Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes
dc.contributor.author | Ruderfer, DM | |
dc.contributor.author | Ripke, S | |
dc.contributor.author | McQuillin, A | |
dc.contributor.author | Boocock, J | |
dc.contributor.author | Stahl, EA | |
dc.contributor.author | Pavlides, JMW | |
dc.contributor.author | Mullins, N | |
dc.contributor.author | Charney, AW | |
dc.contributor.author | Ori, APS | |
dc.contributor.author | Loohuis, LMO | |
dc.contributor.author | Domenici, E | |
dc.contributor.author | Di Florio, A | |
dc.contributor.author | Papiol, S | |
dc.contributor.author | Kalman, JL | |
dc.contributor.author | Trubetskoy, V | |
dc.contributor.author | Adolfsson, R | |
dc.contributor.author | Agartz, I | |
dc.contributor.author | Agerbo, E | |
dc.contributor.author | Akil, H | |
dc.contributor.author | Albani, D | |
dc.contributor.author | Albus, M | |
dc.contributor.author | Alda, M | |
dc.contributor.author | Alexander, M | |
dc.contributor.author | Alliey-Rodriguez, N | |
dc.contributor.author | Als, TD | |
dc.contributor.author | Amin, F | |
dc.contributor.author | Anjorin, A | |
dc.contributor.author | Arranz, MJ | |
dc.contributor.author | Awasthi, S | |
dc.contributor.author | Bacanu, SA | |
dc.contributor.author | Badner, JA | |
dc.contributor.author | Baekvad-Hansen, M | |
dc.contributor.author | Bakker, S | |
dc.contributor.author | Band, G | |
dc.contributor.author | Barchas, JD | |
dc.contributor.author | Barroso, I | |
dc.contributor.author | Bass, N | |
dc.contributor.author | Bauer, M | |
dc.contributor.author | Baune, BT | |
dc.contributor.author | Begemann, M | |
dc.contributor.author | Bellenguez, C | |
dc.contributor.author | Belliveau, RA | |
dc.contributor.author | Bellivier, F | |
dc.contributor.author | Bender, S | |
dc.contributor.author | Bene, J | |
dc.contributor.author | Bergen, SE | |
dc.contributor.author | Berrettini, WH | |
dc.contributor.author | Bevilacqua, E | |
dc.contributor.author | Biernacka, JM | |
dc.contributor.author | Bigdeli, TB | |
dc.contributor.author | Black, DW | |
dc.contributor.author | Blackburn, H | |
dc.contributor.author | Blackwell, JM | |
dc.contributor.author | Blackwood, DHR | |
dc.contributor.author | Pedersen, CB | |
dc.contributor.author | Boehnke, M | |
dc.contributor.author | Boks, M | |
dc.contributor.author | Borglum, AD | |
dc.contributor.author | Bramon, E | |
dc.contributor.author | Breen, G | |
dc.contributor.author | Brown, MA | |
dc.contributor.author | Bruggeman, R | |
dc.contributor.author | Buccola, NG | |
dc.contributor.author | Buckner, RL | |
dc.contributor.author | Budde, M | |
dc.contributor.author | Bulik-Sullivan, B | |
dc.contributor.author | Bumpstead, SJ | |
dc.contributor.author | Bunney, W | |
dc.contributor.author | Burmeister, M | |
dc.contributor.author | Buxbaum, JD | |
dc.contributor.author | Bybjerg-Grauholm, J | |
dc.contributor.author | Byerley, W | |
dc.contributor.author | Cahn, W | |
dc.contributor.author | Cai, G | |
dc.contributor.author | Cairns, MJ | |
dc.contributor.author | Campion, D | |
dc.contributor.author | Cantor, RM | |
dc.contributor.author | Carr, VJ | |
dc.contributor.author | Carrera, N | |
dc.contributor.author | Casas, JP | |
dc.contributor.author | Casas, M | |
dc.contributor.author | Catts, SV | |
dc.contributor.author | Cervantes, P | |
dc.contributor.author | Chambert, KD | |
dc.contributor.author | Chan, RCK | |
dc.contributor.author | Chen, EYH | |
dc.contributor.author | Chen, RYL | |
