School of Biomedical Sciences: Recent submissions
Now showing items 11-20 of 401
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Hypertension alters the function and expression profile of the peptide cotransporters PEPT1 and PEPT2 in the rodent renal proximal tubule
(Springer Science and Business Media LLCAustria, 2022-07)Hypertension is a major risk factor for kidney and cardiovascular disease. The treatment of hypertensive individuals by selected ACE inhibitors and certain di-and tripeptides halts the progression of renal deterioration ... -
Effect of ageing and hypertension on the expression and activity of PEPT2 in normal and hypertrophic hearts
(Springer Science and Business Media LLCAustria, 2021-02)Some dipeptides have been implicated in myocardial protection, but little is known about their membrane transporter PEPT2. The aim of this study was to determine whether the expression and activity of the cardiac-type ... -
Effect of methionine feeding on oxidative stress, intracellular calcium and contractility in cardiomyocytes isolated from male and female rats
(Springer Science and Business Media LLCNetherlands, 2021-05)Homocysteine (Hcy) is a breakdown product of methionine metabolism. The risk of cardiovascular disease (CVD) correlates with an increase in plasma Hcy levels. The aim of this study was to investigate whether 1% methionine ... -
Transcatheter aortic valve implantation versus surgical aortic valve replacement in dialysis-dependent patients: a meta-analysis
(Lippincott, Williams & WilkinsUnited States, 2023-09)<jats:sec> <jats:title>Objectives</jats:title> <jats:p>This meta-analysis aims to compare the clinical outcomes of transcatheter aortic valve implantation (TAVI) versus aortic valve replacement ... -
Modulation of Zebrafish (Danio rerio) Intestinal Mucosal Barrier Function Fed Different Postbiotics and a Probiotic from Lactobacilli
(MDPI AGSwitzerland, 2023-11-30)It is generally accepted that microbes play a critical role in maintaining gut barrier function, making them ideal to target in order to mitigate the effects of intestinal diseases such as inflammatory bowel disease with ... -
Endotoxin as a Marker for Water Quality
(MDPI AGSwitzerland, 2022-12)Background: Water quality testing is vital to protect human health. Current testing relies mainly on culture-based detection of faecal indicator organisms such as Escherichia coli (E.coli). However, bacterial cultures are ... -
Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen
(Springer Science and Business Media LLCEngland, 2023-08-14)The opportunistic fungal pathogen Cryptococcus neoformans causes lethal infections in immunocompromised patients. Macrophages are central to the host response to cryptococci; however, it is unclear how C. neoformans is ... -
Discovery of a polyomavirus in European badgers (Meles meles) and the evolution of host range in the family Polyomaviridae.
(England, 2015-06)Polyomaviruses infect a diverse range of mammalian and avian hosts, and are associated with a variety of symptoms. However, it is unknown whether the viruses are found in all mammalian families and the evolutionary history ... -
Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo
(Proceedings of the National Academy of SciencesUnited States, 2015-07-07)<jats:title>Significance</jats:title> <jats:p>All drugs currently used for the clinical treatment of human cytomegalovirus (HCMV) infection are associated with considerable adverse side effects and with the ...