Peninsula Medical School: Recent submissions
Now showing items 1-10 of 1204
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Evaluating the clinical and cost-effectiveness of a conservative approach to oxygen therapy for invasively ventilated adults in intensive care: Protocol for the UK-ROX trial
(SAGE Publications, 2024)<jats:sec><jats:title>Background:</jats:title><jats:p> In the United Kingdom, around 184,000 adults are admitted to an intensive care unit (ICU) each year with over 30% receiving mechanical ventilation. Oxygen is the ... -
Transformation of autophagic SQSTM1 droplets to SQSTM1-dependent P-bodies
(Informa UK LimitedUnited States, 2024)SQSTM1/p62 droplets play crucial roles in droplets-based macroautophagy/autophagy including selective autophagy and bulk autophagy. We observed that under several stress milieus, SQSTM1 droplets entirely colocalize with ... -
A dominant-negative regulatory mechanism of SQSTM1 droplets-based autophagy
(Informa UK LimitedUnited States, 2022-04-03)SQSTM1/p62 is an autophagy receptor, forming droplets to sequester intracellular polyubiquitinated cargo and mediate its delivery for autophagic clearance. SQSTM1 droplets can function as platforms to allow the formation ... -
Lowering Mutant Huntingtin Levels and Toxicity: Autophagy-Endolysosome Pathways in Huntington's Disease
(Elsevier BVNetherlands, 2020-04)Huntington's disease (HD) is a monogenetic neurodegenerative disease, which serves as a model of neurodegeneration with protein aggregation. Autophagy has been suggested to possess a great value to tackle protein aggregation ... -
Ethnic Inequalities in Sentencing: Evidence from the Crown Court in England and Wales
(Oxford University Press (OUP), 2024) -
How to facilitate NHS professionals to recognise and use skills gained from global health engagement when back in the UK workforce? A participatory action research project to design, pilot and evaluate a series of online leadership workshops
(BMJEngland, 2024-03)<jats:sec><jats:title>Objectives</jats:title><jats:p>Leadership knowledge and skills are known to be developed by health professionals during global health experiences overseas. However, volunteers struggle to recognise ... -
Perioperative oxygenation-what's the stress?
(ElsevierEngland, 2024-06)Oxygen is the most used drug in anaesthesia. Despite such widespread use, optimal perioperative oxygen administration remains highly controversial because of concerns about the competing harms of both hyperoxia and hypoxia. ... -
Standard setting anchor statements: a double cross-over trial of two different methods.
(2021-01)This article was migrated. The article was marked as recommended. Context: We challenge the philosophical acceptability of the Angoff method, and propose an alternative method of standard setting based on how important ... -
Histone H3F3/H3.3 chaperone DAXX converts to modulate SQSTM1 phase condensation for NFE2L2 activation
(Informa UK LimitedUnited States, 2020-01-02)Macroautophagy/autophagy cargo receptor SQSTM1/p62 puncta or clustering formation is critical for its function in cargo recognition and LC3 interaction. Evidence suggests that SQSTM1 puncta formation is a process of ... -
Making progression and award decisions.
(2017-01)This article was migrated. The article was marked as recommended. It is incumbent on medical schools to show, both to regulatory bodies and to the public at large, that their graduating students are "fit for purpose" as ...