Designing clinical trials for future space missions as a pathway to changing how clinical trials are conducted on Earth
dc.contributor.author | Nasser, Mona | |
dc.contributor.author | Peres, N | |
dc.contributor.author | Knight, J | |
dc.contributor.author | Haines, A | |
dc.contributor.author | Young, C | |
dc.contributor.author | Maranan, D | |
dc.contributor.author | Wright, J | |
dc.contributor.author | Carvil, P | |
dc.contributor.author | Robinson, K | |
dc.contributor.author | Westmore, M | |
dc.contributor.author | Griffin, Joanna | |
dc.contributor.author | Halkes, M | |
dc.date.accessioned | 2020-05-27T14:02:56Z | |
dc.date.available | 2020-05-27T14:02:56Z | |
dc.date.issued | 2020-05-29 | |
dc.identifier.issn | 1756-5383 | |
dc.identifier.issn | 1756-5391 | |
dc.identifier.other | jebm.12391 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/15709 | |
dc.description.abstract |
<jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>The project aims to build a framework for conducting clinical trials for long‐term interplanetary missions to contribute to innovation in clinical trials on Earth, especially around patient involvement and ownership.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We conducted two workshops in which participants were immersed in the speculative scenario of an interplanetary mission in which health problems emerged that required medical trials to resolve. The workshops used virtual reality and live simulation to mimic a zero‐gravity environment and visual perception shifts and were followed by group discussion.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Some key aspects for the framework that emerged from the workshops included: (a) approaches to be inclusive in the management of the trial, (b) approaches to be inclusive in designing the research project (patient preference trials, n‐of‐1 trials, designing clinical trials to be part of a future prospective meta‐analysis, etc), (c) balancing the research needs and the community needs (eg, allocation of the participants based on both research and community need), (d) ethics and partnerships (ethics and consent issues and how they relate to partnerships and relationships).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>In identifying some key areas that need to be incorporated in future planning of clinical trials for interplanetary missions, we also identified areas that are relevant to engaging patients in clinical trials on Earth. We will suggest using the same methodology to facilitate more in‐depth discussions on specific aspects of clinical trials in aerospace medicine. The methodology can be more widely used in other areas to open new inclusive conversations around innovating research methodology.</jats:p></jats:sec> | |
dc.format.extent | 153-160 | |
dc.format.medium | Print-Electronic | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Wiley | |
dc.subject | clinical trial methodology | |
dc.subject | clinical trial | |
dc.subject | evidence-based healthcare | |
dc.subject | medical simulation | |
dc.subject | research methodology | |
dc.subject | space mission | |
dc.title | Designing clinical trials for future space missions as a pathway to changing how clinical trials are conducted on Earth | |
dc.type | journal-article | |
dc.type | Journal Article | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000678095900008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 2 | |
plymouth.volume | 13 | |
plymouth.publication-status | Published | |
plymouth.journal | Journal of Evidence-Based Medicine | |
dc.identifier.doi | 10.1111/jebm.12391 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Admin Group - REF | |
plymouth.organisational-group | /Plymouth/Admin Group - REF/REF Admin Group - FoH | |
plymouth.organisational-group | /Plymouth/Faculty of Arts, Humanities and Business | |
plymouth.organisational-group | /Plymouth/Faculty of Arts, Humanities and Business/School of Art, Design and Architecture | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Dental School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Health and Community | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CCT&PS | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dc.publisher.place | England | |
dcterms.dateAccepted | 2020-04-22 | |
dc.rights.embargodate | 2020-6-6 | |
dc.identifier.eissn | 1756-5391 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1111/jebm.12391 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2020-05-29 | |
rioxxterms.type | Journal Article/Review |