Manipulation of subcortical and deep cortical activity in the primate brain using transcranial focused ultrasound stimulation
dc.contributor.author | Folloni, D | |
dc.contributor.author | Verhagen, L | |
dc.contributor.author | Mars, R | |
dc.contributor.author | Fouragnan, Elsa | |
dc.contributor.author | Constans, C | |
dc.contributor.author | Aubry, J-F | |
dc.contributor.author | Rushworth, MFS | |
dc.contributor.author | Sallet, J | |
dc.date.accessioned | 2019-02-21T10:58:36Z | |
dc.date.issued | 2019-02-11 | |
dc.identifier.issn | 0896-6273 | |
dc.identifier.issn | 1097-4199 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/13330 | |
dc.description | Publisher’s embargo period: Embargo set on 04.03.2019 by SR (TIS). | |
dc.description.abstract |
The causal role of an area within a neural network can be determined by interfering with its activity and measuring the impact. Many current reversible manipulation techniques have limitations preventing their application, particularly in deep areas of the primate brain. Here, we demonstrate that a focused transcranial ultrasound stimulation (TUS) protocol impacts activity even in deep brain areas: a subcortical brain structure, the amygdala (experiment 1), and a deep cortical region, the anterior cingulate cortex (ACC, experiment 2), in macaques. TUS neuromodulatory effects were measured by examining relationships between activity in each area and the rest of the brain using functional magnetic resonance imaging (fMRI). In control conditions without sonication, activity in a given area is related to activity in interconnected regions, but such relationships are reduced after sonication, specifically for the targeted areas. Dissociable and focal effects on neural activity could not be explained by auditory confounds. | |
dc.format.extent | 1109-1116.e5 | |
dc.language | eng | |
dc.language.iso | en | |
dc.publisher | Elsevier | |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
dc.subject | amygdala | |
dc.subject | cingulate cortex | |
dc.subject | functional connectivity | |
dc.subject | limbic | |
dc.subject | macaque monkey | |
dc.subject | neuromodulation | |
dc.subject | resting-state connectivity | |
dc.subject | transcranial stimulation | |
dc.subject | ultrasound | |
dc.subject | Amygdala | |
dc.subject | Animals | |
dc.subject | Brain | |
dc.subject | Brain Mapping | |
dc.subject | Functional Neuroimaging | |
dc.subject | Gyrus Cinguli | |
dc.subject | Macaca | |
dc.subject | Magnetic Resonance Imaging | |
dc.subject | Neural Pathways | |
dc.subject | Ultrasonic Waves | |
dc.title | Manipulation of subcortical and deep cortical activity in the primate brain using transcranial focused ultrasound stimulation | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Research Support, Non-U.S. Gov't | |
plymouth.author-url | https://www.ncbi.nlm.nih.gov/pubmed/30765166 | |
plymouth.issue | 6 | |
plymouth.volume | 101 | |
plymouth.publication-status | Published | |
plymouth.journal | Neuron | |
dc.identifier.doi | 10.1016/j.neuron.2019.01.019 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/School of Psychology | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA04 Psychology, Psychiatry and Neuroscience | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
plymouth.organisational-group | /Plymouth/Users by role/Researchers in ResearchFish submission | |
dc.publisher.place | United States | |
dcterms.dateAccepted | 2019-01-14 | |
dc.rights.embargodate | 2020-2-11 | |
dc.identifier.eissn | 1097-4199 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1016/j.neuron.2019.01.019 | |
rioxxterms.licenseref.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
rioxxterms.licenseref.startdate | 2019-02-11 | |
rioxxterms.type | Journal Article/Review |