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dc.contributor.authorHughes, SW
dc.contributor.authorHellyer, PJ
dc.contributor.authorSharp, DJ
dc.contributor.authorNewbould, RD
dc.contributor.authorPatel, MC
dc.contributor.authorStrutton, PH
dc.date.accessioned2020-07-29T12:30:44Z
dc.date.issued2020-06
dc.identifier.issn0730-725X
dc.identifier.issn1873-5894
dc.identifier.urihttp://hdl.handle.net/10026.1/16115
dc.description.abstract

The outcomes from spinal nerve decompression surgery are highly variable with a sizable proportion of elderly foraminal stenosis patients not regaining good pain relief. A better understanding of nerve root compression before and following decompression surgery and whether these changes are mirrored by improvements in symptoms may help to improve clinical decision-making processes. This case study used a combination of diffusion tensor imaging (DTI), clinical questionnaires and motor neurophysiology assessments before and up to 3 months following spinal decompression surgery. In this case report, a 70-year-old women with compression of the left L5 spinal nerve root in the L5-S1 exit foramina was recruited to the study. At 3 months following surgery, DTI revealed marked improvements in left L5 microstructural integrity to a similar level to that seen in the intact right L5 nerve root. This was accompanied by a gradual improvement in pain-related symptoms, mood and disability score by 3 months. Using this novel multimodal approach, it may be possible to track concurrent improvements in pain-related symptoms, function and microstructural integrity of compressed nerves in elderly foraminal stenosis patients undergoing decompression surgery.

dc.format.extent65-70
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoen
dc.publisherElsevier BV
dc.subjectDiffusion tensor imaging
dc.subjectSurgery
dc.subjectPain
dc.subjectMotor Function
dc.subjectSymptoms
dc.subjectStenosis
dc.titleDiffusion tensor imaging of lumbar spinal nerves reveals changes in microstructural integrity following decompression surgery associated with improvements in clinical symptoms: A case report
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/32084517
plymouth.volume69
plymouth.publisher-urlhttp://dx.doi.org/10.1016/j.mri.2020.02.007
plymouth.publication-statusPublished
plymouth.journalMagnetic Resonance Imaging
dc.identifier.doi10.1016/j.mri.2020.02.007
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Psychology
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA04 Psychology, Psychiatry and Neuroscience
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA04 Psychology, Psychiatry and Neuroscience/UoA04 Psychology, Psychiatry and Neuroscience MANUAL
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeNetherlands
dcterms.dateAccepted2020-02-12
dc.rights.embargodate2021-2-19
dc.identifier.eissn1873-5894
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1016/j.mri.2020.02.007
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-06
rioxxterms.typeJournal Article/Review


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