Chemotherapy Dosing Part II: Alternative Approaches and Future Prospects

Date
2007Author
Sewell, GJ
Kaestner, S
Subject
Animals Antineoplastic Agents Carboplatin Dose-Response Relationship, Drug Drug Monitoring Humans Models, Biological Neoplasms
Metadata
Show full item recordAbstract
This overview follows on from part I, which described the current practices used in chemotherapy dosing and the paucity of scientific evidence to support them. In part II, alternative approaches are discussed, both in terms of scientific rationale and practical application. These include therapeutic drug monitoring, the use of pharmacokinetic-pharmacodynamic relationships, flat-fixed dosing, Bayesian modelling and dose banding.
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Publisher
Elsevier BV
Place of Publication
England
Journal
Clinical Oncology
Volume
19
Issue
2
Pagination
99-107
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