ORCID
- Fouragnan, Elsa: 0000-0003-1485-0332
Abstract
The causal role of an area within a neural network can be determined by interfering with its activity and measuring the impact. Many current reversible manipulation techniques have limitations preventing their application, particularly in deep areas of the primate brain. Here, we demonstrate that a focused transcranial ultrasound stimulation (TUS) protocol impacts activity even in deep brain areas: a subcortical brain structure, the amygdala (experiment 1), and a deep cortical region, the anterior cingulate cortex (ACC, experiment 2), in macaques. TUS neuromodulatory effects were measured by examining relationships between activity in each area and the rest of the brain using functional magnetic resonance imaging (fMRI). In control conditions without sonication, activity in a given area is related to activity in interconnected regions, but such relationships are reduced after sonication, specifically for the targeted areas. Dissociable and focal effects on neural activity could not be explained by auditory confounds.
DOI
10.1016/j.neuron.2019.01.019
Publication Date
2019-02-11
Publication Title
Neuron
ISSN
0896-6273
Embargo Period
2020-02-11
Organisational Unit
School of Psychology
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.
Recommended Citation
Folloni, D., Verhagen, L., Mars, R., Fouragnan, E., Constans, C., Aubry, J., Rushworth, M., & Sallet, J. (2019) 'Manipulation of subcortical and deep cortical activity in the primate brain using transcranial focused ultrasound stimulation', Neuron, . Available at: https://doi.org/10.1016/j.neuron.2019.01.019
