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dc.contributor.authorQueirazza, Fen
dc.contributor.authorFouragnan, Een
dc.contributor.authorSteele, JDen
dc.contributor.authorCavanagh, Jen
dc.contributor.authorPhiliastides, MGen
dc.date.accessioned2019-08-21T14:46:39Z
dc.date.issued2019-07en
dc.identifier.urihttp://hdl.handle.net/10026.1/14807
dc.description.abstract

<jats:p>While cognitive behavioral therapy (CBT) is an effective treatment for major depressive disorder, only up to 45% of depressed patients will respond to it. At present, there is no clinically viable neuroimaging predictor of CBT response. Notably, the lack of a mechanistic understanding of treatment response has hindered identification of predictive biomarkers. To obtain mechanistically meaningful fMRI predictors of CBT response, we capitalize on pretreatment neural activity encoding a weighted reward prediction error (RPE), which is implicated in the acquisition and processing of feedback information during probabilistic learning. Using a conventional mass-univariate fMRI analysis, we demonstrate that, at the group level, responders exhibit greater pretreatment neural activity encoding a weighted RPE in the right striatum and right amygdala. Crucially, using multivariate methods, we show that this activity offers significant out-of-sample classification of treatment response. Our findings support the feasibility and validity of neurocomputational approaches to treatment prediction in psychiatry.</jats:p>

en
dc.format.extenteaav4962 - eaav4962en
dc.languageenen
dc.language.isoenen
dc.publisherAmerican Association for the Advancement of Science (AAAS)en
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.titleNeural correlates of weighted reward prediction error during reinforcement learning classify response to cognitive behavioral therapy in depressionen
dc.typeJournal Article
plymouth.issue7en
plymouth.volume5en
plymouth.journalScience Advancesen
dc.identifier.doi10.1126/sciadv.aav4962en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Health: Medicine, Dentistry and Human Sciences
plymouth.organisational-group/Plymouth/Faculty of Health: Medicine, Dentistry and Human Sciences/School of Psychology
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA04 Psychology, Psychiatry and Neuroscience
dcterms.dateAccepted2019-06-25en
dc.rights.embargodate2019-08-28en
dc.identifier.eissn2375-2548en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1126/sciadv.aav4962en
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
rioxxterms.licenseref.startdate2019-07en
rioxxterms.typeJournal Article/Reviewen


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