation, angiogenesis and implications for pharmacotherapy.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/28558815en
plymouth.issue1en
plymouth.volume14en
plymouth.publication-statusPublished onlineen
plymouth.journalJ Neuroinflammationen
dc.identifier.doi10.1186/s12974-017-0881-yen
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Professional Services staff
plymouth.organisational-group/Plymouth/Faculty of Health: Medicine, Dentistry and Human Sciences
plymouth.organisational-group/Plymouth/Faculty of Health: Medicine, Dentistry and Human Sciences/Peninsula Medical School
dc.publisher.placeEnglanden
dcterms.dateAccepted2017-05-15en
dc.identifier.eissn1742-2094en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1186/s12974-017-0881-yen
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-05-30en
rioxxterms.typeJournal Article/Reviewen


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