ORCID
- Rohit Shankar: 0000-0002-1183-6933
- Lance Watkins: 0000-0002-0447-5906
Abstract
Background: Sudden Unexpected Death in Epilepsy (SUDEP) is a leading cause of mortality among people withepilepsy (PWE). Risk factors such as increased seizure frequency, drug-resistant epilepsy, and early epilepsy onsetare well recognised. However, little evidence of the role of seizure severity, specifically Status Epilepticus (SE) onSUDEP risk exists.Objective: To identify mechanisms, risk factors and clinical characteristics overlap between SE and SUDEP.Methods: A scoping review using the PRISMA-ScR model was performed by two reviewers using suitable searchterms. The PubMed Advanced Search tool along with the ancestry method was utilised to identify suitable articles published between 06/1992 and 05/2023. Quantitative, qualitative and mixed method studies wereincluded. A narrative synthesis was undertaken and is presented as themes and subthemes.Results: Of 5453 papers identified in the preliminary search, 50 studies were suitable for final analysis. Keythemes include overlap between SE complications and SUDEP risk factors (pharmaco-resistant generalised tonicclonic epilepsy, intellectual disability), overlap of shared risk factors (alcohol abuse, developmental epilepticencephalopathies) and clinical characteristics (cardiac and respiratory). SE’s role in development of drug-resistantepilepsy was the strongest potential mechanism for SE’s contribution to SUDEP risk. SE’s contribution torecurrent ictal hypoxaemia episodes and lowered heart rate variability suggests a relationship with SUDEPneeding further study.Conclusions: This review identifies research areas of influence of SE on SUDEP risk. Such research could informcounselling for patients concerned about seizure severity in relation to their SUDEP risk and optimise surveillance and subsequent management of post-SE epileptogenic outcomes.
DOI
10.1016/j.yebeh.2024.110085
Publication Date
2024-10-09
Publication Title
Epilepsy and Behavior
Volume
160
ISSN
1525-5050
Keywords
Status Epilepticus, SUDEP, Epilepsy, Risk factor, Mortality
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Shankar, R., Puras, Z., Richardson, S., & Watkins, L. (2024) 'Status Epilepticus a risk factor for Sudden Unexpected Death in Epilepsy (SUDEP): A scoping review and narrative synthesis', Epilepsy and Behavior, 160. Available at: https://doi.org/10.1016/j.yebeh.2024.110085
