ORCID

Abstract

Objective To identify the barriers and facilitators that influence the dissemination of clinical practice guidelines (CPGs) and to explore the perceived usefulness, practical utility, expectations, and unmet needs of end users in relation to current dissemination strategies. Methods This qualitative evidence synthesis (QES) is a part of mixed-methods evidence synthesis. We searched literature from MEDLINE, Embase, CINAHL, Web of Science, Scopus, Epistemonikos, and Agency for Healthcare Research and Quality and Medical Guidelines Clearing house on January 30, 2025. Screening, data extraction and quality appraisal of the included studies were done by at least two authors independently and in duplicate. We performed reflexive thematic analysis of the data related to barriers, facilitators, usefulness, utility, and unmet needs of dissemination products and channels. We assessed the confidence of evidence following the GRADE CERQual methods. Results We screened 31,853 titles and abstracts and found 40 eligible studies to be included in this QES. We identified themes related to barriers and facilitators, practical utility and usefulness, unmet needs of dissemination products, and unmet needs of dissemination channels. Key barriers were weak institutional support, language barriers, skepticism, low awareness, and lack of training programs. Main facilitators were related to leadership and institutional support, consumer and stakeholder involvement, training, and multichannel dissemination. We identified the dissemination strategies that were perceived as useful when focused on improving clinical decision-making and encouraging organization adoption. Key aspects related to practical utility were the improved communication between health-care professionals and patients or carers and better understandability of the guidelines when presented using simple layouts, visual features, and multiple channels including social media. Unmet needs related to dissemination products included a demand for cultural and linguistic inclusivity, active promotion of guidelines, easier navigation through digital formats, and training support for implementation. The key unmet need related to dissemination channels was the visibility and awareness of channels. Conclusion This QES identified key barriers and facilitators of dissemination strategies including unmet needs regarding the products and channels used in these strategies. The results can further inform organizations that develop and disseminate CPGs.

Publication Date

2026-08-01

Publication Title

Journal of Clinical Epidemiology

Volume

196

ISSN

0895-4356

Acceptance Date

2026-04-29

Deposit Date

2026-08-20

Funding

The work was supported by the GELA (Global Evidence, Local Adaptation) project funded by the European and Developing Countries Clinical Trials Partnership implementing the ‘EDCTP2 Program’ (grant agreement number: RIA2020S-3303 GELA RIA2020S). The MAGIC Evidence Ecosystem Foundation, a not-for profit organization, provided the additional support so that the evidence synthesis may take a global perspective beyond the GELA project's focus on sub-Saharan Africa.

Keywords

Barriers, Channels, Clinical practice guidelines, Dissemination, Facilitators, Formats, Needs, Recommendations, Usefulness, Utility

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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