ORCID

Abstract

Well-being captures an individual’s capacity to lead a mean ingful and engaged life. Interventions to address well-being go beyond managing symptoms or supporting daily activity performance. Designing trials to evaluate the effectiveness of such well-being interventions can be challenging. One such challenge is determining what the comparator or control arm should be. Several trials of complex interventions use usual care as a comparator, but this can be particularly challenging when planning trials across multiple countries and health care systems. Therefore, trial design decisions must be informed by a good understanding of what constitutes usual or routine well-being interventions across locations. Our international, multidisciplinary team’s efforts to develop this understand ing across our 8 countries found that efforts to support the well-being of people with progressive multiple sclerosis vary widely. This variability emphasizes the importance of having a consistent way to collect data and report on the components of usual well-being care to inform trial design.

Publication Date

2025-07-24

Publication Title

International Journal of MS Care

Volume

27

Issue

Theme

ISSN

1537-2073

Acceptance Date

2025-03-17

Deposit Date

2026-04-30

Funding

This editorial stems from the project “Living Well With Progressive Multiple Sclerosis” (chief investigator: Roshan das Nair) funded by the International Progressive MS Alliance (Grant PA-2304-41125).

Keywords

usual care, well-being, trial design

First Page

27

Last Page

31

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