ORCID
- Sumanth Kumbargere Nagraj: 0000-0003-1798-3245
Abstract
This systematic review and meta-analysis aims to address whether age can be a determinant of overall survival (OS), disease-free survival (DFS), recurrence, distant metastasis (DM) and second primary (SP) in surgically treated oral and oropharyngeal squamous cell carcinoma (OOPSCC). A total of 4981 cases and 44254 controls from 25 comparative observational studies were included in the analysis. A significantly better OS (matched subgroup analysis: OR 1.64; 95% CI 1.31–2.04, overall analysis: OR 1.48; 95% CI 1.09–2.01) was observed in young patients compared to older adults, with heterogeneity ranging from moderate to severe. Worse DFS (unmatched subgroup analysis OR 0.43; 95% CI 0.27–0.68) was observed in young patients compared to older adults with minimal to moderate heterogeneity. The frequency of recurrence (OR 1.49; 95% CI 1.10–2.02) and DM (OR 1.83; 95% CI 1.10–3.03) was significantly higher in the young patients, as found in unmatched and matched subgroup analysis, with the least heterogeneities. Young age can be considered as an independent prognostic factor for recurrence and distant metastases in OOP-SCC. Larger and methodologically robust observational studies with longer follow-up are needed to establish the definitive role of age as an independent prognostic factor on OS and DFS in OOPSCC.
DOI
10.3390/cancers14081886
Publication Date
2022-04-08
Publication Title
Cancers
Volume
14
Issue
8
ISSN
2072-6694
Keywords
disease-free survival, distant metastasis, oral carcinoma, oropharyngeal squamous cell carcinoma, overall survival, recurrence, second primary, systematic review
Recommended Citation
Panda, S., Lapinska, B., Mohanty, N., Panda, S., Mishra, L., Gopinath, D., Sahoo, A., & Nagraj, S. (2022) 'Are Survival Outcomes Different for Young and Old Patients with Oral and Oropharyngeal Squamous Cell Carcinoma? A Systematic Review and Meta-Analysis', Cancers, 14(8). Available at: https://doi.org/10.3390/cancers14081886