dc.contributor.author | Cheng, W | |
dc.contributor.author | Cheung, EFC | |
dc.contributor.author | Chong, SA | |
dc.contributor.author | Clarke, T-K | |
dc.contributor.author | Cloninger, CR | |
dc.contributor.author | Cohen, D | |
dc.contributor.author | Cohen, N | |
dc.contributor.author | Coleman, JRI | |
dc.contributor.author | Collier, DA | |
dc.contributor.author | Cormican, P | |
dc.contributor.author | Coryell, W | |
dc.contributor.author | Craddock, N | |
dc.contributor.author | Craig, DW | |
dc.contributor.author | Crespo-Facorro, B | |
dc.contributor.author | Crowley, JJ | |
dc.contributor.author | Cruceanu, C | |
dc.contributor.author | Curtis, D | |
dc.contributor.author | Czerski, PM | |
dc.contributor.author | Dale, AM | |
dc.contributor.author | Daly, MJ | |
dc.contributor.author | Dannlowski, U | |
dc.contributor.author | Darvasi, A | |
dc.contributor.author | Davidson, M | |
dc.contributor.author | Davis, KL | |
dc.contributor.author | de Leeuw, CA | |
dc.contributor.author | Degenhardt, F | |
dc.contributor.author | Del Favero, J | |
dc.contributor.author | DeLisi, LE | |
dc.contributor.author | Deloukas, P | |
dc.contributor.author | Demontis, D | |
dc.contributor.author | DePaulo, JR | |
dc.contributor.author | di Forti, M | |
dc.contributor.author | Dikeos, D | |
dc.contributor.author | Dinan, T | |
dc.contributor.author | Djurovic, S | |
dc.contributor.author | Dobbyn, AL | |
dc.contributor.author | Donnelly, P | |
dc.contributor.author | Donohoe, G | |
dc.contributor.author | Drapeau, E | |
dc.contributor.author | Dronov, S | |
dc.contributor.author | Duan, J | |
dc.contributor.author | Dudbridge, F | |
dc.contributor.author | Duncanson, A | |
dc.contributor.author | Edenberg, H | |
dc.contributor.author | Edkins, S | |
dc.contributor.author | Ehrenreich, H | |
dc.contributor.author | Eichhammer, P | |
dc.contributor.author | Elvsashagen, T | |
dc.contributor.author | Eriksson, J | |
dc.contributor.author | Escott-Price, V | |
dc.contributor.author | Esko, T | |
dc.contributor.author | Essioux, L | |
dc.contributor.author | Etain, B | |
dc.contributor.author | Fan, CC | |
dc.contributor.author | Farh, K-H | |
dc.contributor.author | Farrell, MS | |
dc.contributor.author | Flickinger, M | |
dc.contributor.author | Foroud, TM | |
dc.contributor.author | Forty, L | |
dc.contributor.author | Frank, J | |
dc.contributor.author | Franke, L | |
dc.contributor.author | Fraser, C | |
dc.contributor.author | Freedman, R | |
dc.contributor.author | Freeman, C | |
dc.contributor.author | Freimer, NB | |
dc.contributor.author | Friedman, JI | |
dc.contributor.author | Fromer, M | |
dc.contributor.author | Frye, MA | |
dc.contributor.author | Fullerton, JM | |
dc.contributor.author | Gade, K | |
dc.contributor.author | Garnham, J | |
dc.contributor.author | Gaspar, HA | |
dc.contributor.author | Gejman, PV | |
dc.contributor.author | Genovese, G | |
dc.contributor.author | Georgieva, L | |
dc.contributor.author | Giambartolomei, C | |
dc.contributor.author | Giannoulatou, E | |
dc.contributor.author | Giegling, I | |
dc.contributor.author | Gill, M | |
dc.contributor.author | Gillman, M | |
dc.contributor.author | Pedersen, MG | |
dc.contributor.author | Giusti-Rodriguez, P | |
dc.contributor.author | Godard, S | |
dc.contributor.author | Goes, F | |
dc.contributor.author | Goldstein, JI | |
dc.contributor.author | Gopal, S | |
dc.contributor.author | Gordon, SD | |
dc.contributor.author | Gordon-Smith, K | |
