School of Biomedical Sciences: Recent submissions
Now showing items 11-20 of 385
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Calculation of ATP production rates using the Seahorse XF Analyzer
(EMBOEngland, 2023-08-07)Oxidative phosphorylation and glycolysis are the dominant ATP-generating pathways in mammalian metabolism. The balance between these two pathways is often shifted to execute cell-specific functions in response to stimuli ... -
Combined molnupiravir-nirmatrelvir treatment improves the inhibitory effect on SARS-CoV-2 in macaques
(American Society for Clinical InvestigationUnited States, 2023-02-22)The periodic emergence of SARS-CoV-2 variants of concern (VOCs) with unpredictable clinical severity and ability to escape preexisting immunity emphasizes the continued need for antiviral interventions. Two small molecule ... -
Bovine Herpesvirus-4 Based Vaccine Provides Protective Immunity against Streptococcus suis Disease in a Rabbit Model
(MDPI AGSwitzerland, 2023-05-20)Streptococcus suis (S. suis) is a bacterial pathogen of pigs that has a major animal health and economic impact on the pig industry. Bovine herpesvirus-4 (BoHV-4) is a new virus-based vaccine vector that has been used for ... -
Pandemic Struggles of the Mad Professor
(Oxford University Press (OUP)United States, 2021-03-16) -
What’s really down the hospital plughole?
(Elsevier BVEngland, 2023-08)As reported in recent articles in this journal and others, hospital wastewater plumbing systems (WPS) are increasingly being highlighted as an important source of nosocomial infections [ [1] , [2] ]. Potential interventions ... -
ErbB- and MUC1-targetted CAR-T cell immunotherapy of oral squamous cell carcinoma
(Frontiers Media SA, 2023-03-13)Chimeric antigen receptor T (CAR-T) cell therapy has shown great success in treating B cell malignancies however, there are many challenges which limit their therapeutic efficacy in solid tumours. Immunotherapy of head ... -
Subunit Vaccine Targeting Phosphate ABC Transporter ATP-Binding Protein, PstB, Provides Cross-Protection against Streptococcus suis Serotype 2, 7, and 9 in Mice
(MDPI AG, 2023-01-09)Streptococcus suis is a significant pathogen in pigs and a newly emerging zoonotic agent in humans. The presence of multiple serotypes and strains with diversified sequence types in pig herds highlights the need for the ... -
Genistein and coumestrol reduce MCF-7 breast cancer cell viability and inhibit markers of preferential metastasis, bone matrix attachment and tumor-induced osteoclastogenesis
(ElsevierUnited States, 2023-05-15)The propensity of breast cancer to preferentially metastasize to the skeleton is well known. Once established in bone metastatic breast cancers have a poor prognosis due to their ability to promote extensive bone loss ... -
The effects of acute hypoxia on cognitive and cardiovascular parameters in healthy subjects
(Academia.edu, 2023-03-16)Background: Hypoxia can affect the health and safety of patients and persons in various occupations. There is uncertainty surrounding the effect acute hypoxia may have on cognition and the cardiovascular system. Aims: The ... -
Whole genomes of deep-sea sponge-associated bacteria exhibit high novel natural product potential
(Oxford University Press (OUP)England, 2023-02-22)Abstract Global antimicrobial resistance is a health crisis that can change the face of modern medicine. Exploring diverse natural habitats for bacterially-derived novel antimicrobial compounds has historically been a ...
