Molnupiravir inhibits SARS-CoV-2 variants including Omicron in the hamster model
dc.contributor.author | Rosenke, K | |
dc.contributor.author | Okumura, A | |
dc.contributor.author | Lewis, MC | |
dc.contributor.author | Feldmann, F | |
dc.contributor.author | Meade-White, K | |
dc.contributor.author | Bohler, WF | |
dc.contributor.author | Griffin, A | |
dc.contributor.author | Rosenke, R | |
dc.contributor.author | Shaia, C | |
dc.contributor.author | Jarvis, Michael A | |
dc.contributor.author | Feldmann, H | |
dc.date.accessioned | 2022-05-24T08:44:05Z | |
dc.date.available | 2022-05-24T08:44:05Z | |
dc.date.issued | 2022-07-08 | |
dc.identifier.issn | 2379-3708 | |
dc.identifier.issn | 2379-3708 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/19258 | |
dc.description.abstract |
The effectiveness of exercise and physical therapy for children with ataxia is poorly understood. The aim of this systematic review was to critically evaluate the range, scope and methodological quality of studies investigating the effectiveness of exercise and physical therapy interventions for children with ataxia. The following databases were searched: AMED, CENTRAL, CDSR, CINAHL, ClinicalTrials.gov, EMBASE, Ovid MEDLINE, PEDro and Web of Science. No limits were placed on language, type of study or year of publication. Two reviewers independently determined whether the studies met the inclusion criteria, extracted all relevant outcomes, and conducted methodological quality assessments. A total of 1988 studies were identified, and 124 full texts were screened. Twenty studies were included in the review. A total of 40 children (aged 5-18 years) with ataxia as a primary impairment participated in the included studies. Data were able to be extracted from eleven studies with a total of 21 children (aged 5-18 years), with a range of cerebellar pathology. The studies reported promising results but were of low methodological quality (no RCTs), used small sample sizes and were heterogeneous in terms of interventions, participants and outcomes. No firm conclusions can be made about the effectiveness of exercise and physical therapy for children with ataxia. There is a need for further high-quality child-centred research. | |
dc.format.extent | e160108- | |
dc.format.medium | Electronic | |
dc.language | en | |
dc.language.iso | eng | |
dc.publisher | American Society for Clinical Investigation | |
dc.subject | COVID-19 | |
dc.subject | Drug therapy | |
dc.subject | Mouse models | |
dc.subject | Virology | |
dc.subject | Animals | |
dc.subject | Cricetinae | |
dc.subject | Cytidine | |
dc.subject | Humans | |
dc.subject | Hydroxylamines | |
dc.subject | SARS-CoV-2 | |
dc.subject | COVID-19 Drug Treatment | |
dc.title | Molnupiravir inhibits SARS-CoV-2 variants including Omicron in the hamster model | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Research Support, N.I.H., Intramural | |
dc.type | Research Support, Non-U.S. Gov't | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000824846400001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 13 | |
plymouth.volume | 7 | |
plymouth.publication-status | Published | |
plymouth.journal | JCI Insight | |
dc.identifier.doi | 10.1172/jci.insight.160108 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/School of Biomedical Sciences | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dc.publisher.place | United States | |
dcterms.dateAccepted | 2022-05-13 | |
dc.rights.embargodate | 2023-3-1 | |
dc.identifier.eissn | 2379-3708 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1172/jci.insight.160108 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.type | Journal Article/Review |