dc.contributor.author | Gratten, J | |
dc.contributor.author | Gray, E | |
dc.contributor.author | Green, Elaine | |
dc.contributor.author | Green, MJ | |
dc.contributor.author | Greenwood, TA | |
dc.contributor.author | Grigoroiu-Serbanescu, M | |
dc.contributor.author | Grove, J | |
dc.contributor.author | Guan, W | |
dc.contributor.author | Gurling, H | |
dc.contributor.author | Parra, JG | |
dc.contributor.author | Gwilliam, R | |
dc.contributor.author | de Haan, L | |
dc.contributor.author | Hall, J | |
dc.contributor.author | Hall, M-H | |
dc.contributor.author | Hammer, C | |
dc.contributor.author | Hammond, N | |
dc.contributor.author | Hamshere, ML | |
dc.contributor.author | Hansen, M | |
dc.contributor.author | Hansen, T | |
dc.contributor.author | Haroutunian, V | |
dc.contributor.author | Hartmann, AM | |
dc.contributor.author | Hauser, J | |
dc.contributor.author | Hautzinger, M | |
dc.contributor.author | Heilbronner, U | |
dc.contributor.author | Hellenthal, G | |
dc.contributor.author | Henskens, FA | |
dc.contributor.author | Herms, S | |
dc.contributor.author | Hipolito, M | |
dc.contributor.author | Hirschhorn, JN | |
dc.contributor.author | Hoffmann, P | |
dc.contributor.author | Hollegaard, MV | |
dc.contributor.author | Hougaard, DM | |
dc.contributor.author | Huang, H | |
dc.contributor.author | Huckins, L | |
dc.contributor.author | Hultman, CM | |
dc.contributor.author | Hunt, SE | |
dc.contributor.author | Ikeda, M | |
dc.contributor.author | Iwata, N | |
dc.contributor.author | Iyegbe, C | |
dc.contributor.author | Jablensky, AV | |
dc.contributor.author | Jamain, S | |
dc.contributor.author | Jankowski, J | |
dc.contributor.author | Jayakumar, A | |
dc.contributor.author | Joa, I | |
dc.contributor.author | Jones, I | |
dc.contributor.author | Jones, LA | |
dc.contributor.author | Jonsson, EG | |
dc.contributor.author | Julia, A | |
dc.contributor.author | Jureus, A | |
dc.contributor.author | Kahler, AK | |
dc.contributor.author | Kahn, RS | |
dc.contributor.author | Kalaydjieva, L | |
dc.contributor.author | Kandaswamy, R | |
dc.contributor.author | Karachanak-Yankova, S | |
dc.contributor.author | Karjalainen, J | |
dc.contributor.author | Karlsson, R | |
dc.contributor.author | Kavanagh, D | |
dc.contributor.author | Keller, MC | |
dc.contributor.author | Kelly, BJ | |
dc.contributor.author | Kelsoe, J | |
dc.contributor.author | Kennedy, JL | |
dc.contributor.author | Khrunin, A | |
dc.contributor.author | Kim, Y | |
dc.contributor.author | Kirov, G | |
dc.contributor.author | Kittel-Schneider, S | |
dc.contributor.author | Klovins, J | |
dc.contributor.author | Knight, J | |
dc.contributor.author | Knott, SV | |
dc.contributor.author | Knowles, JA | |
dc.contributor.author | Kogevinas, M | |
dc.contributor.author | Konte, B | |
dc.contributor.author | Kravariti, E | |
dc.contributor.author | Kucinskas, V | |
dc.contributor.author | Kucinskiene, ZA | |
dc.contributor.author | Kupka, R | |
dc.contributor.author | Kuzelova-Ptackova, H | |
dc.contributor.author | Landen, M | |
dc.contributor.author | Langford, C | |
dc.contributor.author | Laurent, C | |
dc.contributor.author | Lawrence, J | |
dc.contributor.author | Lawrie, S | |
dc.contributor.author | Lawson, WB | |
dc.contributor.author | Leber, M | |
dc.contributor.author | Leboyer, M | |
dc.contributor.author | Lee, PH | |
dc.contributor.author | Keong, JLC | |
dc.contributor.author | Legge, SE | |
dc.contributor.author | Lencz, T | |
dc.contributor.author | Lerer, B | |
