Neural correlates of weighted reward prediction error during reinforcement learning classify response to cognitive behavioral therapy in depression
dc.contributor.author | Queirazza, F | |
dc.contributor.author | Fouragnan, Elsa | |
dc.contributor.author | Steele, JD | |
dc.contributor.author | Cavanagh, J | |
dc.contributor.author | Philiastides, MG | |
dc.date.accessioned | 2019-08-21T14:46:39Z | |
dc.date.issued | 2019-07 | |
dc.identifier.issn | 2375-2548 | |
dc.identifier.issn | 2375-2548 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/14807 | |
dc.description.abstract |
<jats:p>While cognitive behavioral therapy (CBT) is an effective treatment for major depressive disorder, only up to 45% of depressed patients will respond to it. At present, there is no clinically viable neuroimaging predictor of CBT response. Notably, the lack of a mechanistic understanding of treatment response has hindered identification of predictive biomarkers. To obtain mechanistically meaningful fMRI predictors of CBT response, we capitalize on pretreatment neural activity encoding a weighted reward prediction error (RPE), which is implicated in the acquisition and processing of feedback information during probabilistic learning. Using a conventional mass-univariate fMRI analysis, we demonstrate that, at the group level, responders exhibit greater pretreatment neural activity encoding a weighted RPE in the right striatum and right amygdala. Crucially, using multivariate methods, we show that this activity offers significant out-of-sample classification of treatment response. Our findings support the feasibility and validity of neurocomputational approaches to treatment prediction in psychiatry.</jats:p> | |
dc.format.extent | eaav4962-eaav4962 | |
dc.format.medium | Electronic-eCollection | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | American Association for the Advancement of Science (AAAS) | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Adult | |
dc.subject | Amygdala | |
dc.subject | Brain | |
dc.subject | Cognitive Behavioral Therapy | |
dc.subject | Depressive Disorder, Major | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Image Processing, Computer-Assisted | |
dc.subject | Magnetic Resonance Imaging | |
dc.subject | Male | |
dc.subject | Neuroimaging | |
dc.subject | Reward | |
dc.title | Neural correlates of weighted reward prediction error during reinforcement learning classify response to cognitive behavioral therapy in depression | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Research Support, Non-U.S. Gov't | |
plymouth.author-url | https://www.ncbi.nlm.nih.gov/pubmed/31392266 | |
plymouth.issue | 7 | |
plymouth.volume | 5 | |
plymouth.publication-status | Published | |
plymouth.journal | Science Advances | |
dc.identifier.doi | 10.1126/sciadv.aav4962 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/School of Psychology | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA04 Psychology, Psychiatry and Neuroscience | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
plymouth.organisational-group | /Plymouth/Users by role/Researchers in ResearchFish submission | |
dc.publisher.place | United States | |
dcterms.dateAccepted | 2019-06-25 | |
dc.rights.embargodate | 2019-8-28 | |
dc.identifier.eissn | 2375-2548 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1126/sciadv.aav4962 | |
rioxxterms.licenseref.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
rioxxterms.licenseref.startdate | 2019-07 | |
rioxxterms.type | Journal Article/Review |