Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo
dc.contributor.author | Spiess, K | |
dc.contributor.author | Jeppesen, MG | |
dc.contributor.author | Malmgaard-Clausen, M | |
dc.contributor.author | Krzywkowski, K | |
dc.contributor.author | Dulal, K | |
dc.contributor.author | Cheng, T | |
dc.contributor.author | Hjortø, GM | |
dc.contributor.author | Larsen, O | |
dc.contributor.author | Burg, JS | |
dc.contributor.author | Jarvis, MA | |
dc.contributor.author | Garcia, KC | |
dc.contributor.author | Zhu, H | |
dc.contributor.author | Kledal, TN | |
dc.contributor.author | Rosenkilde, MM | |
dc.date.accessioned | 2023-11-02T15:30:21Z | |
dc.date.available | 2023-11-02T15:30:21Z | |
dc.date.issued | 2015-07-07 | |
dc.identifier.issn | 0027-8424 | |
dc.identifier.issn | 1091-6490 | |
dc.identifier.uri | https://pearl.plymouth.ac.uk/handle/10026.1/21559 | |
dc.description.abstract |
<jats:title>Significance</jats:title> <jats:p>All drugs currently used for the clinical treatment of human cytomegalovirus (HCMV) infection are associated with considerable adverse side effects and with the development of drug resistance that results in therapy failure. Here we describe a novel, rationally designed fusion toxin protein (FTP)-based strategy to target HCMV on the basis of its virally expressed G protein-coupled receptor (US28) and cognate chemokine ligand. Viral G protein-coupled receptors are expressed by a number of other clinically important viruses. We suggest that FTP-based molecules targeting virally expressed 7TM receptors may represent a new class of drugs amenable for development against complex viral pathogens.</jats:p> | |
dc.format.extent | 8427-8432 | |
dc.format.medium | Print-Electronic | |
dc.language | en | |
dc.publisher | Proceedings of the National Academy of Sciences | |
dc.subject | HCMV | |
dc.subject | 7TM GPCR | |
dc.subject | protein engineering | |
dc.subject | antiviral drug | |
dc.subject | chemokine | |
dc.title | Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo | |
dc.type | journal-article | |
dc.type | Article | |
plymouth.author-url | https://www.ncbi.nlm.nih.gov/pubmed/26080445 | |
plymouth.issue | 27 | |
plymouth.volume | 112 | |
plymouth.publication-status | Published | |
plymouth.journal | Proceedings of the National Academy of Sciences | |
dc.identifier.doi | 10.1073/pnas.1509392112 | |
plymouth.organisational-group | |Plymouth | |
plymouth.organisational-group | |Plymouth|Research Groups | |
plymouth.organisational-group | |Plymouth|Faculty of Health | |
plymouth.organisational-group | |Plymouth|Research Groups|Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | |Plymouth|Research Groups|Institute of Translational and Stratified Medicine (ITSMED)|CBR | |
plymouth.organisational-group | |Plymouth|REF 2021 Researchers by UoA | |
plymouth.organisational-group | |Plymouth|Users by role | |
plymouth.organisational-group | |Plymouth|Users by role|Academics | |
plymouth.organisational-group | |Plymouth|REF 2021 Researchers by UoA|UoA01 Clinical Medicine | |
plymouth.organisational-group | |Plymouth|Faculty of Health|School of Biomedical Sciences | |
dc.publisher.place | United States | |
dc.date.updated | 2023-11-02T15:30:20Z | |
dc.identifier.eissn | 1091-6490 | |
dc.rights.embargoperiod | forever | |
rioxxterms.versionofrecord | 10.1073/pnas.1509392112 |