dc.contributor.author | Levinson, DF | |
dc.contributor.author | Levy, SE | |
dc.contributor.author | Lewis, CM | |
dc.contributor.author | Li, JZ | |
dc.contributor.author | Li, M | |
dc.contributor.author | Li, QS | |
dc.contributor.author | Li, T | |
dc.contributor.author | Liang, K-Y | |
dc.contributor.author | Liddle, J | |
dc.contributor.author | Lieberman, J | |
dc.contributor.author | Limborska, S | |
dc.contributor.author | Lin, K | |
dc.contributor.author | Linszen, DH | |
dc.contributor.author | Lissowska, J | |
dc.contributor.author | Liu, C | |
dc.contributor.author | Liu, J | |
dc.contributor.author | Lonnqvist, J | |
dc.contributor.author | Loughland, CM | |
dc.contributor.author | Lubinski, J | |
dc.contributor.author | Lucae, S | |
dc.contributor.author | Macek, M | |
dc.contributor.author | MacIntyre, DJ | |
dc.contributor.author | Magnusson, PKE | |
dc.contributor.author | Maher, BS | |
dc.contributor.author | Mahon, PB | |
dc.contributor.author | Maier, W | |
dc.contributor.author | Malhotra, AK | |
dc.contributor.author | Mallet, J | |
dc.contributor.author | Malt, UF | |
dc.contributor.author | Markus, HS | |
dc.contributor.author | Marsal, S | |
dc.contributor.author | Martin, NG | |
dc.contributor.author | Mata, I | |
dc.contributor.author | Mathew, CG | |
dc.contributor.author | Mattheisen, M | |
dc.contributor.author | Mattingsdal, M | |
dc.contributor.author | Mayoral, F | |
dc.contributor.author | McCann, OT | |
dc.contributor.author | McCarley, RW | |
dc.contributor.author | McCarroll, SA | |
dc.contributor.author | McCarthy, MI | |
dc.contributor.author | McDonald, C | |
dc.contributor.author | McElroy, SL | |
dc.contributor.author | McGuffin, P | |
dc.contributor.author | McInnis, MG | |
dc.contributor.author | McIntosh, AM | |
dc.contributor.author | McKay, JD | |
dc.contributor.author | McMahon, FJ | |
dc.contributor.author | Medeiros, H | |
dc.contributor.author | Medland, SE | |
dc.contributor.author | Meier, S | |
dc.contributor.author | Meijer, CJ | |
dc.contributor.author | Melegh, B | |
dc.contributor.author | Melle, I | |
dc.contributor.author | Meng, F | |
dc.contributor.author | Mesholam-Gately, RI | |
dc.contributor.author | Metspalu, A | |
dc.contributor.author | Michie, PT | |
dc.contributor.author | Milani, L | |
dc.contributor.author | Milanova, V | |
dc.contributor.author | Mitchell, PB | |
dc.contributor.author | Mokrab, Y | |
dc.contributor.author | Montgomery, GW | |
dc.contributor.author | Moran, JL | |
dc.contributor.author | Morken, G | |
dc.contributor.author | Morris, DW | |
dc.contributor.author | Mors, O | |
dc.contributor.author | Mortensen, PB | |
dc.contributor.author | Mowry, BJ | |
dc.contributor.author | Mühleisen, TW | |
dc.contributor.author | Müller-Myhsok, B | |
dc.contributor.author | Murphy, KC | |
dc.contributor.author | Murray, RM | |
dc.contributor.author | Myers, RM | |
dc.contributor.author | Myin-Germeys, I | |
dc.contributor.author | Neale, BM | |
dc.contributor.author | Nelis, M | |
dc.contributor.author | Nenadic, I | |
dc.contributor.author | Nertney, DA | |
dc.contributor.author | Nestadt, G | |
dc.contributor.author | Nicodemus, KK | |
dc.contributor.author | Nievergelt, CM | |
dc.contributor.author | Nikitina-Zake, L | |
dc.contributor.author | Nimgaonkar, V | |
dc.contributor.author | Nisenbaum, L | |
dc.contributor.author | Nordentoft, M | |
dc.contributor.author | Nordin, A | |
dc.contributor.author | Nöthen, MM | |
