Genome wide significant locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar Type.
dc.contributor.author | Green, Elaine | |
dc.date.accessioned | 2017-08-30T09:59:03Z | |
dc.date.issued | 2017-08-29 | |
dc.identifier.issn | 1552-4841 | |
dc.identifier.issn | 1552-485X | |
dc.identifier.uri | http://hdl.handle.net/10026.1/9879 | |
dc.description.abstract |
Studies have suggested that Research Diagnostic Criteria for Schizoaffective Disorder Bipolar type (RDC-SABP) might identify a more genetically homogenous subgroup of bipolar disorder. Aiming to identify loci associated with RDC-SABP, we have performed a replication study using independent RDC-SABP cases (n = 144) and controls (n = 6,559), focusing on the 10 loci that reached a p-value <10-5 for RDC-SABP in the Wellcome Trust Case Control Consortium (WTCCC) bipolar disorder sample. Combining the WTCCC and replication datasets by meta-analysis (combined RDC-SABP, n = 423, controls, n = 9,494), we observed genome-wide significant association at one SNP, rs2352974, located within the intron of the gene TRAIP on chromosome 3p21.31 (p-value, 4.37 × 10-8 ). This locus did not reach genome-wide significance in bipolar disorder or schizophrenia large Psychiatric Genomic Consortium datasets, suggesting that it may represent a relatively specific genetic risk for the bipolar subtype of schizoaffective disorder. | |
dc.format.extent | 767-771 | |
dc.format.medium | Print-Electronic | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Wiley | |
dc.subject | Research Diagnostic Criteria | |
dc.subject | SABP | |
dc.subject | schizoaffective disorder bipolar type | |
dc.subject | TRAIP | |
dc.title | Genome wide significant locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar Type. | |
dc.type | journal-article | |
dc.type | Journal Article | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000415128100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 8 | |
plymouth.volume | 174 | |
plymouth.publication-status | Published | |
plymouth.journal | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics | |
dc.identifier.doi | 10.1002/ajmg.b.32572 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/School of Biomedical Sciences | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
dc.publisher.place | United States | |
dcterms.dateAccepted | 2017-06-30 | |
dc.rights.embargodate | 2018-8-29 | |
dc.identifier.eissn | 1552-485X | |
dc.rights.embargoperiod | 12 months | |
rioxxterms.versionofrecord | 10.1002/ajmg.b.32572 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/under-embargo-all-rights-reserved | |
rioxxterms.licenseref.startdate | 2017-08-29 | |
rioxxterms.type | Journal Article/Review |