On the mechanism by which dietary nitrate improves human skeletal muscle function
dc.contributor.author | Affourtit, C | |
dc.contributor.author | Bailey, SJ | |
dc.contributor.author | Jones, AM | |
dc.contributor.author | Smallwood, MJ | |
dc.contributor.author | Winyard, PG | |
dc.date.accessioned | 2015-08-20T07:22:03Z | |
dc.date.available | 2015-08-20T07:22:03Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1664-042X | |
dc.identifier.issn | 1664-042X | |
dc.identifier.other | ARTN 211 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/3531 | |
dc.description.abstract |
Inorganic nitrate is present at high levels in beetroot and celery, and in green leafy vegetables such as spinach and lettuce. Though long believed inert, nitrate can be reduced to nitrite in the human mouth and, further, under hypoxia and/or low pH, to nitric oxide. Dietary nitrate has thus been associated favorably with nitric-oxide-regulated processes including blood flow and energy metabolism. Indeed, the therapeutic potential of dietary nitrate in cardiovascular disease and metabolic syndrome-both aging-related medical disorders-has attracted considerable recent research interest. We and others have shown that dietary nitrate supplementation lowers the oxygen cost of human exercise, as less respiratory activity appears to be required for a set rate of skeletal muscle work. This striking observation predicts that nitrate benefits the energy metabolism of human muscle, increasing the efficiency of either mitochondrial ATP synthesis and/or of cellular ATP-consuming processes. In this mini-review, we evaluate experimental support for the dietary nitrate effects on muscle bioenergetics and we critically discuss the likelihood of nitric oxide as the molecular mediator of such effects. | |
dc.format.extent | 211- | |
dc.format.medium | Electronic-eCollection | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | Frontiers Media SA | |
dc.subject | dietary nitrate | |
dc.subject | nitrite | |
dc.subject | nitric oxide | |
dc.subject | oxygen cost of human exercise | |
dc.subject | cellular bioenergetics | |
dc.subject | skeletal muscle mitochondria | |
dc.subject | coupling efficiency of oxidative phosphorylation | |
dc.subject | ATP turnover | |
dc.title | On the mechanism by which dietary nitrate improves human skeletal muscle function | |
dc.type | journal-article | |
dc.type | Review | |
plymouth.author-url | https://www.ncbi.nlm.nih.gov/pubmed/26283970 | |
plymouth.issue | JUL | |
plymouth.volume | 6 | |
plymouth.publication-status | Published online | |
plymouth.journal | Frontiers in Physiology | |
dc.identifier.doi | 10.3389/fphys.2015.00211 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/School of Biomedical Sciences | |
plymouth.organisational-group | /Plymouth/PS - Doctoral College | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dc.publisher.place | Switzerland | |
dcterms.dateAccepted | 2015-07-14 | |
dc.identifier.eissn | 1664-042X | |
dc.rights.embargoperiod | No embargo | |
rioxxterms.versionofrecord | 10.3389/fphys.2015.00211 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2015 | |
rioxxterms.type | Journal Article/Review | |
plymouth.funder | Why do pancreatic beta cells waste energy?::MRC |