dc.contributor.author | Nwulia, EA | |
dc.contributor.author | O’Callaghan, E | |
dc.contributor.author | O’Donovan, C | |
dc.contributor.author | O’Dushlaine, C | |
dc.contributor.author | O’Neill, FA | |
dc.contributor.author | Oedegaard, KJ | |
dc.contributor.author | Oh, S-Y | |
dc.contributor.author | Olincy, A | |
dc.contributor.author | Olsen, L | |
dc.contributor.author | Oruc, L | |
dc.contributor.author | Van Os, J | |
dc.contributor.author | Owen, MJ | |
dc.contributor.author | Paciga, SA | |
dc.contributor.author | Palmer, CNA | |
dc.contributor.author | Palotie, A | |
dc.contributor.author | Pantelis, C | |
dc.contributor.author | Papadimitriou, GN | |
dc.contributor.author | Parkhomenko, E | |
dc.contributor.author | Pato, C | |
dc.contributor.author | Pato, MT | |
dc.contributor.author | Paunio, T | |
dc.contributor.author | Pearson, R | |
dc.contributor.author | Perkins, DO | |
dc.contributor.author | Perlis, RH | |
dc.contributor.author | Perry, A | |
dc.contributor.author | Pers, TH | |
dc.contributor.author | Petryshen, TL | |
dc.contributor.author | Pfennig, A | |
dc.contributor.author | Picchioni, M | |
dc.contributor.author | Pietilainen, O | |
dc.contributor.author | Pimm, J | |
dc.contributor.author | Pirinen, M | |
dc.contributor.author | Plomin, R | |
dc.contributor.author | Pocklington, AJ | |
dc.contributor.author | Posthuma, D | |
dc.contributor.author | Potash, JB | |
dc.contributor.author | Potter, SC | |
dc.contributor.author | Powell, J | |
dc.contributor.author | Price, A | |
dc.contributor.author | Pulver, AE | |
dc.contributor.author | Purcell, SM | |
dc.contributor.author | Quested, D | |
dc.contributor.author | Ramos-Quiroga, JA | |
dc.contributor.author | Rasmussen, HB | |
dc.contributor.author | Rautanen, A | |
dc.contributor.author | Ravindrarajah, R | |
dc.contributor.author | Regeer, EJ | |
dc.contributor.author | Reichenberg, A | |
dc.contributor.author | Reif, A | |
dc.contributor.author | Reimers, MA | |
dc.contributor.author | Ribases, M | |
dc.contributor.author | Rice, JP | |
dc.contributor.author | Richards, AL | |
dc.contributor.author | Ricketts, M | |
dc.contributor.author | Riley, BP | |
dc.contributor.author | Rivas, F | |
dc.contributor.author | Rivera, M | |
dc.contributor.author | Roffman, JL | |
dc.contributor.author | Rouleau, GA | |
dc.contributor.author | Roussos, P | |
dc.contributor.author | Rujescu, D | |
dc.contributor.author | Salomaa, V | |
dc.contributor.author | Sanchez-Mora, C | |
dc.contributor.author | Sanders, AR | |
dc.contributor.author | Sawcer, SJ | |
dc.contributor.author | Schall, U | |
dc.contributor.author | Schatzberg, AF | |
dc.contributor.author | Scheftner, WA | |
dc.contributor.author | Schofield, PR | |
dc.contributor.author | Schork, NJ | |
dc.contributor.author | Schwab, SG | |
dc.contributor.author | Scolnick, EM | |
dc.contributor.author | Scott, LJ | |
dc.contributor.author | Scott, RJ | |
dc.contributor.author | Seidman, LJ | |
dc.contributor.author | Serretti, A | |
dc.contributor.author | Sham, PC | |
dc.contributor.author | Weickert, CS | |
dc.contributor.author | Shehktman, T | |
dc.contributor.author | Shi, J | |
dc.contributor.author | Shilling, PD | |
dc.contributor.author | Sigurdsson, E | |
dc.contributor.author | Silverman, JM | |
dc.contributor.author | Sim, K | |
dc.contributor.author | Slaney, C | |
dc.contributor.author | Slominsky, P | |
dc.contributor.author | Smeland, OB | |
dc.contributor.author | Smoller, JW | |
dc.contributor.author | So, H-C | |
dc.contributor.author | Sobell, JL | |
dc.contributor.author | Soderman, E | |
dc.contributor.author | Hansen, CS | |
dc.contributor.author | Spencer, CCA | |
dc.contributor.author | Spijker, AT | |
dc.contributor.author | St Clair, D | |
dc.contributor.author | Stefansson, H | |
dc.contributor.author | Stefansson, K | |
dc.contributor.author | Steinberg, S | |
dc.contributor.author | Stogmann, E | |
dc.contributor.author | Stordal, E | |
dc.contributor.author | Strange, A | |
dc.contributor.author | Straub, RE | |
dc.contributor.author | Strauss, JS | |
dc.contributor.author | Streit, F | |
dc.contributor.author | Strengman, E | |
dc.contributor.author | Strohmaier, J | |
dc.contributor.author | Stroup, TS | |
dc.contributor.author | Su, Z | |
dc.contributor.author | Subramaniam, M | |
dc.contributor.author | Suvisaari, J | |
dc.contributor.author | Svrakic, DM | |
dc.contributor.author | Szatkiewicz, JP | |
dc.contributor.author | Szelinger, S | |
dc.contributor.author | Tashakkori-Ghanbaria, A | |
dc.contributor.author | Thirumalai, S | |
dc.contributor.author | Thompson, RC | |
dc.contributor.author | Thorgeirsson, TE | |
dc.contributor.author | Toncheva, D | |
dc.contributor.author | Tooney, PA | |
dc.contributor.author | Tosato, S | |
dc.contributor.author | Toulopoulou, T | |
dc.contributor.author | Trembath, RC | |
dc.contributor.author | Treutlein, J | |
dc.contributor.author | Trubetskoy, V | |
dc.contributor.author | Turecki, G | |
dc.contributor.author | Vaaler, AE | |
dc.contributor.author | Vedder, H | |
dc.contributor.author | Vieta, E | |
dc.contributor.author | Vincent, J | |
dc.contributor.author | Visscher, PM | |
dc.contributor.author | Viswanathan, AC | |
dc.contributor.author | Vukcevic, D | |
dc.contributor.author | Waddington, J | |
dc.contributor.author | Waller, M | |
dc.contributor.author | Walsh, D | |
dc.contributor.author | Walshe, M | |
dc.contributor.author | Walters, JTR | |
dc.contributor.author | Wang, D | |
dc.contributor.author | Wang, Q | |
dc.contributor.author | Wang, W | |
dc.contributor.author | Wang, Y | |
dc.contributor.author | Watson, SJ | |
dc.contributor.author | Webb, BT | |
dc.contributor.author | Weickert, TW | |
dc.contributor.author | Weinberger, DR | |
dc.contributor.author | Weisbrod, M | |
dc.contributor.author | Weiser, M | |
dc.contributor.author | Werge, T | |
dc.contributor.author | Weston, P | |
dc.contributor.author | Whittaker, P | |
dc.contributor.author | Widaa, S | |
dc.contributor.author | Wiersma, D | |
dc.contributor.author | Wildenauer, DB | |
dc.contributor.author | Williams, NM | |
dc.contributor.author | Williams, S | |
dc.contributor.author | Witt, SH | |
dc.contributor.author | Wolen, AR | |
dc.contributor.author | Wong, EHM | |
dc.contributor.author | Wood, NW | |
dc.contributor.author | Wormley, BK | |
dc.contributor.author | Wu, JQ | |
dc.contributor.author | Xi, S | |
dc.contributor.author | Xu, W | |
dc.contributor.author | Young, AH | |
dc.contributor.author | Zai, CC | |
dc.contributor.author | Zandi, P | |
dc.contributor.author | Zhang, P | |
dc.contributor.author | Zheng, X | |
dc.contributor.author | Zimprich, F | |
dc.contributor.author | Zollner, S | |
dc.contributor.author | Corvin, A | |
dc.contributor.author | Fanous, AH | |
dc.contributor.author | Cichon, S | |
dc.contributor.author | Rietschel, M | |
dc.contributor.author | Gershon, ES | |
dc.contributor.author | Schulze, TG | |
dc.contributor.author | Cuellar-Barboza, AB | |
dc.contributor.author | Forstner, AJ | |
dc.contributor.author | Holmans, PA | |
dc.contributor.author | Nurnberger, JI | |
dc.contributor.author | Andreassen, OA | |
dc.contributor.author | Lee, SH | |
dc.contributor.author | O’Donovan, MC | |
dc.contributor.author | Sullivan, PF | |
dc.contributor.author | Ophoff, RA | |
dc.contributor.author | Wray, NR | |
dc.contributor.author | Sklar, P | |
dc.contributor.author | Kendler, KS | |
dc.date.accessioned | 2018-09-10T18:32:50Z | |
dc.date.available | 2018-09-10T18:32:50Z | |
dc.date.issued | 2018-06-14 | |
dc.identifier.issn | 0092-8674 | |
dc.identifier.issn | 1097-4172 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/12333 | |
dc.description | publisher: Elsevier articletitle: Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes journaltitle: Cell articlelink: https://doi.org/10.1016/j.cell.2018.05.046 content_type: article copyright: © 2018 Elsevier Inc. | |
dc.description.abstract |
Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology. Understanding the genetic factors contributing to the shared and disorder-specific symptoms will be crucial for improving diagnosis and treatment. In genetic data consisting of 53,555 cases (20,129 bipolar disorder [BD], 33,426 schizophrenia [SCZ]) and 54,065 controls, we identified 114 genome-wide significant loci implicating synaptic and neuronal pathways shared between disorders. Comparing SCZ to BD (23,585 SCZ, 15,270 BD) identified four genomic regions including one with disorder-independent causal variants and potassium ion response genes as contributing to differences in biology between the disorders. Polygenic risk score (PRS) analyses identified several significant correlations within case-only phenotypes including SCZ PRS with psychotic features and age of onset in BD. For the first time, we discover specific loci that distinguish between BD and SCZ and identify polygenic components underlying multiple symptom dimensions. These results point to the utility of genetics to inform symptomology and potential treatment. | |
dc.format.extent | 1705-1715.e16 | |
dc.format.medium | ||
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Elsevier (Cell Press) | |
dc.subject | bipolar disorder | |
dc.subject | polygenic risk | |
dc.subject | psychosis | |
dc.subject | schizophrenia | |
dc.subject | subphenotypes | |
dc.subject | Bipolar Disorder | |
dc.subject | Case-Control Studies | |
dc.subject | Genetic Loci | |
dc.subject | Genome-Wide Association Study | |
dc.subject | Humans | |
dc.subject | Multifactorial Inheritance | |
dc.subject | Odds Ratio | |
dc.subject | Phenotype | |
dc.subject | Risk | |
dc.subject | Schizophrenia | |
dc.subject | White People | |
dc.title | Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Research Support, N.I.H., Extramural | |
dc.type | Research Support, Non-U.S. Gov't | |
plymouth.author-url | https://www.ncbi.nlm.nih.gov/pubmed/29906448 | |
plymouth.issue | 7 | |
plymouth.volume | 173 | |
plymouth.publication-status | Published | |
plymouth.journal | Cell | |
dc.identifier.doi | 10.1016/j.cell.2018.05.046 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
dc.publisher.place | United States | |
dcterms.dateAccepted | 2018-05-21 | |
dc.rights.embargodate | 2019-6-14 | |
dc.identifier.eissn | 1097-4172 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1016/j.cell.2018.05.046 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2018-06-14 | |
rioxxterms.type | Journal Article/Review |